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Mechanical performance and cyocompatibility of PU/PLCL nanofibrous electrospun scaffolds for skin regeneration

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Engineered Regeneration 2022年第1期3卷 53-58页

作者： Xiang Gao Meiling Wen Yang Liu Tian Hou Meiwen An Institute of biomedical Engineering College of Biomedical EngineeringTaiyuan University of TechnologyShanxi Key Laboratory of Material Strength&Structural ImpactTaiyuanShanxi030024China Research center for Nano-Biomaterials&Regenerative Medicine Department of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Skin tissue engineering with considerable skin regeneration capability is an urgent need for the wound *** current challenge for researchers is to develop a bionic scaffold that imitates the extracellular matrix for the regeneration of the damaged *** our study,poly(L-lactide-co-caprolactone)(PLCL)was blended with polyurethane(PU)to obtain nanofibrous scaffolds via *** electrospun fibers with 50%PLCL content had a certain number of intersections and jointing points,and exhibited significantly enhanced mechani-cal properties combined with suitable ***,cell activities demonstrated that PU/PLCL membranes had significantly biological advantages in enhanced growth of human skin fibroblasts with spreading morphology compared with PU membranes,indicating good cytocompatibility of composite *** findings proved that PU/PLCL electrospun membranes have great potential in applications of skin tissue engineering.

关键词： Electrospun membranes Poly(L-lactide-co-caprolactone) Polyurethane Human skin fibroblasts Skin tissue engineering

Comparison of fatty acid profile of three adipose tissues in Ningxiang pigs

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Animal Nutrition 2018年第3期4卷 256-259页

作者： Qianming Jiang Chenyan Li Yuannian Yu Yueteng Xing Dingfu Xiao Bin Zhang Hunan Co-innovation center of Animal Production Safety College of Animal Science and Technology Hunan Agricultural University

The present study is conducted to determinate fatty acids(FA) composition in 3 adipose tissues. Subcutaneous and perirenal adipose tissues were prepared from 24 Ningxiang castrated boars and 24 castrated gilts fattened by a traditional diet for 56 d, respectively. The results showed that the FA profile in the 3 adipose tissues(dorsal subcutaneous adipose [DSA], abdominal subcutaneous adipose [ASA], and perirenal adipose [PA]) differed greatly. In boars, the proportions of oleic acid(c18:1 n9 c)(P < 0.05), cis-11-20 c acid(c20:1)(P < 0.05), and a-linolenic acid(c18:3 n3)(P < 0.05) in DSA were the highest among 3 adipose tissues, whereas palmitic acid(c16:0)(P < 0.05) and stearic acid(c18:0)(P < 0.05) in DSA had the lowest proportion. In gilts, cis-11-20 c acid(c20:1)(P < 0.05) in DSA was the highest, while stearic acid(c18:0)(P < 0.05) in subcutaneous adipose was the lowest among these deposits. Overall, the results indicate that from external to inner carcass of boars, the sum of saturated fatty acids(SFA) increase, but the sum of monounsaturated fatty acids(MUFA) decrease, while ASA of gilts have the greatest proportion of MUFA and the lowest SFA. Sex and adipose locations as significant effects on the FA profile are interaction.

关键词： Fatty acid Dorsal subcutaneous adipose Abdominal subcutaneous adipose Perirenal adipose Ningxiang pig

TiO2-Loaded WO3 Composite Films for Enhancement of Photocurrent Density

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Chinese Physics Letters 2017年第2期34卷 112-116页

作者： Wen-Gui Wang Li Zhu Yu-Yan Weng Wen Dong College of Physics Optoelectronics and EnergyCollaborative Innovation Center of Suzhou Nano Science and Jiangsu Key Laboratory of Thin FilmsSoochow UniversitySuzhou 215006

Titanium dioxide （TiO2） loaded tungsten trioxide （WO3） composite films are prepared by an E-beam vapor system. Associated with the existence of a heterojunction at the interface of TiO2 and WO3, the prepared TiO2-WO3 composite film shows enhanced photocurrent density, four times than the pure WO3 film illuminated under xenon lamp, and higher incident-photon-to-current conversion e^ciency. By varying the initial TiO2 film thickness, such composite structures could be optimized to obtain the highest photocurrent density. We believe that thin TiO2 films improve the light response and increase the surface roughness of WO3 films. Furthermore, the existence of the heterojunction results in the e^cient charge carriers＇ separation, transfer process, and a lower recombination of electron-hole pairs, which is beneficial for the enhancement of photocurrent density.

关键词： TiO2-Loaded WO3 Composite Films for Enhancement of Photocurrent Density FTO

An Object-Oriented Diagnostic Model for the Quantification of Porewater Geochemistry in Marine Sediments

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Journal of Earth Science 2015年第5期26卷 648-660页

作者： Hong Ye Tao Yang Guorong Zhu Shaoyong Jiang State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering Nanjing University Collaborative innovation center of South China Sea Studies Nanjing University State Key Laboratory of Geological Processes and Mineral Resources Faculty of Earth Resources Collaborative Innovation Center for Exploration of Strategic Mineral Resources China University of Geosciences

The reaction-transport model is widely used to identify and quantify dissolved chemical species in sediment porewaters. In this paper, a modularized code framework of diagenetic model was proposed as a diagnostic tool to fit the porewater profiles in marine sediments. Based on the conservation principle of the finite volume method, we combined the discretized diagenetic equations with various geochemical reactions, including but not limited to methanogenesis, sulfate reduction, etc.. The code was organized in object-oriented FORTRAN and verified with literature parameters, which proved its robustness and effectiveness. Finally, three different sites（IODP Expedition 311 Site U1327, UBGH2-1_1, ODP Leg204 Site 1245） are exemplified as case studies.

关键词： porewater diagenesis reaction-transport model

Multifunctional mesoporous silica nanoparticles for biomedical applications

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5807-5834页

作者： Bolong Xu Shanshan Li Rui Shi Huiyu Liu Beijing Advanced innovation center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic CompositesBionanomaterials&Translational Engineering LaboratoryBeijing Key Laboratory of BioprocessBeijing Laboratory of Biomedical MaterialsBeijing University of Chemical Technology100029 BeijingChina National center for Orthopaedics Beijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan Hospital100035 BeijingChina

Mesoporous silica nanoparticles(MSNs)are recognized as a prime example of nanotechnology applied in the biomedical field,due to their easily tunable structure and composition,diverse surface functionalization properties,and excellent *** the past two decades,researchers have developed a wide variety of MSNs-based nanoplatforms through careful design and controlled preparation techniques,demonstrating their adaptability to various biomedical application *** the continuous breakthroughs of MSNs in the fields of biosensing,disease diagnosis and treatment,tissue engineering,etc.,MSNs are gradually moving from basic research to clinical *** this review,we provide a detailed summary of MSNs in the biomedical field,beginning with a comprehensive overview of their development *** then discuss the types of MSNs-based nanostructured architectures,as well as the classification of MSNs-based nanocomposites according to the elements existed in various inorganic functional ***,we summarize the primary purposes of surface-functionalized modifications of *** the following,we discuss the biomedical applications of MSNs,and highlight the MSNs-based targeted therapeutic modalities currently *** the importance of clinical translation,we also summarize the progress of MSNs in clinical ***,we take a perspective on the future direction and remaining challenges of MSNs in the biomedical field.

关键词： nanoparticles breakthrough inorganic

Integrated data mining and network pharmacology to discover a novel traditional Chinese medicine prescription against diabetic retinopathy and reveal its mechanism

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TMR Modern Herbal Medicine 2024年第2期7卷 41-55页

作者： Kai-Lun Zhang Xu Wang Xiang-Wei Chang Jun-Fei Gu Bo-Yang Zhu Shi-Bing Wei Bo Wu Can Peng Jiu-Sheng Nie De-Ling Wu College of Pharmacy Anhui University of Chinese MedicineHefei 230012China School of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China MOE-Anhui Joint Collaborative innovation center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials Anhui University of Chinese MedicineHefei 230012China Institute of Pharmaceutics Anhui Academy of Chinese MedicineHefei 230012China Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Anhui University of Chinese MedicineHefei 230012China Engineering Technology Research center of Modernized Pharmaceutics Anhui Education Department(AUCM)Hefei 230012China The First Clinical Medical College Anhui University of Chinese MedicineHefei 230012China

Background:Diabetic retinopathy(DR)is currently the leading cause of blindness in elderly individuals with *** Chinese medicine(TCM)prescriptions have shown remarkable effectiveness for treating *** study aimed to screen a novel TCM prescription against DR from patents and elucidate its medication rule and molecular mechanism using data mining,network pharmacology,molecular docking and molecular dynamics(MD)***:TCM prescriptions for treating DR was collected from patents and a novel TCM prescription was identified using data ***,the mechanism of the novel TCM prescription against DR was explored by constructing a network of core TCMs-core active ingredients-core targets-core ***,molecular docking and MD simulation were employed to validate the findings from network ***:The TCMs of the collected prescriptions primarily possessed bitter and cold properties with heat-clearing and supplementing effects,attributed to the liver,lung and kidney ***,a novel TCM prescription for treating DR was identified,composed of Lycii Fructus,Chrysanthemi Flos,Astragali Radix and Angelicae Sinensis *** core active ingredients and ten core targets of the novel TCM prescription for treating DR were ***,the novel TCM prescription played a crucial role for treating DR by inhibiting inflammatory response,oxidative stress,retinal pigment epithelium cell apoptosis and retinal neovascularization through various pathways,such as the AGE-RAGE signaling pathway in diabetic complications and the MAPK signaling ***,molecular docking and MD simulation demonstrated that almost all core active ingredients exhibited satisfactory binding energies to core ***:This study identified a novel TCM prescription and unveiled its multi-component,multi-target and multi-pathway characteristics for treating *** findings provide a scientific basis and novel insights into

关键词： TCM prescriptions diabetic retinopathy medication rule molecular mechanism data mining network pharmacology molecular docking

PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton,modulating emotional behavior

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Zoological Research 2024年第3期45卷 535-550页

作者： Laidong Yu Fangfang Zeng Mengshu Fan Kexuan Zhang Jingjing Duan Yalu Tan Panlin Liao Jin Wen Chenyu Wang Meilin Wang Jialong Yuan Xinxin Pang Yan Huang Yangzhou Zhang Jia-Da Li Zhuohua Zhang Zhonghua Hu Hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China center for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China National Clinical Research center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Provincial Clinical Research center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China MOE Key Lab of Rare Pediatric Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China Department of Neurosciences University of South China Medical SchoolHengyangHunan 421001China

Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain *** abnormalities,such as defects in the density and morphology of postsynaptic dendritic spines,underlie the pathology of various neuropsychiatric *** 17(PCDH17)is associated with major mood disorders,including bipolar disorder and ***,the molecular mechanisms by which PCDH17 regulates spine number,morphology,and behavior remain *** this study,we found that PCDH17 functions at postsynaptic sites,restricting the number and size of dendritic spines in excitatory *** overexpression of PCDH17 in the ventral hippocampal CA1 results in spine loss and anxiety-and depression-like behaviors in ***,PCDH17 interacts with actin-relevant proteins and regulates actin filament(F-actin)***,PCDH17 binds to ROCK2,increasing its expression and subsequently enhancing the activity of downstream targets such as LIMK1 and the phosphorylation of cofilin serine-3(Ser3).Inhibition of ROCK2 activity with belumosudil(KD025)ameliorates the defective F-actin organization and spine structure induced by PCDH17 overexpression,suggesting that ROCK2 mediates the effects of PCDH17 on F-actin content and spine ***,these findings reveal a novel mechanism by which PCDH17 regulates synapse development and behavior,providing pathological insights into the neurobiological basis of mood disorders.

关键词： Synapse development Dendritic spine Mood disorder Actin cytoskeleton Animal behavior

Design of Si3N4 ridge-slot micro-ring resonator and generation of dual-comb based on orthogonally bicolor pumping

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Optoelectronics Letters 2024年第11期20卷 647-653页

作者： WEN Jin WANG Qian YU Huimin WU Zhengwei ZHANG Hui School of Science Xi'an Shiyou University Shaanxi Engineering Research center of Oil and Gas Resource Optical Fiber Detection Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas wells

A novel high quality-factor（Q） micro-ring resonator（MRR） structure based on the Si3N4ridge-slot waveguide is proposed, and the MRR is pumped by orthogonally polarized bicolor pumping to generate dual-comb.

关键词： A

Acidic domains differentially read histone H3 lysine 4 methylation status and are widely present in chromatin-associated proteins

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Science China(Life Sciences) 2017年第2期60卷 138-151页

作者： Meng Wu Wei Wei Jiwei Chen Rong Cong Tieliu Shi Jiwen Li Jiemin Wong James X.Du Shanghai Key Laboratory of Regulatory Biology the Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Collaborative innovation center for Cancer Medicine Sun Yat-Sen University Cancer CenterGuangzhou 510060China University de Lyon Ecole Normale Supdrieure de LyonCNRS USR 3010Laboratoire Joliot-CurieLyon 69364France

Histone methylation is believed to provide binding sites for specific reader proteins, which translate histone code into biological function. Here we show that a family of acidic domain-containing proteins including nucleophosmin （NPM 1）, pp32, SET/TAF 113, nucleolin （NCL） and upstream binding factor （UBF） are novel H3K4me2-binding proteins. These proteins exhibit a unique pattern of interaction with methylated H3K4, as their binding is stimulated by H3K4me2 and inhibited by H3K4mel and H3K4me3. These proteins contain one or more acidic domains consisting mainly of aspartic and/or glutamic residues that are necessary for preferential binding of H3K4me2. Furthermore, we demonstrate that the acidic domain with sufficient length alone is capable of binding H3K4me2 in vitro and in vivo. NPM1, NCL and UBF require their acidic domains for association with and transcriptional activation ofrDNA genes. Interestingly, by defining acidic domain as a sequence with at least 20 acidic residues in 50 continuous amino acids, we identified 655 acidic domain-containing protein coding genes in the human genome and Gene Ontology （GO） analysis showed that many of the acidic domain proteins have chromatin-related functions. Our data suggest that acidic domain is a novel histone binding motif that can differentially read the status of H3K4 methylation and is broadly present in chromatin-associated proteins.

关键词： histone methylation H3K4mel H3K4me2 H3K4me3 acidic domain histone code transcription chromatin