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Inorganic Nanozyme with Combined Self-Oxygenation/degradable Capabilities for Sensitized Cancer Immunochemotherapy

Nano-Micro Letters 2019年第4期11卷 308-325页

作者： Jie Wang Lan Fang Ping Li Lang Ma Weidan Na Chong Cheng Yueqing Gu dawei deng department of Pharmaceutical Engineering and department of biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 211198People’s Republic of China Institute of Chemistry and Biochemistry Freie Universitat BerlinTakustrasse 314195 BerlinGermany State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory of Natural Medicines National R&D Center for Chinese Herbal Medicine ProcessingChina Pharmaceutical UniversityNanjing 211198People’s Republic of China

recently emerged cancer immunochemotherapy has provided enormous new possibilities to replace traditional chemotherapy in fighting ***,the treatment efficacy is hampered by tumor hypoxiainduced immunosuppression in tumor microenvironment(TME).Herein,we fabricated a self-oxygenation/degradable inorganic nanozyme with a core-shell structure to relieve tumor hypoxia in cancer *** integrating the biocompatible CaO2 as the oxygen-storing component,this strategy is more effective than the earlier designed nanocarriers for delivering oxygen or H2O2,and thus provides remarkable oxygenation and long-term capability in relieving hypoxia throughout the tumor ***,in vivo tests validate that the delivery system can successfully relieve hypoxia and reverse the immunosuppressive TME to favor antitumor immune responses,leading to enhanced chemoimmunotherapy with cytotoxic T lymphocyte-associated antigen 4 ***,a facile,robust and effective strategy is proposed to improve tumor oxygenation by using self-decomposable and biocompatible inorganic nanozyme reactor,which will not only provide an innovative pathway to relieve intratumoral hypoxia,but also present potential applications in other oxygen-favored cancer therapies or oxygen deficiency-originated diseases.

关键词： Inorganic nanozyme Self-oxygenation nanoreactor Biodegradable nanomedicine Immunochemotherapy Cancer treatment

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runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP,TGFβ,and Wnt signaling in articular cartilage formation and osteoarthritis

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Bone research 2022年第4期10卷 882-892页

作者： Yan Zhang Tao Zuo Abigail McVicar Hui-Lin Yang Yi-Ping Li Wei Chen department of Pathology University of Alabama at BirminghamBirminghamAL 35294USA Key Laboratory of biomedical Information Engineering of Ministry of Education Biomedical Informatics and Genomics CenterSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049 ShaanxiP.R.China department of Orthopaedics the First Affiliated Hospital of Soochow UniversityOrthopaedic Institute of Soochow University899 Pinghai RoadSuzhou 215031 JiangsuP.R.China division in Cellular and Molecular Medicine Department of Pathology and Laboratory MedicineTulane University School of MedicineTulane UniversityNew OrleansLA 70112USA

runt-related transcription factor 1(runx1)plays a key role in cartilage formation,but its function in articular cartilage formation is *** generated non-inducible and inducible runx1-deficient mice(runx1^(f/f)Col2α1-Cre and runx1^(f/f)Col2α1-CreEr mice)and found that chondrocyte-specific runx1-deficient mice developed a spontaneous osteoarthritis(OA)-like phenotype and showed exacerbated articular cartilage destruction under OA,characterized by articular cartilage degradation and cartilage ossification,with decreased Col2α1 expression and increased Mmp13 and Adamts5 ***-sequencing analysis of hip articular cartilage from the runx1^(f/f)Col2α1-Cre mice compared to that from wild-type mice and subsequent validation analyses demonstrated that runx1 is a central regulator in multiple signaling pathways,converging signals of the Hippo/Yap,TGFβ/Smad,and Wnt/β-catenin pathways into a complex network to regulate the expression of downstream genes,thereby controlling a series of osteoarthritic pathological ***-sequencing analysis of mutant knee joints showed that runx1’s role in signaling pathways in articular cartilage is different from that in whole knee joints,indicating that runx1 regulation is *** analysis confirmed that runx1 deficiency decreased the levels of YAP and p-Smad2/3 and increased the levels of activeβ-*** of runx1 dramatically increased YAP expression in ***-associated virus-mediated runx1 overexpression in the knee joints of osteoarthritic mice showed the protective effect of runx1 on articular cartilage damaged in *** results notably showed that runx1 is a central regulator of articular cartilage homeostasis by orchestrating the YAP,TGFβ,and Wnt signaling pathways in the formation of articular cartilage and OA,and targeting runx1 and its downstream genes may facilitate the design of novel therapeutic approaches for OA.

关键词： cartilage homeostasis protective

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Harnessing cytokine-induced killer cells to accelerate diabetic wound healing:an approach to regulating post-traumatic inflammation

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regenerative Biomaterials 2024年第2期3卷 88-99页

作者： Yixi Yang Cheng Zhang Yuan Jiang Yijun He iawei Cai Lin Liang Zhaohuan Chen Sicheng Pan Chu Hua Keke Wu Le Wang Zhiyong Zhang Translational research Centre of regenerative Medicine and 3d Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseDepartment of Orthopaedic SurgeryMedical Technology and Related Equipment Research for Spinal Injury TreatmentCity Key LaboratoryThe Third Affliated Hospital of Guangzhou Medical UniversitySchool of Biomedical EngineeringGuangzhou MedicalUniversityGuangzhouGuangdong510150P.R.China department of Osteoarthropathy and Sports Medicine Panyu Central HospitalGuangzhou 511400P.R.China

Impaired immunohomeostasis in diabetic wounds prolongs infiammation and cytokine dysfunction,thus,delaying or pre-venting wound-surface *** clinical studies have been conducted on cytokine-induced killer(CIK)cells recently,as they can be easily proliferated using a straightforward,inex-pensive ***,the function of CIK cells in regulat-ing inflammatory environments has been drawing attention for clinical *** the current investigation,we discovered the regenerative capacity of these cells in the chal-lenging environment of wounds that heal poorly due to *** demonstrated that the intravenous injection of CIK cells can re-establish a proregenerative inflammatory *** *** accelerateskin healing in diabetic *** results indicated that CIK cell treatment affects macrophage polarization and restores the function regenerative cells under hyperglycemic *** novel cellular therapy offers a promising intervention for clinical applic tions through specific inflammatory regulation functions.

关键词： macrophage diabetic wound post-traumatic inflammation cytokine-induced killer cells vascularization

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Open-source algorithm and software for computed tomography-based virtual pancreatoscopy and other applications

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 239-249页

作者： Haofan Huang Xiaxia Yu Mu Tian Weizhen He Shawn Xiang Li Zhengrong Liang Yi Gao School of biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060China Laboratory for Imaging research and informatics State University of New YorkStony BrookNY 11794USA Shenzhen Key Laboratory of Precision Medicine for Hematological Malignancies Shenzhen 518060China Marshall Laboratory of biomedical Engineering Shenzhen 518060China Peng Cheng Laboratory Shenzhen 518066China

Pancreatoscopy plays a significant role in the diagnosis and treatment of pancreatic ***,the risk of pancreatoscopy is remarkably greater than that of other endoscopic procedures,such as gastroscopy and bronchoscopy,owing to its severe *** comparison,virtual pancreatoscopy(VP)has shown notable ***,because of the low resolution of current computed tomography(CT)technology and the small diameter of the pancreatic duct,VP has limited clinical *** this study,an optimal path algorithm and super-resolution technique are investigated for the development of an open-source software platform for VP based on 3d *** proposed segmentation of the pancreatic duct from the abdominal CT images reached an average dice coefficient of 0.85 with a standard deviation of *** to the excellent segmentation performance,a fly-through visualization of both the inside and outside of the duct was successfully reconstructed,thereby demonstrating the feasibility of *** addition,a quantitative analysis of the wall thickness and topology of the duct provides more insight into pancreatic diseases than a fly-through *** entire VP system developed in this study is available at https://***/gaoyi/***.

关键词： Pancreatic cancer Pancreatic duct segmentation Virtual pancreatoscopy 3d Slicer

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Social Choice Meets Graph drawing: How to Get Subexponential Time Algorithms for ranking and drawing Problems

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Tsinghua Science and Technology 2014年第4期19卷 374-386页

作者： Henning Fernau Fedor V.Fomin daniel Lokshtanov Matthias Mnich Geevarghese Philip Saket Saurabh FB 4-Abteilung Informatikwissenschaften Universitt Trier D-54286 TrierGermany the department of informatics University of Bergen N-5020 Bergen Norway Max-Planck-Institut fr Informatik D-66123 Saarbrcken Germany the Institute of Mathematical Sciences Chennai - 600113 India

We analyze a common feature of p-Kemeny AGGregation（p-KAGG） and p-One-Sided Crossing Minimization（p-OSCM） to provide new insights and findings of interest to both the graph drawing community and the social choice community. We obtain parameterized subexponential-time algorithms for p-KAGG—a problem in social choice theory—and for p-OSCM—a problem in graph drawing. These algorithms run in time O＊（2O（√k log k））,where k is the parameter, and significantly improve the previous best algorithms with running times O.1.403k/and O.1.4656k/, respectively. We also study natural ＂above-guarantee＂ versions of these problems and show them to be fixed parameter tractable. In fact, we show that the above-guarantee versions of these problems are equivalent to a weighted variant of p-directed feedback arc set. Our results for the above-guarantee version of p-KAGG reveal an interesting contrast. We show that when the number of ＂votes＂ in the input to p-KAGG is odd the above guarantee version can still be solved in time O＊（2O（√k log k））, while if it is even then the problem cannot have a subexponential time algorithm unless the exponential time hypothesis fails（equivalently, unless FPT d M[1]）.

关键词： Kemeny aggregation one-sided crossing minimization parameterized complexity subexponential-time algorithms social choice theory graph drawing directed feedback arc set

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Three-dimensional,isotropic imaging of mouse brain using multi-view deconvolution light sheet microscopy

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Journal of Innovative Optical Health Sciences 2017年第5期10卷 94-100页

作者： Sa Liu Jun Nie Yusha Li Tingting Yu dan Zhu Peng Fei School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan 430074 P.R.China Britton Chance center for biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 P.R.China

We present a threedimensional(3d)isotropic imaging of mouse brain using light-sheet fuo-rescent microscopy(LSFM)in conjumction with a multi-view imaging *** common single view LSFM is used for mouse brain imaging,the brain tissue is 3d imaged under eight views in our study,by a home-built selective plane ilumination microscopy(SPIM).An output image containing complete structural infornation as well as significantly improved res olution(~4 times)are then computed based on these eight views of data,using a bead-guided multi-view registration and *** superior imaging quality,the astrocyte and pyrarmidal neurons together with their subcellular nerve fbers can be clearly visualized and *** further incuding other computational methods,this study can be potentially scaled up to map the conectome of whole mouse brain with a simple *** microscope.

关键词： Light sheet fuorescent microscopy multi-view dconvolution mouse brain imaging isotropic

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Area and volume ratios for prediction of visual outcome in idiopathic macular hole

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1255-1260页

作者： Xing-Yun Geng Hui-Qun Wu Jie-Hui Jiang Kui Jiang Jun Zhu Yi Xu Jian-Cheng dong Zhuang-Zhi Yan The Institute of biomedical Engineering School of Communication and Information EngineeringShanghai University department of Medical informatics Medical School of Nantong University department of Ophthalmology Affiliated Hospital of Nantong University

AIM： To predict the visual outcome in patients undergoing macular hole surgery by two novel three-dimensional morphological parameters on optical coherence tomography （OCT）： area ratio factor （ArF） and volume ratio factor （VrF）. METHOdS： A clinical case series was conducted, including 54 eyes of 54 patients with an idiopathic macular hole （IMH）. Each patient had an OCT examination before and after surgery. Morphological parameters of the macular hole, such as minimum diameter, base diameter, and height were measured. Then, the macular hole index （Mill）, tractional hole index （THI）, and hole form factor （HFF） were calculated. Meanwhile, novel postoperative macular hole （MH） factors, ArF and VrF were calculated by three-dimensional morphology. Bivariate correlations were performed to acquire asymptotic significance values between the steady best corrected visual acuity （BCVA） after surgery and 2d/3d arguments of MH by the Pearson method with two-tailed test. All significant factors were analyzed by the receiver operating characteristic （rOC） curve analysis of SPSS software which were responsible for vision recovery. rOC curves analyses were performed to further discuss the different parameters on the prediction of visual outcome. rESULTS： The mean and standard deviation values of patients＇ age, symptoms duration, and follow-up time were 64.8＋8.9y （range： 28-81）, 18.6＋11.5d （range： 2-60）, and 11.4＋0.4mo （range： 6-24）, respectively. Steady-post-BCVA analyzed with bivariate correlations was found to be significantly correlated with base diameter （r＇0.521, P〈0.001）, minimum diameter （r=0.514, P〈0.001）, MHI （r -0.531, P〈0.001）, THI （r=-0.386, P=-0.004）, HFF （r=-0.508, P〈0.001）, and ArF （r=-0.532, P〈0.001）. Other characteristic parameters such as age, duration of surgery, height, diameter hole index, and VrF were not statistically significant with steady-post-BCVA. According to area under the curve （AUC） values, values of ArF, MHI, HFF, minimum diameter, THI, and base dia

关键词： optical coherent imaging prognostic evaluation idiopathic macular hole morphological features

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Spatial control of robust transgene expression in mouse artery endothelium under ultrasound guidance

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2704-2706页

作者： renfa Liu Shuai Qu Yunxue Xu Hanjoong Jo Zhifei dai department of biomedical Engineering College of Future TechnologyNational Biomedical Imaging CenterPeking UniversityBeijingChina Wallace H.Coulter department of biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlantaUSA

dear Editor,dysfunctional vascular endothelial cells(ECs)contribute to the pathophysiology of several cardiovascular diseases,such as atherosclerosis and its life-threatening complications.1 Gene therapy can be a valuable approach to modulate endothelial cell function for the prevention of ***,there is still a lack of method for transgene expression in vascular endothelium.2 Herein,an effective and specific strategy was established for noninvasive spatial control of transgene expression into the target region of the mouse artery without systemic spillover using an ultrasound and microbubble(MB)guided adenoassociated viral vector(UMGAAV)(Supplementary Fig.S1).To the best of our knowledge,this is the first report on noninvasive spatial control of transgene expression in arterial endothelium in vivo.

关键词： endothelium prevention atherosclerosis

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A Magnetic-driven Multi-motion robot with Position/Orientation Sensing Capability

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research 2024年第1期2023卷 675-685页

作者： Liwen Zhang Song Zhao Xinzhao Zhou Xueshan Jing Yu Zhou Yan Wang Yantong Zhu Xiaolin Liu Zehui Zhao deyuan Zhang Lin Feng Huawei Chen School of Mechanical Engineering and Automation Beihang UniversityBeijingChina Beijing Advanced Innovation center for biomedical Engineering Beihang UniversityBeijingChina

Miniature magnetic-driven robots with multimode motions and high-precision pose sensing capacity(position and orientation)are greatly demanded in in situ manipulation in narrow opaque enclosed *** magnetic robots have been carried out,whereas their deformations normally remain in single mode,and the lack of the robot’s real-time status leads to its beyond-sight remagnetization and manipulation being *** function integration of pose sensing and multimode motion is still of ***,a multimotion thin-film robot is created in a novel multilayer structure with a magneticdriven layer covered by a heating-sensing conductive *** a heating-sensing layer not only can segmentally and on-demand heat the magnetic-driven layer for in situ magnetization reprogramming and multimode motions but also can precisely detect the robot’s pose(position and orientation)from its electrical-resistance effect by creating a small deformation under preset magnetic fields.

关键词： robot robot motion

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d-type neuropeptide decorated AIEgen/rENP hybrid nanoprobes with light-driven rOS generation ability for NIr-Ⅱ fluorescence imaging-guided through-skull photodynamic therapy of gliomas

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Aggregate 2024年第1期5卷 185-195页

作者： Xuelu He Yuan Luo Yanying Li Yuanbo Pan ryan T.K.Kwok Lulu He Xiaolin duan Pengfei Zhang Aiguo Wu Ben Zhong Tang Juan Li Ningbo Key Laboratory of biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboP.R.China Guangdong Key Laboratory of Nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenP.R.China department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and Technology(HKUST)KowloonP.R.China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenP.R.China

Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in ***-induced emission(AIE)photosensitizers-based photodynamic therapy(PdT)has emerged as a promising therapeutic strategy for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIr)***,most AIE photosensitizers suffered from poorly penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability,which greatly limited the clinical practice of AIE photosensitizers for especially deep-seated brain tumor *** this work,we developed a multifunctional NIr-driven theranostic agent through hybrid of AIE photosensitizers TINd with rare-earth doping nanoparticles(rENPs)NaGdF4:Nd/Yb/Tm with up/down dual-mode conversion *** theranostic agent was further decorated with d-type neuropeptide dNPY for crossing BBB and targeting *** the 808-nm light irradiation,the down-conversion NIr-II luminescence could indicate the position glioma and the upconversion NIr-I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in *** results demonstrate that the integration of dtype neuropeptide,AIE photosensitizers and rENPs could be promising candidates for in vivo NIr-II fluorescence image-guided through-skull PdT treatments of brain tumors.

关键词： aggregation-induced emission d-type neuropeptide glioma photodynamic therapy rare-earth doping nanoparticles

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