检索结果-南通市图书馆

IL-15 temporally reorients IL-10 biased B-la cells toward I L- 12 expression

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2016年第2期13卷 229-239页

作者： Amlan Kanti Ghosh Debolina Sinha Subhadeep Mukherjee Ratna Biswas Tapas Biswas Division of Immunology National Institute of Cholera and Enteric Diseases Kolkata India

Interleukin （IL）-15 is known to strongly modulate T-cell function; however, its role in controlling mucosal immunity, including its ability to modulate B-la cell activity, remains to be elucidated. Here, we show that IL-15 upregulates activation molecules and the costimulatory molecule CD80 on viable B-la cells. Cell activation was accompanied by the depletion of sialic acid-binding immunoglobulin-like lectin （Siglec）-G, an inhibitor of cell activation that is present on B-la cells. The IL-15 receptor CD122 was stimulated on B-la cells by the cytokine showing its direct involvement in IL-15-mediated responses. IL-IO is responsible for the long term survival of B-la cells in culture, which is initially promoted by IL-15. The upregulation of IL-IO was followed by the appearance of suppressor of cytokine signaling （SOCS）I in the presence of IL-15 and the loss of IL-IO. This resulted in the cells switching to IL-12 expression. This anti-inflammatory to pro-inflammatory shift in the B-la cell character was independent of the cell-specific marker CD5, which remained highly expressed throughout the in vitro life of the cells. The presence of the immunosuppressive receptor programmed cell death （PD）-I and its ligand PD-L2 were features of a predominantly IL-IO response. PD-1 and PD-L2 can mediate juxtacrine signaling. However, the abrogation of PD-1 and its ligand was observed when the cells expressed IL-12. This demonstrates an inverse relationship between the receptor and ligand and the pro-inflammatory cytokine. The induction of IgM and IgA, which can play pivotal roles in mucosal immunity, was promoted in the presence of IL-15. Collectively, the data implicate IL-15 as the master cytokine that induces B-la cells to mount a mucosal immune response.

关键词： B-la cells IgM innate immunity interleukin-12 generation interleukin-15

Curcumin as a potential therapeutic candidate for Helicobacter pylori associated diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第9期22卷 2736-2748页

作者： Avijit Sarkar Ronita De Asish K Mukhopadhyay Division of Bacteriology National Institute of Cholera and Enteric Diseases

Curcumin, a yellow pigment and principal polyphenolic Curcuminoid obtained from the turmeric rhizome Curcuma longa, is commonly used as a food-coloring agent. Studies suggest that curcumin has a wide range of beneficial properties e.g., anti-inflammatory, antioxidant, anti-cancer, anti-proliferative, anti-fungal and anti-microbial. These pleiotropic activities prompted several research groups to elucidate the role of curcumin in Helicobacter pylori(H. pylori) infection. This is the first review with this heading where we discussed regarding the role of curcumin as an anti-H. pylori agent along with its potential in other gastrointestinal diseases. Based on several in vitro, early cell culture, animal research and few pre-clinical trials, curcumin projected as a potential therapeutic candidate against H. pylori mediated gastric pathogenesis. This review sheds light on the anti-H. pylori effects of curcumin in different models with meticulous emphasis on its anti-oxidant, anti-inflammatory and anti-carcinogenic effects as well as some critical signaling and effecter molecules. Remarkably, non-toxic molecule curcumin fulfills the characteristics for an ideal chemopreventive agent against H. pylori mediated gastric carcinogenesis but the foremost challenge is to obtain the optimum therapeutic levels of curcumin, due to its low solubility and poor bioavailability. Further, we have discussed about the possibilities for improving its efficacy and bioavailability. Lastly, we concluded with the anticipation that in near future curcumin may be used to develop a therapeutic drug against H. pylori mediated gastric ailments through improved formulation or delivery systems, facilitating its enhanced absorption and cellular uptake.

关键词： Curcumin Helicobacter pylori Duodenal ulcer Gastric cancer Anti-oxidant Anti-inflammatory Nuclear factor-κ B

Characterization of whole genomes from recently emerging Mpox cases in several regions of China,2023

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第5期67卷 1079-1081页

作者： Changcheng Wu Lunbiao Cui Yang Pan Ziquan Lv Mingxiao Yao Wenling Wang Fei Ye Weibang Huo Li Zhao Baoying Huang Fengcai Zhu Roujian Lu Yao Deng Quanyi Wang Wenjie Tan NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China NHC Key Laboratory of enteric Pathogenic Microbiology Jiangsu Provincial Medical Key Laboratory of Pathogenic Microbiology in Emerging Major Infectious DiseasesJiangsu Provincial Center for Disease Control and PreventionNanjing 210009China Beijing Center for Disease Prevention and Control Beijing 100013China Central Laboratory Shenzhen Center for Disease Control and PreventionShenzhen 518055China Shandong Center for Disease Control and Prevention Jinan 250014China

Dear Editor,Mpox(formerly known as monkeypox)is a zoonotic disease caused by infection with the monkeypox virus(MPXV).Mpox cases have been sporadic over the past few decades,with outbreaks occurring in only a limited ... 详细信息

关键词： cases primarily imported

Oligomerization of Vibrio cholerae Hemolysin Induces CXCR3 Upregulation and Activation of B-1a Cell

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2008年第3期5卷 231-234页

作者： Gayatri Mukherjee Kalyan K Banerjee Tapas Biswas Divisions of Immunology national institute of cholera and enteric diseases P-33 C.I.T. Road Scheme XM Kolkata-700 010 West Bengal India biochemistry national institute of cholera and enteric diseases P-33 C.I.T. Road Scheme XM Kolkata-700 010 West Bengal India

The hemolysin oligomer promotes the proliferation of B-1a cells and the expression of CD25, which is indicative of cell activation, on B-1a cells. The upregulation of CD86 induced by the oligomer showed its selective bias for the B7-2 member of B7 family while the monomer failed to induce these effects. The oligomer induced the expression of CXCR3, associated with B cell activation, while the monomer induced the expression of CXCL4, a powerful angiostatic chemokine. In conclusion, we found that B-1a cells responded to the apoptogenic monomer by expressing CXCL4, whereas oligomerization of the immunogen induced CXCR3 to shift the response towards activation.

关键词： B-1a cell CD86 CXCL4 CXCR3 Vibrio cholerae hemolysin

Indistinguishable cellular changes in gastric mucosa between Helicobacter pylori infected asymptomatic tribal and duodenal ulcer patients

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第9期15卷 1105-1112页

作者： Dhira Rani Saha Simanti Datta Santanu Chattopadhyay Rajashree Patra Ronita De Krishnan Rajendran Abhijit Chowdhury Thandavaryan Ramamurthy Asish Kumar Mukhopadhyay Division of Histology & Electron microscopy. national institute of cholera and enteric diseases P 33 CIT Road Scheme XM Beliaghata Kolkata 700010 India School of digestive diseases Institute of Post Graduate Medical Education and Research 244 AJC Bose Road Kolkata 700020 India Division of Bacteriology National Institute of Cholera and Enteric Diseases P 33 CIT Road Scheme XM Beliaghata Kolkata 700010 India Data management Division National Institute of Cholera and Enteric Diseases P 33 CIT Road Scheme XM Beliaghata Kolkata 700010 India

AIM： To investigate the changing pattern of different histological parameters occurring in the stomach tissue of Helicobacter pylori （H pylori） infected tribal populations and duodenal ulcer patients among ethnic Bengalis and correlation of the genotypes of H pylori with different histological parameters. METHODS： One hundred and twelve adult individuals were enrolled into this study between 2002 and 2004. Among them, 72 had clinical features of duodenal ulcer （DU） from ethnic Bengali population and 40 were asymptomatic ethnic tribals. Endoscopic gastric biopsy samples were processed for histology, genotyping and rapid urease test. Histologically, haematoxylin and eosin staining was applied to assess the pathomorphological changes and a modified Giemsa staining was used for better detection of Hpylori. For intestinal metaplasia, special stainings, i.e. Alcian blue periodic acid-Schiff and high iron diamine-Alcian blue staining, were performed. PCR was performed on bacterial DNA to characterize the presence or absence of virulence-associated genes, like cagA, and distribution of different alleles of vacA and iceA. RESULTS： Intraglandular neutrophil infiltration, a hallmark of activity of gastritis, was present in 34 （94%） of tribals （TRs） and 42 （84%） of DU individuals infected with H pylori. Lymphoid follicles and aggregates, which are important landmarks in H pylori infection, were positive amongst 15 （41%） of TRs and 20 （40%） of DU subjects. Atrophic changes were observed in 60% and 27.7%, respectively, among DU cases and tribals （P 〉 0.003）. Metaplastic changes were detected in low numbers in both groups. Moderate to severe density distribution of Hpylori in the gastric mucosa was 63% among TRs, whereas it was 62% in DU subjects. There were no significant differences in the distribution of virulence-associated genes like cagA, vacA and iceA of H pylori strains carried by these two populations. CONCLUSION： Our study showed almost similar distribution of inflammato

关键词： Helicobacter pylori Tribal Neutrophil Mononuclear cells infiltration Lymphoid follicles

Novel virulence factor dupA of Helicobacter pylori as an important risk determinant for disease manifestation:An overview

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第32期26卷 4739-4752页

作者： Jawed Alam Avijit Sarkar Bipul Chandra Karmakar Mou Ganguly Sangita Paul Asish K Mukhopadhyay Division of Infectious diseases Institute of Life ScienceBhubaneswar 751023India Division of Bacteriology ICMR-National Institute of Cholera and Enteric DiseasesKolkata 700010India

Helicobacter pylori(***)is a microaerophilic,Gram-negative,human gastric pathogen found usually in the mucous lining of *** infects more than 50%of the world’s population and leads to gastroduodenal *** outcome of disease depends on mainly three factors:Host genetics,environment and bacterial *** these,bacterial virulence factors such as cagA,vacA are well known for their role in disease ***,based on the global epidemiological results,none of the bacterial virulence(gene)factors was found to be associated with particular diseases like duodenal ulcer(DU)in all ***,substantial importance has been provided for research in strain-specific genes outside the cag pathogenicity island,especially genes located within the plasticity *** found within the plasticity regions was first demonstrated in 2005 and was proposed for duodenal ulcer development and reduced risk of gastric cancer in certain geographical *** to the discrepancies in report from different parts of the world in DU development related to *** virulence factor,dupA became an interesting area of research in elucidating the role of this gene in the disease *** this review,we shed light on the detailed information available on the polymorphisms in dupA and their clinical *** have critically appraised several pertinent studies on dupA and discussed their merits and *** review also highlights dupA gene as an important biomarker for DU in certain populations.

关键词： Helicobacter pylori Plasticity region Duodenal ulcer Gastric cancer dupA gene

Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: Exploratory screening reveals high frequency of occult HBV infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第27期13卷 3730-3733页

作者： Prasun Bhattacharya Partha Kumar Chandra Sibnarayan Datta Arup Banerjee Subhashish Chakraborty Krishnan Rajendran Subir Kumar Basu Sujit Kumar Bhattacharya Runu Chakravarty institute of Blood Transfusion Medicine and Immunohematology Kolkata India ICMR Virus Unit Kolkata India national institute of cholera and enteric diseases Kolkata India

AIM: To evaluate the prevalence of markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among blood donors in Kolkata, Eastern India for two consecutive years and to conduct a pilot study to explore the presence of HBV DNA among hepatitis B surface antigen (HBsAg) negative but anti-HBc positive blood donors. METHODS: Seroprevalence of HBsAg, anti-HCV and anti-HIV was studied among 113 051 and 106 695 voluntary blood donors screened in 2004 and 2005, respectively. Moreover, a pilot study on 1027 HBsAg negative donors was carried out for evaluating the presence of HBV DNA by PCR on HBsAg negative/anti- HBc positive donors. RESULTS: A statistically significant increase in the prevalence of HBV (1448 vs 1768, P < 0.001), HIV (262 vs 374, P < 0.001), HCV (314 vs 372, P = 0.003) and syphilis (772 vs 853, P = 0.001) infections was noted among blood donors of Kolkata West Bengal in 2005 as compared to 2004. Moreover, the exploratory study on 1027 HBsAg negative donors revealed that 188 (18.3%)of them were anti-HBc positive out of which 21% were positive for HBV DNA. CONCLUSION: The findings of this study underscore the significantly increasing endemicity of hepatitis viruses, syphilis and HIV among the voluntary blood donors of our community. The pilot study indicates a high rate of prevalence of HBV DNA among HBsAg negative/anti-HBc positive donors and thus emphasizes the need for a more sensitive and stringent screening algorithm for blood donations.

关键词： Hepatitis B virus Human immunodeficiency virus Hepatitis C virus Blood donation Occult HBV infection

Therapeutic methods for diarrhea in children

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2000年第4期6卷 497-500页

作者： S.K. Bhattacharya Director National Institute of Cholera and Enteric DiseasesP-33CIT Road.Scheme XMBeliaghataCalcutta 700010INDIA

DEFINITIONAcute diarrhoea is defined as passage of loose or waterystools at least three times in a 24 h *** loosestools contain blood,it is called bloody diarrhoea(dysentery).It is the consistency of the stools which ismost important rather than the ***-fed babiesoften pass'pasty'stools frequently which is not *** raother can often tell accurately whether child hasdiarrhoea or not.

关键词： diarrhea infantile/therapy dehydration antibiotics infusion intravenous water-electrolyte balance antidiarrheals nutritional requirements

Comparison of 1 Versus 2 Doses of Quadrivalent Influenza Vaccine in 3-8-Year-Old Children with Different Immunological States—Jiangsu Province,China,2021

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China CDC weekly 2024年第19期6卷 424-430,I0002-I0004页

作者： Qian Liu Pengfei Jin Jingxin Li Xiaoqin Chen Chenhao Wang Qingbin Lu Wei Jiang Shixuan Zhang Lairun Jin Hongxin Pan Xue Guo Fengcai Zhu School of Public Health Southeast UniversityNanjing CityJiangsu ProvinceChina Jiangsu Provincial Medical Innovation Center National Health Commission Key Laboratory of Enteric Pathogenic MicrobiologyJiangsu Provincial Center for Disease Control and PreventionNanjing CityJiangsu ProvinceChina Donghai County Center for Disease Control and Prevention Donghai CityJiangsu ProvinceChina Changchun institute of Biological Products Co. Ltd.Changchun CityJilin ProvinceChina Department of Laboratorial Science and Technology&Vaccine Research Center School of Public HealthPeking UniversityBeijingChina Key Laboratory of Epidemiology of Major diseases(Peking University) Ministry of EducationBeijingChina

Summary What is already known about this topic?The quadrivalent influenza vaccine(QIV)provides protection against a broader range of influenza strains by including strains of influenza A/H1N1,A/H3N2,B/Yamagata,and B/*** is added by this report?This study aimed to assess the immunogenicity and safety of administering a single dose compared to two doses of QIV in children,taking into consideration their previous influenza vaccination history.

关键词： ent doses Jiangsu