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Ultra-short-course and intermittent TB47-containing oral regimens produce stable cure against Buruli ulcer in a murine model and prevent the emergence of resistance for Mycobacterium ulcerans

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Acta Pharmaceutica Sinica B 2021年第3期11卷 738-749页

作者： Yamin Gao HMAdnan Hameed Yang Liu Lingmin Guo Cuiting Fang Xirong Tian Zhiyong Liu Shuai Wang Zhili Lu Md Mahmudul Islam Tianyu Zhang State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China University of Chinese Academy of Sciences Beijing 100049China Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China

Buruli ulcer(BU),caused by Mycobacterium ulcerans,is currently treated with rifampin estreptomycin or rifampineclarithromycin daily for 8 weeks recommended by World Health Organization(WHO).These options are lengthy with severe side effects.A new anti-tuberculosis drug,TB47,targeting QcrB in cytochrome bc1:aa3 complex is being developed in ***47-containing regimens were evaluated in a well-established murine model using an autoluminescent *** *** TB47-resistant spontaneous *** mutants were selected and their qcrB genes were *** in vivo activities of TB47 against both low-level and high-level TB47-resistant mutants were tested in BU murine ***,we show that TB47-containing oral 3-drug regimens can completely cure BU in 2 weeks for daily use or in 3 weeks given twice per week(6 doses in total).All high-level TB47-resistant mutants could only be selected using the low-level mutants which were still sensitive to TB47 in *** is the first report of double mutations in QcrB in *** summary,TB47-containing regimens have promise to cure BU highly effectively and prevent the emergence of drug *** QcrB mutations found here may guide the potential clinical molecular diagnosis of resistance and the discovery of new drugs against the high-level resistant mutants.

关键词： Mycobacterium ulcerans Buruli ulcer Electron transport chain QcrB Chemotherapy TB47 Drug resistance Clofazimine

Process of becoming a mother in women receiving donated egg: Based on the grounded theory

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Asian pacific Journal of Reproduction 2020年第4期9卷 182-191页

作者： Mitra Zandi Sahar Dabaghi Narges Bagheri-Lankarani Reza Omani-Samani Mojtaba Naderi-Taheri Nursing Department School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehranIran Department of Epidemiology and Reproductive Health Reproductive Biomedicine Research CenterRoyan Institute for Reproductive BiomedicineACECRTehranIran Department of Community Health and Geriatric Nursing School of Nursing and MidwiferyUniversity of Medical SciencesTehranIran

Objective:To elucidate theoretically the safety and identity of mothers receiving egg and the process of becoming a ***:This study was conducted during 7 months from July 2018 to January 2019 by using a grounded theory *** women at the gestational age who received oocyte were selected with purposive sampling method and then entered the study using theoretical *** who had not decided definitely to participate and had not started the treatment course yet were excluded from the *** participating mothers were 28-44 years old with a mean age of(37.00±2.49)years.A total of 30 interviews were *** were collected by unstructured deep interviews and field *** interview duration ranged between 19 to 74 min with a mean time of 40 min and they were performed ***:Data analysis showed that"feeling of insecurity in personal and familial identity"formed in the context of"exposure to socio-cultural constraints"was the main problem of mothers receiving donated *** led to a set of coping strategies as"gradual acceptance","attempts to maintain the marital life","sensitivity in selecting donor","sensitivity in fetal care","seeking information and consultation","challenging the internal restlessness",and"treatment follow-up",all indicating the concept of"protection of personal and familial identity"as the core ***:The challenge faced by Iranian mothers receiving donated oocyte in the constrained sociocultural context forms a multilateral and all-inclusive insecurity.

关键词： Infertility Motherhood process Donated egg Identity insecurity Grounded theory Nursing Iran

Effectiveness of Disinfection of Anesthetics Tubes in Oral Surgery -An in Vitro Study

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Journal of Pharmacy and Pharmacology 2017年第7期5卷 424-429页

作者： José Kayque Neves Mayke Felipp de Araújo Martins Josefa Elaine Silva Germinio Maria Cristina de ndrade Sibele Ribeiro de Oliveira Dentistry course Research Group on Pathology of Communicable and Non-Communicable Diseases (GPPATO) Centro Universitário Tabosa de Almeida/Asces-Unita University district Caruaru/Pernambuco 55016-901 Brazil biomedicine course Research Group on Pathology of Communicable and Non-Communicable Diseases (GPPATO) Centro Universitário Tabosa de Almeida/Asces-Unita University district Caruaru/Pernambuco 55016-901 Brazil

Context： Anesthetic tubes are always on the surgical table, for this reason, it＇s necessary to perform its disinfection, generally by chemicals. Aim： Was to analyze the effectiveness of tubes decontamination made by disinfectant substances used in a clinical setting and to identify the microorganisms found on their surface. Materials and Methods： 14 anesthetic tubes were collected from dental clinic, on 5 groups. 01 plastic and 01 glass tubes that were not submitted to any disinfection process composed the control group and they had been sown in Agar Blood. Experimental groups underwent immersion and fixation with the proposed chemicals for 1 minute, laminar flow hood was used to seed it in Agar Blood and then it was transferred to incubator for 24 hours at 37℃. Tests were used to identify the main Gram positive pathogenic genera. Gram-negative pathogenic colonies isolated were seeded in biochemical means of identification. Results： It was possible to identify the presence of Staphylococcus coagulase negative, Staphylococcus aureus, Streptococcus viridans, Staphylococcus saprophyticus, Escherichia coli and Acinetobacter spp, as well as the effectiveness of chemical solutions proposed in this study. Conclusions： All chemical solutions proposed in this study were effective for the surface disinfection process of anesthetic tubes.

关键词： Anesthetics antimicrobial effect disinfection oral surgery microbiology.

Factors Associated with Umbilical Cord Stump Healing Practices: Literature Review

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Open Journal of Obstetrics and Gynecology 2020年第8期10卷 1067-1078页

作者： Marilya Rodrigues Reis Marília Cordeiro de Sousa Lays de Souza Silva Lívia Roberta Rodrigues Conceição Marcela de Andrade Silvestre Camila de Pina Soares Sudário Renata Calciolari Rossi Janaína Valadares Guimarães Thaíla Corrêa Castral Karina Machado Siqueira Pedro Teixeira Meireles Bruno Belmonte Martineli Gomes George Kemil Abdalla Douglas Reis Abdalla Ana Karina Marques Salge Faculty of Nursing Federal University of Goiás Goiania Brazil UNIOESTE Presidente Prudente Brazil Medicine course University of Uberaba Uberaba MG Brazil biomedicine University of Sao Paulo Ribeirao Preto Brazil Health Sciences Faculty of Human Talents Uberaba Brazil

Objective: To analyze the evidence in the evolution of scientific production on the factors associated with curative practices of the umbilical stump. Materials and Methods: The study data collection took place in April 2017. The electronic databases used to search the articles were: PubMed (National Library of Medicine and National Institutes of Health) and VHL (Virtual Health Library). We used the keywords “perinatal care”, “umbilical cord”, “patient care team”, “neonatology”, “newborn”, in the Portuguese, English and Spanish languages, accompanied by the expression AND and selected through DeCS (Descriptors in Health Sciences). Results: A final sample of 9 articles was obtained from the PubMed and VHL databases, which met the inclusions criteria. It has been found that traditional umbilical stump care practices are still present in many communities, however, have been replaced by appropriate practices, the most recommended being: chlorhexidine 4% sanitation, soap and water and alcohol antisepsis 70%. Conclusions: There is a need for multi-professional involvement, approaching these women since pregnancy, with detailed information and accessible language about proper care with the newborn and the umbilical stump.

关键词： Perinatal Care The Umbilical Cord Patient Care Team Neonatology Newborn

Lachesis Muta Muta: State of the Art

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Journal of Life Sciences 2021年第1期15卷 1-10页

作者： Grazielle Delaroli Pilon Yoko Oshima-Franco biomedicine course University of Sorocaba(UNISO)Rodovia Raposo Tavares km 92.5SorocabaSP 18023-000Brazil Post-Graduate Program in Pharmaceutical Sciences University of Sorocaba(UNISO)Rodovia Raposo Tavares km 92.5SorocabaSP 18023-000Brazil

This article was carried out to gather a collection of data extracted from several studies about the snake Lachesis muta muta(surucucu),encompassing in this information from the effects and properties of its venom,case report,treatment and even *** was addressed throughout the study by referring mainly to their venom,which in isolated fractions,as LHFI,LHFII,LmTX-I,among others,present several activities,among which stand out are:coagulant,hemorrhagic,proteolytic and ***,other studies involving its diagnosis,treatment,cytotoxicity,edema,inflammation,genotoxicity and mutagenicity have also been carried *** bibliographic survey initially made,followed by the selection of collected data,was properly organized in the text using the narrative method,so that the findings could be chronologically distributed in a ***,it was possible to conclude that all these studies were and are of paramount importance to help understand the pathophysiology of envenoming by this snake,in addition to pointing out the Bothrops-Lachesis antivenom,opening a wide therapeutic window for numerous applications.

关键词： Lachesis muta muta snake venom state of the art

Scientific Evidence about the Assistance Provided to the Newborn with Meconium Elimination:Integrative Literature Review

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Open Journal of Obstetrics and Gynecology 2020年第4期10卷 504-515页

作者： Marília Cordeiro de Sousa Lívia Roberta Rodrigues Conceicao Marcela de Andrade Silvestre Lays de Souza Silva Camila de Pina Soares Sudário Renata Calciolari Rossi Janaína Valadares Guimaraes Thaila Correa Castral Karina Machado Siqueira Pedro Teixeira Meireles Bruno Belmonte Martineli Gomes George Kemil Abdalla Douglas Reis Abdalla Ana Karina Marques Salge Faculty of Nursing Federal University of GoiásGoianiaBrazil Western ParanáState University CascavelBrazil Medicine course University of UberabaUberabaBrazil biomedicine University of Sao PauloRibeirao PretoBrazil Health Sciences Faculty of Human TalentsUberabaBrazil

The Meconial Aspiration Syndrome (MAS) is a complication caused by the presence of meconium amniotic fluid with consequent aspiration, being responsible for important rates of perinatal morbidity and mortality. This study aims to analyze the bibliographical production on newborn care with meconium elimination in the delivery room. It was a literature integrative review electronically based. Most of the studies referred to tracheal intubation and exogenous surfactant ministration as main care methods. The Meconium Aspiration Syndrome is presented as main theme. It is understood that health care professionals must develop knowledge, skills and actions, showing conduct based on scientific, critical and reflexive knowledge with purposeful interventions directed to the patient’s needs.

关键词： Perinatal Care Meconium Aspiration Syndrome Newborn

Pregnancy: Protection of the Hyperactive Brain, or a Risk Factor?

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Journal of Behavioral and Brain Science 2014年第7期4卷 334-341页

作者： Zakaria I. Nanobashvili Irine G. Bilanishvili Arkadi G. Surmava Nata G. Bukia Marine P. Butskrikidze Lamara I. Machavariani Nino T. Samsieshvili Maia G. Barbaqadze Irma G. Khachidze Nadejda A. Khizanishvili Department of Neurophysiology Ivane Beritashvili Center of Experimental Biomedicine Tbilisi Georgia

The main objective of the study was to determine the effect of gestation and postgestation periods on development and course of seizure activity. The data obtained in the study showed that i) there is a reduction of both EEG and behavioral seizures during gestation in the presence of hippocampal epileptogenic locus (kindling model);ii) suppression of audiogenic seizures occurs in gestation, and development of audiogenic kindling and decrease of seizure reactions occur in the pseudogestation state. It is assumed that in gestation period the intensification of the possible endogenous inhibitory mechanisms follows the course of seizure activity.

关键词： Gestation Kindling Audiogenic Seizures Rats

T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway

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Cellular & Molecular Immunology 2017年第6期14卷 497-510页

作者： Jose-Ignacio Rodriguez-Barbosa Carlos Fernandez-Renedo Ana Maria Bravo Moral Leo Biihler Maria-Luisa del Rio Transplantation Immunobiology Section Institute of Biomedicine University of Leon and Castilla and Leon Regional Transplantation Coordination Leon University Hospital Leon Spain Department of Veterinary Clinical Sciences University of Santiago de Compostela Veterinary Faculty Lugo Spain Visceral and Transplantation Surgery Department of Surgery University Hospitals of Geneva and Faculty of Medicine Geneva Switzerland

The molecular pathways contributing to humoral-mediated allograft rejection are poorly defined. In this study, we assessed the role of the herpesvirus entry mediator/B- and T-lymphocyte attenuator （HVEM/BTLA） signalling pathway in the context of antibody-mediated allograft rejection. An experimental setting was designed to elucidate whether the blockade of HVEM/BTLA interactions could modulate de novo induction of host antidonor-specific antibodies during the course of graft rejection. To test this hypothesis, fully allogeneic major histocompatibility complex-mismatched skin grafts were transplanted onto the right flank of recipient mice that were treated with isotype control, anti-CD40L or modulatory antibodies of the HVEM/BTLA signalling pathway. The frequencies of CD4 T follicular helper （Tfh） cells （B220-, CD4＋ CXCR5＋ PD-lhigh）, extrafollicular helper cells （B220-, CD4＋ CXCR5- PD-1＋ and PD-1-） and germinal centre （GC） B cells （B220＋Fas＋ GL7＋） were analysed by flow cytometry in draining and non-draining lymph nodes at day 10 post transplantation during the acute phase of graft rejection. The host antidonor isotype-specific humoral immune response was also assessed. Whereas blockade of the CD40/CD40L pathway was highly effective in preventing the allogeneic humoral immune response, antibody-mediated blockade of the HVEM/BTLA-interacting pathway affected neither the expansion of Tfh cells nor the expansion of GC B cells. Consequently, the course of the host antidonor antibody-mediated response proceeded normally, without detectable evidence of impaired development. In summary, these data indicate that HVEM/BTLA interactions are dispensable for the formation of de novo host antidonor isotype-specific antibodies in transplantation.

关键词： BTLA (CD272) humoral immunity HVEM (TNFRSF14, CD270) T follicular helper cells transplantation

Specific Inhibition of Integrin α3β1-Mediated Tumor Metastasis by a Triple Negative Breast Cancer-Targeted Aptamer

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Specific Inhibition of Integrin α3β1-Mediated Tumor Metast...