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Signal acquisition of brain-computer interfaces:A medical-engineering crossover perspective review

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Fundamental Research 2025年第1期5卷 3-16页

作者： Yike Sun Xiaogang Chen Bingchuan Liu Liyan Liang Yijun Wang Shangkai Gao Xiaorong Gao Department of biomedical Engineering Tsinghua UniversityBeijing 100084China Institute of biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China Center for Intellectual Property and Innovation Development China Academy of Information and Communications TechnologyBeijing 100161China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China

Brain-computer interface(BCI)technology represents a burgeoning interdisciplinary domain that facilitates direct communication between individuals and external *** efficacy of BCI systems is largely contingent upon the progress in signal acquisition *** paper endeavors to provide an exhaustive synopsis of signal acquisition technologies within the realm of BCI by scrutinizing research publications from the last ten *** review synthesizes insights from both clinical and engineering viewpoints,delineating a comprehensive two-dimensional framework for understanding signal acquisition in *** delineate nine discrete categories of technologies,furnishing exemplars for each and delineating the salient challenges pertinent to these *** review furnishes researchers and practitioners with a broad-spectrum comprehension of the signal acquisition landscape in BCI,and deliberates on the paramount issues presently confronting the *** enhancements in BCI signal acquisition should focus on harmonizing a multitude of disciplinary *** equilibrium between signal fidelity,invasiveness,biocompatibility,and other pivotal considerations is *** doing so,we can propel BCI technology forward,bolstering its effectiveness,safety,and depend-ability,thereby contributing to an auspicious future for human-technology integration.

关键词： Brain-computer interface Signal acquisition technologies Surgery Detection Human computer interaction

pH-responsive AIE nanogels for synergistic chemo-photodynamic cancer therapy with imaging guidance

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science China Chemistry 2025年第04期 1445-1455页

作者： Yilin Zhu Liping Zhang Rongyuan Zhang Chenghan He Han Yang Yong Liu Ryan T.K.Kwok Jacky W.Y.Lam Jianwei Sun Jing Feng Zheng Zhao Cuiping Yao Ben Zhong Tang Institute of biomedical Photonics and Sensing School of Life Science and TechnologyXi'an Jiaotong University Clinical Translational Research Center of Aggregation-Induced Emission The Second Affiliated HospitalSchool of MedicineSchool of Science and EngineeringShenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen (CUHK-Shenzhen) Department of Urology Jining NO.1 People's Hospital AIE Institute Department of Chemistry the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionDivision of Life ScienceState Key Laboratory of Molecular Neuroscienceand Department of Biological and Chemical EngineeringThe Hong Kong University of Science and Technology

Photodynamic therapy(PDT) is a promising cancer treatment that uses photosensitizers(PSs) to generate cytotoxic reactive oxygen species(ROS) under light, but improving its efficacy is crucial for clinical applications. To address this, we propose a smart nanoplatform(P@BAO-DOX) for synergistic chemo-photodynamic therapy, featuring efficient PDT, controllable drug release, and fluorescence imaging guidance. We designed an aggregation-induced emission(AIE)-based PS(BAO) with effective ROS generation and NIR-II fluorescence. Additionally, BAO as a PS and doxorubicin(DOX) as a chemo drug were encapsulated in p H-responsive nanogels(PNA) to obtain P@BAO-DOX nanogels. Upon uptake by tumor cells, the nanogel releases drugs in acidic conditions, leading to cell death. White light irradiation further triggers BAO to produce substantial ROS,enhancing phototoxicity and synergistic chemo-PDT cancer therapy. Thus, P@BAO-DOX nanogels, as a smart nanoplatform,offer precise drug release and efficient ROS generation for imaging-guided chemo-PDT synergistic therapy, showing promise in advancing cancer treatment.

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Single-molecule techniques in studying the molecular mechanisms of DNA synapsis in non-homologous end-joining repair

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Biophysics Reports 2025年第1期11卷 46-55页

作者： Yuhao Jiang Chao Zhao Chenyang Zhang Weilin Li Di Liu Bailin Zhao Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University Institute of Molecular and Translational Medicine (IMTM) and Department of Biochemistry and Molecular Biology Xi'an Jiaotong University Health Science Center Institute of biomedical and Health Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences

DNA double-strand breaks(DSBs) are the most severe form of DNA damage, primarily repaired by the non-homologous end joining(NHEJ) pathway. A critical step in this process is DNA synapsis, where the two broken ends are brought together to facilitate timely repair. Deficiencies in NHEJ synapsis can lead to improper DNA end configurations, potentially resulting in chromosomal translocations. NHEJ synapsis is a highly dynamic, multi-protein mediated assembly process. Recent advances in single-molecule techniques have led to significant progress in understanding the molecular mechanisms driving NHEJ synapsis. In this review, we summarize single-molecule methods developed for studying NHEJ synapsis, with a particular focus on the single-molecule fluorescence resonance energy transfer(sm FRET)technique. We discuss the various molecular mechanisms of NHEJ synapsis uncovered through these studies and explore the coupling between synapsis and other steps in NHEJ. Additionally, we highlight the strategies, limitations, and future directions for single-molecule studies of NHEJ synapsis.

关键词： Single-molecule techniques smFRET Magnetic tweezers Non-homologous end joining (NHEJ) DNA Synapsis

Nutrients deprivation of biomimetic nanozymes for cascade catalysis triggered and oxidative damage induced tumor eradication

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Chinese Chemical Letters 2025年第03期 379-384页

作者： Yingtao Zhong Ziwen Qiu Yanmei Li Jiaqi Huang Zhenming Lu Renjiang Kong Ni Yan Hong Cheng School of biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical University

Deprivation of glucose and lactate provides an effective pathway to terminate the nutrients supplement for tumor growth. In this work, biomimetic nanozymes called m@BGLC are constructed for catalytic tumor inhibition through nutrients deprivation and oxidative damage induction. Concretely, the catalytic enzymes of glucose oxidase(GOx), lactate oxidase(LOx) and chloroperoxidase(CPO) are precrosslinked with bovine serum albumin(BSA) to construct nanozymes, which are then biomimetic functionalized with cancer cell membrane to prepare m@BGLC. Benefiting from the biomimetic camouflage with homologous cell membrane, m@BGLC inherit homotypic binding and immune escape abilities, facilitating the tumor targeting accumulation and preferable cell internalization for improved drug delivery ***, under the cascade catalysis of nanozymes, m@BGLC consume glucose and lactate for tumor starvation therapy through nutrients deprivation, and meanwhile, the resulting hyprochloric acid(HCl O) causes an oxidative damage of cells to synergistically inhibit tumor growth. In vitro and in vivo findings demonstrate a robust tumor eradication effect of m@BGLC without obvious adverse reactions via the targeted combination therapy. Such cascade catalytic nanomedicine may inspire the development of sophisticated strategies for tumor combination therapy under unfavorable tumor microenvironments.

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Impact of COVID-19 Response Measures on Physicochemical Parameters of Surface Waters in Yaoundé City

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Journal of Geoscience and Environment Protection 2025年第1期13卷 444-456页

作者： Marie Christine Tombedi Serge Eteme Enama Georgia Elna Ambada Ndzengue Lucie Leme Banock Claudine Ntsama Essomba Department of Animal Biology and Physiology Faculty of Science University of Yaound I Yaound Cameroon Pharmacy Unit Faculty of Medicine and Biomedical Sciences University of Yaound I Yaound Cameroon

The widespread use of disinfectants and various medications in response to the COVID-19 pandemic has raised concerns about their potential impact on the characteristics of natural waters. To assess the effect of the COVID-19 response on surface waters in Yaoundé, various physicochemical parameters of three rivers (Mfoundi, Tongolo, and Mingoa) were examined over 8 months. The selection of these rivers was based on their proximity to hospitals involved in COVID-19 patient management. Physico-chemical parameters were measured following standard protocols, and their spatiotemporal variations and the influence of various factors, were examined. The results revealed that, during the study period, the values for temperature (23˚C to 30˚C), dissolved oxygen (14% to 90%), pH (6.2 to 9.5), electrical conductivity (100 to 662 µS/cm), oxidability (0.19 to 42.19 mg/l), and suspended solids (1 to 725 mg/l) exhibited variations, except for total dissolved solids (30 to 470 mg/l), whose levels remained within the recommended limit (s = 0.812, P = 0.014) with oxidability levels in the Tongolo river. The COVID-19 response measures had a limited negative effect on the surface waters of Yaoundé during the study period. This could be attributed to the disproportionate application of hygiene measures among the city’s populations. Additionally, the lack of flow observed in certain rivers requires particular attention from authorities and the populations to safeguard the city’s ecosystems.

关键词： COVID-19 Environmental Health Watercourses Physicochemical Parameters Cameroon

Self-assembling chemically modified siRNA nanorings for RNAi therapy and neuroprotection in Alzheimer's disease

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science China Chemistry 2025年

作者： Yifan Jiang Lisha Li Xiao Fang Tao Zeng Lichao Su Yichang Liu Ying Wu Jinyu Li Peng Lyu Zhonglei Lu Chunhua Lu Huanghao Yang New Cornerstone science Laboratory Ministry of Education Key Laboratory for Analytical Science of Food Safety and BiologyCollege of Chemistry Fuzhou University Fujian Key Laboratory of Medical Analysis Fujian Academy of Medical Sciences Department of Neurosurgery Fujian Institute of Brain Disorders and Brain Science Fujian Clinical Research Center for Neurological Diseases First Affiliated Hospital Fujian Medical University National & Local Joint biomedical Engineering Research Center on Photodynamic Technologies College of Chemistry Fuzhou University College of Biological science and Technology Fuzhou University School of Medicine Fuzhou University

The development of RNA interference(RNAi) therapy offers a potential solution for Alzheimer's disease(AD). However, the brain-blood barrier(BBB) with its selective permeability and pharmacokinetic-related challenges poses restrictions on the delivery of small interfering RNA(siRNA) to the central nervous system(CNS). In this study, we demonstrate that the incorporation of 2'-fluoro(2'-F) substitutions and L-carnitine modification facilitates the self-assembly of siRNA through triple interaction, leading to the formation of nanorings, called LCSF-NR. Based on the enhanced cellular uptake and lysosomal escape by 2'-F substitution and the transport across the BBB promoted by L-carnitine, the nanorings realized the improved braintargeted delivery of siRNA, both in zebrafish and mice models. Moreover, our findings highlight the therapeutic potential of LCSF-NR formulation in an AD zebrafish model through a synergistic effect of downregulating the β-site APP cleavage enzyme1(BACE1) gene and L-carnitine-mediated neuroprotection, effectively inhibiting pathological processes. Overall, these results suggest that the chemical modification-based siRNA self-assembly strategy enables trans-BBB delivery and presents a concise approach for synergistic therapy of AD.

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Antidepressive and anxiolytic effects of a combination of Saffron and Chamomile in rats and their relationship with serotonin using in vivo methods

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Journal of Traditional Chinese Medicine 2025年第1期45卷 49-56页

作者： Faiq Amin Saara Ahmad Muhammad Wasim Asra Khan Fazal Manzoor Arain Zehra Batool Saiqa Tabassum Saima Khaliq Noreen Samad Saida Haider Department of Biological and biomedical sciences the Aga Khan University Maternal and Children's Health Research Institute Shunde Women and Children's HospitalGuangdong Medical University Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of Karachi Department of Biosciences Shaheed Zulfikar Ali Bhutto Institute of Science and Technology Department of Biochemistry Federal Urdu University of ScienceArts and Technology Department of Biochemistry Bahauddin Zakariya University Department of Biochemistry University of Karachi

OBJECTIVE: To explore the potential of combining natural herbs like chamomile and saffron for the management of anxiety and depression. METHODS: A rodent model of Major Depressive Disorder(MDD) and anxiety, secondary to streptozotocin-induced diabetes mellitus was made. A total of 6 rat groups were chosen; healthy and diseased controls; and diseased test groups of fluoxetine, saffron, chamomile, and combined saffron and chamomile treated(n = 6/group). Activity by forced swim test(FST), elevated plus maze test(EPMT), and correlations with biochemical markers like serum glucose, tryptophan, C-reactive protein(CRP), brain derived neurotrophic factor(BDNF) and 5-hydroxytryptamine 2C receptor(5HT2CR) expression, were assessed at the end of the 3rd week of the treatment. A one-way analysis of variance with a post-hoc Tukey's test was applied. RESULTS: The combined herbal treatment group showed significantly better(P < 0.05) than all other groups in terms of anti-hyperglycemic effect. All treatments improved the CRP levels; however, the combination group was also significantly better than fluoxetine and the individual herb groups. Only the herb groups showed efficacy in the FST with added benefits of the combination group over the healthy controls and similar trends in the EPMT. However, expression of 5HT2CR was repressed while BDNF was elevated through treatment. CONCLUSION: This study shows that in comparison to treatment with a SSRI, and individual herbs, the combination of chamomile and saffron showed overall improved outcomes.

关键词： chamomile crocus depression diabetes mellitus

The study of antibacterial activity of cationic poly(β-amino ester)regulating by amphiphilic balance

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Chinese Chemical Letters 2025年第2期36卷 332-336页

作者： Chong Liu Ling Li Jiahui Gao Yanwei Li Nazhen Zhang Jing Zang Cong Liu Zhaopei Guo Yanhui Li Huayu Tian School of Materials science and Engineering Changchun University of Science and Technology School of Materials science and Engineering Xiamen University of Technology Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences College of Chemistry and Chemical Engineering Xiamen University

It is well known that cationic polymers have excellent antimicrobial capacity accompanied with high biotoxicity, to reduce biotoxicity needs to decrease the number of cationic groups on polymers, which will influence antimicrobial activity. It is necessary to design a cationic polymer mimic natural antimicrobial peptide with excellent antibacterial activity and low toxicity to solve the above dilemma. Here,we designed and prepared a series of cationic poly(β-amino ester)s(PBAEs) with different cationic contents, and introducing hydrophobic alkyl chain to adjust the balance between antimicrobial activity and biotoxicity to obtain an ideal antimicrobial polymer. The optimum one of synthesized PBAE(hydrophilic cationic monomer:hydrophobic monomer = 5:5) was screened by testing cytotoxicity and minimum inhibitory concentration(MIC), which can effectively kill S. aureus and E. coli with PBAE concentration of15 μg/m L by a spread plate bacteriostatic method and dead and alive staining test. The way of PBAE killing bacterial was destroying the membrane like natural antimicrobial peptide observed by scanning electron microscopy(SEM). In addition, PBAE did not exhibit hemolysis and cytotoxicity. In particular, from the result of animal tests, the PBAE was able to promote healing of infected wounds from removing mature S. aureus and E. coli on the surface of infected wound. As a result, our work offers a viable approach for designing antimicrobial materials, highlighting the significant potential of PBAE polymers in the field of biomedical materials.

关键词： Amphiphilic balance Antimicrobial Cationic polymers Michael addition polymerization Poly(β-amino ester)s

Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway

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World Journal of Gastroenterology 2025年第6期31卷 44-61页

作者： Han-Ning Xuan Yuan Hyun Sung Kim Gye Ryeol Park Jae Eun Ryu Ji Eun Kim In Young Kang Hye Young Kim Seung Min Lee Ju Hee Oh Eileen L Yoon Dae Won Jun Department of Internal Medicine Hanyang University School of MedicineSeoul 04763South Korea Department of Pathology Hanyang University School of MedicineSeoul 04763South Korea Department of Translational Medicine Graduate School of Biomedical Science and EngineeringHanyang UniversitySeoul 04763South Korea Department of Obstetrics and Gynecology Institute of Women’s Medical Life ScienceYonsei Cancer CenterSeverance HospitalYonsei University College of MedicineSeoul 04763South Korea Department of Internal Medicine Sanggye Paik HospitalInje University College of MedicineSeoul 01757South Korea

BACKGROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver *** study aims to specifically investigate the role of MLKL’s adenosine triphosphate(ATP)-binding pocket in facilitating necroptosis-independent pathways that may contribute to liver disease *** focusing on this mechanism,we seek to identify potential therapeutic targets that can modulate MLKL activity,offering new strategies for the prevention and treatment of liver-related *** To investigate the possibility of using the ATP-binding pocket-associated,necro-ptosis-independent MLKL pathway as a target for liver *** Cell death following necroptosis stimuli was evaluated using cell proliferation assays,flow cytometry,and electron microscopy in various *** human liver organoid system was used to evaluate whether the MLKL ATP pocket-binding inhibitor could attenuate ***,alcoholic and non-alcoholic fatty liver diseases animal models were used to determine whether MLKL ATP pocket inhibitors could attenuate liver *** While an MLKL ATP pocket-binding inhibitor did not prevent necroptosis-induced cell death in RAW 264.7 cells,it did reduce the necroptosis-led expression of CXCL2,ICAM,and ***,MLKL ATP pocket inhibitor diminishes the expression of CXCL2,ICAM,and VCAM by inhibiting the IκB kinase and nuclear factor kappa-B pathways without inducing necroptosis-induced cell death in two-dimensional cell culture as well as the human-derived liver organoid *** MLKL ATP-binding inhibitor was ineffective in non-alcoholic fatty liver disease animal models,MLKL ATP-binding inhibitor attenuated hepatic inflammation in the alcoholic liver disease *** MLKL ATP pocket-binding inhibitor exerted anti-inflammatory effects through the necroptosis-independent MLKL pathway in an animal model of alcoholic liver disease.

关键词： RAW 264.7 cell Cell death Necroptosis Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease