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CYP1A1,CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms

World Journal of Gastroenterology 2016年第45期22卷 9974-9983页

作者： Glaucia Maria M Fernandes Anelise Russo Marcela Alcantara Proenca Nathalia Fernanda Gazola Gabriela Helena Rodrigues Patrícia Matos Biselli-Chicote Ana Elizabete Silva Joao Gomes Netinho érika Cristina Pavarino Eny Maria Goloni-Bertollo Genetics and Molecular biology Research Unit-UPGEM Department of Molecular Biology Sao José do Rio Preto Medical School FAMERP departament of biology UNESP-Sao Paulo State University departament of Surgery and Coloproctology Service Sao José do Rio Preto Medical School FAMERP

AIM To investigate the contribution of polymorphisms in the CYP1A1, CYP2E1 and EPHX1 genes on sporadic colorectal cancer(SCRC) risk. METHODS Six hundred forty-one individuals(227 patients with SCRC and 400 controls) were enrolled in the study. The variables analyzed were age, gender, tobacco and alcohol consumption, and clinical and histopathological tumor parameters. The CYP1A1 *2A, CYP1A1 *2C CYP2E1 *5B and CYP2E1 *6 polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). The EPHX1 Tyr113 His, EPHX1 His139 Arg and CYP1A1 *2C polymorphisms were detected by real-time PCR. Chisquared test and binary logistic regression were used in the statistical analysis. Haplotype analysis was conducted using the Haploview program, version *** Age over 6 2 years was a risk factor for SCRC development(OR = 7.54, 95%CI: 4.94-11.50, P < 0.01). Male individuals were less susceptible to SCRC(OR = 0.55, 95%CI: 0.35-0.85, P < 0.01). The CYP2E1*5B polymorphism was associated with SCRC in the codominant(heterozygous genotype: OR = 2.66, 95%CI: 1.64-4.32, P < 0.01), dominant(OR = 2.82, 95%CI: 1.74-4.55, P < 0.01), overdominant(OR = 2.58, 95%CI: 1.59-4.19, P < 0.01), and log-additive models(OR = 2.84, 95%CI: 1.78-4.52, P < 0.01). The CYP2E1*6 polymorphism was associated with an increased SCRC risk in codominant(heterozygous genotype: OR = 2.81, 95%CI: 1.84-4.28, P < 0.01; homozygous polymorphic : OR = 7. 3 2, 9 5 % C I : 1.85-28.96, P < 0.01), dominant(OR = 2.97, 95%CI: 1.97-4.50, P < 0.01), recessive(OR = 5.26, 95%CI: 1.35-20.50, P = 0.016), overdominant(OR = 2.64, 95%CI: 1.74-4.01, P < 0.01), and log-additive models(OR = 2.78, 95%CI: 1.91-4.06, P < 0.01). The haplotype formed by the minor alleles of the CYP2E1*5B(C) and CYP2E1*6(A) polymorphisms was associated with SCRC(P = 0.002). However, the CYP1A1 *2A, CYP1A1 *2C, EPHX1 Tyr113 His and EPHX1 His139 Arg polymorphisms were not associated with *** In conclusion, the

关键词： Single-nucleotide polymorphisms Colorectal neoplasms Cytochrome P-450 CYP2E1 Cytochrome P-450 CYP1A1 Epoxide hydrolases 1

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Would behavioral thermoregulation enable pregnant viviparous tropical lizards to cope with a warmer world?

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Integrative Zoology 2017年第5期12卷 379-395页

作者： Saúl LÓPEZ-ALCAIDE Miguel NAKAMURA Eric N.SMITH Enrique MARTÍNEZ-MEYER departament of Zoology Institute of BiologyNational Autonomous University of MexicoMexico CityMexico Center for Research in Mathematics GuanajuatoMexico Amphibian and Reptile Diversity Research Center and Department of biology University of Texas at ArlingtonArlingtonTexasUSA

Sceloporus lizards depend on external heat to achieve their preferred temperature(Tsel)for performing physiological *** both in the field and laboratory indicates that pregnant females of this Genus select body temperatures(Tb)lower than 34℃ as higher temperatures may be lethal to ***,thermoregulation is crucial for successful embryo *** the increase in global air temperature,it is expected that the first compensatory response of species that inhabit tropical climates will be behavioral *** tested whether viviparous Sceloporus formosus group lizards in the wild exhibited differences in thermoregulatory behavior to achieve the known Tsel for developing embryos regardless of local thermal *** quantified field active body temperature,thermoregulatory behavior mechanisms(time of sighting,microhabitat used and basking time)and available microhabitat thermal conditions(*** temperature)for 10 lizard species during gestation,distributed along an altitudinal *** applied both conventional and phylogenic analyses to explore whether Tb or behavioral thermoregulation could be regulated in response to different thermal *** species showed no significant differences in field Tb during gestation regardless of local thermal *** contrast,they exhibited significant differences in their behavioral thermoregulation associated with local environmental *** on these observations,the differences in thermoregulatory behavior identified are interpreted as compensatory adjustments to local thermal *** conclude that these species may deal with higher temperatures predicted for the tropics by modulating their thermoregulatory behavior.

关键词： altitudinal gradient behavior global warming Sceloporus formosus thermal stress

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Analysis of metabolic alterations in Arabidopsis following changes in the carbon dioxide and oxygen partial pressures

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Journal of Integrative Plant biology 2014年第9期56卷 941-959页

作者： Alexandra Florian Stefan Timm Zoran Nikoloski Takayuki Tohge Hermann Bauwe Wagner L.Araujo Alisdair R.Fernie Max Planck Institute for Molecular Plant Physiology Department of Plant Physiology University of Rostock Max-Planck Partner group at the departament of Plant biology Federal University of Vicosa

As sessile organisms,plants are subject to a multitude of environmental variations including several which directly affect their interaction with the *** the indiscriminant nature of Rubisco,the relative rates of photosynthesis and photorespiration are known to be responsive to changes in gas ***,comprehensive profiling methods have not yet been applied in order to characterize the wider consequences of these changes on primary metabolism in ***,although transcriptional profiling has revealed that a subset of photorespiratory enzymes are co-expressed,whether transcriptional responses play a role in short-term responses to atmospheric compositional changes remains *** address these questions,plants Arabidopsis thaliana（Arabidopsis） ecotype Columbia（Col-O） grown under normal air conditions were transferred to different CO_2 and O_2 concentrations and characterized at the physiological,molecular,and metabolic levels following this *** results reveal alterations in the components,which are directly involved in,or supporting,photorespiration,including transcripts and metabolite *** results further highlight that the majority of the regulation of these pathways is not mediated at the level of transcription and that the photorespiratory pathway is essential also in conditions in which flux through the pathway is minimized,yet suggest that flux through this pathway is not mediated at the level of transcription.

关键词： Carbon dioxide partial pressures gene expression metabolic profiling oxygen partial pressures

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Small-scale edaphic heterogeneity as a floristic-structural complexity driver in Seasonally Dry Tropical Forests tree communities

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Journal of Forestry Research 2020年第6期31卷 2347-2357页

作者： Cle´ber Rodrigo de Souza Jean Daniel Morel Alisson Borges Miranda Santos Wilder Bento da Silva Vinı´cius Andrade Maia Polyanne Aparecida Coelho Vanessa Leite Rezende Rubens Manoel dos Santos Forest Sciences departament Federal University of LavrasCx.P.3037Lavras 37200-000Brazil biology Department Federal University of LavrasCx.P.3037Lavras 37200-000Brazil

Our work aimed to test the hypothesis that soil microscale heterogeneity act as a community ecological driver,increasing diversity and promoting structural shifts on the Seasonally Dry Tropical Forest(SDTF)tree *** evaluated the relationship between microscale edaphic variations and floristic–structural patterns of tree communities in a SDTF fragment located in the southern end of the Brazilian Caatinga *** and soil data were obtained through 27 sample units of 400 m2(20 m 920 m),within each one we measured and identified at species level all arboreal individuals with Circumference at the Breast Height greater or equal to 10 cm,and also collected the soil *** the data we evaluated soil variation influence on the tree community structural and floristic patterns trough generalized linear *** explained the small-scale structural and floristic variations,contributing significantly to biomass,sprouting and to floristic relationships between sample *** was also observed a possible relation of the result with the Caatinga domain biogeographic history,due the presence of Sedimentary Caatinga species,which are not expected for the study *** plays an important role in driving small-scale complexity and diversity of SDTF,but we also suggest that Caatinga biogeographic events have influence on the high heterogeneity patterns.

关键词： Caatinga domain Edaphic variables Sprouting Sedimentary Caatinga

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Morphological,physiological and biochemical traits of Cordia trichotoma under phosphorous application and a water-retaining polymer

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Journal of Forestry Research 2021年第2期32卷 855-865页

作者： Álvaro Luís Pasquetti Berghetti Maristela Machado Araujo Luciane Almeri Tabaldi Felipe Turchetto Suelen Carpenedo Aimi Daniele Guarienti Rorato Carina Marchezan Adriana Maria Griebeler Felipe Manzoni Barbosa Gustavo Brunetto Department of Forest Science Federal University of Santa MariaSanta MariaBrazil Department of Soil Science Federal University of Santa MariaSanta MariaBrazil biology departament Federal University of Santa MariaSanta MariaBrazil

The application of phosphorus(P)and a waterretaining polymer to the soil can increase the availability of P for Cordia trichotoma,having a positive effect on the *** objective of this study was to evaluate the morphological,physiological and biochemical characteristics of *** plants were cultivated in a red argisol and treated with 120,240 and 360 kg P2O5 ha^(−1)and no phosphorous addition as a control,in the presence(5 g L^(−1)per seedling)and absence of a water-retaining *** months after planting,survival,height,stem diameter,shoot and root dry matter,leaf area,photosynthetic pigment concentration,chlorophyll a fluorescence,acid phosphatase enzyme activity(APase)and P in tissues and soil were *** polymer had no effect on survival and the other *** addition of P increased growth,dry matter production,photosynthetic pigment concentrations,the use of light energy and maximum quantum yield of photosystem *** cultivated in soil with 240 kg P2O5 ha^(−1)application had 4.7 and 5.4 times more shoot and root dry matter,respectively,than control *** dosage also showed 52.1%greater photochemical energy use than the control *** cultivated without the addition of P showed higher activity of the APase enzyme.

关键词： Fluorescence Louro-Pardo Morphological traits Phosphate nutrition Photosynthetic apparatus

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Induction and Characterization of Embryogenic Callus in Cotyledons Leaves of Tabebuia roseo-alba

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Journal of Agricultural Science and Technology(B) 2012年第8期2卷 950-955页

作者： Jorge Marcelo Padovani Porto Patricia Duarte de Oliveira Paiva Renato Paiva Eduardo Alves departament of biology Federal University of Lavras Lavras 37200-000 Brazil departament of Agriculture Federal University of Lavras Lavras 37200-000 Brazil departament of Plant Pathology Federal University of Lavras Lavras 37200-000 Brazil

Seeds from Tabebuia roseo-alba lose viability very fast. Moreover, the seed germination rate is very low, reaching approximately 40%. This study aimed at the in vitro induction of embryogenic callus. This technology allows subsequent plant regeneration as an alternative for the production of T. roseo-alba seedlings. Seeds were germinated in vitro and after 20 days, cotyledonary leaves, hypocotyls and root segments excised from these seedlings were used as explants. They were inoculated on MS medium supplemented with sucrose （30 g/L）, agar （5.0 g/L） and different auxins. The effect of 2,4-D, picloram and NAA at concentrations 0.0, 0.5, 1.0, 2.0 and 4.0 mg/L was evaluated. For the analysis of callus with embryogenic characteristics, ultra-structural study by scanning electron microscopy and cytochemical test with carmine were performed. The results showed that the culture medium supplemented with 4 mg/L NAA presented induction of callus with embryogenic characteristics in all explants used, with cotyledonary leaves showing the highest percentage （70% of explants with embryogenic characteristics）. The use of 2, 4-D and picloram was efficient for callus formation in different explants, but no embryogenic characteristics were observed. From the ultra-structural analysis of callus with embryogenic characteristics, it was found that cells from different explant sources had isodiametric format. This format is similar to somatic embryos in globular stage. The cytochemical analysis confirmed the presence of pro-embryogenic cells in callus mass. Callus induced from cotyledonary leaves presented 46% positive reaction to carmine acetic.

关键词： Carmine acetic isodiametric cell NAA tissue culture ultra-structural analysis.

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A WW Domain-Containing Protein Forms Immune Nuclear Bodies against Begomoviruses

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Molecular Plant 2018年第12期11卷 1449-1465页

作者： lara P. Calil lana P.S. Quadros Thais C. Araujo Christiane E.M. Duarte Bianca C. Gouveia-Mageste Jose Cleydson F. Silva Otavio J.B. Brustolini Ruan M. Teixeira Caue N. Oliveira Rafael W.M.M. Milagres Gilberto S. Martins Joanne Chory Pedro A.B. Reis Joao Paulo B. Machado Elizabeth P.B. Fontes departament of Biochemistry and Molecular biology Universidade Federal de Vigosa Vigosa Minas Gerais 36570-000 Brazil Nati onal In stitute of Science and Tech no logy in Plant-Pest Interactions Bioagro Universidade Federal de Vicosa Vinosa Minas Gerais 36570-000 Brazil departament of Genetics Universidade Federal do Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil Howard Hughes Medical Institute and Plant biology Laboratory The Salk Institute of Biological Studies La Jolla CA 92037 USA Agronomy Institute Universidade Federal de Vigosa Campus Florestal Florestal Minas Gerais 35690-000 Brazil These authors contributed equally to this article

The bipartite begomoviruses (Geminiviridae family), which are DNA viruses that replicate in the nucleus of infected cells, encode the nuclear shuttle protein (NSP) to facilitate the translocation of viral DNA from the nucleus to the cytoplasm via nuclear pores. This intracellular trafficking of NSP-DNA complexes is accessorized by the NSP-interacting guanosine triphosphatase (NIG) at the cytosolic side. Here, we report the nuclear redistribution of NIG by AtWWPI, a WW domain-containing protein that forms immune nuclear bodies (NBs) against begomoviruses. We demonstrated that AtWWPI relocates NIG from the cytoplasm to the nucleus where it is confined to AtWWP1-NBs, suggesting that the NIG-AtWWP1 interaction may interfere with the NIG pro-viral function associated with its cytosolic localization. Consistent with this assumpti on joss AtWWPI functi on cuased plants more susceptible to begomovirus infection, whereas overexpression of AWWP1 enhaneed plant resistance to begomovirus. Furthermore, we found that a mutant versi on of AtWWPI defective for NB formatio n was noIonger capable of interacti ng with and relocating NIG to the nucleus and lost its immune function against begomovirus. The antiviral function of AtWWP1-NBs, however, could be antagonized by viral infection that induced either the disruption or a decrease in the number of AtWWP1-NBs. Collectively, these results led us to propose that AtWWPI organizes nuclear structures into nuclear foci, which provide intrinsic immunity against begomovirus infection.

关键词： nuclear bodies antiviral immunity begomovirus NIG AtWWP1

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Give progesterone a chance

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Neural Regeneration Research 2014年第15期9卷 1422-1424页

作者： Florencia Labombarda Daniel Garcia-Ovejero Laboratory of Neuroendocrine Biochemistry Institute of Biology and Experimental Medicine CONICET Vuelta de Obligado 2490Buenos AiresArgentina departament of Human Biochemistry School of MedicineBuenos Aires University Paraguay 2155Buenos AiresArgentina Neuroinflammation Laboratory National Hospital For Paraplegics(SESCAM) ToledoSpain

There is currently no standard pharmacological treatment for spinal cord injury. Here, we suggest that progesterone, a steroid hormone, may be a promising therapeutical candidate as it is already for traumatic brain injury, where it has reached phase II clinical trials. We rely on previous works showing anti-inflammatory, neuroprotective and promyelinating roles for progesterone after spinal cord injury and in our recent paper, in which we demonstrate that progesterone diminishes lesion, preserves white matter integrity and improves locomotor recovery in a clinically relevant model of spinal cord lesion.

关键词： spinal cord injury myelin trauma neuroprotection progesterone

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Leaves of Field-Grown Mastic Trees Suffer Oxidative Stress at the Two Extremes of their Lifespan

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Journal of Integrative Plant biology 2012年第8期54卷 584-594页

作者： Marta Juvany Maren Müller Sergi Munn-Bosch departament de Biologia Vegetal Facultat de BiologiaUniversitat de BarcelonaAvinguda Diagonal643E-08028 BarcelonaSpain

Leaf senescence is a complex phenomenon occurring in all plant species, but it is still poorly understood in plants grown in Mediterranean field conditions and well-adapted to harsh climatic conditions. To better understand the physiological processes underlying leaf senescence in mastic trees （Pistacia lentiscus L.）, we evaluated leaf growth, water and N content, photosystem II （PSII） photochemistry, lipid peroxidation and levels of photosynthetic pigments, antioxidants, abscisic acid, and salicylic acid and jasmonic acid during the complete leaf lifespan, from early expansion to late senescence in relation to natural climatic conditions in the field. While mature leaves suffered from water and N deficit during late spring and summer, both young （emerging） and old （senescing） leaves were most sensitive to photo- oxidative stress, as indicated by reductions in the Fv/Fm ratio and enhanced lipid peroxidation during late autumn and winter. Reductions in the FvlFm ratio were associated with low ^-tocopherol （vitamin E） levels, while very old, senescing leaves additionally showed severe anthocyanin losses. We have concluded that both young （emerging） and old （senescing） leaves suffer oxidative stress in mastic trees, which may be linked in part to suboptimal temperatures during late autumn and winter as well as to low vitamin E levels.

关键词： Leaf senescence lentisc (Pistacea lentiscus L.) oxidative stress phytohormones seasonal effects.

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G protein-coupled receptor 37(GPR37) emerges as an important modulator of adenosinergic transmission in the striatum

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Neural Regeneration Research 2019年第11期14卷 1912-1914页

作者： Xavier Morato Rodrigo A. Cunha Francisco Ciruela Unitat de Farmacologia Departament Patologia i Terapeutica ExperimentalFacultat de MedicinaInstituto de Investigacion Biomedica de Bellvitge (IDIBELL)Universitat de BarcelonaL’Hospitalet de LlobregatBarcelonaSpainInstitut de NeurocienciesUniversitat de BarcelonaBarcelonaSpain (Morato X Ciruela F) Center for Neuroscience and Cell Biology (CNC)-Center for Neurosciences and Cell BiologyUniversity of CoimbraCoimbraPortugalFaculty of MedicineUniversity of CoimbraCoimbraPortugal

G protein-coupled receptor 37 (GPR37), also known as parkin associated endothelin-like (Pael) receptor, is an orphan G protein- coupled receptor, which suffers a defective parking ubiquitination in autosomal recessive Parkinson’s disease promoting its endoplasmic reticulum aggregation and stress, neurotoxicity and neuronal death (Takahashi and Imai, 2003). Interestingly, we have demonstrated previously that GPR37 heteromerizes with adenosine A2A receptor (A2AR) in the striatum (Morato et al., 2017;Sokolina et al., 2017).

关键词： G protein-coupled receptor 37(GPR37) important modulator adenosinergic transmission

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