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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen Xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

Fabrication and characterization of electrospun poly-L-lactide/gelatin graded tubular scaffolds: Toward a new design for performance enhancement in vascular tissue engineering

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Progress in Natural Science:Materials International 2015年第5期25卷 405-413页

作者： A.Yazdanpanah M.Tahmasbi G.Amoabediny J.Nourmohammadi F.Moztarzadeh M.Mozafari biomaterials group Faculty of Biomedical Engineering (Center of Excellence) Amirkabir University of Technology School of Mechanical Engineering Sharif University of Technology Faculty of Chemical Engineering College of Engineering University of Tehran biomaterials group Faculty of New Sciences and Technologies University of Tehran bioengineering Research group Nanotechnology and Advanced Materials Department Materials and Energy Research Center (MERC)

In this study, a new design of graded tubular scaffolds have been developed for the performance enhancement in vascular tissue *** graded poly-L-lactide(PLLA) and gelatin fibrous scaffolds produced by electrospining were then characterized. The morphology,degradability, porosity, pore size and mechanical properties of four tubular scaffolds(graded PLLA/gelatin, layered PLLA/gelatin, PLLA and gelatin scaffolds) have been investigated. The tensile tests demonstrated that the mechanical strength and also the estimated burst pressure of the graded scaffolds were significantly increased in comparison with the layered and gelatin scaffolds. This new design, resulting in an increase in the mechanical properties, suggested the widespread use of these scaffolds in vascular tissue engineering in order to prepare more strengthened vessels.

关键词： Tubular scaffolds Electrospinning Poly-L-lactide Gelatin Vascular tissue engineering

Micro and nano-enabled approaches to improve the performance of plasma electrolytic oxidation coated magnesium alloys

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Journal of Magnesium and Alloys 2021年第5期9卷 1497-1517页

作者： Safoora Farshid Mahshid Kharaziha biomaterials Research group Department of Materials EngineeringIsfahan University of TechnologyIsfahan***Iran

Magnesium(Mg)and its alloys have become a hot research topic in various industries owing to the specific physical and chemical ***,high corrosion rate is considered the key *** electrolytic oxidation(PEO)method is a simple strategy to deposit an oxide layer on the surface of light metals such as magnesium alloys,to control corrosion rate and promote some other properties,depending on their ***,their features including their micropore size,distribution,and interconnectivity,and microcracks have not been improved to an acceptable level to support long-term performances of the magnesium-based *** have introduced micro/nano-enabled approaches to enhance various properties of PEO coatings such as corrosion resistance,tribological properties,self-healing ability,bioactivity,biocompatibility,antibacterial properties,or catalytic *** strategies consist of incorporating of micro and nanoparticles into the PEO layers to produce multi-functional surfaces or the formation of multi-layered coatings to cover the defects of PEO *** this perspective,the present paper aims to overview various nano/micro-enabled strategies to promote the properties of PEO coatings on magnesium *** main focus is given to the functional changes that occurred in response to the incorporation of various types of nano/micro-structures into the PEO coatings on magnesium alloys.

关键词： Plasma electrolytic oxidation Corrosion resistance Tribological properties Biological properties Micro and multi-layer coatings

Utilization of High Sulfur Raw Materials in Iron Ore Pellets

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Journal of Iron and Steel Research International 2013年第10期20卷 32-38页

作者： ZHU De-qing RUAN Zhi-yong CHUN Tie-jun PAN Jian School of Minerals Processing and bioengineering Central South University Liuzhou Iron and Steel group

Pyrite cinder and high sulfur magnetite were used as raw materials to produce iron ore pellets. Good quali ties of green balls and fired pellets were obtained from the feed comprising 50G pyrite cinder and 50% high sulfur magnetite concentrate at a small scale. Small scale tests were proven by pilot-scale tests. The high grade fired pel lets, assaying 63. 22% Fe, were analyzed, and the compressive strength of fired pellets was over 2 500 N/pellet. The fired pellets possessed excellent metallurgical performances, such as reducibility index higher than 67%, reduction swelling index lower than 15% and low temperature reduction degradation index （＋ 3.15 mm） higher than 1%, which can be used as the hurden for blast furnace.

关键词： pyrite cinder high sulfur magnetite iron ore pellet metallurgical performance

Bioleaching of low grade nickel sulfide mineral in column reactor

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中国有色金属学会会刊：英文版 2008年第6期18卷 1480-1484页

作者：甄世杰覃文庆闫忠强张雁生王军任浏祎 School of Minerals Processing and bioengineering Central South University Jinchuan group Ltd.(JNMC)

Jinchuan 低等级镍(0.4%0.6% Ni，集体部分) 硫化物矿物质矿石包含氧化镁的一个显著地高的内容(30%35% MgO，集体部分) 在主要脉石矿物质在场。Bioleaching 被执行调查可行性由于它花去要求的相对简洁， eco 友好的操作和低资本处理矿... 详细信息

Jinchuan 低等级镍(0.4%0.6% Ni，集体部分) 硫化物矿物质矿石包含氧化镁的一个显著地高的内容(30%35% MgO，集体部分) 在主要脉石矿物质在场。Bioleaching 被执行调查可行性由于它花去要求的相对简洁， eco 友好的操作和低资本处理矿物质。混合 mesophiles 从在中国从几个酸矿收集的酸矿排水样品被充实。认为氧化镁被酸答案和过多的 Mg2+ 容易提取将超过混合 mesophiles 的忍耐，三个有效工具被用来在 bioleaching 操作期间减少氧化镁的劣势。他们是混合 mesophiles 的改编改进忍耐；预先沥滤移开很可滤取的氧化镁并且周期怀孕沥滤答案的部分流血基于混合 mesophiles 的忍耐控制 Mg2+ 的水平。镍(90.3%) 和钴(88.6%) 的抽取成功地在沥滤的 300 d 以内被完成从用在周围的温度的一个列反应堆的 Jinchuan 低等级镍硫化物矿物质矿石的过程。

关键词：混合中温菌硫化镍矿镁砂生物浸取

Effect of mineral processing wastewater on flotation of sulfide minerals

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中国有色金属学会会刊：英文版 2009年第2期19卷 454-457页

作者：陈建明刘润清孙伟邱冠周 School of Resource Processing and bioengineering Central South University Liuzhou China Tin group Company Limited

The effects of mineral processing wastewater on sulfide minerals were investigated by flotation,infrared spectrometry and electrochemistry test. The results show that lead-concentrate water can improve the flotation of galena,while the sulfur-concentrate water has negative effect on flotation of galena compared with distilled water. The flotation behavior of pyrite is contrary to that of galena in three kinds of water. Infrared spectra indicate that the residual collector in the lead-concentrate water is beneficial to the formation of lead xanthate on the surface of galena. Electrochemistry results indicate that electrochemistry reaction on galena surface has apparent change. The anode polarization is improved and cathode polarization is depressed.

关键词：浮选行为选矿废水硫化矿电化学测试红外光谱方铅矿电化学反应阴极极化

Strengthening pelletization of manganese ore fines containing high combined water by high pressure roll grinding and optimized temperature elevation system

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Journal of Central South University 2014年第9期21卷 3485-3491页

作者：朱德庆余为周仙霖潘建 School of Minerals Processing and bioengineering Central South University Wuhan Iron and Steel (group) CORP

Pelletization is one of useful processes for the agglomeration of iron ore or concentrates. However, manganese ore fines are mainly agglomerated by sintering due to its high combined water which adversely affects the roasting performance of pellets. In this work, high pressure roll grinding(HPRG) process and optimization of temperature elevation system were investigated to improve the strength of fired manganese ore pellets. It is shown that the manganese ore possesses good ballability after being pretreated by HPRG twice, and good green balls were produced under the conditions of blending 2.0% bentonite in the feed, balling for 7 min at 16.00% moisture. High quality roasted pellets with the compressive strength of 2711 N per pellet were manufactured through preheating at 1050 °C for 10 min and firing at 1335 °C for 15 min by controlling the cracks formation. The fired manganese pellets keep the strength by the solid interconnection of recrystallized pyrolusite grains and the binding of manganite liquid phase which filled the pores and clearance among minerals. The product pellets contain high Mn grade and low impurities, and can be used to smelt ferromanganese, which provides a possible way to use imported manganese ore fines containing high combined water to produce high value ferromanganese.

关键词： manganese ore fines containing high combined water pelletization high pressure roll grinding optimized temperatureelevation system consolidation mechanism

Magnesium implant degradation provides immunomodulatory and proangiogenic effects and attenuates peri-implant fibrosis in soft tissues

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Bioactive Materials 2023年第8期26卷 353-369页

作者： Heithem Ben Amara Diana C.Martinez Furqan A.Shah Anna Johansson Loo Lena Emanuelsson Birgitta Norlindh Regine Willumeit-Römer Tomasz Plocinski Wojciech Swieszkowski Anders Palmquist Omar Omar Peter Thomsen Department of biomaterials Institute of Clinical SciencesSahlgrenska AcademyUniversity of GothenburgGothenburgSweden biomaterials group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWarsawPoland Institute of Metallic biomaterials Helmholtz-Zentrum HereonGeesthachtGermany

Implants made of magnesium(Mg)are increasingly employed in patients to achieve osteosynthesis while degrading in *** Mg implants and Mg^(2+)have been suggested to possess anti-inflammatory properties,the clinically observed soft tissue inflammation around Mg implants is ***,using a rat soft tissue model and a 1-28 d observation period,we determined the temporo-spatial cell distribution and behavior in relation to sequential changes of pure Mg implant surface properties and Mg^(2+)*** to nondegradable titanium(Ti)implants,Mg degradation exacerbated initial *** of Mg degradation products at the tissue-implant interface,culminating at 3 d,actively initiated chemotaxis and upregulated mRNA and protein immunomodulatory markers,particularly inducible nitric oxide synthase and toll-like receptor-4 up to 6 d,yet without a cytotoxic *** vascularization was demonstrated morphologically,preceded by high expression of vascular endothelial growth *** transition to appropriate tissue repair coincided with implant surface enrichment of Ca and P and reduced peri-implant Mg^(2+)*** implants revealed a thinner fibrous encapsulation compared with *** detailed understanding of the relationship between Mg material properties and the spatial and time-resolved cellular processes provides a basis for the interpretation of clinical observations and future tailoring of Mg implants.

关键词： Magnesium Biodegradable implants Inflammation Foreign-body reaction Gene expression Neovascularization

Commercial wound dressings for the treatment of exuding wounds:an in-depth physico-chemical comparative study

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Burns & Trauma 2022年第1期10卷 465-478页

作者： Manon Minsart Sandra Van Vlierberghe Peter Dubruel Arn Mignon Polymer Chemistry&biomaterials Research group Centre of Macromolecular ChemistryDepartment of Organic and Macromolecular ChemistryGhent UniversityKrijgslaan 281Building S4-bis9000 GhentBelgium Smart Polymeric biomaterials Research group Biomaterials and Tissue Engineering(SIEM)@Campus Group T LeuvenAndreas Vesaliusstraat 133000 LeuvenBelgium

Background:Nowadays,a wide range of wound dressings is already commercially *** selection of the dressing is of paramount importance as inappropriate wound management and dressing selection can delay the wound healing *** only can this be distressing for the patient,but it can also contribute to complications such as maceration and subsequent *** researchers are targeting the design of dressings with superior properties over existing commercial ***,reported results in the state-of-the-art are rarely benchmarked against commercial *** aim of this study was to determine several characteristics of a large variety of the most frequently used commercial wound dressings,providing an overview for both practitioners and ***:For this comparative study,11 frequently used commercial wound dressings were selected,representing the different *** morphology was studied using scanning electron *** dressings were characterized in terms of swelling capacity(water,phosphate buffered saline and simulated wound fluid),moisture vapour transmission rate(MVTR)and moisture uptake capacity(via dynamic vapour sorption)as well as mechanical properties using tensile testing and ***:The selected dressings showed distinctive morphological differences(fibrous,porous and/or gel)which was reflected in the different ***,the swelling capacities ranged between 1.5 and 23.2 g/g(water),2.1 and 17.6 g/g(phosphate buffered saline)or 2.9 and 20.8 g/g(simulated wound fluid).The swelling capacity of the dressings in water increased even further upon freeze-drying,due to the formation of *** MVTR values varied between 40 and 930 g/m^(2)/24 *** maximal moisture uptake capacity varied between 5.8%and 105.7%at 95%relative *** commercial dressings exhibited a superior mechanical strength,due to either being hydrophobic or ***:The present work not only offers i

关键词： Wound dressings Burns Exuding wounds Wound healing Exudate management Physico-chemical