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Effects of different doses of glucose and fructose on central metabolic pathways and intercellular wireless communication networks in humans

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food science and Human Wellness 2024年第4期13卷 1906-1916页

作者： Dingqiang Lu Yujiao Liu Miao Zhao Shuai Yuan Danyang Liu Xinqian Wang Yixuan Liu Yifei Zhang Ming Li Yufeng Lü Guangchang Pang Ruijuan Ren college of biotechnology&food science Tianjin University of CommerceTianjin Key Laboratory of Food BiotechnologyTianjin 300314China Tianjin Institute for food Safety Inspection Technology Tianjin 300134China

Fructose and glucose are often widely used in food processing and may contribute to many metabolic *** observe the effects of different doses of glucose and fructose on human metabolism and cellular communication,volunteers were given low,medium,and high doses of glucose and *** cytokines,glucose,lactate,nicotinamide adenine dinucleotide(NADH)and metabolic enzymes were assayed,and central carbon metabolic pathway networks and cytokine communication networks were *** results showed that the glucose and fructose groups basically maintained the trend of decreasing catabolism and increasing anabolism with increasing *** with glucose,low-dose fructose decreased catabolism and increased anabolism,significantly enhanced the expression of the inflammatory cytokine interferon-γ(IFN-γ),macrophage-derived chemokine(MDC),induced protein-10(IP-10),and eotaxin,and significantly reduced the activity of isocitrate dehydrogenase(ICDH)and pyruvate dehydrogenase complexes(PDHC).Both medium and high doses of fructose increase catabolism and anabolism,and there are more cytokines and enzymes with significant ***,multiple cytokines and enzymes show strong relevance to metabolic regulation by altering the transcription and expression of enzymes in central carbon metabolic ***,excessive intake of fructose should be reduced to avoid excessive inflammatory responses,allergic reactions and autoimmune diseases.

关键词： Fructose Glucose Central carbon metabolic pathway Metabolic enzymes Cytokine network

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The interaction mechanism between zein and folic acid in alkaline aqueous solutions:an experimental and molecular simulation study

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food Quality and Safety 2024年第1期8卷 166-178页

作者： Jun Zhu Yiling Yao Yuying Liao Lala Cai Wenqi Zhang Nuo Hong Wenlin Sun Chunhua Xiong Lanying Yao School of food science and biotechnology Zhejiang Gongshang UniversityHangzhouChina

Objectives:Folic acid is a vitamin that is not highly soluble in water and is sensitive to the ***,it is important to find suitable *** study aimed to exemplify the interaction of folic acid with zein in alkaline aqueous solutions and shed light on how zein can be used as a carrier for folic *** and Methods:Zein and folic acid were separately dissolved in NaOH solutions with a PH of *** solution and folic acid solution were combined in specific *** methods including multi-spectroscopy,dynamic light scattering,and electron microscopy combining with molecular dynamics simulations were used to study the interaction mechanism between zein and folic acid in alkaline aqueous ***:Fluorescence spectroscopy showed that the quenching of zein by folic acid was mainly static,and the main driving force behind this interaction was van der Waals forces and hydrogen *** formation of zein–folic acid complexes was confirmed by ultraviolet–visible spectroscopy,Fourier transform infrared spectroscopy,and circular dichroism *** results also showed that the structure of zein changed when it interacted with folic *** light scattering analysis revealed that the addition of folic acid caused proteins to *** aggregates of the complexes had an irregular shape and were large,as observed by scanning electron microscopy and transmission electron *** simulation was used to further investigate the interaction *** to these findings,the folic acid molecule interacted with zein in a shallow recess near the protein *** dominant forces at play in the zein–folic acid interaction were van der Waals forces and electrostatic forces,including hydrogen ***:The zein alkali-soluble system is very suitable for folic acid delivery.

关键词： Zein folic acid alkaline aqueous solutions molecular simulation interaction mechanism.

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Oral administration of Bacillus coagulans TQ-35 alleviates allergic responses in OVA-sensitive BALB/c mice

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food science and Human Wellness 2024年第3期13卷 1246-1257页

作者： Yifan Wang Shanjun Chen Chong Wang Yi Zhang Hongliang Zeng Linglin Fu Yanbo Wang food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China college of food science Fujian Agriculture and Forestry UniversityFuzhou 350002China School of food and Health Beijing Technology and Business UniversityBeijing 100048China

Bacillus coagulans has been extensively studied so far,but there has been a lack of research on its usage in *** this study,we designed to assess the effect of different concentrations of *** on food allergy in a BALB/c mouse model of ovalbumin(OVA)-induced food allergy and its effect on gut *** assessment of symptoms,specific immunoglobulin E(IgE),T-cell differentiation,and related gene expression levels in sensitized mice by assay indicated that high doses of oral *** could alleviate allergic *** with ***,in the high-dose group,significantly reduced IgE and IgG1 levels and modulated the balance of T helper type 1 cell(Th1)and Th2 and the expression of relevant genes in the spleen.16S rRNA analysis showed that probiotics improved the structure of the microbiota,in particular by boosting the percentage of Clostridia,Bacteroides vulgatus and Enterococcus faecium,and by increasing the abundance of microbial species,thereby modulating the immune ***,this study can provide insights into the practical application of *** doses to alleviate OVA allergy.

关键词： Bacillus coagulans TQ-35 food allergy Ovalbumin(OVA) Gut microbiota

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Polyphenol components in black chokeberry(Aronia melanocarpa)as clinically proven diseases control factors——an overview

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food science and Human Wellness 2024年第3期13卷 1152-1167页

作者： Ningxuan Gao Chi Shu Yuehua Wang Jinlong Tian Yuxi Lang Chenyu Jin Xingyue Cui Hanqian Jiang Shi’an Liu Zhiying Li Wei Chen Hao Xu Bin Li Department of food science College of FoodShenyang Agricultural UniversityShenyang 110161China Department of food science and Nutrition College of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058China Chaoyang Beihe food Co. Ltd.Chaoyang 122100China

The black chokeberry is rich in polyphenols,including flavonoids with anthocyanins,flavanols and lavonols as the main components and a variety of phenolic acids represented by chlorogenic *** of these polyphenols,black chokeberry has the effect of preventing and adjuvant therapy *** study summarized the current research results on the types and contents of functional components in black chokeberry,and analyzed their digestion,absorption and metabolism in human *** this basis,the disease control functions that have been proved effective in clinical research were reviewed and *** studies showed that black chokeberry have good prevention and adjuvant therapy effects on hyperlipidemia,hypertension,diabetes and *** there are different functional components in black chokeberry,its prevention and treatment of the same disease can come from multiple pathways,which provides a more reliable effectiveness for the disease control of different populations.

关键词： Black chokeberry Hyperlipidemia Hypertension Diabetes Inflammation

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Selenium nanoparticles biosynthesized by Eurotium cristatum with antimicrobial activity

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food science and Human Wellness 2024年

作者： Nanyang Li Yanru Yang Jianrui Qi Jiahui Li Yifan Cheng Zhao Li Tianli Yue Yahong Yuan college of food science and Engineering Northwest A&F University college of food science and Technology Northwest University Xi'an college of Bioengineering and biotechnology Tianshui Normal University

Selenium nanoparticles (SeNPs) are increasingly recognized for their exceptional antibacterial properties. This study aimed to develop a green， safe， and efficient method for the biosynthesis of SeNPs using the fungus Eurotium cristatum (E. cristatum)， a novel approach in SeNP synthesis. The process yielded (36.4 ± 4.22) mg of SeNPs per 1.2 mmol/L sodium selenite supplementation. These SeNPs exhibited an average diameter of 231.7 nm and a negative charge， and they remained stable when stored at 4℃. UV-vis revealed a maximum absorption peak at 212 nm， suggesting effective nanoparticle formation. FT-IR indicated that proteins and carbohydrates in the mycelium contributed to the SeNP synthesis. Concentrations of SeNPs below 50 μg Se/mL did not exhibit cytotoxic effects on the growth and proliferation of human hepatocyte L-02 cells. The minimum inhibitory concentration of SeNPs was found to be 2 mg/mL against both Methicillin-resistant Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative). The SeNPs compromised the cellular integrity of test strains， causing leakage of intracellular contents and disruption of the oxidative stress system， leading to irreversible damage. Our results demonstrate the potential of SeNPs biosynthesized by E. cristatum to act as effective antibacterial agents， signifying a novel and promising approach to developing natural antimicrobial solutions.

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Enhanced extracellular production of alpha-lactalbumin from Bacillus subtilis through signal peptide and promoter screening

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food science and Human Wellness 2024年第4期13卷 2310-2316页

作者： Yuqi Zhu Pengdong Sun Chunjian Li Yu Zhang Yu Wang Jingyuan Li Yanfeng Liu Jian Chen Yang Deng college of food science and Engineering Qingdao Agricultural UniversityQingdao 266109China Key Laboratory of Special food Processing(Co-construction by Ministry and Province) Ministry of Agriculture Rural AffairsQingdao Agricultural UniversityQingdao 266109China Qingdao Special food Research Institute Qingdao 266109China science Center for Future foods Engineering Research Center of Ministry of Education on Food Synthetic BiotechnologyJiangsu Province Engineering Research Center of Food Synthetic BiotechnologyJiangnan UniversityWuxi 214122China Key Laboratory of Carbohydrate Chemistry and biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China

Alpha-lactalbumin(α-LA)is a major whey protein found in breast milk and plays a crucial role in the growth and development of *** this study,Bacillus subtilis RIK1285 harboring AprE signal peptide(SP)was selected as the original strain for the production ofα-*** was found thatα-LA was identified in the pellet after ultrasonic disruption and centrifugation instead of in the fermentation *** original strain most likely only producedα-LA intracellular,but not *** improve the expression and secretion ofα-LA in RIK1285,a library of 173 homologous SPs from the *** 168 genome was fused with target LALBA gene in the pBE-S vector and expressed extracellularly in *** YjcN was determined to be the best signal *** in supernatant were observed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and purified by nickel column to calculate the highest yield signal *** addition,different promoters(P_(aprE),P_(43),and P_(glv))were compared and *** results indicated that the strain RIK1285-pBE-P_(glv)-YjcN-LALBA had the highestα-LA yield,reaching 122.04μg/*** study demonstrates successful expression and secretion of humanα-LA in *** and establishes a foundation for simulating breast milk for infant formulas and developing bioengineered milk.

关键词： Bacillus subtilis Alpha-lactalbumin Bioengineering milk Signal peptide Promoter screening

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Epicatechin attenuates lead(Pb)-induced cognitive impairment in mice:regulation on Nrf2 signaling pathway,and interference on the interaction between Pb with albumin

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food science and Human Wellness 2024年第2期13卷 1065-1078页

作者： Dai Cheng Qianqian Yu Kexin Zhu Dingdong Bu Zijian Wu State Key Laboratory of food Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China School of biotechnology and food science Tianjin University of CommerceTianjin 300134China

Epicatechin(EC)was used in this study to antagonize the cognitive dysfunction caused by lead(Pb)exposure in ***-week-old male Kunming mice were treated with PbCl_(2)(20 mg/kg)and/or EC(50 mg/kg)by gavage administration for 4 *** water maze test showed that EC could improve memory dysfunction induced by *** antagonized Ca^(2+)overload,activated Nrf2 signaling pathway and reduced the accumulation of Pb in the brain and serum,which suggested that EC might alter Pb distribution in *** vitro,spectroscopic analysis,potentiometric titration and docking studies were applied to inquiry into the interaction between bovine serum albumin(BSA)and Pb^(2+)in presence or absence of *** was proved to chelate Pb^(2+)and reduced the interaction between BSA and Pb^(2+).In summary,EC might protect Pb-induced cognitive impairment by activating Nrf2 signaling pathway,and suppressing Pb accumulation via interference on the binding of Pb to albumin.

关键词： Lead Epicatechin Bovine serum albumin Interaction Oxidative stress

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Effects of Enteromorpha prolifera polysaccharides on growth performance,intestinal barrier function and cecal microbiota in yellow-feathered broilers under heat stress

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Journal of Animal science and biotechnology 2024年第1期15卷 344-361页

作者： Wenchao Liu Huimei Liu Yaoyao Wang Zhongxiang Zhao Balamuralikrishnan Balasubramanian Rajesh Jha Department of Animal science College of Coastal Agricultural SciencesGuangdong Ocean UniversityZhanjiangGuangdong 524088People’s Republic of China Department of food science and biotechnology College of Life ScienceSejong UniversitySeoul 05006South Korea Department of Human Nutrition Food and Animal SciencesCollege of Tropical Agriculture and Human ResourcesUniversity of Hawaii at ManoaHonoluluHI 96822USA

Background Global warming leading to heat stress(HS)is becoming a major challenge for broiler *** study aimed to explore the protective effects of seaweed(Enteromorpha prolifera)polysaccharides(EPS)on the intestinal barrier function,microbial ecology,and performance of broilers under HS.A total of 144 yellow-feathered broilers(male,56 days old)with 682.59±7.38 g were randomly assigned to 3 groups:1)TN(thermal neutral zone,23.6±1.8℃),2)HS(heat stress,33.2±1.5℃ for 10 h/d),and 3)HSE(HS+0.1%EPS).Each group contained 6 replicates with 8 broilers per *** study was conducted for 4 weeks;feed intake and body weights were measured at the end of weeks 2 and *** the end of the feeding trial,small intestine samples were collected for histomorphology,antioxidant,secretory immunoglobulin A(s Ig A)content,apoptosis,gene and protein expression analysis;cecal contents were also collected for microbiota analysis based on 16S r DNA *** Dietary EPS promoted the average daily gain(ADG)of broilers during 3–4 weeks of HS(P<0.05).At the end of HS on broilers,the activity of total superoxide dismutase(T-SOD),glutathione S-transferase(GST),and the content of s Ig A in jejunum were improved by EPS supplementation(P<0.05).Besides,dietary EPS reduced the epithelial cell apoptosis of jejunum and ileum in heat-stressed broilers(P<0.05).Addition of EPS in HS group broilers'diet upregulated the relative m RNA expression of Occludin,ZO-1,γ-GCLc and IL-10 of the jejunum(P<0.05),whereas downregulated the relative m RNA expression of NF-κB p65,TNF-αand IL-1βof the jejunum(P<0.05).Dietary EPS increased the protein expression of Occludin and ZO-1,whereas it reduced the protein expression of NF-κB p65 and MLCK(P<0.01)and tended to decrease the protein expression of TNF-α(P=0.094)in heat-stressed ***,the proportions of Bacteroides and Oscillospira among the three groups were positively associated with jejunal apoptosis and pro-inflammatory cytokine ex

关键词： Broilers Cecal microbiota Heat stress Intestinal barrier function Seaweed polysaccharides

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Elaidic acid leads to mitochondrial dysfunction via mitochondria-associated membranes triggers disruption of mitochondrial calcium fluxes

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food science and Human Wellness 2024年第1期13卷 287-298页

作者： Hui Liu Xuenan Li Ziyue Wang Lu Li Yucai Li Haiyang Yan Yuan Yuan college of food science and Engineering Jilin UniversityChangchun 130062China

Elaidic acid(EA)stimulation can lead to endoplasmic reticulum stress(ERS),accompanied by a large release of Ca^(2+),and ultimately the activation of NLRP3 inflammasome in Kupffer cells(KCs).Mitochondrial instability or dysfunction may be the key stimulating factors to activate NLRP3 inflammasome,and sustained Ca^(2+)transfer can result in mitochondrial *** focused on KCs to explore the damage to mitochondria by *** EA stimulation,cells produced an oxidative stress(OS)response with a significant increase in ROS *** experiments and the addition of inhibitors revealed that the increase in the level of intracellular Ca^(2+)led to Ca^(2+)accumulation in the mitochondrial matrix via mitochondria-associated membranes(MAMs).This was accompanied by a significant release of m ROS,loss of MMP and ATP,and a significant increase in mitochondrial permeability transition pore opening,ultimately leading to mitochondrial *** findings confirmed the mechanism that EA induced mitochondrial Ca^(2+)imbalance in KCs via MAM,ultimately leading to mitochondrial ***,EA induced OS and the decrease of MMP and ATP in rat liver,and significant lesions were found in liver *** of the inner mitochondrial cristae and mitochondrial vacuolization occurred,with a marked increase in lipid droplets.

关键词： Elaidic acid(EA) Mitochondria-associated membranes(MAMs) Calcium Endoplasmic reticulum Mitochondria dysfunction

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Preventive effect of kiwi berry(Actinidia arguta)on loperamide-induced constipation

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food science and Human Wellness 2024年第3期13卷 1410-1421页

作者： Jiyue Zhang Bin Li Ningxuan Gao Haikun Li Xingyue Cui Hanqian Jiang Siyi Tang Chenyu Jin Jinlong Tian college of food science Shenyang Agricultural UniversityShenyang 110866China

Constipation is a common intestinal *** berries can effectively prevent ***,studies have yet to be done to determine how kiwi berries prevent *** two weeks,mice in this study were continually orally gavaged with kiwi berry,loperamide,or a combination of the *** study found that the kiwi group's feces had more water than the constipated *** addition,kiwi berries can speed up gastrointestinal transit(GI),shorten the time it takes to pass the first dark stool,and dramatically enhance body weight *** the interstitial cells of Caj al(ICC)cells and colon tissues,alterations in the protein expression of vasoactive intestinal peptide(VIP),cyclic adenosine monophosphate(cAMP),protein kinase A(PKA),and aquapcrin-3(AQP3)were *** 3,6,and 12 h of ICC cells and mouse colon,the kiwi group's VIP,cAMP,PKA,and AQP3 protein expression levels were lower than those of the constipated *** kiwi berry can decrease the Firmicutes to Bacteroidetes ratio and boost the diversity and quantity of gut *** influencing the gut microbiota and VIP-cAMP-PKA-AQP3 signaling pathway,kiwi berries prevent constipation.

关键词： Kiwi berry Constipation VIP-cAMP-PKA-AQP3 Gut microbiota

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