检索结果-南通市图书馆

Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee William J.Mack Department of integrative Anatomical sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Simple model based on artificial neural network for early prediction and simulation winter rapeseed yield

在线全文

学校读者我要写书评

暂无评论

Journal of integrative Agriculture 2019年第1期18卷 54-61页

作者： Gniewko Niedba?a institute of biosystems Engineering Faculty of Agronomy and BioengineeringPoznań University of Life Sciences

The aim of the research was to create a prediction model for winter rapeseed *** constructed model enabled to perform simulation on 30 June,in the current year,immediately before *** artificial neural network with multilayer perceptron(MLP) topology was used to build the predictive *** model was created on the basis of meteorological data(air temperature and atmospheric precipitation) and mineral fertilization *** data were collected in the period 2008–2017 from 291 productive fields located in Poland,in the southern part of the Opole *** assessment of the forecast quality created on the basis of the neural model has been verified by defining forecast errors using relative approximation error(RAE),root mean square error(RMS),mean absolute error(MAE),and mean absolute percentage error(MAPE) *** important feature of the created predictive model is the ability to forecast the current agrotechnical year based on current weather and fertilizing *** lowest value of the MAPE error was obtained for a neural network model based on the MLP network of 21:21-13-6-1:1 structure,which was 9.43%.The performed sensitivity analysis of the network examined the factors that have the greatest impact on the yield of winter *** highest rank 1 was obtained by an independent variable with the average air temperature from 1 January to 15 April of 2017(designation by the T1-4_CY model).

关键词： forecast MLP network neural model prediction error sensitivity analysis yield simulation

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Effect of Eu^(3+),Bi^(3+),and Li^(+) doping on luminescent property of GdNbO_(4)

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第1期42卷 66-75,I0003页

作者： S.W.Wi Y.S.Lee Department of Physics and integrative institute of Basic sciences Soongsil UniversitySeoul06978Republic of Korea

We investigated the emission properties of Eu^(3+)-doped GdNbO_(4)-based oxide phosphors,aiming at improving the Eu^(3+)emission by codoping of Bi^(3+)and Li^(+).Eu^(3+)singly doped,Eu^(3+)and Bi^(3+)doubly doped,and Eu^(3+),Bi^(3+),and Li^(+)triply doped GdNbO_(4)were prepared using a high-temperature solid-state reaction *** red-orange emissions from Eu^(3+)in the singly doped samples are significantly improved by the codoping of Bi^(3+),mainly due to the energy transfer from Bi^(3+)to Eu^(3+).The additional codoping of Li^(+)is found to increase the Eu^(3+)emission *** improvement might be attributed to the increase in the photoluminescent quantum yield originating from larger grain sizes and better crystallinity.A detailed analysis of the X-ray diffraction pattern and the asymmetric ratio estimated from the photoluminescence spectra show that the local lattice environment around Eu^(3+)in GdNbO_(4)does not change significantly with the codoping of Bi^(3+)and Li^(+).Our results indicate that Li^(+)doping is a promising way to improve the emission properties of rare-earth ion-doped GdNbO_(4)phosphors.

关键词： Eu^(3+) GdNbO_(4) Codoping of Li^(+) Photoluminescence Sensitizer Rare earths

Demystifying Mechanosensitive Piezo Ion Channels

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2016年第3期32卷 307-309页

作者： X.Z.Shawn Xu Life sciences institute and Department of Molecular and integrative Physiology University of Michigan

Mechanosensitive channels mediate touch,hearing,proprioception,and blood pressure *** proteins,including Piezo1 and Piezo2,represent a new class of mechanosensitive channels that have been reported to play key roles in most,if not all,of these *** structural architecture and molecular mechanisms by which Piezos act as mechanosensitive channels,however,remain *** new studies have now provided critical insights into the atomic structure and molecular basis of the ion permeation and mechano-gating properties of the Piezo1 channel.

关键词： Mechanosensation Mechanosensory echanotransduction Mechanical Cryo-EM Piezo

“Love Is Strong, and You＇re so Sweet”： JAGGER Is Essential for Persistent Synergid Degeneration and Polytubey Block in Arabidopsis thaliana

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2016年第4期9卷 601-614页

作者： Ana Marta Pereira Margarida Sofia Nobre Sara Cristina Pinto Ana Lucia Lopes Mario Luis Costa Simona Masiero Silvia Coimbra Departamento de Biologia Faculdade de Ciencias da Universidade do Porto Rua do Campo Alegre 4169-007 Porto Portugal Plant Functional Genomics Group Biosystems and Integrative Sciences Institute (BiolSI) 4169-007 Porto Portugal Dipartimento di BioScienze Universita degli Studi di Milano 20133 Milan Italy Present address: institute of Plant Biology and ZUrich-Basel Plant Science Center University of ZUrich Zolikerstrasse 107 8008 Zurich Switzerland

Successful double fertilization and subsequent seed development in flowering plants requires the delivery of two sperm cells, transported by a pollen tube, into the embryo sac of an ovule. The embryo sac cells tightly control synergid cell death, and as a result the polyspermy block. Arabinogalactan proteins are highly glycosylated proteins thought to be involved in several steps of the reproductive process. We show that JAGGER, Arabinogalactan Protein 4, is an important molecule necessary to prevent the growth of multiple pollen tubes into one embryo sac in Arabidopsis thaliana. In jagger, an AGP4 knockout mutant, the pistils show impaired pollen tube blockage as a consequence of the survival of the persistent synergid. JAGGER seems to be involved in the signaling pathway that leads to a blockage of pollen tube attraction. Our results shed light on the mechanism responsible for preventing polyspermy in Arabidopsis and for safe- guarding successful fertilization of all ovules in one pistil, ensuring seed set and the next generation.

关键词： Polytubey persistent synergid arabinogalactan proteins polyspermy

Massive Molecular Parallel Evolution of the HSP90AA1 Gene between High-elevation Anurans

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Herpetological Research 2018年第3期9卷 195-200页

作者： Hong JIN Bin LU Jinzhong FU Chengdu institute of Biology Chinese Academy of Sciences Department of integrative Biology University of Guelph

HSP90 AA1 is part of the heat shock protein 90 gene family and has important functions against heat stress. We report a case of molecular level parallel evolution of the HSP90 AA1 gene in high elevation amphibians. HSP90 AA1 gene sequences of four high-elevation anurans, Bufo gargarizans, Nanorana parkeri, Rana kukunoris, and Scutiger boulengeri, were compared along with five of their low-elevation relatives. A total of 16 amino-acid sites were identified as parallel evolution between N. parkeri and R. kukunoris. We generated both model based（Zhang and Kumar＇s test） and empirical data based（parallel/divergence plotting） null distributions for non-parallel evolution, and both methods clearly determined that the observed number of parallel substitutions were significantly more than the null expectation. Furthermore, on the HSP90 AA1 gene tree, N. parkeri and R. kukunoris formed a strongly supported clade that was away from their respective relatives. This study provides a clear case of molecular parallel evolution, which may have significant implications in understanding the genetic mechanisms of high-elevation adaptation.

关键词： molecular parallel evolution high-elevation case study amphibian HSP90AA1 gene

Prepare for Future Challenges JIPB's 2013 Editorial Board Meeting Report

在线全文

学校读者我要写书评

暂无评论

Journal of integrative Plant Biology 2013年第11期55卷 999-1001页

作者： Chun-Ming Liu Journal of integrative Plant Biology institute of Botany Chinese Academy of sciences

JIPB＇s 2013 Editorial Board Meeting ReportOn July 4th, 2013, JIPB＇s Board Meeting was held in Lijiang, a scenic town in the Yunnan Province, China. The Board Meeting coincided with the 2013 International Symposium on integrative Plant Biology （July 5 to 7, 2013）, which was also organized by JIPB （Figures 1, 2）. The board meeting runs once in every two years. In total 37 editorial board members from 10 counties attended the meeting.

关键词： Prepare for Future Challenges JIPB’s 2013 Editorial Board Meeting Report

RNA-directed DNA methylation and demethylation in plants

在线全文

学校读者我要写书评

暂无评论

Science China(Life sciences) 2009年第4期52卷 331-343页

作者： CHINNUSAMY Viswanathan institute for integrative Genome Biology and Department of Botany and Plant sciences University of California Riverside

RNA-directed DNA methylation (RdDM) is a nuclear process in which small interfering RNAs (siRNAs) direct the cytosine methylation of DNA sequences that are complementary to the siRNAs. In plants, double stranded-RNAs (dsRNAs) generated by RNA-dependent RNA polymerase 2 (RDR2) serve as precursors for Dicer-like 3 dependent biogenesis of 24-nt siRNAs. Plant specific RNA polymerase IV (Pol IV) is presumed to generate the initial RNA transcripts that are substrates for RDR2. siRNAs are loaded onto an argonaute4-containing RISC (RNA-induced silencing complex) that targets the de novo DNA methyltransferase DRM2 to RdDM target loci. Nascent RNA transcripts from the target loci are generated by another plant-specific RNA polymerase, Pol V, and these transcripts help recruit com- plementary siRNAs and the associated RdDM effector complex to the target loci in a transcrip- tion-coupled DNA methylation process. Small RNA binding proteins such as ROS3 may direct tar- get-specific DNA demethylation by the ROS1 family of DNA demethylases. Chromatin remodeling en- zymes and histone modifying enzymes also participate in DNA methylation and possibly demethylation. One of the well studied functions of RdDM is transposon silencing and genome stability. In addition, RdDM is important for paramutation, imprinting, gene regulation, and plant development. Lo- cus-specific DNA methylation and demethylation, and transposon activation under abiotic stresses suggest that RdDM is also important in stress responses of plants. Further studies will help illuminate the functions of RdDM in the dynamic control of epigenomes during development and environmental stress responses.

关键词： abiotic stress plant development siRNAs DNA methylation demethylation RdDM

Understand comprehensive perspectives of evolution

在线全文

学校读者我要写书评

暂无评论

integrative Zoology 2023年第2期18卷 206-207页

作者： Wenhua XIONG integrative Zoology institute of Zoology Chinese Academy of SciencesChina Office of the International Society of Zoological sciences

Evolution is the key to understanding the theories of *** in biology makes sense except in the light of evolution(Dobzhansky 1973).Beyond the traditional method of morphology,we are aware of the possibilities of new scientific discoveries to be cognizant of the development of anatomy,paleontology,computational biology,phylogenetic analysis,and molecular means.

关键词： evolution anatomy Beyond