检索结果-南通市图书馆

Natural Products and bioprospecting 2019年第5期9卷 345-349页

作者： Zaenal Sugiyanto Benediktus Yohan Soeharyo Hadisaputro Edi Dharmana Catharina Suharti Winarto Kis Djamiatun Fifin LRahmi R.Tedjo Sasmono Faculty of Health Science Dian Nuswantoro UniversityJl.Imam Bonjol 270Semarang 50131Indonesia Doctoral Program in Medical and Health Sciences Faculty of MedicineDiponegoro UniversityJl.Prof.Sudarto SHTembalangSemarang 50275Indonesia Eijkman Institute for Molecular Biology Ministry of ResearchTechnology and Higher EducationJl.Diponegoro 69Jakarta 10430Indonesia Faculty of Medicine Diponegoro UniversityJl.Prof.Sudarto SHTembalangSemarang 50275Indonesia

Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue *** active compound of mangosteen fruit pericarps,α-mangostin,has been commonly used as traditional medicine and dietary *** examined the effect ofα-mangostin against dengue virus(DENV)infection in human peripheral blood mononuclear cells(PBMC)by the measurement of virus titer and TNF-αand IFN-γcytokines concentration post *** concentration ofα-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24-and 48-h post *** results support the potential use ofα-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.

关键词： Dengue Antiviral Mangostin Cytokine PBMC

The Chemistry and Biological Activities of Natural Products from Northern African Plant Families:From Taccaceae to Zygophyllaceae

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and bioprospecting 2016年第2期6卷 63-96页

作者： Fidele Ntie-Kang Leonel E.Njume Yvette I.Malange Stefan Gunther Wolfgang Sippl Joseph N.Yong Department of Pharmaceutical Chemistry Martin-Luther University of Halle-WittenbergWolfgang-Langenbeck-Str.406120 Halle(Saale)Germany Department of Chemistry Faculty of ScienceUniversity of BueaP.O.Box 63BueaCameroon Department of Chemistry Faculty of ScienceChemical and Bioactivity Information CentreUniversity of BueaP.O.Box 63BueaCameroon Institute of Pharmaceutical Sciences Research Group Pharmaceutical BioinformaticsAlbert-Ludwigs-Universitat FreiburgHermann-Herder-Strasse 979104 FreiburgGermany

Traditional medicinal practices have a profound influence on the daily lives of people living in developing countries,particularly in Africa,since the populations cannot generally afford the cost of Western *** have undertaken to investigate the correlation between the uses of plants in Traditional African medicine and the biological activities of the derived natural products,with the aim to validate the use of traditional medicine in Northern African *** literature is covered for the period 1959-2015 and part III of this review series focuses on plant families with names beginning with letters T to *** authors have focused on curating data from journals in natural products and *** each journal home page,a query search based on country name was *** articles‘‘hits’’were then verified,one at a time,that the species was harvested within the Northern African geographical *** current data partly constitutes the bases for the development of the Northern African natural compounds *** review discusses 284 plant-based natural compounds from 34 species and 11 *** was observed that the ethnobotanical uses of less than 40%of the plant species surveyed correlated with the bioactivities of compounds identified.

关键词： Africanflora Biologicalactivities Ethnobotany Naturalproducts Traditionalmedicine

Analysis of Four Solvatomorphs of Betulin by TG-DTA-EI/PI-MS System Equipped with the Skimmer-Type Interface

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and bioprospecting 2020年第3期10卷 141-152页

作者： Peng-Hui Yuan Yan-Cai Bi Bin Su De-Zhi Yang Ning-Bo Gong Li Zhang Yang Lu Guan-Hua Du Beijing City Key Laboratory of Polymorphic Drugs Center of Pharmaceutical PolymorphsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050People’s Republic of China Soteria Pharmaceutical Co. LtdLaiwu 271100People’s Republic of China Beijing City Key Laboratory of Drug Target and Screening research National Center for Pharmaceutical ScreeningInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050People’s Republic of China

Betulin(BE)has exceedingly become a potential natural product,providing multiple pharmacological and biological activi-ties,including anti-cancer,anti-viral,and anti-inflammatory *** research indicated that the solvatomorphism of BE can easily occur through crystallization with different organic *** property of BE can directly affect its extraction,isolation,and preparation *** this study,a system of thermogravimetry(TG)-differential thermal analysis(DTA)coupled with mass spectrometry(MS)with electron ionization(EI)and photoionization(PI)capability,equipped with the skimmer-type interface(i.e.,skimmer-type interfaced TG-DTA-EI/PI-MS system),as a real-time and onsite analysis technique,was ***,four solvatomorphs of BE,namely,with pyridine and water(A),sec-butanol(B),n,n-dimethylformamide(DMF)(C),and isopropanol(V),were analyzed for the first ***,five kinds of the main volatile gaseous species,including H2O,pyridine,sec-butanol,DMF,and isopropanol,were identified ***,the multi-step desolvation processes of the four solvatomorphs of BE were revealed by this system for the first *** system showed great potential for the rapid and accurate analysis of various solvatomorphs of natural products.

关键词： Betulin Solvatomorphs TG-MS PI method

Preparation and Certification of a New Salvianolic Acid A Reference Material for Food and Drug research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and bioprospecting 2020年第2期10卷 67-75页

作者： Dezhi Yang Bin Su Yancai Bi Li Zhang Baoxi Zhang Junke Song Yang Lu Guanhua Du Beijing City Key Laboratory of Polymorphic Drugs Center of Pharmaceutical PolymorphsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050People’s Republic of China Soteria Pharmaceutical Co. Ltd.Laiwu 271100People’s Republic of China Beijing City Key Laboratory of Drug Target and Screening research National Center for Pharmaceutical ScreeningInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050People’s Republic of China

Salvianolic acid A(Sal A),a water-soluble ingredient in Danshen,has various biological *** A and its impurities have similar physical and chemical properties,as well as strong reducibility;therefore,they are difficult to prepare and *** this study,high-purity Sal A was obtained by purification of sephadex chromatography and preparative ***,HPLC-DAD tandem ECD and HPLC-DAD tandem MS methods were used for non-volatile organic impurity analysis,ICP-MS method was used for non-volatile inorganic impurities and mass balance method and quantitative nuclear magnetic resonance were employed to certify the *** structures of Sal A and its relative impurities were validated by nuclear magnetic resonance spectroscopy and mass spectrometry,and their contents were quantified as *** the principles of ISO Guides 34:2009 and 35:2005,a Sal A reference material was certified,covering homogeneity studies,stability studies,characterization,and uncertainty estimations.

关键词： Certified reference material Salvianolic acid A Mass balance method qNMR High resolution mass spectrum

Prioritised identification of structural classes of natural products from higher plants in the expedition of antimalarial drug discovery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and bioprospecting 2023年第1期13卷 348-367页

作者： Phanankosi Moyo Luke Invernizzi Sephora M.Mianda Wiehan Rudolph Andrew W.Andayi Mingxun Wang Neil R.Crouch Vinesh J.Maharaj Department of Chemistry Faculty of Natural and Agricultural SciencesBiodiscovery CenterUniversity of PretoriaPrivate Bag X 20HatfieldPretoria 0028South Africa Department of Physical and Biological Sciences Murang’a University of Technology Murang’aMurang’aKenya Computer Science and Engineering University of California Riverside900 University AveRiversideCA 92521USA Biodiversity research and Monitoring Directorate South African National Biodiversity InstituteBerea RoadP.O.Box 52099Durban 4007South Africa School of Chemistry and Physics University of KwaZulu-NatalDurban 4041South Africa

The emergence and spread of drug-recalcitrant Plasmodium falciparum parasites threaten to reverse the gains made in the fight against *** measures need to be taken to curb this impending *** higher plant-derived sesquiterpene,quinoline alkaloids,and naphthoquinone natural product classes of compounds have previously served as phenomenal chemical scaffolds from which integral antimalarial drugs were *** successes serve as an inspiration for the continued investigation of plant-derived natural products compounds in search of novel molecular templates from which new antimalarial drugs could be *** aim of this study was to identify potential chemical scaffolds for malaria drug discovery following analysis of historical data on phytochemicals screened in vitro against *** identify these novel scaffolds,we queried an in-house manually curated database of plant-derived natural product compounds and their in vitro biological *** products were assigned to different structural classes using *** identify the most promising chemical scaffolds,we then correlated natural compound class with bioactivity and other data,namely(i)potency,(ii)resistance index,(iii)selectivity index and(iv)physicochemical *** used an unbiased scoring system to rank the different natural product classes based on the assessment of their bioactivity *** this analysis we identified the top-ranked natural product pathway as the *** top three ranked super classes identified were(i)pseudoalkaloids,(ii)naphthalenes and(iii)tyrosine alkaloids and the top five ranked classes(i)quassinoids(of super class triterpenoids),(ii)steroidal alkaloids(of super class pseudoalkaloids)(iii)cycloeudesmane sesquiterpenoids(of super class triterpenoids)(iv)isoquinoline alkaloids(of super class tyrosine alkaloids)and(v)naphthoquinones(of super class naphthalenes).Launched chemical space of these identified classes of compou

关键词： Natural products Compound classes Phytochemicals Plasmodium falciparum Antiplasmodial drug resistance Malaria Drug development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生物多样性的开发利用:对环境和发展的影响

AMBIO－人类环境杂志 2002年第6期31卷 491-493页

作者： Shivcharn S.Dhillion Hanne Svarstad Cathrine Amundsen Hans Chr.Bugge 周立志 Centre for Development and the Environment University of Oslo Division for Man-Environment Studies NorwegianInstitute for Nature research(NINA)Fakkelgarden Department of Public and International Law University of Oslo

生物多样性保护是1992年里约热内卢世界首脑会议上提交签署的二项密切相关的立法条约之一。迄今为止,180多个国家加入该条约。条约签署国必须制定法律法规确保实现生物多样性的保护,亦即:①保护生物多样性;②可持续地利用生物多样的组分... 详细信息

生物多样性保护是1992年里约热内卢世界首脑会议上提交签署的二项密切相关的立法条约之一。迄今为止,180多个国家加入该条约。条约签署国必须制定法律法规确保实现生物多样性的保护,亦即:①保护生物多样性;②可持续地利用生物多样的组分;③公正平等地分享利用遗传资源所获得的利益。生物多样性保护引入了资源国遗传资源所有权的新体系。

关键词：生物多样性生物资源生物多样开发生物多样利用生物多样性保护环境发展影响

LC-ESI-IT-MS/MS and MALDI-TOF Approach:Identification of Natural Polymers from Rhizophora mangle Barks and Determination of Their Analgesic and Anti-inflammatory Properties

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Natural Products and bioprospecting 2019年第1期9卷 23-34页

作者： Leonardo Mendes de Souza Mesquita Caroline Fabri Bittencourt Rodrigues Claudia Quintino da Rocha Mayara Silveira Bianchim Clenilson Martins Rodrigues Vanda Maria de Oliveira Henrique Hessel Gaeta Mariana Novo Belchor Marcos Hikari Toyama Wagner Vilegas Laboratory of Bioprospection of Natural Products(LBPN) UNESP-Sao Paulo State University/Coastal Campus of Sao VicentePc¸a Infante Dom Henrique S/NSao VicenteSao Paulo CEP:11330-900Brazil Laborato´rio de Estudos Avanc¸ados em Fitomedicamentos(LEAF) UFMA-Federal University of MaranhaoAv.dos Portugueses1966-BacangaSao Luı´sMaranhao CEP:65080-805Brazil Embrapa Agroenergy Brazilian Agricultural Research CorporationW3 NortePqEBBrası´liaDF 70770-901Brazil

We recognize the chemical composition of the acetonic extract of Rhizophora mangle barks(AERM)using mass spectrometry analysis[liquid chromatography(LC)–ESI–IT-MS/MS and matrix-assisted laser desorption/ionization-time of flight-MS(MALDI-TOF)].Analgesic activity was evaluated by formalin and tail-flick experimental ***-inflammatory activity was performed by paw edema test induced by carrageenan and 48/80 *** first series of experiments involved[LC]–FIA–IT-MS/MS with 11 separated catechins derivatives until degree of polymerization 3(DP3).The spectra obtained by MALDI-TOF analysis of the AERM presented two homologous series:one based on polymers of m/z 288 Da increments(up to DP12)and another series based on polymers of m/z[288?162]Da increments(up to DP11).In addition to these series of flavan-3-ol,each DP had a subset of masses with a variation of-16 Da(homologous series of afzelechins-m/z 873–3465 Da)and +16 Da(homologous series of gallocatechins-m/z 905–3497 Da).A similar pattern with homologous series of gallocatechins and afzelechins could also be observed for a fifth and a sixth monohexoside series:glucogallocatechins(m/z 779–3371)and glucoafzelechins(m/z 747–3339).The intraperitoneal administration of different doses of AERM(50,150 and 300 lg mL^(-1))have a morphine-like effect and intense anti-inflammatory activity.

关键词： Catechins Tannins Morphine-likeeffect Anti-inflammatory Mangroves

Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and bioprospecting 2021年第1期11卷 127-135页

作者： Yun-Li Zhao Zhong-Ping Gou Jian-Hua Shang Wan-Yi Li Yu Kuang Ming-Yuan Li Xiao-Dong Luo State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Provincial Center for Research&Development of Natural ProductsSchool of Chemical Science and TechnologyYunnan UniversityKunming 650091P.R.China Institute of Drug Clinical Trials West China HospitalSichuan UniversityChengdu 610041China West China School of Basic Medical Sciences&Forensic Medicine Sichuan UniversityChengdu 610041China

Alstonia scholaris could be used as a traditional medicinal plant in China for the treatment of acute respiratory,which might be caused by respiratory tract *** investigation tested the anti-infective effects of total alkaloids extract(TA)from leaves of ***,and as a result,TA inhibited herpes simplex virus type 1(HSV-1),respiratory syncytial virus(RSV)and influenza A virus(H1N1)in vitro *** addition,the survival days of mice were prolonged,and the lung weights and mortality of mice were decreased significantly,after oral administrated TA in H1N1 and beta-hemolytic streptococcus infectious models in vivo *** finding supported partly the traditional usage of *** in the treatment of respiratory infections.

关键词： Alstonia scholaris Total alkaloids Acute respiratory infections Anti-virus Anti-bacteria

Purity and Uncertainty Study of CRM Betulin by DSC

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and bioprospecting 2020年第5期10卷 317-324页

作者： Li Zhang Peng-Hui Yuan De-Zhi Yang Yan-Cai Bi Bin Su Bao-Xi Zhang Fu-Qing Wang Yang Lu Guan-Hua Du Beijing City Key Laboratory of Polymorphic Drugs Center of Pharmaceutical PolymorphsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050People’s Republic of China Soteria Pharmaceutical Co. Ltd.Laiwu 271100People’s Republic of China China Pharmaceutical Enterprises Association Beijing 100044People’s Republic of China Beijing City Key Laboratory of Drug Target and Screening research National Center for Pharmaceutical ScreeningInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050People’s Republic of China

Betulin(BE)can be obtained from many plants,such as those belonging Betulaceae family,and pharmacological investigations showed its notable biological properties and good potential for food and pharmaceutical *** investigated the homogeneity,stability,purity,and uncertainty of a newly certified reference material(CRM)of *** certified purity value for the CRM of BE was 99.56%with an extended uncertainty of 0.07%(k=2,P=0.95),as determined by differential scanning calorimetry(DSC).In this study,DSC was used for the first time for purity determination of *** its high accuracy,precision,and reproducibility,DSC can be used as an alternative technique for purity determination of CRMs in the pharmaceutical and food industry.

关键词： Betulin DSC Purity determination Uncertainty study

Cytotoxic phenazine and antiallergic phenoxazine alkaloids from an arctic Nocardiopsis dassonvillei SCSIO 502F

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and bioprospecting 2023年第1期13卷 287-293页

作者： Yue Song Qi-Yang Li Meng-Jing Cong Xiao-Yan Pang Bo Chen Yong-Hong Liu Li Liao Jun-Feng Wang CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Innovation Academy of South China Sea Ecology and Environmental EngineeringSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Key Laboratory for Polar Science MNRPolar Research Institute of ChinaShanghai 200136China Department of Pharmacology and Therapeutics McGill UniversityMontreal H3A 0G4Canada University of Chinese Academy of Sciences 19 Yuquan RoadBeijing 100049China Sanya Institute of Marine Ecology and Engineering Sanya 572000China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200240China

Microbes well-adapted to the Arctic Ocean are promising for producing novel compounds,due to their fancy strategies for adaptation and being *** new phenazine alkaloids(1 and 2)and one new phenoxa-zine(3)were isolated from Nocardiopsis dassonvillei 502F,a strain originally isolated from Arctic deep-sea *** analysis of the genome of Nocardiopsis dassonvillei 502F revealed the presence of 16 putative biosynthetic gene clusters(BGCs),including a phenazine *** of the isolated compounds were evaluated for their antibacterial,antiallergic,and cytotoxic *** them,compounds 4 and 5 exhibited potent in vitro cytotoxic activities against osteosarcoma cell line 143B with IC_(50) values 0.16 and 20.0μM,***,the results of antiallergic activities of compounds 6-8 exhibited inhibitory activities with IC_(50) values of 10.88±3.05,38.88±3.29,and 2.44±0.17μg/mL,respectively(IC_(50)91.6μM for the positive control loratadine).

关键词： Nocardiopsis dassonvillei Arctic Ocean Phenazine Phenoxazine Cytotoxic Antiallergic