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Single-cell transcriptomic profiling of non-hematopoietic circulating cells in mid-gestational mouse embryos

Journal of Genetics and Genomics 2021年第6期48卷 508-511页

作者： Yanyan Li Yanjuan Chen Xiaona Zheng Yun Gao Yuxuan Zheng Zongcheng Li Han He Fuchou Tang Bing Liu Yu Lan Key Laboratory for Regenerative medicine of Ministry of Education Institute of HematologySchool of MedicineJinan UniversityGuangzhouGuangdong 510632China Integrated Chinese and Western medicine Postdoctoral Research Station Jinan UniversityGuangzhouGuangdong 510632China biomedical institute for pioneering investigation via convergence College of Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Experimental Hematology Institute of HematologyFifth Medical Center of Chinese PLA General HospitalBeijing 100071China

The circulatory system is indispensable for an animal’s normal *** addition to well-characterized hematopoietic cells,several types of circulating non-hematopoietic cells have been identified in adult mice(Zhang and ... 详细信息

关键词： hematopoietic gestational circulating

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Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies

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National Science Review 2020年第8期7卷 1306-1318页

作者： Kai Yu Yuqiong Hu Fan Wu Qiufang Guo Zenghui Qian Waner Hu Jing Chen Kuanyu Wang Xiaoying Fan Xinglong Wu John EJ Rasko Xiaolong Fan Antonio Iavarone Tao Jiang Fuchou Tang Xiao-Dong Su biomedical pioneering Innovation center (BIOPIC) School of Life Sciences Peking University Beijing Advanced Innovation center for Genomics School of Life Sciences Peking University biomedical institute for pioneering investigation via convergence and center for reproductive medicine Ministry of Education Key Laboratory of Cell Proliferation and Differentiation Department of Molecular Neuropathology Beijing Neurosurgical Institute Capital Medical University Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Chinese Glioma Genome Atlas Network (CGGA) and Asian Glioma Genome Atlas Network (AGGA) Peking-Tsinghua center for Life Sciences Peking University Gene and Stem Cell Therapy Program Centenary Institute University of Sydney Department of Cell and Molecular Therapies Royal Prince Alfred Hospital Beijing Key Laboratory of Gene Resource and Molecular Development Laboratory of Neuroscience and Brain Development Beijing Normal University institute for Cancer Genetics Herbert Irving Comprehensive Cancer Center Columbia University Medical Center Department of Pathology & Cell Biology Columbia University Medical Center Department of Neurology Columbia University Medical Center center of Brain Tumor Beijing Institute for Brain Disorders

Brain tumors are among the most challenging human tumors for which the mechanisms driving progression and heterogeneity remain poorly understood. We combined single-cell RNA-seq with multi-sector biopsies to sample and analyze single-cell expression profiles of gliomas from 13 Chinese patients. After classifying individual cells, we generated a spatial and temporal landscape of glioma that revealed the patterns of invasion between the different sub-regions of gliomas. We also used single-cell inferred copy number variations and pseudotime trajectories to inform on the crucial branches that dominate tumor *** dynamic cell components of the multi-region biopsy analysis allowed us to spatially deconvolute with unprecedented accuracy the transcriptomic features of the core and those of the periphery of glioma at single-cell level. Through this rich and geographically detailed dataset, we were also able to characterize and construct the chemokine and chemokine receptor interactions that exist among different tumor and non-tumor cells. This study provides the first spatial-level analysis of the cellular states that characterize human gliomas. It also presents an initial molecular map of the cross-talks between glioma cells and the surrounding microenvironment with single-cell resolution.

关键词： glioma heterogeneity multi-sector biopsy single-cell RNA-seq

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