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Saccharomyces cerevisiae CNCm I-3856 in irritable bowel syndrome: An individual subject meta-analysis

World Journal of Gastroenterology 2017年第2期23卷 336-344页

作者： Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux Lesaffre Human Care Lesaffre Group biofortis-mérieux nutris ciences Lesaffre Yeast Corporation Lesaffre Group CHU Lille Department of GastroenterologyClaude Huriez Hospital Lille University North of France INSERm U995

AImTo confirm previous conclusions on Saccharomyces cerevisiae (S. cerevisiae) CNCm I-3856 for irritable bowel syndrome (IBS) *** individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCm I-3856 supplementation on gastrointestinal (GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve (AUC) and weekly means], responder status, and bowel movements (stool frequency and consistency). Statistical analyses were conducted in Intent to Treat (ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline (“IBS-C ≥ 2 subpopulation”).RESULTSS. cerevisiae CNCm I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC (W5-W8)] with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group (P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group (P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit (a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder (reduction of 1 a.u. of abdominal pain/discomfort) comp

关键词： Irritable bowel syndrome Saccharomyces cerevisiae Constipation Abdominal pain Probiotics

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