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A scaffold with zinc-whitlockite nanoparticles accelerates bone reconstruction by promoting bone differentiation and angiogenesis

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Nano research 2023年第1期16卷 757-770页

作者： Mingming Wang Jiaxin Yao Shihong Shen Chunning Heng Yanyi Zhang Tao Yang Xiaoyan Zheng Shaanxi Key Laboratory of degradable biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China Biotech.&Biomed.research Institute Northwest UniversityXi’an 710069China Xi’an Giant Biogene Technology Co. Ltd.Xi’an 710069China Shaanxi Key Laboratory for Theoretical Physics Frontiers Institute of Modern PhysicsNorthwest UniversityXi’an 710127China

The therapy of bone defects based on advanced biological scaffolds offers the most promising therapeutic strategy for bone *** is still challenging to develop scaffolds with the mechanical,osteogenic,angiogenic,and antibacterial properties required for bone defect ***,a novel organic/inorganic composite scaffold(zinc-whitlockite(ZnWH)/G/H)was synthesized using gellan gum(GG),human-like collagen(HLC),and ZnWH *** scaffold had excellent mechanical properties,adjustable swelling ratio,and interconnected pore *** addition to its excellent biocompatibility,it could promote osteogenic differentiation by releasing ZnWH nanoparticles to stimulate human bone marrow mesenchymal stem cells(hBMSCs)to upregulate the levels of alkaline phosphatase(ALP),osteocalcin(OCN),and osteopontin(OPN).In addition,this study showed that ZnWH nanoparticles could also promote angiogenesis by upregulating the paracrine secretion of vascular endothelial growth factor(VEGF)in *** the same time,the scaffold could inhibit the proliferation of *** 12 weeks of treatment in the rabbit femoral defect model,the ZnWH/G/H scaffold significantly accelerated the process of bone ***,these results demonstrate that the prepared novel nanocomposite scaffold,ZnWH/G/H,offers a promising candidate for bone regeneration.

关键词： bone repair nanocomposite scaffold zinc-whitlockite osteogenesis angiogenesis

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Back-to-Front Ordering of Triangles in digital Terrain Models over regular Grids

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Journal of Computer Science & Technology 2018年第6期33卷 1192-1203页

作者： Jesús Alonso robert Joan-Arinyo informatics in Engineering Group Technical University of Catalonia 08028 Barcelona Catalonia center for biomedical Engineering research Sant Joan de Ddu Research Institute 08028 Barcelona Catalonia Visualization Interaction and Virtual Reality Group Technical University of Catalonia 08028 Barcelona Catalonia

Visiting triangles that conform a digital terrain model is a core operation in a number of fields like animationand video games or generating profiles, cross-sections, and contours in civil engineering. Perfornfing the visit in an efficientmanner is an issue specially when the output of the traversal depends in some way on additional parameters or informationchanging over time, for example, a moving point of view. In this work we report a set of rules that, given a digital terrainmodel defined over a regular grid and an arbitrary point of view outside the terrain, define a total back-to-front order in theset of digital terrain model triangles with respect to the point. The set of rules is minimal, complete and correct. To assesshow the rules perform, we have implemented a CPU-based algorithm for realistically rendering height fields defined overregular grids. The algorithm does not make use of the z-buffer or shaders featured by our graphics card. We show how ouralgorithm is implemented and show visual results obtained from synthetic and real data. We further discuss the algorithmperformance with respect to two algorithms： a naive algorithm that visits triangles according to grid indices and does notsolve the hidden line problem, and the z-buffer provided by the graphics card featured by our computer. Our algorithmallows real-time interaction when the point of view arbitrarily moves in 3d space and we show that its performance is asgood as that of the z-buffer graphics card.

关键词： back-to-front ordering digital terrain model elevation terrain model triangle strip, visibility

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Gene expression profile of peripheral blood in colorectal cancer

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World Journal of Gastroenterology 2014年第39期20卷 14463-14471页

作者： Yu-Tien Chang Chi-Shuan Huang Chung-Tay Yao Sui-Lung Su Harn-Jing Terng Hsiu-Ling Chou Yu-Ching Chou Kang-Hua Chen Yun-Wen Shih Chian-Yu Lu Ching-Huang Lai Chen-En Jian Chiao-Huang Lin Chien-Ting Chen Yi-Syuan Wu Ke-Shin Lin Thomas Wetter Chi-Wen Chang Chi-Ming Chu division of biomedical Statistics and informatics School of Public Health National Defense Medical Center division of Colorectal Surgery Cheng Hsin Rehabilitation Medical Center department of Surgery Cathay General Hospital department of Epidemiology School of Public Health National Defense Medical Center Advpharma Inc. department of Nursing Far Eastern Memorial Hospital and Oriental Institute of Technology department of Nursing School of Medicine Chang Gung University Air Force Combatant Command National Defense Ministry Institute of Medical Biometry and informatics Heidelberg University Germany department of biomedical informatics and Medical Education University of Washington Seattle United States

AIM: Optimal molecular markers for detecting colorectal cancer (CrC) in a blood-based assay were evaluated.

关键词： Colorectal cancer Gene expression Microarray Internet

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Protein tyrosine phosphatases:emerging role in cancer therapy resistance

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Cancer Communications 2024年第6期44卷 637-653页

作者： Min Zhao Wen Shuai Zehao Su Ping Xu Aoxue Wang Qiu Sun Guan Wang Innovation center of Nursing research Nursing Key Laboratory of Sichuan ProvinceDepartment of BiotherapyCancer Center and State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalWest China School of NursingSichuan UniversityChengduSichuanP.R.China West China biomedical Big data center Med-X Center for InformaticsSichuan UniversityChengduSichuanP.R.China Emergency department Zigong Fourth People’s HospitalChengduSichuanP.R.China

Background:Tyrosine phosphorylation of intracellular proteins is a posttranslational modification that plays a regulatory role in signal transduction during cellular *** of signal transduction proteins caused by protein tyrosine phosphatases(PTPs)contributed their role as a convergent node to mediate cross-talk between signaling *** the context of cancer,PTP-mediated pathways have been identified as signaling hubs that enabled cancer cells to mitigate stress induced by clinical *** is achieved by the promotion of constitutive activation of growth-stimulatory signaling pathways or modulation of the immune-suppressive tumor *** evidences suggested that anticancer drugs will release their greatest therapeutic potency when combined with PTP inhibitors,reversing drug resistance that was responsible for clinical failures during cancer *** covered:This review aimed to elaborate recent insights that supported the involvement of PTP-mediated pathways in the development of resistance to targeted therapy and immune-checkpoint *** opinion:This review proposed the notion of PTP inhibition in anticancer combination therapy as a potential strategy in clinic to achieve long-term tumor *** clinical trials are currently underway to assess the safety and efficacy of combination therapy in advanced-stage tumors.

关键词： cancer treatment combination therapy drug resistance protein tyrosine phosphatase

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FAST rECONSTrUCTION METHOd BASEd ON COMMON UNIFIEd dEVICE ArCHITECTUrE(CUdA)FOr MICrO-CT

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Journal of Innovative Optical Health Sciences 2010年第1期3卷 39-43页

作者： GUOTAO QUAN TANGYOU SUN YONG dENG Britton Chance center for biomedical Photonics Wuhan National Laboratory for Optoelectronics—Huazhong University of Science and Technology Wuhan 430074 P.R.China

Three-dimensional image reconstruction with Feldkamp,davis,and Kress(FdK)algorithm is the most time consuming part in *** parallel algorithm based on the computer cluster is capable of accelerating image reconstruction speed;however,the hardware is very *** this paper,using the most current graphics processing units(GPU),we present a method based on common unified device architecture(CUdA)for speeding up the Micro-CT image reconstruction *** most time consuming filtering and back-projection parts of the FdK algorithm are parallelized for the CUdA *** CUdA-based reconstruction speed and image qualities are compared with CPU results for the projecting data of the Micro-CT *** results show that the 3d image reconstruction speed based on CUdA is ten times faster than the speed with *** conclusion the FdK algorithm based on CUdA for Micro-CT can reconstruct the 3d image right after the end of data acquisition.

关键词： Micro-CT FdK CUdA GPU

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VISUALIZATION OF HEAd ANd NECK CANCEr MOdELS WITH A TrIPLE FUSION rEPOrTEr GENE

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Journal of Innovative Optical Health Sciences 2012年第4期5卷 48-56页

作者： YING ZHENG QIAOYA LIN HONGLIN JIN JUAN CHEN ZHIHONG ZHANG Britton Chance center for biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology Wuhan 430074P.R.China MoE Key Laboratory for biomedical Photonics department of biomedical Engineering Huazhong University of Science and Technology Wuhan 430074 P.R.China Campbell Family Cancer research Institute and Ontario Cancer Institute University Health Network TorontoP.R.Canada

The development of experimental animal models for head and neck tumors generally rely on the biol uminescence imaging to achieve the dynamic monitoring of the tumor growth and metastasis due to the complicated anatomical *** the bioluminescence imaging is largely affected by the intracellular luciferase expression level and external d-luciferin concentrations,its imaging accuracy requires further ***,a new triple fusion reportelr gene,which consists of a herpes simplex virus type 1 thymidine kinase(TK)gene for radioactive imaging,a far-red fuorescent protein(mLumin)gene for fuorescent imaging,and a firefly luciferase gene for bioluminescence imaging,was introduced for in vrivo observation of the head and neck tumors through multi-modality *** show that fuorescence and bioluminescence signals from mLumin and luciferase,respectively,were clearly observed in tumor cells,and TK could activate suicide pathway of the cells in the presence of nucleotide analog-ganciclovir(GCV),demonstrating the effecti veness of individual functions of each ***,subcutaneous and metastasis animal models for head and neck tumors using the fusion reporter gene-expressing cell lines were established,allowing multi-modality imaging in ***,the established tumor models of head and neck cancer based on the newly developed triple fusion reporter gene are ideal for monitoring tumor growth,assessing the drug therapeutic efficacy and verifying the effec-tiveness of new treatments.

关键词： Head and neck cancer tumor metastasis model three fusion reporter gene far-red fluorescent protein frefly luciferase multi-modality imaging

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dietary phytochemicals: As a potential natural source for treatment of Alzheimer's disease

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Food Innovation and Advances 2023年第1期2卷 36-43页

作者： Zhuo ren Haixia Yang Chenhui Zhu daidi Fan Jianjun deng Shaanxi Key Laboratory of degradable biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringBiotech&Biomed Research InstituteSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China

Alzheimer's disease(Ad)is a common neurodegenerative disease,which seriously impairs human health and *** present,scientists have proposed more than a dozen hypotheses about the pathogenesis of Ad,including the tau propagation ***,the exact ultimate pathogenic factor of Ad remains *** on the current hypotheses,some anti-Ad drugs(e.g.,donepezil and Ketamine)have been developed and used in clinical treatment,which fall into two main categories,acetylcholinesterase inhibitors(AChEIs)and N-methyl-d-aspartate(NMdA)receptor antagonists,the former representative drug is donepezil,and the latter representative drug is *** these drugs have undesirable side effects,it is necessary to find safer alternatives for Ad ***,dietary phytochemicals have the advantages of wide source,safety,and high biological activity,which is the natural route for screening anti-Ad *** this study,several representatives’dietary phytochemicals with anti-Ad effect,including resveratrol,lycopene,gallic acid,berberine,ginsenoside rg1,pseudoginsenoside-F11,ginsenoside rh2,artemisinin,and torularhodin were selected from the published data over the last 10 years and their potential molecular mechanisms and clinical applications reviewed in the treatment of Ad.

关键词： drugs Alzheimer treatment

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Effects of CuInS_(2)nanoparticles on the alignment control of liquid crystals

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Nano research 2022年第8期15卷 7542-7548页

作者： dongyu Zhao Yuanyuan Guo Weihua Bi Xin Li ran duan Lin Guo Beijing Advanced Innovation center for biomedical Engineering School of ChemistryBeihang UniversityBeijing 100191China

Liquid crystal-nanoparticle composite systems have attracted particular attention for both academic interests and applications in inducing macroscopic alignment,altering electro-optic response of the liquid crystal hosts,and generating ordered,tunable soft ***,the synthesis of two shapes of CuInS_(2)nanoparticles,tremelliform-like CuInS_(2)and frame-like CuInS_(2),and their utilization in producing uniform homeotropic alignment of liquid crystals are *** exploring the mechanism in detail,the crystal structures of CuInS_(2)nanoparticles were found to rely heavily on the reaction solvents during the growth process,which in turn play a significant role on the anchor of liquid crystal *** achieved homeotropic alignment shows high thermal stability,owing to the outstanding stability of the CuInS_(2)*** addition,combining this feasible method with parallel-aligning technique,variable pretilt angles in a range of~0.9°to~7.2°could be continuously achieved.

关键词： CuInS_(2)nanoparticles morphology liquid crystals alignment pretilt angle

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Synthesis, characterization r）oly [LA-co-（GIc-alt-Lys）] for and biological evaluation of nerve regeneration scaffold

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Frontiers of Materials Science 2014年第1期8卷 95-101页

作者： Yi-Xia YIN Ji-Ling YI Li-Juan XIE Qiong-Jiao YAN Hong-Lian dAI Shi-Pu LI biomedical Materials and Engineering research center Wuhan University of Technology Wuhan 430070 China

A novel nerve repairing material poly [LA-co.（GIc-alt-Lys）] （PLGL） was synthesized. The viability and growth of Schwann cells （SCs） co-cultured With poly （d, L- lactic acid）（PdLLA） films （control group） and PLGL films were evaluated by MTT assay and SEM observation. Then, contact angle measurement, histological assessment and enzyme-linked immunosorbent assay （ELISA） testing on inflammatory-related cyto- kines such as IL-10 and TGF-β1 were performed. The results showed that, compared with PdLLA, PLGL films possesses better hydrophilicity, biocompatibility, degradation property and less inflammatory reaction. The present study indicated that PLGL scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration.

关键词： Schwann cell (SC) poly [LA-co-(GIc, alt-Lys)] (PLGL) implantation inflammatory factor biocompatibility

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Bioreactor design and validation for manufacturing strategies in tissue engineering

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Bio-design and Manufacturing 2022年第1期5卷 43-63页

作者： diana Lim Eric S.renteria drake S.Sime Young Min Ju Ji Hyun Kim Tracy Criswell Thomas d.Shupe Anthony Atala Frank C.Marini Metin N.Gurcan Shay Soker Joshua Hunsberger James J.Yoo Wake Forest Institute for regenerative Medicine Wake Forest School of MedicineWinston-SalemNC 27157USA center for biomedical informatics Wake Forest School of MedicineWinston-SalemNC 27157USA regenMed development Organization(reMdO) Winston SalemNC 27106USA

The fields of regenerative medicine and tissue engineering offer new therapeutic options to restore,maintain or improve tissue function following disease or *** maximize the biological function of a tissue-engineered clinical product,specific conditions must be maintained within a bioreactor to allow the maturation of the product in preparation for ***,the bioreactor should be designed to mimic the mechanical,electrochemical and biochemical environment that the product will be exposed to in ***-time monitoring of the functional capacity of tissue-engineered products during manufacturing is a critical component of the quality management *** present review provides a brief overview of bioreactor engineering *** addition,strategies for bioreactor automation,in-line product monitoring and quality assurance are discussed.

关键词： Bioreactor Monitoring sensors and automation Manufacturing Tissue engineering regenerative medicine

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