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Natural isothiocyanates of the genus Capparis as potential agonists of apoptosis and antitumor drugs

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World Journal of Pharmacology 2023年第4期12卷 35-52页

作者： Lumír Hanuš Tuvia Naor Tatyana Gloriozova Valery M Dembitsky Institute for Drug Research School of PharmacyFaculty of MedicineHebrew UniversityEin Kerem CampusJerusalem 91120Israel Food Chemistry KibbutzYotvata 8882000Israel Department of bioinformatics Institute of Biomedical ChemistryMoscow 119121Russia Centre for Applied Research and Innovation Lethbridge CollegeLethbridge AB T1K 1L6Canada

BACKGROUND Using gas chromatography-mass spectrometry(GC/MS)analysis,we examined the composition of volatile components present in the yellow and green fruits,seeds,and jam of the scrambling shrub Capparis cartilaginea(***).These plant samples were collected from Kibbutz Yotvata in *** all the tested samples,isothiocyanates were *** the PASS program,we ascertained the biological activity of these isothiocyanates present in the Capparis *** study results highlighted that all isothiocyanates could potentially act as apoptosis agonists,making them strong candidates for antitumor *** information holds significant value for the fields of medicinal chemistry,pharmacology,and practical *** To investigate the volatile components present in the yellow and green fruits,seeds,and jam of the *** shrub using GC/MS analysis,to detect isothiocyanates in all the analyzed plant samples,and to assess the biological activity of these isothiocyanates utilizing the PASS *** We utilized two primary methods to analyze the volatile compounds present in the yellow and green fruits,seeds,and jams of the ***,native to *** identified biologically active isothiocyanates in these *** anticipated biological activities were determined using the PASS program,with the most dominant activities being apoptosis agonist,anticarcinogenic,and antineoplastic specifically for genitourinary *** Fruits,seeds,and jams containing isothiocyanates,which exhibit antineoplastic and anticarcinogenic activities,could be suggested for cancer prevention and *** isothiocyanates,with therapeutic potential in this realm,could be recommended as potent anticancer agents in practical medicine following clinical *** The discovery that isothiocyanates exhibit potent antineoplastic and anticarcinogenic activities was ***,certain isothiocyanates demonstrated antifu

关键词： Capparis cartilaginea Fruits Seeds Isothiocyanates Apoptosis Anticancer

Genome and transcriptome of Papaver somniferum Chinese landrace CHM indicates that massive genome expansion contributes to high benzylisoquinoline alkaloid biosynthesis

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Horticulture Research 2021年第1期8卷 38-50页

作者： Li Pei Baishi Wang Jian Ye Xiaodi Hu Lihong Fu Kui Li Zhiyu Ni Zhenlong Wang Yujie Wei Luye Shi Ying Zhang Xue Bai Mengwan Jiang Shuhui Wang Chunling Ma Shujin Li Kaihui Liu Wanshui Li Bin Cong Institute of Forensic Science Ministry of Public SecurityNo.17 South Muxidi LaneXicheng District100038 BeijingPeople’s Republic of China College of Forensic Medicine Hebei Medical UniversityHebei Key Laboratory of Forensic MedicineInnovation Center of Forensic Medical Molecular IdentificationNo.361 Zhongshan East Road050017 ShijiazhuangHebeiPeople’s Republic of China Novogene bioinformatics Institute BeijingPeople’s Republic of China Hebei University No.180 Wusidong RoadBaodingHebei ProvincePeople’s Republic of China School of Life Sciences Zhengzhou UniversityNo.100 Science Road450001 ZhengzhouHenanPeople’s Republic of China Gansu Academy of Agri-Engineering Technology No.234 Xinzhen RoadHuangyang TownLiangzhou District733006 WuweiGansuPeople’s Republic of China Wuhan Botanical Garden Chinese Academy of Sciences430074 WuhanPeople’s Republic of China

Opium poppy(Papaver somniferum)is a source of morphine,codeine,and semisynthetic derivatives,including oxycodone and ***,we report the de novo assembly and genomic analysis of *** traditional landrace‘Chinese Herbal Medicine’.Variations between the 2.62 Gb CHM genome and that of the previously sequenced high noscapine 1(HN1)variety were also *** 79,668 protein-coding genes,we functionally annotated 88.9%,compared to 68.8%reported in the HN1 *** family and 4DTv comparative analyses with three other Papaveraceae species revealed that opium poppy underwent two whole-genome duplication(WGD)*** first of these,in ancestral Ranunculales,expanded gene families related to characteristic secondary metabolite production and disease *** more recent species-specific WGD mediated by transposable elements resulted in massive genome *** carrying structural variations and large-effect variants associated with agronomically different phenotypes between CHM and HN1 that were identified through our transcriptomic comparison of multiple organs and developmental stages can enable the development of new *** genomic and transcriptomic analyses will provide a valuable resource that informs future basic and agricultural studies of the opium poppy.

关键词： alkaloid expansion benzyl

A New Method Based on Evolutionary Algorithm for Symbolic Network Weak Unbalance

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Journal on Internet of Things 2019年第2期1卷 41-53页

作者： Yirong Jiang Weijin Jiang Jiahui Chen Yang Wang Yuhui Xu Lina Tan Liang Guo Tonghua Normal University Tonghua134002China Key Laboratory of Hunan Province for New Retail Virtual Reality Technology Hunan University of CommerceChangsha410205China Institute of Big Data and Internet Innovation Hunan University of CommerceChangsha410205China School of Computer Science and Technology Wuhan University of TechnologyWuhan430073China School of bioinformatics University of MinnesotaTwin CitiesUSA

The symbolic network adds the emotional information of the relationship,that is,the“+”and“-”information of the edge,which greatly enhances the modeling ability and has wide application in many *** unbalance is an important indicator to measure the network *** paper starts from the weak structural equilibrium theorem,and integrates the work of predecessors,and proposes the weak unbalanced algorithm EAWSB based on evolutionary *** on the large symbolic networks Epinions,Slashdot and WikiElections show the effectiveness and efficiency of the proposed *** EAWSB,this paper proposes a compression-based indirect representation method,which effectively reduces the size of the genotype space,thus making the algorithm search more complete and easier to get better solutions.

关键词： Weak structural balance signed networks evolutionary algorithms incremental computation compressed representation

Natural therapeutics for cancer treatment:success,challenges,and prospect

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Journal of Bio-X Research 2023年第2期6卷 61-72页

作者： Debasmita Dubey Shakti Rath Rajesh Kumar Meher Sanghamitra Mishra Soumya Surath Panda Subhashree Ray Subrat Kumar Tripathy Medical Research Laboratory IMS and SUM HospitalSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar 751003OdishaIndia Central Research Laboratory Institute of Dental SciencesSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar 751003OdishaIndia Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyotiviharBurlaSambalpurOdishaIndia Department of Critical Care Medicine IMS and SUM HospitalSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar 751003OdishaIndia Department of Oncology IMS and SUM HospitalSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar 751003OdishaIndia Department of Biochemistry IMS and SUM HospitalSiksha“O”Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia.

Cancer is a terrifying disease that has become one of the world’s most challenging health concerns,necessitating a proactive approach to its *** is a rich source of new chemical entities and a promising avenue for cancer *** of their different modes of action on target events in many ways,nature-derived chemicals are considered good possibilities for anticancer drug *** current review article highlights recent breakthroughs in cancer therapeutics,including natural therapeutic molecules and their mechanisms of action against cancer treatment,as well as their limits,challenges,and *** the review,article data have been collected from previously studied and published research reports,clinical evaluations,case studies,and clinical statistical data generated by scientific research organizations of *** chemical structures have been drawn using computational software(chemsketch).The development of promising candidates that can prevent or reduce the proliferation of cancer cells without causing adverse effects from these therapeutics is now ***,nature-derived products are a game-changer because they are simple,safer,environmentally friendly,low-cost,quick,and less toxic than traditional treatment ***,many bioactive chemicals and their analogs have been discovered as possible anticancer treatment *** the review,the potent therapeutics phytochemicals derived from nature with their tremendous anticancer effects with limitations and prospects have been studied and analyzed based on previously published articles and reports.

关键词： cancer treatment chemotherapy drug resistance natural therapy toxicity

Corrigendum to“Development of methods for detecting the fate of mesenchymal stem cells regulated by bone bioactive materials”[***.6(3)(2021)613-626]

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生物活性材料(英文) 2023年第6期24卷 251-251页

作者： Le Jiang Zhongqun Liu Zhaoyan Wang Yijun Su Yingjin Wang Yaojie Wei Yanan Jiang Zhanrong Jia Chunyang Ma Fangli Gang Nan Xu Lingyun Zhao Xiumei Wang Qiong Wu Xiong Lu Xiaodan Sun State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084PR China Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and EngineeringTsinghua UniversityBeijing100084PR China Key Lab of Advanced Technologies of Materials of Ministry of Education School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu610031PR China MOE Key Laboratory of bioinformatics Tsinghua UniversityBeijing100084PR China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing100084PR China School of Life Sciences Tsinghua UniversityBeijing100084PR China

The authors regret that the last name and first name of all authors are reversed in the original *** correct writing is as follows:Le Jiang,a,b#;Zhongqun Liu,a,b#;Zhaoyan Wang,d,e,f;Yijun Su,a,b;Yingjin Wang,a,b;Yaojie Wei,a,b;Yanan Jiang,c;Zhanrong Jia,c;Chunyang Ma,a,b;Fangli Gang,a,b;Nan Xu,a,b;Lingyun Zhao,a,b;Xiumei Wang,a,b;Qiong Wu,d,e,f;Xiong Lu,c,*and Xiaodan Sun,a,b,**** Key Laboratory of New Ceramics and Fine Processing,School of Materials Science and Engineering,Tsinghua University,Beijing 100084,People’s Republic of China;*** Laboratory of Advanced Materials of Ministry of Education of China,School of Materials Science and Engineering,Tsinghua University,Beijing 100084,People’s Republic of China;*** Lab of Advanced Technologies of Materials of Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu 610031,People’s Republic of China *** Key Laboratory of bioinformatics,Tsinghua University,Beijing,100084,People’s Republic of China *** for Synthetic and Systems Biology,Tsinghua University,Beijing,100084,People’s Republic of China *** of Life Sciences,Tsinghua University,Beijing,100084,People’s Republic of China.

关键词： reversed Republic Chengdu

PNAS：科学焉已在蝙蝠机体中发现白血病病毒的史前祖先

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现代生物医学进展 2017年第11期17卷 I0002-I0002页

作者： Helena Farkašová[a], Tomáš Hron[a], Jan Pačes[b] Pavel Hulva[c],[d] Petr Benda[c],[e] Robert James Gifford[f], Daniel Elleder[a], [a]Laboratory of Viral and Cellular Genetics Institute of Molecular Genetics The Czech Academy of Sciences Prague 14220 Czech Republic [b]Laboratory of Genomics and bioinformatics Institute of Molecular Genetics The Czech Academy of Sciences Prague 14220 Czech Republic [c]Department of Zoology Charles University Prague 12844 Czech Republic [d]Department of Biology and Ecology University of Ostrava Ostrava 71000 Czech Republic [e]Department of Zoology National Museum (Natural History) Prague 11579 Czech Republic [f]MRC-University of Glasgow Centre for Virus Research Glasgow G12 8TA United Kingdom

近日,一项刊登在国际杂志PNAS上的研究报告中,来自格拉斯哥大学和捷克科学院的研究人员通过研究在蝙蝠的基因组中发现了引发罕见类型白血病的病毒家族的古老DNA痕迹。

关键词：白血病病毒科学院蝙蝠祖先机体研究人员 DNA 基因组

Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： Javier Martin-Broto Jeronimo Martinez-Garcia David SMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa Javier Martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas Pablo Romero Javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4

PARK16 rs708730 Polymorphism Decreases Parkinson’s Disease Risk in European Ancestry Population:A Meta-analysis

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Journal of Geriatric Medicine 2019年第2期1卷 15-22页

作者： Zhijie Han Baochu Wei Chenghong Zhang Hongtian Zhu Lei Tang Ruili Lin Dian He Yang Zhang Pingrong Yang Junquan He Pingshun Song 无 Materia Medica Development Group Institute of Medicinal ChemistryLanzhou University School of PharmacyLanzhou730000China Department of bioinformatics School of Basic MedicineChongqing Medical UniversityChongqing400016China Lanzhou Pulmonary Hospital Lanzhou730046China Gansu Institute for Drug Control Lanzhou730070China Lanzhou Weihuan Biological Science and Technology Development Co. Ltd.Lanzhou730000China

Parkinson’s disease(PD)is a complex fatal chronic neurodegenerative disease most common in elderly *** early genome-wide association studies(GWAS)found that the minor allele variant of PARK16 rs708730 polymorphism is a significant protective factor for PD in Caucasian ***,these results cannot be repeated by the following studies in Caucasian populations and other *** considered that the inconsistency of the findings may be caused by the small-scale samples or the heterogeneity among different ***,in this study,we synthesized the previous related GWAS studies through three authoritative sources,and used the large-scale samples(10,645 PD cases and 30,499 controls)to reevaluate the association between rs708730 polymorphism and *** results showed that there is no association between them in Asian ancestry ***,in European ancestry population,we found that the minor allele variant(G)of rs708730 polymorphism is significantly associated with a decreased risk of ***,our findings further verified the association of rs708730 with PD and show its genetic heterogeneity among different populations,which can help to develop a better understanding of the PD’s pathogenesis.

关键词： Parkinson’s disease Genome-wide association studies Meta-analysis PARK16 rs708730 polymorphism

Discovery of Simple Sequence Repeat Markers through Transcriptome Analysis of Baccaurea motleyana

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Journal of Food Science and Engineering 2020年第2期10卷 33-46页

作者： Khairun Hisam Nasir Muhammad Fairuz Mohd Yusof Mohd Shahril Firdaus Abdul Razak Siti NorsaidahIbrahim Mira Farzana Mohamad Moktar Khadijah Awang Mohd Shukri Mat Ali Centre for Molecular Marker Discovery and Validation(CMDV) Agri-Omic dan BioinformaticsBiotechnology and Nanotechnology Research CentreMalaysian Agricultural Research and Development Institute(MARDI)Serdang 43400SelangorMalaysia Industrial Crop Research Centre Malaysian Agricultural Research and Development Institute(MARDI)Serdang 43400SelangorMalaysia Horticulture Research Centre Malaysian Agricultural Research and Development Institute(MARDI)Serdang 43400SelangorMalaysia

Baccaurea motleyana(rambai)is underutilized fruits that are native to Malaysia,Indonesia and *** this study,a total of 54,779 unigenes identified from rambai transcriptome were used for simple sequence repeat(SSR)analysis by MIcroSAtellite(MISA).A total of 20,420 SSRs were found to be distributed within 37.27%of the total number of *** repeats represented the main type,accounting for 64.04%,followed by trinucleotide repeats(20.28%)and dinucleotide repeats(19.94%).Gene annotation to seven databases has a success ratio of 68.53%(National Center for Biotechnology Information(NCBI)protein sequences),53.68%(NCBI nucleotide sequences),27.43%(Kyoto Encyclopedia of Genes and Genome Ortholog),56.0%(SwissProt),52.44%(Protein family),53.99%(Gene Ontology)and 26.44%(Kluster of Orthologous Group).Further rambai SSRs were randomly selected and validated to ***(rambai),***(tampoi),***(jentik-jentik),***(pupor)and ***(setambun).

关键词： Baccaurea SSR transcriptome gene annotation and SSR validation