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Thermal Stresses and Theorem on Decomposition

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Transactions of Nanjing University of Aeronautics and Astronautics 2014年第2期31卷 175-179页

作者： Valeriy Lokhov Yuriy Nyashin Department of Theoretical Mechanics and biomechanics Perm National Research Polytechnic University

The thermal expansion strain is considered as a special case of *** authors proved the theorem on decomposition of eigenstrain existing in a body into two constituents:Impotent eigenstrain(not causing stress in any point of a body)and nilpotent eigenstrain(not causing strain in any point of a body).According to this theorem,the thermal stress can be easily found through the nilpotent *** the eigenstrain is an impotent one,the thermal stress *** this case,the eigenstrain must be *** authors suggest a new approach to measure of eigenstrain incompatibility and hence to estimate of thermal stresses.

关键词： eigenstrain thermal stresses decomposition impotent eigenstrain nilpotent eigenstrain functional space

Unlocking the potential of transdermal drug delivery

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International Journal of Smart and Nano Materials 2024年第3期15卷 432-468页

作者： Shuang Li Jianhao Wu Xiangjun Peng Xi-Qiao Feng Institute of biomechanics and Medical Engineering Applied Mechanics LaboratoryDepartment of Engineering MechanicsTsinghua UniversityBeijingChina

Transdermal drug delivery(TDD)has gained clinical approval over several decades,with extensive research dedicated to novel drug and device *** notable research progress,the mar-ket adoption of TDD devices has not met anticipated levels,with oral administration and injection remaining predominant delivery *** maximize the potential of TDD,we identify bottlenecks hinder-ing its widespread clinical application and propose promising research *** begin by analyzing stringent demands necessary to truly benefit patients,addressing significant challenges in biomechanics,nanomedicine,and flexible ***,we delve into skin anatomy,enhancement strategies,nano-carriers,and their under-lining mechanisms,highlighting the importance and framework of quantitative *** on these discussions,we highlight the core strength of TDD,such as automatic precise administration based on feedback and high delivery efficiencies,especially applicable to localized conditions(e.g.,central nervous system diseases,tumors).Finally,we envision the future of intelligent TDD device and its opera-tion scenario,aiming to steer research efforts toward faster translation of laboratory innovations into widely used products for sufferers.

关键词： Transdermal drug delivery biomechanics nanomedicine flexible electronics

Analysis of the shape of heavy droplets on flat and spherical surface

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Science China(Physics,Mechanics & Astronomy) 2012年第6期55卷 1118-1124页

作者： WANG XueWei YU Yang biomechanics and Biomaterials laboratory Department of MechanicsSchool of Aerospace EngineeringBeijing Institute of TechnologyBeijing 100081China

In this study,a theoretical model was established for predicting the equilibrium shape of the droplet on flat and spherical *** theoretical equilibrium shape of heavy droplets could be obtained once contact angle and volume of droplets were *** showed that the predictions of the theoretical flat model were in good agreement with the shape obtained by Surface Evolver when the contact angle is below 120 and the droplet size is on the order of capillary *** available range will decrease and increase when the heavy droplet is on convex and concave spherical surface,respectively,in contrast to that on flat *** available range will decrease more for higher curvature of convex spherical surfaces.

关键词： equilibrium shape heavy droplet ellipsoidal model Surface Evolver simulation

Mechanomics： an emerging field between biology and biomechanics

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Protein & Cell 2014年第7期5卷 518-531页

作者： Jiawen Wang Dongyuan Lu Debin Mao Mian Long Center for biomechanics and Bioengineering and Key laboratory of Microgravity Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China

Cells sense various in vivo mechanical stimuli, which initiate downstream signaling to mechanical forces. While a body of evidences is presented on the impact of limited mechanical regulators in past decades, the mechanisms how biomechanical responses globally affect cell function need to be addressed. Complexity and diversity of in v/vo mechanical clues present dis- tinct patterns of shear flow, tensile stretch, or mechanical compression with various parametric combination of its magnitude, duration, or frequency. Thus, it is required to understand, from the viewpoint of mechanobiology, what mechanical features of cells are, why mechanical properties are different among distinct cell types, and how forces are transduced to down- stream biochemical signals. Meanwhile, those in vitro isolated mechanical stimuli are usually coupled together in vivo, suggesting that the different factors that are in effect individually could be canceled out or orchestrated with each other. Evidently, omics analysis, a powerful tool in the field of system biology, is advantageous to combine with mechanobiology and then to map the fullset of mechanically sensitive proteins and transcripts encoded by its genome. This new emerging field, namely mechanomics, makes it possible to elucidate the global responses under systematically-varied mechanical stimuli. This review discusses the current advances in the related fields of mechanomics and elaborates how cells sense external forces and activate the biological responses.

关键词： mechanomics mechanobiology proteomics transcriptomics

Spreading of human neutrophils on an ICAM-1-immobilized substrate under shear flow

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Chinese Science Bulletin 2012年第7期57卷 769-775页

作者： ZHAN DongYing ZHANG Yan LONG Mian Key laboratory of Microgravity National Microgravity Laboratory and Center of Biomechanics and BioengineeringInstitute of MechanicsChinese Academy of SciencesBeijing 100190China

Neutrophil (PMN) spreading on endothelium, mediated by the interactions between surface-bound β2 integrin and intercellular adhesion molecule-1 (ICAM-1) in the inflammatory cascade, is crucial for PMN post-adhesion and trans-migration in blood flow. The underlying mechanisms by which shear flow regulates PMN spreading dynamics are not well understood. Here, a parallel-plate flow chamber assay was applied to quantify the time course of PMN adhesion and spreading on an ICAM-1-immobilized substrate. Two types of shear flow, steady flows at shear stresses of 0.2, 0.5, and 1 dyne/cm2 and stepwise flows at 0, 1, and 10 dyne/cm2, were used to elucidate the impact of shear flow on cell adhesion and spreading. The number of adhered PMNs, the fraction of spreading PMNs and the projected area of spread PMNs were determined and were found to correlate with the distribution of surface-bound β2 integrin subunit (CD11a, CD11b, or CD18). The results indicate that PMN spreading on an ICAM-1 substrate is bi-directionally regulated under shear flow. CD11a, CD11b and CD18 subunits of β2 integrin contribute distinctly to PMN spreading on ICAM-1 substrates. This work provides new insights into understanding PMN spreading on the endothelium, mediated by β2 integrin and ICAM-1 under shear flow.

关键词： ICAM-1 中性粒细胞剪切流场基板传播细胞间粘附分子1 扩散动力学血管内皮细胞

A comparison of base running and sliding techniques in collegiate baseball with implications for sliding into first base

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Journal of Sport and Health Science 2016年第3期5卷 361-367页

作者： Travis Ficklin Jesus Dapena Alexander Brunfeldt biomechanics laboratory University of Northern Iowa Department of Kinesiology Indiana University Biomedical Engineering University of Michigan

Purpose: The purpose of this study was to compare 4 techniques for arrival at a base after sprinting maximally to reach it: sliding head-first, sliding feet-first, running through the base without slowing, and stopping on the base. A secondary purpose of the study was to determine any advantage there may be to diving into first base to arrive sooner than running through the ***: Two high-definition video cameras were used to capture 3-dimensional kinematics of sliding techniques of 9 intercollegiate baseball players. Another video camera was used to time runs from first base to second in 4 counterbalanced conditions: running through the base, sliding head-first, sliding feet-first, and running to a stop. Mathematical modeling was used to simulate diving to first base such that the slide would begin when the hand touches the ***: Based upon overall results, the quickest way to the base is by running through it, followed by head-first, feet-first, and running to a ***: There was a non-significant trend toward an advantage for diving into first base over running through it, but more research is needed,and even if the advantage is real, the risks of executing this technique probably outweigh the miniscule gain.

关键词： Baseball biomechanics First base Running Sliding

Developing a microfluidic-based system to quantify cell capture efficiency

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Science China(Life Sciences) 2009年第2期52卷 173-181页

作者： YANG Fan, GAO YuXin, ZHANG Yan, CHEN Juan & LONG Mian National Microgravity laboratory and Center for biomechanics and Bioengineering, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China National Microgravity laboratory and Center for biomechanics and Bioengineering Institute of Mechanics Chinese Academy of Sciences Beijing China

Micro-fabrication technology has substantial potential for identifying molecular markers expressed on the surfaces of tissue cells and viruses. It has been found in several conceptual prototypes that cells with such markers are able to be captured by their antibodies immobilized on microchannel substrates and unbound cells are flushed out by a driven flow. The feasibility and reliability of such a microflu- idic-based assay, however, remains to be further tested. In the current work, we developed a microflu- idic-based system consisting of a microfluidic chip, an image grabbing unit, data acquisition and analysis software, as well as a supporting base. Specific binding of CD59-expressed or BSA-coupled human red blood cells (RBCs) to anti-CD59 or anti-BSA antibody-immobilized chip surfaces was quan- tified by capture efficiency and by the fraction of bound cells. Impacts of respective flow rate, cell concentration, antibody concentration and site density were tested systematically. The measured data indicated that the assay was robust. The robustness was further confirmed by capture efficiencies measured from an independent ELISA-based cell binding assay. These results demonstrated that the system developed provided a new platform to effectively quantify cellular surface markers effectively, which promoted the potential applications in both biological studies and clinical diagnoses.

关键词： cell surface marker microfluidic capture efficiency

Magnesium based degradable biomaterials： A review

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Frontiers of Materials Science 2014年第3期8卷 200-218页

作者： Xue-Nan GU Shuang-Shuang LI Xiao-Ming LI Yu-Bo FAN Key laboratory for biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beihang University Beijing 100191 China

Magnesium has been suggested as a revolutionary biodegradable metal for biomedical applications. The corrosion of magnesium, however, is too rapid to match the rates of tissue healing and, additionally, exhibits the localized corrosion mechanism. Thus it is necessary to control the corrosion behaviors of magnesium for their practical use. This paper comprehensively reviews the research progress on the development of representative magnesium based alloys, including Mg-Ca, Mg-Sr, Mg-Zn and Mg-REE alloy systems as well as the bulk metallic glass. The influence of alloying element on their microstructures, mechanical properties and corrosion behaviors is summarized. The mechanical and corrosion properties of wrought magnesium alloys are also discussed in comparison with those of cast alloys. Furthermore, this review also covers research carried out in the field of the degradable coatings on magnesium alloys for biomedical applications. Calcium phosphate and biodegradable polymer coatings are discussed based on different preparation techniques used. We also compare the effect of different coatings on the corrosion behaviors of magnesium alloys substrate.

关键词： magnesium alloy degradable biomaterial coating degradation corrosion

Alternative splicing and expression of the insulin-like growth factor (IGF-1) gene in osteoblasts under mechanical stretch

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Chinese Science Bulletin 2006年第22期51卷 2731-2736页

作者： XIAN Chengyu WANG Yuanliang ZHANG Bingbing TANG Liling PAN Jun LUO Yanfeng JIANG Peng LI Dajun Bioengineering College Research Center of Bioinspired Materials Science and Engineering Key Laboratory for Biomechanics & Tissue Engineering Under The State Ministry of Education Chongqing University Chongqing 400044 China

(IGF-1 ) 像胰岛素的生长因素 1 支持造骨细胞区别和骨头形成，和它的表示被机械段导致，因此， IGF-1 被认为连接机械刺激和本地织物回答的一个受动器分子。在这研究，一台机械拉长设备被设计把生理的水平静电干扰或周期的拉长刺激用... 详细信息

(IGF-1 ) 像胰岛素的生长因素 1 支持造骨细胞区别和骨头形成，和它的表示被机械段导致，因此， IGF-1 被认为连接机械刺激和本地织物回答的一个受动器分子。在这研究，一台机械拉长设备被设计把生理的水平静电干扰或周期的拉长刺激用于造骨细胞。IGF-1 mRNA 的不同 isoforms 被 RT-PCR 用各自的教材从房间放大，这些放大产品被定序。产品被发现被造骨细胞有选择地在拉长刺激下面生产的拼接的 IGF-1 的 iso 形式。ThisIGF-1 isoform 与原来在肌肉细胞被识别的 mechano 生长因素(MGF ) 有相同顺序。肝类型 IGF (***-1 ) 和在在段刺激下面的造骨细胞的 MGF 的表示的规定进一步用半量的 RT-PCR 被学习。Stretchstimulation 被发现 IGF-1 (***-1 和 MGF ) 的表示到职业人员警句，并且为两 isoformsexpression，更多被周期的段有效地比静态的段刺激。MGF 仅仅在受到机械段的造骨细胞被检测，建议 MGF 是段敏感生长因素。MGF 的表示比 ***-1 的早达到顶点，它类似于他们在肌肉的规定并且作为在肌肉房间在骨头建议了 MGF 和 ***-1 的类似的角色。在造骨细胞的 MGF 和 ***-1 的功能将被进一步试验性的研究建立。

关键词：胰岛素类生长因子-1 IGF-1 成骨细胞拉伸