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Chinese Journal of Polymer Science 2010年第5期28卷 705-713页

作者：李新松 biomaterials and drug delivery laboratories School of Chemistry and Chemical EngineeringSoutheast University

Poly（vinylidenefluoride-hexafluoropropylene）（PVDF-HFP） nanofiber membranes with improved hydrophilicity and protein fouling resistance via surface graft copolymerization of hydrophilic monomers were prepared. The surface modification involves atmospheric pressure glow discharge plasma （APGDP） pretreatment followed by graft copolymerization of poly（ethylene glycol） methyl ether methacrylate （PEGMA）. The success of the graft modification with PEGMA on the PVDF-HFP fibrous membrane is ascertained by X-ray photoelectron spectroscopy （XPS） and attenuated total reflectance Fourier transform infrared measurements （ATR-FTIR）. The hydrophilic property of the nanofiber membranes is assessed by water contact angle measurements. The results show that the PEGMA grafted PVDF-HFP nanofiber membrane has a water contact angle of 0° compared with the pristine value of 132°. The protein adsorption was effectively reduced after PEGMA grafting on the PVDF-HFP nanofiber membrane surface. The PEGMA polymer grafting density on the PVDF-HFP membrane surface is measured by the gravimetric method, and the filtration performance is characterized by the measurement of water flux. The results indicate that the water flux of the grafted PVDF-HFP fibrous membrane increases significantly with the increase of the PEGMA grafting density.

关键词： Poly(vinylidenefluoride-hexafluoropropylene) Nanofiber membrane Graft polymerization Hydrophilic property Protein fouling resistance.

ELECTROSPINNING OF ZEIN/CHITOSAN COMPOSITE FIBROUS MEMBRANES

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Chinese Journal of Polymer Science 2010年第2期28卷 171-179页

作者：李新松 biomaterials and drug delivery laboratories School of Chemistry and Chemical EngineeringSoutheast University

Zein/chitosan composite fibrous membranes were fabricated from aqueous ethanol solutions by electrospinning. Poly（vinyl pyrrolidone）（PVP） was introduced to facilitate the electrospinning process of zein/chitosan composites. The asspun zein/chitosan/PVP composite fibrous membranes were characterized by scanning electron microscopy （SEM） and tensile tests. SEM images indicated that increasing zein and PVP concentrations led to an increase in average diameters of the composite fibers. In order to improve stability in wet stage and mechanical properties, the composite fibrous membranes were crosslinked by hexamethylene diisocyanate （HDI）. The crosslinked composite fibrous membranes showed slight morphological change after immersion in water for 24 h. Mechanical tests revealed that tensile strength and elongation at break of the composite fibrous membranes were increased after crosslinking, whereas Young＇s modulus was decreased.

关键词： Electrospinning Zein Chitosan Crosslinking Fibrous membrane.

ENHANCING HYDROPHILICITY AND PROTEIN RESISTANCE OF SILICONE HYDROGELS BY PLASMA INDUCED GRAFTING WITH HYDROPHILIC POLYMERS

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Chinese Journal of Polymer Science 2010年第4期28卷 547-554页

作者：李新松 biomaterials and drug delivery laboratories School of Chemistry and Chemical EngineeringSoutheast University

The hydrophilicity of silicone hydrogels used as soft corneal contact lens plays an important role in wearing comfort. In order to enhance hydrophilicity and protein resistance, silicone hydrogel membranes were modified by atmospheric pressure glow discharge plasma （APGDP） induced surface graft polymerization of N-vinyl pyrrolidone （NVP） and poly（oligoethylene glycol methyl ether methacrylate）（PEGMA） in this paper. XPS analysis demonstrated the success of graft polymerization of NVP and PEGMA onto the surface of silicone hydrogel membranes. The hydrophilicity of silicone hydrogels was characterized by the measurement of water contact angle （WCA）. The result showed that NVP grafted silicone hydrogel has the WCA of about 68° and PEGMA grafted silicone hydrogel has the lowest WCA of about 62°, while the pristine silicone hydrogel is hydrophobic with the WCA of about 103°. Protein resistance of silicone hydrogels was investigated by the method of bicinchoninic acid assay using bovine serum albumin （BSA） as a model. It＇s found that the grafted silicone hydrogel has a significant improvement of protein resistance, and PEGMA grafting is more efficient for the reduction of protein adsorption than NVP grafting. The silicone hydrogel membranes grafted with NVP and PEGMA are good candidates of soft corneal contact lenses.

关键词： Silicone hydrogel APGDP Graft polymerization Hydrophilicity

IMPROVED OXYGEN PERMEABILITY AND MECHANICAL STRENGTH OF SILICONE HYDROGELS WITH INTERPENETRATING NETWORK STRUCTURE

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Chinese Journal of Polymer Science 2010年第6期28卷 849-857页

作者： Jing-jing Wang Xin-song Li biomaterials and drug delivery laboratories School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China

The interpenetrating polymer network(IPN) silicone hydrogels with improved oxygen permeability and mechanical strength were prepared by UV-initiated polymerization of monomers including methacryloxypropyl tris(trimethylsiloxy)silane(TRIS),2-hydroxyethylmethacrylate(HEMA) and N-vinyl pyrrolidone(NVP) in the presence of free radical photoinitiator and cationic *** polymerization mechanism was investigated by the formation of gel *** structure of IPN hydrogels was characterized by Fourier transform infrared spectroscopy(FTIR), differential scanning calorimetry(DSC) and transmission electron microscopy(TEM).The results showed that the IPN hydrogels exhibited a heterogeneous *** mechanical properties,surface wettability and oxygen permeability were examined by using a tensile tester,a contact angle goniometer and an oxygen transmission tester,*** equilibrium water content of the hydrogels was measured by the gravimetric *** results revealed that the IPN hydrogels possessed hydrophilic surface and high water *** exhibited improved oxygen permeability and mechanical strength because of the incorporation of TRIS.

关键词： Interpenetrating polymer network Silicone hydrogel Photopolymerization Oxygen permeability Mechanical strength

Pulmonary immunization:deposition site is of minor relevance for influenza vaccination but deep lung deposition is crucial for hepatitis B vaccination

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Acta Pharmaceutica Sinica B 2019年第6期9卷 1231-1240页

作者： Jasmine Tomar Wouter FTonnis Harshad P.Patil Anne H.de boer Paul Hagedoorn Rita Vanbever Henderik W.Frijlink Wouter L.J.Hinrichs Department of Pharmaceutical Technology and Biopharmacy University of GroningenGroningen 9713 AVthe Netherlands Advanced drug delivery and biomaterials Louvain Drug Research Institute(LDRI)Universite catholique de LouvainBrussels 1200Belgium

Vaccination via the pulmonary route could be an attractive alternative to parenteral *** towards the best site of antigen deposition within the lungs to induce optimal immune responses has conflicting results which might be dependent on the type of vaccine and/or its physical ***,in this study,we explored whether deep lung deposition is crucial for two different vaccines,i.e.,influenza and hepatitis B *** view of this,influenza subunit vaccine and hepatitis B surface antigen were labeled with a fluorescent dye and then *** data showed that after pulmonary administration to mice the powders were deposited in the trachea/central airways when a commercially available insufflator was used while deep lung deposition was achieved when an in-house built aerosol generator was *** studies revealed that comparable immune responses were induced upon trachea/central airways or deep lung targeting of dry influenza vaccine ***,for hepatitis B vaccine,no immune responses were induced by trachea/central airways deposition whereas they were considerable after deep lung ***,we conclude that deep lung targeting is not a critical parameter for the efficacy of pulmonary administered influenza vaccine whereas for hepatitis B vaccine it is.

关键词： Inhalation Powders Deep lung deposition Influenza Hepatitis B

Re-evaluating the importance of carbohydrates as regenerative biomaterials

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Regenerative biomaterials 2019年第1期6卷 1-12页

作者： Heidi F.Oldenkamp Julia E.Vela Ramirez Nicholas A.Peppas Institute for biomaterials Drug Deliveryand Regenerative Medicine McKetta Department of Chemical Engineering Department of Biomedical Engineering Department of Pediatrics Dell Medical School Department of Surgery and Perioperative Care Dell Medical School Division of Molecular Pharmaceutics and drug delivery College of PharmacyThe University of Texas at AustinAustinTX 78712USA

Introduction Carbohydrates are the most abundant natural biomaterials in the *** interacting with cells of a variety of levels,they take part in essential functions of organisms including cellular communication,inflammation,infection development and *** carbohydrate–cell interactions occur on a variety of levels through glycoconjugates such as glycolipids,glycosaminoglycans(GAGs),glycoproteins and proteoglycans[1–4].The roles of carbohydrates in biological systems pose them as some of the most sought-after *** use of these multifaceted molecules provides the opportunity to tailor desired responses depending on the target application[1–5].

关键词： carbohydrate regenerative biomaterials polysaccharide tissue engineering

Multiple nano-drug delivery systems for intervertebral disc degeneration: Current status and future perspectives

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Bioactive Materials 2023年第5期23卷 274-299页

作者： Wenzhao Liu Zhanjun Ma Yonggang Wang Jingjing Yang The Second Clinical Medical College Lanzhou UniversityLanzhou730030GansuChina Louvain drug Research Institute Advanced Drug Delivery and BiomaterialsUniversit´e Catholique de LouvainUCLouvain1200BrusselsBelgium Department of Orthopedics Lanzhou University Second HospitalLanzhou730030GansuChina

Low back pain(LBP)is a common disease that imposes a huge social and economic burden on *** disc(IVD)degeneration(IVDD)is often considered to be the leading cause of LBP and further aggravate and cause serious spinal *** established treatment strategy for IVDD consists of physiotherapy,pain medication by drug therapy,and,if necessary,surgery,but none of them can be treated from the etiology;that is,it cannot fundamentally reverse IVD and reconstruct the mechanical function of the *** the development of nanotechnology and regenerative medicine,nano-drug delivery systems(NDDSs)have improved treatment results because of their good biodegradability,biocompatibility,precise targeted specific drug delivery,prolonged drug release time,and enhanced drug efficacy,and various new NDDSs for drugs,proteins,cells,and genes have brought light and hope for the treatment of *** review summarizes the research progress of NDDSs in the treatment of IVDD and provides prospects for using NDDSs to address the challenges of *** hope that the ideas generated in this review will provide insight into the precise treatment of IVDD.

关键词： Intervertebral disc degeneration Nanotechnology drug delivery system Nanocarriers Nanoparticles

Hydroxyapatite nanoparticles drive the potency of Toll-like receptor 9 agonist for amplified innate and adaptive immune response

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Nano Research 2022年第10期15卷 9286-9297页

作者： Qin Zeng Ruiqi Wang Yuchen Hua Hongfeng Wu Xuening Chen You-cai Xiao Qiang Ao Xiangdong Zhu Xingdong Zhang National Engineering Research Center for biomaterials Sichuan UniversityChengdu 610064China NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative biomaterials&Institute of Regulatory Science for Medical Devices&NMPA Research Base of Regulatory Science for Medical Devices Sichuan UniversityChengdu 610064China College of Biomedical Engineering Sichuan UniversityChengdu 610064China Key Laboratory of drug-Targeting and drug delivery System of the Education Ministry and Sichuan Province Sichuan UniversityChengdu 610041China

The potency of Toll-like receptor 9(TLR9)agonist to drive innate immune response was limited due to immune suppression or tolerance during TLR9 signaling activation in immune *** we addressed this problem by introducing hydroxyapatite nanoparticles(HANPs)to CpG ODN(CpG),a TLR9 *** study revealed that HANPs concentration and durationdependently reprogramed the immune response by enhancing the secretion of immunostimulatory cytokines(tumor necrosis factorα(TNFα)or IL-6)while reducing the production of immunosuppressive cytokine(IL-10)in macrophages in response to ***,the enhanced immune response benefited from increased intracellular Ca2+in macrophage by the addition of ***,we found exposure to HANPs impacted the mitochondrial function of macrophages in support of the synthesis of adenosine triphosphate(ATP),the production of nicotinamide adenine dinucleotide(NAD),and reactive oxygen species(ROS)in the presence or absence of *** vaccinated mice model,only one vaccination with a mixture of CpG,HANPs,and OVA,a model antigen,allowed the development of a long-lasting balanced humoral immunity in mice without any histopathological change in the local injection ***,this study revealed that HANPs could modulate the intracellular calcium level,mitochondrial function,and immune response in immune cells,and suggested a potential combination adjuvant of HANPs and TLR9 agonist for vaccine development.

关键词： hydroxyapatite nanoparticles Toll-like receptor 9 intracellular calcium mitochondrial function adaptive immune response

Nanowire-mediated miRNA delivery

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Science China(Life Sciences) 2024年第11期67卷 2532-2534页

作者： Yuan Wang Bing Chen Laboratory for biomaterials and drug delivery Department of AnesthesiologyDivision of Critical Care MedicineBoston Children’s HospitalHarvard Medical SchoolBoston 02115USA College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China

In the ever-evolving nanomedicine and biotechnology,the pursuit of advanced drug delivery systems that induce precise positioning and targeting in the complex biological landscape for personalized and efficient therapies has become a paramount endeavor(Vargason et al.,2021).Central to this trend is the delivery of functional microRNAs(miRNAs),which play crucial roles in regulating gene expression(Li et al.,2021).Specifically,by binding to target messenger RNAs(mRNAs),miRNAs can control protein synthesis or lead to mRNA degradation through various cellular processes such as differentiation,proliferation,apoptosis,and immune *** processes are essential for regenerative medicine,immune modulation,and disease treatment(e.g.,cancers,chronic infections and autoimmune disorders)where gene expression is dysregulated(Kara et al.,2022).

关键词： precise landscape

Toward Artificial Peptide Nanocapsules

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Nano-Micro Letters 2024年第10期16卷 240-243页

作者： Yuan Wang Bing Chen Laboratory for biomaterials and drug delivery Department of AnesthesiologyDivision of Critical Care MedicineBoston Children's HospitalHarvard Medical SchoolBostonMA 02115USA College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023People's Republic of China

HIGHLIGHTS The formation of peptide nanocapsules is facilitated by a gradient interface,where the differential solvent concentration drives the peptides to preferentially localize and *** peptide nanocapsules,characterized by their hollow structures,demonstrated potential as carriers for targeted drug delivery.1 Introduction Peptide nanocapsules are a type of nanoscale delivery system that encapsulates active substances within a shell composed of peptides,leveraging the unique properties of peptides such as biocompatibility and biodegradability[1].Historically,the development of peptide nanocapsules was inspired primordially by the natural biological processes.

关键词： Peptide nanocapsules Self-assembly drug delivery Nanomedicine