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Initial failures of anti-tau antibodies in Alzheimer’s disease are reminiscent of the amyloid-βstory

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Neural Regeneration Research 2023年第1期18卷 117-118页

作者： Bruno P.Imbimbo Claudia Balducci Stefania Ippati Mark Watling Department of Research&Development Chiesi FarmaceuticiParmaItaly Department of Neuroscience Istituto di Ricerche Farmacologiche“Mario Negri”IRCCSMilanItaly San Raffaele Scientific Institute San Raffaele HospitalMilanItaly CNS&Pain Department TranScrip Ltd.ReadingUK

Tau is an important protein of the central nervous system formed by 352-441 amino acids and encoded by the MAPT(microtubule-associated protein tau)gene on chromosome 17 which generates 6 *** is located in axons,dendrites,nucleus,cell membrane,and synapses of *** protein is also expressed to a lesser extent in astrocytes and oligodendrocytes,although its role in these cells has been little *** protein is also present in the interstitial fluid and can cross into the cerebrospinal fluid(CSF)and reach the systemic circulation.

关键词： tau Alzheimer cerebrospinal

Energy-aware Integrated Scheduling for Container Terminals with Conflict-free AGVs

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Journal of Systems Science and Systems Engineering 2023年第4期32卷 413-443页

作者： Zhaolin Zhong Yiyun Guo Jihui Zhang Shengxiang Yang Institute of Complexity Science School of AutomationQingdao UniversityQingdao266071China Shandong Key Laboratory of Industrial Control Technology Qingdao266071China Qingdao Port International Company Ltd.Qingdao266011China Institute of Artificial Intelligence School of Computer Science and InformaticsDe Montfort UniversityLeicesterLE19BHUK

For automated container terminals,the effective integrated scheduling of different kinds of equipment such as quay cranes(QCs),automated guided vehicles(AGVs),and yard cranes(YCs)is of great significance in reducing energy consumption and achieving sustainable *** at the joint scheduling of AGVs and YCs with consideration of conflict-free path planning for AGVs as well as capacity constraints on AGV-mate which is also called buffer bracket in blocks,a mixed integer programming model is established to minimize the energy consumption of AGVs and YCs for the given loading/unloading task.A solution method based on a novel bi-level genetic algorithm(BGA),in which the outer and the inner layer search the optimal dispatching strategy for QCs and YCs,respectively,is *** validity of the model and the algorithm is verified by simulation experiments,which take the Port of Qingdao as an example and the performance under different conflicting resolution strategies is *** results show that,for the given task,the proposed solution to conflict-free path and the schedule provided by the algorithm can complete the task with minimum energy consumption without loss of AGVs utilization,and the number of AGV-mates should be adjusted according to the task rather than keeping *** results indicate that our proposed approach could efficiently find solutions within 6%optimality *** consumption is dropped by an average of 15%.

关键词： Automated container terminal conflict-free routing energy saving improved genetic algorithm

Performance of the Enhanced Liver Fibrosis Score,Comparison with Vibration-controlled Transient Elastography Data,and Development of a Simple Algorithm to Predict Significant Liver Fibrosis in a Community-based Liver Service:A Retrospective Evaluation

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 800-808页

作者： Tina Reinson Janisha Patel Mead Mathews Derek Fountain Ryan M.Buchanan Christopher DByrne Nutrition and Metabolism Faculty of MedicineUniversity of SouthamptonSouthamptonUK National Institute for Health and Care Research Southampton Biomedical Research CenterUniversity Hospital SouthamptonSouthamptonUK Hepatology Department University Hospital SouthamptonSouthamptonUK St Mary’s Surgery SouthamptonUK Core Minutes ltd RingwoodUK Clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthamptonUK

Background and Aims:Liver fibrosis is a key risk factor for cirrhosis,hepatocellular carcinoma and end stage liver *** National Institute for Health and Care Excellence guidelines for assessment for advanced(≥F3)liver fibrosis in people with nonalcoholic fatty liver disease recommend the use of enhanced liver fibrosis(ELF)test,followed by vibration-controlled transient elastography(VCTE).Performance of ELF at predicting significant(≥F2)fibrosis in real-world practice is *** assess the accuracy of ELF using VCTE;investigate the optimum ELF cutoff value to identify≥F2and≥F3;and develop a simple algorithm,with and without ELF score,for detecting≥***:Retrospective evaluation of patients referred to a Community Liver Service for VCTE,Jan-Dec *** included:body mass index(BMI),diabetes status,alanine aminotransferase(ALT)levels,ELF score and biopsy-validated fibrosis stages according to ***:Data from 273 patients were available.n=110 patients had *** showed fair performance for≥F2 and≥F3,area under the curve(AUC)=0.70,95%confidence interval(CI)0.64-0.76 and AUC=0.72,95%CI:0.65-0.79 ***≥F2 Youden's index for ELF=9.85 and for≥F3,ELF=*** ALT,BMI,and HbA1c(ALBA algorithm)to predict≥F2 showed good performance(AUC=0.80,95%CI:0.69-0.92),adding ALBA to ELF improved performance(AUC=0.82,95%CI:0.77-0.88).Results were independently ***:Optimal ELF cutoff for≥F2 is 9.85 and 9.95 for≥***,BMI,and HbA1c(ALBA algorithm)can stratify patients at risk of≥*** is improved by adding ALBA.

关键词： Primary health care Retrospective evaluation Liver disease Diabetes Nonalcoholic fatty liver disease

Improvement of Drill Performance in Metal Cutting Using MoST Solid Lubricant Coatings

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材料热处理学报 2004年第5B期25卷 870-874页

作者： N.R. Thomas D.G. Teer S. Hickman Teer Coatings ltd. West Stone House West Stone Berry Hill Industrial Estate Droitwich WR9 9AS UKTeer Coatings Ltd. West Stone House West Stone Berry Hill Industrial Estate Droitwich WR9 9AS UKTeer Coatings Ltd. West Stone House West Stone Berry Hill Industrial Estate Droitwich WR9 9AS UK

Coated tools are widely used in today’s metal cutting industries and have significantly improved machining productivity through reducing operation costs and time. This paper presents the results of a systematic study of the performance of HSS drills coated with CrTiAIN and drills with a top solid lubricant coating of MoST?. The tests were performed on a Haas vertical machining centre under wet and dry cutting conditions to machine through holes in medium carbon steel workpieces. The feed force and torque were recorded throughout some of the tests using a force dynamometer, while the tool wear was monitored and measured. It was found that MoST? coatings even under accelerated conditions improve the tool life significantly based on their unique properties and very low friction.

关键词：金属切割 MoST 固态润滑剂钻头

Regulating microstructure and composition by carbonizing in-situ grown metal-organic frameworks on cotton fabrics for boosting electromagnetic wave absorption

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Nano Research 2024年第8期17卷 7290-7300页

作者： Jie Jin Hongsen Long Hu Liu Yan Guo Tiantian Bai Ben Bin Xu Mohammed A.Amin Hua Qiu Mohamed H.Helal Chuntai Liu Changyu Shen Zeinhom M.El-Bahy Zhanhu Guo State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410000China School of Electronic Engineering North China University of Water Resources and Electric PowerZhengzhou 450046China Complex Conditions of High-end Tire Technology Innovation Center Shuguang Rubber Industry Research&Design Institute Co.LtdGuilin 541004China Integrated Composites Lab Department of Mechanical and Civil EngineeringNorthumbria UniversityNewcastle Upon TyneNE18STUK Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Chemistry Faculty of Arts and ScienceNorthern Border UniversityRafha 73213Saudi Arabia Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City 11884CairoEgypt

High-temperature carbonized metal-organic frameworks(MOFs)derivatives have demonstrated their superiority for promising electromagnetic wave(EMW)absorbers,but they still suffer from limited EMW absorption capacity and narrow *** the advantage of microstructure and chemical composition regulation for the design of EMW absorber,hierarchical heterostructured MoS_(2)/CoS_(2)-Co_(3)O_(4)@cabonized cotton fabric(CF)(MCC@CCF)is prepared by growing ZIF-67 MOFs onto CF surface,chemical etching,and *** from the dual loss mechanism of magnetic-dielectric multicomponent carbonized MOFs,chemical etching and carbonization process can effectively introduce abundant micro-gap structure that can result in better impedance matching and stronger absorption capacity via internal reflection,doped heteroatoms(Mo,N,S)to supply additional dipolar polarization loss,and numerous heterointerfaces among MoS_(2),CoS_(2),Co_(3)O_(4),and CCF that produce promoted conduction loss and interfacial polarization ***,a minimal reflection loss of−52.87 dB and a broadest effective absorption bandwidth of 6.88 GHz were achieved via tunning the sample thickness and filler loading,showing excellent EMW absorption *** research is of great value for guiding the research on MOFs derivatives based EMW absorbing materials.

关键词： metal-organic frameworks hierarchical structure chemical etching sulfurization electromagnetic wave absorption

Monitoring dynamics of defects and single Fe atoms in N-functionalized few-layer graphene by in situ temperature programmed scanning transmission electron microscopy

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Journal of Energy Chemistry 2022年第1期31卷 520-530,I0014页

作者： Rosa Arrigo Takeo Sasaki June Callison Diego Gianolio Manfred Erwin Schuster School of Science Engineering and EnvironmentUniversity of SalfordManchester M54WTUK Diamond Light Source Harwell Science and Innovation CampusDidcot 0X1/ODEUK JEOL uk ltd.JEOL House 1-2 Silver CourtWatchmeadWelwyn Garden CityHerts AL71LTUK Department of Chemistry University College London20 Gordon StreetLondon WC1H OAJUK uk Catalysis Hub Research Complex at Harwell(RCaH)Rutherford Appleton LaboratoryHarwell Oxon 0X11 OFAUK Johnson Matthey Technology Centre Reading RG49NH.UK

In this study,we aim to contribute an understanding of the pathway of formation of Fe species during top-down synthesis of dispersed Fe on N-functionalized few layer graphene,widely used in *** use X-ray absorption spectroscopy to determine the electronic structure and coordination geometry of the Fe species and in situ high angle annular dark field scanning transmission electron microscopy combined with atomic resolved electron energy loss spectroscopy to localize these,identify their chemical configuration and monitor their dynamics during thermal *** show the high mobility of peripheral Fe atoms,first diffusing rapidly at the trims of the graphene layers and at temperatures as high as 573 K,diffusing from the edge planes towards in-plane locations of the graphene layers forming three-,four-coordinated metal sites and more complexes polynuclear Fe *** process occurs via bond C-C breaking which partially reduces the extension of the graphene ***,the vast majority of Fe is segregated as a metal *** dynamic interconversion depends on the structural details of the surrounding graphitic environment in which these are formed as well as the Fe loading.N species appear stabilizing isolated and polynuclear Fe species even at temperatures as high as 873 *** significance of our results lies on the fact that single Fe atoms in graphene are highly mobile and therefore a structural description of the electroactive sites as such is insufficient and more complex species might be more relevant,especially in the case of multielectron transfer *** we provide the experimental evidence of the formation of these polynuclear Fe-N sites and their structural characteristics.

关键词： HAADF-STEM Single Fe atom sites N-doped Few-layer graphene Dinuclear Fe species

Impact of estuarine reclamation projects on saltwater intrusion and freshwater resource

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Journal of Oceanology and Limnology 2023年第1期41卷 38-56页

作者： Hanghang LU Jianrong ZHU Qing CHEN Ming LI Shunqi PAN Shenliang CHEN CCCC National Engineering Research Center of Dredging Technology and Equipment Co. Ltd.Shanghai 200082China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200062China Civil Engineering and Industrial Design School of EngineeringLiverpool UniversityLiverpool L693GHUK Hydro-environmental Research Centre School of EngineeringCardiff UniversityCardiff CF243AAUK

Estuarine projects can change local topography and influence water transport and saltwater *** Changjiang(Yangtze)River estuary is a multichannel estuary,and four major reclamation projects have been implemented in the Changjiang River estuary in recent years:the Xincun Shoal reclamation project(RP-XCS),the Qingcao Shoal reclamation project(RP-QCS),the Eastern Hengsha Shoal reclamation project(RP-EHS),and the Nanhui Shoal reclamation project(RP-NHS).The effects of the four reclamation projects and each project on the saltwater intrusion and water resources in the Changjiang River estuary were simulated in a 3D numerical *** show that for a multichannel estuary,local reclamation projects change the local topography and water diversion ratio(WDR)between channels and influence water and salt transport and freshwater utilization in the *** spring tide,under the cumulative effect of the four reclamation projects,the salinity decreases by approximately 0.5in the upper reaches of the North Branch and increases by 0.5-1.0 in the middle and lower reaches of the North *** the North Channel,the salinity decreases by approximately *** the North Passage,the salinity increases by *** the South Passage,the salinity increases by approximately 0.5 in the upper reaches and decreases by 0.2-0.5 on the north side of the middle and lower *** neap tide,the cumulative effects of the four reclamation projects and the individual projects are similar to those during spring tide,but there are some *** effects of an individual reclamation project on WDR and saltwater intrusion during spring and neap tides are simulated and analyzed in *** cumulative effect of the four reclamation projects favors freshwater usage in the Changjiang River estuary.

关键词： reclamation projects saltwater intrusion freshwater resources numerical model Changjiang River estuary

The Optimization Study about Fault Self-Healing Restoration of Power Distribution Network Based on Multi-Agent Technology

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Computers, Materials & Continua 2020年第10期65卷 865-878页

作者： Fuquan Huang Zijun Liu Tinghuang Wang Haitai Zhang Tony Yip Shenzhen Power Utility Co. Ltd.Shenzhen518000China Shandong Kehui Electric Power Automation Co. Ltd.Zibo255000China Kehui International ltd. Studio 206Mill Studio Business CentreCrane MeadWareHertsSG129PYUK

In order to quickly and accurately locate the fault location of the distribution network and increase the stability of the distribution network,a fault recovery method based on multi-objective optimization algorithm is *** optimization of the power distribution network fault system based on multiagent technology realizes fast recovery of multi-objective fault,solve the problem of network learning and parameter adjustment in the later stage of particle swarm optimization algorithm falling into the local extreme value dilemma,and realize the multi-dimensional nonlinear optimization of the main grid and the auxiliary *** system proposed in this study takes power distribution network as the goal,applies fuzzy probability algorithm,simplifies the calculation process,avoids local extreme value,and finally realizes the energy balance between each power *** results show that the Multi-Agent Technology enjoys priority in restoring important load,shortening the recovery time of power grid balance,and reducing the overall line loss rate of power ***,the power grid fault self-healing system can improve the safety and stability of the important power grid,and reduce the economic loss rate of the whole power grid.

关键词： Multi agent technology power distribution network fault self-healing

Significant Lifetime Enhancement in QLEDs by Reducing Interfacial Charge Accumulation via Fluorine Incorporation in the ZnO Electron Transport Layer

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Nano-Micro Letters 2022年第12期14卷 432-446页

作者： Dong Seob Chung Tyler Davidson-Hall Giovanni Cotella Quan Lyu Peter Chun Hany Aziz Department of Electrical and Computer Engineering Waterloo Institute for NanotechnologyUniversity of Waterloo200 University Avenue WestWaterlooON N2L 3G1Canada Ipswich Research Centre Huawei Technologies Research&Development(UK)Ltd.Phoenix House(B55)Adastral ParkIpswich IP53REUK Ottawa IC Laboratory Huawei Canada19 Allstate ParkwayMarkhamON L3R 5B4Canada

ZnO nanoparticles are widely used for the electron transport layers(ETLs)of quantum dots light emitting devices(QLEDs).In this work we show that incorporating fluorine(F)into the ZnO ETL results in significant enhancement in device electroluminescence stability,leading to LT50 at 100 cd m^(−2) of 2,370,000 h in red QLED,47X longer than the control devices.X-ray photo-electron spectroscopy,time-of-flight secondary ion mass spectroscopy,photoluminescence and electrical measurements show that the F passivates oxygen vacancies and reduces electron traps in *** photoluminescence versus bias measurements and capacitance-voltage-luminance measurements reveal that the CF4 plasma-treated ETLs lead to increased electron concentration in the QD and the QD/hole transport layer interface,subsequently decreasing hole accumulation,and hence the higher *** findings provide new insights into the critical roles that optimizing charge distribution across the layers play in influencing stability and present a novel and simple approach for extending QLED lifetimes.

关键词： Colloidal quantum dots Quantum dots light emitting device Device stability Zinc oxide nanoparticles Fluorine