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Active spatial control of photothermal heating and thermo-actuated convective flow by engineering a plasmonic metasurface with heterodimer lattices

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Photonics research 2022年第11期10卷 2642-2657页

作者： ZHIMIN JING PEIHANG LI CUIPING MA JIAYING WANG ROBERTO CAPUTO alexander OGOVOROV ARUP NEOGI HONGXING XU ZHIMING WANG Institute of Fundamental and Frontier sciences University of Electronic Science and Technology of ChinaChengdu 610054China Physics Department University of CalabriaRende I-87036Italy Department of Physics and Astronomy and Nanoscale and Quantum Phenomena Institute Ohio UniversityAthensOhio 45701USA School of Physics and Technology Center for Nanoscience and NanotechnologyWuhan UniversityWuhan 430072China Institute for Advanced Study Chengdu UniversityChengdu 610106China

Thermo-plasmonics, using plasmonic structures as heat sources, has been widely used in biomedical and microfluidic applications. However, a metasurface with single-element unit cells, considered as the sole heat source in a unit cell, functions at a fixed wavelength and has limited control over the thermo-plasmonically induced hydrodynamic effects. Plasmonic metasurfaces with metal disk heterodimer lattices can be viewed to possess two heat sources within a unit cell and are therefore designed to photo-actively control thermal distributions and fluid dynamics at the nanoscale. The locations of heat sources can be switched, and the direction of the convective flow in the central region of the unit cell can be reversed by shifting the wavelength of the excitation source without any change in the excitation direction or physical actuation of the structural elements. The temperature and velocity of a fluid are spatiotemporally controlled by the wavelength selectivity and polarization sensitivity of the plasmonic metasurface. Additionally, we investigate the effects of geometric parameters on the surface lattice resonances and their impact on the temperature and fluid velocity of the optofluidic system. Our results demonstrate excellent optical control of these plasmonic metasurface heating and thermal convection performances to design flexible platforms for microfluidics.

关键词： excitation reversed flow

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Double-AOTF-based aberration-free spectral imaging endoscopic system for biomedical applications

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Journal of Innovative Optical Health sciences 2015年第3期8卷 72-77页

作者： alexander Machikhin Vitold Pozhar Vladislav Batshev Scientic and Technological center of Unique Instrumentation RAS Butlerova Street 15Moscow 117342Russia Bauman Moscow State Technical University 2nd Baumanskaya Street 5Moscow 105005Russia

The problem of in vrivo photoluminescence diagnostics of the tissues acessible by endoscopes is *** spectral imaging module attachable to conventional rigid and flexible medical endoscopes is developed and *** is based on a double acousto-optical tunable filter(AOTF)and a specialized optical coupling *** module provides wide field of view(FOV),absence of image distortions,random spectral access,fast spectral image acquisition at any wavelength in the visible range and accurate measurement of reflectance spectrum in each pixel of the *** of typical biomedical samples are presented and *** spectra are compared to the reference data.

关键词： Spectral imaging spectrasoopy double monochromatization acousto-optical tunable fiter photoluminescence diagnostics endoscopy

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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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近期选择和牦牛渐渗共同促进黄牛对高原的适应性（英文）

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Science Bulletin 2024年第21期 3415-3424页

作者：吕阳汪富文成海建韩静党瑞华夏小婷王会钟金城 Johannes A.Lenstra 张虎才韩建林 David E.MacHugh Ivica Medugorac Maulik Upadhyay alexander S.Leonard 丁赫杨筱芮王明山索朗曲吉巴桑珠扎普布曲珍斯朗旺姆尼玛仓决达瓦马伟东刘建勇张继才黄必志祁兴山李付强黄永震马云王禹高元鹏吕文发雷初朝陈宁博 Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F University Key Laboratory of Animal Production Product Qualityand SecurityMinistry of EducationCollege of Animal Science and TechnologyJilin Agricultural University Institute of Animal Science and Veterinary Medicine Shandong Academy of Agricultural SciencesShandong Key Lab of Animal Disease Control and Breeding College of Veterinary Medicine Northwest A&F University Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Sichuan Province and Ministry of EducationSouthwest Minzu University Faculty of Veterinary Medicine Utrecht University Institute for Ecological research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan University Southwest United Graduate School Yazhouwan National Laboratory CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agriculture Sciences (CAAS) Animal Genomics Laboratory UCD School of Agriculture and Food ScienceUniversity College Dublin UCD Conway Institute of Biomolecular and biomedical research University College Dublin Population Genomics Group Department of Veterinary SciencesLMU Munich Animal Genomics ETH ZurichUniversitaetstrasse 2 State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of Sciences Institute of Animal Husbandry and Veterinary Science Xizang Autonomous Region Academy of Agricultural and Animal Husbandry Sciences Shigatse City Kangma County Shaogang Township Agriculture and Animal Husbandry Comprehensive Service center Shaanxi Province Agriculture & Husbandry Breeding Farm Yunnan Academy of Grassland and Animal Science Animal Husbandry Bureau in Biyang County Hunan Tianhua Industrial Corporation Ltd. Key Laboratory of Ruminant Molecular and Cellular Breeding of Ningxia Hui Autonomo

During the past 3000 years,cattle on the Qinghai-Xizang Plateau have developed adaptive phenotype under the selective pressure of hypoxia,ultraviolet (UV) radiation,and extreme *** genetic mech anism underlying this rapid adaptation is not yet well ***,we present whole-genome rese quencing data for 258 cattle from 32 cattle breeds/populations,including 89 Tibetan cattle representing eight populations distributed at altitudes ranging from 3400 m to 4300 *** genomic analysis revealed that Tibetan cattle exhibited a continuous phylogeographic cline from the East Asian taurine to the South Asian indicine *** found that recently selected genes in Tibetan cattle were related to body size (HMGA2 and NCAPG) and energy expenditure (DUOXA2).We identified signals of sympatric introgres sion from yak into Tibetan cattle at different altitudes,covering 0.64%–3.26%of their genomes,which included introgressed genes responsible for hypoxia response (EGLN1),cold adaptation (LRP11),DNA damage repair (LATS1),and UV radiation resistance (GNPAT).We observed that introgressed yak allele were associated with noncoding variants,including those in present *** Tibetan cattle,three yak introgressed SNPs in the EGLN1 promoter region reduced the expression of EGLN1,suggesting that these genomic variants enhance hypoxia *** together,our results indicated complex adaptation processes in Tibetan cattle,where recently selected genes and introgressed yak alleles jointly facilitated rapid adaptation to high-altitude environments.

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Computational cytometer based on magnetically modulated coherent imaging and deep learning

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Light(Science & Applications) 2019年第1期8卷 385-399页

作者： Yibo Zhang Mengxing Ouyang Aniruddha Ray Tairan Liu Janay Kong Bijie Bai Donghyuk Kim alexander Guziak Yi Luo Alborz Feizi Katherine Tsai Zhuoran Duan Xuewei Liu Danny Kim Chloe Cheung Sener Yalcin Hatice Ceylan Koydemir Omai B.Garner Dino Di Carlo Aydogan Ozcan Electrical and Computer Engineering Department University of CaliforniaLos AngelesCA 90095USA Department of Bioengineering University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute University of CaliforniaLos AngelesCA 90095USA Department of Physics and Astronomy University of ToledoToledoOH 43606USA Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA Yale School of Medicine New HavenCT 06510USA Department of Biochemistry University of CaliforniaLos AngelesCA 90095USA Department of Pathology and Laboratory Medicine University of CaliforniaLos AngelesCA 90095USA Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesCA 90095USA Jonsson Comprehensive Cancer center University of CaliforniaLos AngelesCA 90095USA Department of Surgery David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA

Detecting rare cells within blood has numerous applications in disease *** rare cell detection techniques are typically hindered by their high cost and low ***,we present a computational cytometer based on magnetically modulated lensless speckle imaging,which introduces oscillatory motion to the magneticbead-conjugated rare cells of interest through a periodic magnetic force and uses lensless time-resolved holographic speckle imaging to rapidly detect the target cells in three dimensions(3D).In addition to using cell-specific antibodies to magnetically label target cells,detection specificity is further enhanced through a deep-learning-based classifier that is based on a densely connected pseudo-3D convolutional neural network(P3D CNN),which automatically detects rare cells of interest based on their spatio-temporal features under a controlled magnetic *** demonstrate the performance of this technique,we built a high-throughput,compact and cost-effective prototype for detecting MCF7 cancer cells spiked in whole blood *** serial dilution experiments,we quantified the limit of detection(LoD)as 10 cells per millilitre of whole blood,which could be further improved through multiplexing parallel imaging channels within the same *** compact,cost-effective and high-throughput computational cytometer can potentially be used for rare cell detection and quantification in bodily fluids for a variety of biomedical applications.

关键词： rare magnetic speckle

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