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Therapeutic actions of terpenes in neurodegenerative disorders and their correlations with the regulation and remodeling of the extracellular matrix

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BIOCELL 2025年第1期49卷 109-125页

作者： RENATA DA SILVA CARNEIRO MATEUS HENRIQUE DE ALMEIDA DA COSTA JOSÉZILTON LIMA VERDE SANTOS VALDILÉIA TEIXEIRA UCHÔA LUCIANO DA SILVA LOPES ANDERSON NOGUEIRA MENDES laboratory of Science in Innovation and Technology-LACITEC Department of Biophysics and PhysiologyFederal University of PiauíTeresina64049Brazil laboratory of Natural Products and Bioprospecting Natural Sciences CenterState University of PiauíTeresina64018Brazil laboratory of Experimental Neurochemistry Research-LAPNEX Department of Biophysics and PhysiologyFederal University of PiauíTeresina64049Brazil

Neurodegenerative diseases are a major public health challenge,mainly affecting the elderly population and compromising their cognitive,sensory,and motor ***,available therapies focus on alleviating symptoms and slowing the progression of these conditions,but they do not yet offer a definitive *** this scenario,terpenes emerge as promising natural alternatives due to their neuroprotective *** compounds can reduce the formation of protein aggregates,neutralize free radicals,and inhibit pro-inflammatory enzymes,which are crucial factors in the development of neurodegenerative *** addition,terpenes also play an important role in the regulation and remodeling of the extracellular matrix,a key target for improving neuronal *** such as linalool,pinene,and eugenol,among others,have potential therapeutic effects by modulating inflammatory and oxidative stress processes,the main factors that contribute to the progression of these *** suggest that these compounds act on signaling pathways that regulate the extracellular matrix,improving neuronal integrity and,consequently,cognitive and motor *** work aims to review the potential of terpenes in the treatment of neurodegenerative disorders,with emphasis on their ability to regulate oxidative stress and inflammation,as well as to remodel the extracellular *** interaction between these mechanisms points to the promising use of terpenes as an innovative and natural therapeutic approach to combat these diseases.

关键词： Terpenes Neurodegenerative Disorders Extracellular matrix

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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

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Selective G6PDH inactivation for Helicobacter pylori eradication with transformed polysulfide

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Science China Life Sciences 2025年

作者： Xiaonan Wang Ning Zhou Xuejiao J.Gao Zijing Zhu Minmin Sun Qian Wang Haolin Cao Xuetong Wu Caiyu Zhou Qingkang Zheng Ye Yuan Yuan Liu Lei Chen Jing Jiang Pengcheng Bu Lizeng Gao CAS Engineering laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences School of Life Sciences University of Chinese Academy of Sciences College of Chemistry and Chemical Engineering Jiangxi Normal University Key laboratory of Epigenetic Regulation and Intervention Institute of Biophysics Chinese Academy of Sciences Nanozyme laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University Nanozyme laboratory in Zhongyuan Henan Academy of Innovations in Medical Science

Alternative treatment for the highly prevalent Helicobacter pylori infection is imperative due to rising antibiotic resistance. We unexpectedly discovered that the anti-H. pylori component in garlic is hydrogen polysulfide（H2S_n, n≥2）, not organic polysulfides. Studies on the mechanism of action（MoA） show that H2S_nspecifically inactivates H. pylori glucose-6-phosphate dehydrogenase（G6PDH） by interfering with electron transfer from glucose-6-phosphate（G6P） to nicotinamide adenine dinucleotide phosphate（NADP+）. However, low H2S_nyield makes garlic derivatives hard to be a reliable donor of H2S_nto treat H. pylori infection. To address this challenge, we established a polysulfide transformation process from garlic organosulfur compounds into Fe3S4that generates H2S_nwith a 25–58 times increase in *** chitosan encapsulation, we designed a gastric-adaptive H2S_nmicroreactor（GAPSR） that eradicates H. pylori with 250 times higher efficiency under gastric conditions. A single GAPSR achieves more rapid H. pylori eradication than combined antibiotics therapy without disturbing the gut microbiota. These findings indicate a distinct MoA transformation mediated by polysulfide as an alternative candidate to treat H. pylori infection.

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In situ synthetic C encapsulatedδ-MnO_(2with)O vacancies:a versatile programming in bio-engineering

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Science Bulletin 2025年第2期70卷 203-211页

作者： Wei Lv Zilei Shen Junlin Liu Xudong Li Fang Ding Dongyue Zhang Licheng Miao Xuefeng Lyu Ruijie Li Miaomiao Wang Yiming Li Jingwen Meng Chao Xu Institute of Energy Power Innovation North China Electric Power UniversityBeijing 102206China Key laboratory of Epigenetic Regulation and Intervention Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Key laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China Collaborative Innovation Center of Integrated Exploitation of Bayan Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou 014010China

In this study,we successfully synthesized aδ-MnO_(2)cathode with O vacancies,encapsulated by C derived from pyromellitic acid,using a facile hydrothermal method followed by annealing in an Ar *** cathode’s structural stability and charge transfer kinetics are enhanced by inhibiting the formation of the by-product Zn_(4)SO_(4)(OH)_(6)4H_(2)O,regulating the Mn valence state,and suppressing the Jahn–Teller effect through the synergy of C encapsulation and O *** results in remarkable electrochemical performance,including a large capacity of 421.2 mAh g^(-1)at 0.1 A g^(-1),a high specific energy density of595.53 Wh kg^(-1),and exceptional long-cycle life stability with 90.88%over 4000 cycles at 10 A g^(-1),together with superior coulombic efficiency(~100%)in pure ZnSO_(4)***,the cathode materials demonstrate specific antitumor *** brief,this work introduces an in situ synthetic C encapsulatedδ-MnO_(2)with O vacancies expected to be applied in both large-scale energy storage and biomedicine.?2024 Science China *** by Elsevier *** Science China *** rights are reserved,including those for text and data mining,AI training,and similar technologies.

关键词： Zn-ion batteries C encapsulation O vacancies Synergistic effect Bio-engineering

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Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases

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Science China(Life Sciences) 2025年第1期68卷 303-305页

作者： Ziqian Xu Lianpan Dai Jun Liu National Key laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) National Institute for Viral Disease Control and PreventionChineseCenter for Disease Control and PreventionBeijing 102206China CAS Key laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Vector-borne viruses,transmitted among humans and animal hosts through bites of vectors such as mosquitoes and ticks,pose a great and ongoing threat to public health and biosafety(Yang et al.,2022).Among them,dengue virus-induced epidemics,have dramatically increased worldwide in recent *** report released by the World Health Organization(WHO)at the end of 2023 showed that dengue epidemic globally surged in 2023,with the number of reported cases nearing a historical *** the first four months of 2024,more than 6 million people worldwide were infected by dengue virus,with more than 2,000 *** countries around the world especially the American countries issued warnings,reporting three times the number of dengue cases compared with the same period last *** global climate change,population growth,and urbanization,flaviviral diseases transmitted by Aedes mosquitoes remain a major global biosecurity challenge.

关键词： diseases globally

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Oxidative degradation and upcycling of polyethylene wastes

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Science China Chemistry 2025年第2期68卷 430-443页

作者： Yizhen Che Yanfen Wu Zhiqiang Niu State Key laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Ordos laboratory Ordos 017010China

Plastics have become omnipresent in modern life due to their versatility and ***,this convenience comes at the cost of substantial waste *** inherent chemical stability of plastics complicates its recycling,leading to environmental pollution and ecological *** mini-review highlights recent advancements in addressing this challenge by oxidative transformation of polyethylene(PE)into new functional polymers,value-added chemicals,and carbon-based *** first discuss the introduction of hydroxyl,carbonyl groups onto PE with a focus on the functionalization degree and ***,approaches for PE oxidation into dicarboxylic acids and short-chain oxidized PE are described and compared,with an emphasis on the tandem reactions for converting mixed dicarboxylic acids into other value-added *** also briefly discuss the oxidative transformation of PE into carbon-based materials and summarize the progress in qualitative and quantitative analysis of oxidation ***,we conclude this mini-review by highlighting the challenges and opportunities in the field.

关键词： oxidation polyethylene upcycling chemical conversion plastics

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Copper homeostasis and neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi Li Kaifei Xu Guoqing Wang Feng Zhang International Research laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

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High-throughput experimentation and machine learning-promoted synthesis of α-phosphoryloxy ketones via Ru-catalyzed P(O)O–H insertion reactions of sulfoxonium ylides

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Science China Chemistry 2025年第2期68卷 679-686页

作者： An Lin Jingyuan Liu Yougen Xu Haiting Wu Yating Chen Yan Zhang Lebin Su Xiaodan Zhao Kuangbiao Liao Institute of Organic Chemistry&MOE Key laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhou 510006China Guangzhou National laboratory Guangzhou 510005China Bioland laboratory Guangzhou 510005China

Herein,we report a novel and highly efficient method for the synthesis ofα-phosphoryloxy carbonyl compounds via Rucatalyzed P(O)O–H insertion reactions of sulfoxonium ylides and phosphinic acids,with the assistance of high-throughput experimentation(HTE)and machine learning(ML).A variety of P(O)O−H derivatives,including diarylphosphates,alkyl phosphates,and alkoxyphosphates,are competent candidates to react with sulfoxonium ylides in this transformation,and variousα-phosphoryloxy carbonyls and propylene phosphates are directly *** approach utilizes readily available sulfoxonium ylide as a carbene precursor,and features mild conditions,operational simplicity,and broad functional groups tolerance,and could be used for late-stage functionalization of structurally complex bioactive ***,a conducive exploration of the reaction space is also conducted(756 reactions)and a machine learning model for reaction yield prediction has been developed and applied,showcasing the practical application of this newly workflow(HTE-ML)in the field of synthetic chemistry.

关键词： α-phosphoryloxy ketones high-throughput experimentation machine learning P(O)O-H insertion sulfoxonium ylides

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Morphology and phylogeny of two species of Bathypathes from the tropical western Pacific,with description of a new species

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Journal of Oceanology and Limnology 2025年第1期43卷 248-260页

作者： Ting LÜ Zifeng ZHAN Kuidong XU laboratory of Marine Organism Taxonomy and Phylogeny Qingdao Key Laboratory of Marine Biodiversity and ConservationInstitute of OceanologyChinese Academy of SciencesQingdao 266071China laboratory for Marine Biology and Biotechnology Laoshan LaboratoryQingdao 266237China University of Chinese Academy of Sciences Beijing 100049China

The black coral genus Bathypathes Brook,1889 represents a relatively diverse and ecologically important assemblage comprising the deep-sea hard substrate *** phylogenetic investigations have revealed the polyphyletic nature of Bathypathes,urging further morphological analysis to understand its *** combing morphological and molecular data,we describe Bathypathes multifurcata *** report *** Molodtsova,Opresko&Wagner,2022based on the specimens collected from the tropical western *** phylogenetic topology reconstructed using nuclear ITS1-5.8S-ITS2 and three mitochondrial fragments suggests the separation of Bathypathes into four *** analysis of morphological characters,particularly the colony branch and pinnule patterns also roughly classify Bathypathes into four morphological groups A–*** A is characterized by the unbranched colony and the subopposite arrangement of *** contrast to Group A,Groups B–D have the alternately arranged *** these,Group C exhibits a distinctly long unpinnulated stem compared to Groups B and *** B has unbranched colony,relatively short unpinnulated stem,and spines on pinnules have blunt *** Group D,large colonies(higher than 40 cm)have one or a few branches,small colonies(less than 40 cm)are unbranched,and spines on pinnules have acute *** data particularly those species without sequences are necessary to verify the classification of these groups.

关键词： Antipatharia black coral taxonomy phylogeny seamount western Pacific

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A new multi-DOF envelope forming process for fabricating spiral bevel gears with back taper tooth

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Chinese Journal of Aeronautics 2025年第1期38卷 568-585页

作者： Xinghui HAN Yanhui WANG Lin HUA Wuhao ZHUANG Fangyan ZHENG Wei FENG Hubei Key laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Longzhong laboratory Xiangyang 441000China

Spiral bevel gears are critical transmission components,and are widely used in the aerospace *** paper proposes a new multi-DOF envelope forming process for fabricating spiral bevel ***,the multi-DOF envelope forming principle of spiral bevel gears is ***,the design methods for the envelope tool geometry and movement are proposed based on the envelope geometry and movement ***,the metal flow and tooth filling laws are revealed through 3D FE simulation of the multi-DOF envelope forming process of a typical spiral bevel ***,a new method for separating the envelope tool and the formed spiral bevel gear with back taper tooth is proposed to avoid their ***,experiments on multi-DOF envelope forming of this typical spiral bevel gear are conducted using new heavy load multi-DOF envelope forming *** simulation and experimental results show the feasibility of the proposed multi-DOF envelope forming process for fabricating spiral bevel gears with back taper tooth and the corresponding process design methods.

关键词： Multi-DOF envelope forming Spiral bevel gear Back taper tooth Metal flow Process design

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