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Neuromodulatory effects of ethyl acetate fraction of Zingiber officinale Roscoe extract in rats with lead-induced oxidative stress

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Journal of Integrative Medicine 2019年第2期17卷 125-131页

作者： Mary Abiola Okesola Basiru Olaitan Ajiboye Babatunji Emmanuel Oyinloye Oluwafemi Adeleke Ojo department of biochemistry Covenant University department of biochemistry Afe Babalola University department of biochemistry University of Ilorin

Objective: This study investigated the ameliorative potential of Zingiber officinale Roscoe extract against lead-induced brain damage in rats.Methods: Thirty male rats were divided into 5 groups of 6 rats each. Lead-acetate toxicity was induced by intraperitoneal injection(10 mg/kg body weight(b.w.)) in Groups B–E. Group A(control) and Group B(lead-acetate) were left untreated; vitamin C(200 mg/kg b.w.) was administered to Group C; ethyl acetate fraction from Z. officinale extract(200 and 100 mg/kg b.w.) was administered to Group D and E by oral gavage once daily for 7 days. Changes in the content of some key marker enzymes such as acetylcholinesterase(AChE), butyrylcholinesterase(BChE), monoamine oxidase(MAO), epinephrine, dopamine,Na^+/K^+-ATPase, catalase(CAT), superoxide dismutase(SOD) and glutathione peroxidase(GPx) as well as malonaldehyde(MDA) levels were determined in serum.Results: Exposure to lead acetate resulted in a significant decrease(P < 0.05) in the activities of BChE,AChE, Na^+/K^+-ATPase, SOD, CAT and GPx with a corresponding increase in the levels of MDA, xanthine oxidase, epinephrine, dopamine and MAO relative to the control group. Levels of all disrupted parameters were alleviated by co-administration of Z. officinale fraction and by the standard drug, vitamin C.Conclusion: These results suggest that ethyl acetate fraction of Z. officinale extract attenuates leadinduced brain damage and might have therapeutic potential as a supplement that can be applied in lead poisoning.

关键词： Zingiber officinale Acetylcholinesterase Monoamine oxidase Na^(+)/K^(+)-ATPase Lead acetate Neurodegenerative disorders

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Releasing the power of co-activation for battery ion storage

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National Science Review 2023年第9期10卷 117-118页

作者： Yiying Wu department of Chemistry and biochemistry The Ohio State University

The extensive application of energy storage technology has resulted in an expanding demand for lithium resources,whose limited availability cannot support the long-term market penetration of lithiumion batteries (LIBs).Potassium-ion batteries (PIBs) have rapidly entered the research field recently as a scalable alternative energy storage system to LIBs,

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High-fat-diet induced obesity and diabetes mellitus in Th1 and Th2 biased mice strains:A brief overview and hypothesis

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Chronic Diseases and Translational Medicine 2023年第1期9卷 14-19页

作者： Prakash Somi Sankaran department of biochemistry Christian Medical CollegeVelloreIndia

Obesity and diabetes mellitus are common metabolic diseases prevalent worldwide.Mice are commonly used to study the pathogenesis of these two conditions.Obesity and diabetes mellitus are induced by administering a high-fat diet in many studies although other diet-induced models are also used.Several factors may influence the outcome of the studies done to study diet-induced obesity in mice.The immune system plays a crucial role in the susceptibility of mice to develop obesity and metabolic disease.In this article,the reasons for differences in susceptibility to develop obesity and diabetes mellitus in mice in response to high-fat-diet feeding and the influence of immunological bias of the mice strain used in studies are evaluated.Mice strains that induce proinflammatory and Th1-type immune responses are found to be susceptible to high-fat-diet-induced obesity.A few studies which directly compared the effect of a high-fat diet on obesity and diabetic phenotype in Th1-and Th2-biased mice strains were briefly analyzed.Based on the observations,it is proposed that the liver and adipose tissue may respond differently to high-fat-diet feeding regimens in Th1-and Th2-biased mice strains.For instance,in Th1-biased mice,adipose tissue fat content was high both in the baseline as well as in response to a high-fat diet whereas in the liver,it was found to be less.It can be inferred that the immune responses to diet-induced models may provide insights into the pathogenesis of obesity and diabetes mellitus.

关键词： Balbc mice C57bl/6 mice diabetes mellitus immunometabolism obesity Th1/Th2 bias

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Genetic and epigenetic control on clock genes in multiple sclerosis

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Journal of Genetics and Genomics 2022年第1期49卷 74-76页

作者： Tarek K.Motawi Olfat G.Shaker Soha O.Hassanin Shaymaa G.Ibrahim Mahmoud A.Senousy Biochemistry Department Faculty of PharmacyCairo UniversityCairoEgypt Medical biochemistry and Molecular Biology department Faculty of MedicineCairo UniversityCairoEgypt Biochemistry Department Faculty of PharmacyModern University for Technology and Information(MTI)CairoEgypt

The study of circadian rhythm performance is prominent in chronic diseases, such as multiple sclerosis(MS). Circadian rhythm dysregulation has been observed in several neurodegenerative disorders, including MS, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease(Videnovic et al., 2014;Hedstr om et al.,2015). In addition, subjects who work in shifts have an increased risk of developing MS(Hedstr om et al., 2015). Furthermore, impaired sleep and alertness are common symptoms of MS and neurodegenerative disorders(Videnovic et al., 2014).

关键词： Huntington impaired

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Profiling of seminal antioxidant indices and sperm quality in Plasmodium bergheiinduced malarial mice treated with Phyllanthus amarus

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Asian pacific Journal of Reproduction 2022年第2期11卷 84-92页

作者： Williams Oshiegbu Chinwendu Obogheneophruhe Elu Innocent Onyesom department of biochemistry Delta State UniversityAbrakaNigeria department of Medical biochemistry Delta State UniversityAbrakaNigeria

Objective:To evaluate the antiplasmodial activity of Phyllanthus(P.)amarus crude ethanol leaf extract and its effects on semen quality in male BALB/c mice.Methods:A total of 36 adult mice were divided into six groups,with 6 mice each.Five groups were infected with Plasmodium(P.)berghei,and one group was left uninfeceted.Of the five infected groups,one group was left untreated,three groups were treated with varying doses(100,250 and 400 mg/kg)of P.amarus crude ethanol leaf extract orally for 4 days,and another group was treated with standard drug,artemether and lumefantrine(Lonart®DS).Antiplasmodial activity,seminal quality,some biochemical indices(neutral毩-glucosidase,fructose,and citric acid)in seminal plasma and seminal antioxidant markers(catalase,glutathione peroxidase,reduced glutathione,malondialdehyde,total antioxidant capacity,and acid phosphates)were determined.The mice were euthanized 3 days post treatment and semen was collected from the caudal epididymis and processed for analysis using documented methods and procedures.Results:Malarial infection led to oxidative stress,causing a significant decline in seminal quality(P<0.05).However,treatment with P.amarus crude ethanol leaf extract alleviated oxidative stress and significantly improved seminal quality.The improvement was dose-dependent and compared well with the standard drug,artemether and lumefantrine(Lonart®DS)treatment.Conclusions:The ethanol leaf extracts of P.amarus alleviate male reproductive capacity during malaria infection in murine model by enhancing antioxidant activities.

关键词： Malaria Sperm quality Phyllanthus amarus Seminal oxidative stress Seminal antioxidant markers Antioxidants Ethanol extracts Antimalarials

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Coal fy ash:an emerging material for water remediation

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International Journal of Coal Science & Technology 2022年第3期9卷 18-49页

作者： N.B.Singh Anupam Agarwal Anindita De Pragya Singh department of Chemistry and biochemistry Sharda UniversityGreater NoidaIndia

Coal fy ash(CFA)is a byproduct of thermal power plant and collected from fue gases by separator.Composition of CFA depends on the type of coal used and it has both crystalline and amorphous character.It is considered to be an environmental pollutant and used in number of areas.CFA is a useful material and widely used in cement production and as a promising adsorbent for water remediation.CFA used for remediation of wastewater solves problems related to water quality issues and waste management.The physical properties such as porosity,surface area,morphology,and chemical composition(iron oxide,alumina,silica,titania,etc.)make CFA efcient material for wastewater treatment.CFA is also converted to geopolymer,which is used as an adsorbent and photocatalyst.Dye,organic compounds,toxic heavy metal ions,etc.have been removed using CFA and modifed CFA adsorbents.Diferent adsorption efciencies have been reported for diferent adsorbate and CFA adsorbents.Numbers of adsorption isotherm and kinetic models have been discussed.

关键词： Coal fy ash Adsorbent Dye Geopolymer Water remediation Pollutants

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Microbiome therapeutics:exploring the present scenario and challenges

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Gastroenterology Report 2022年第1期10卷 18-36页

作者： Monika Yadav Nar Singh Chauhan department of biochemistry Maharshi Dayanand UniversityRohtakHaryanaIndia

Human gut-microbiome explorations have enriched our understanding ofmicrobial colonization,maturation,and dysbiosis in health-and-disease subsets.The enormousmetabolic potential of gutmicrobes and their role in themaintenance of human health is emerging,with new avenues to use themas therapeutic agents to overcome human disorders.Microbiome therapeutics are aimed at engineering the gutmicrobiome using additive,subtractive,ormodulatory therapy with an application of native or engineeredmicrobes,antibiotics,bacteriophages,and bacteriocins.This approach could overcome the limitation of conventional therapeutics by providing personalized,harmonized,reliable,and sustainable treatment.Its huge economic potential has been shown in the global therapeuticsmarket.Despite the therapeutic and economical potential,microbiome therapeutics is still in the developing stage and is facing various technical and administrative issues that require research attention.This review aims to address the current knowledge and landscape ofmicrobiome therapeutics,provides an overview of existing health-and-disease applications,and discusses the potential future directions ofmicrobiomemodulations.

关键词： microbiome therapeutics human microbiome engineered microbiome probiotics prebiotics fecal microbiome transplantation

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Ecdysis triggering hormone peptide in the African malaria mosquito Anopheles gambiae:The peptide structure for receptor activation

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Insect Science 2022年第5期29卷 1309-1317页

作者： Hawa Dembele Moritz Mating Rupinder Singh Soheila Fatehi Alvaro I.Herrera Yoonseong Park Om Prakash department of biochemistry and Molecular Biophysics Kansas State UniversityManhattanKansas66506 department of Entomology Kansas State UniversityManhattanKansas66506 department of Chemistry&biochemistry Auburn UniversityAuburnAlabamaUSA

Infections by mosquito-borne diseases represent one of the leading causes of death in third world countries.The rapid progression of resistance to conventional insecticide causes a significant threat to the highly efficient preventive methods currently in place.Insect neuropeptidergic system offers potential targets to control the insect vectors.The essential roles of the neuropeptide ecdysis triggering hormone(ETH)in insect development and reproduction led us to attempt understanding of the fundamentals of the biochemical interaction between ETH and its receptor in the African malaria mosquito Anopheles gambiae.One of two ETH peptides of the African malaria mosquito(AgETH1),a small peptide hormone with 17 amino acid residues(SESPGFFIKLSKSVPRI-NH2),was studied to elucidate its molecular structure.N-termini deletions and mutations of conserved amino acids in the ligand revealed the critical residues for the receptor activation.The solution structure of AgETH1 using 2D 1H-1H nuclear magnetic resonance(NMR)spectroscopy and nuclear overhauser effect(NOE)derived constraints revealed a short alpha helix between residues 3S and 11S.The NMR solution structure of AgETH1 will be of significant assistance for designing a new class of insecticidal compounds that acts on the AgETH receptor aiming for in silico docking studies.

关键词： Anopheles gambiae ecdysis triggering hormone G protein-coupled receptor insect malaria neuropeptide NMR spectroscopy

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Developing molecular-level models for organic field-effect transistors

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National Science Review 2021年第4期8卷 167-180页

作者： Haoyuan Li Jean-Luc Brédas School of Chemistry and biochemistry and Center for Organic Photonics and Electronics Georgia Institute of Technology department of Chemistry and biochemistry University of Arizona

Organic field-effect transistors(OFETs) are not only functional devices but also represent an important tool for measuring the charge-transport properties of organic semiconductors(OSs). Thus, efforts to understand the performance and characteristics of OFET devices are not only useful in helping achieve higher device efficiencies but also critical to ensuring accuracy in the evaluations of OS charge mobilities.These studies rely on OFET device models, which connect the measured current characteristics to the properties of the OSs. Developing such OFET models requires good knowledge of the charge-transport processes in OSs. In device active layers, the OS thin films are either amorphous(e.g. in organic light-emitting diodes and organic solar cells) or crystalline(e.g. those optimized for charge transport in OFETs). When the electronic couplings between adjacent OS molecules or polymer chain segments are weak, the charge-transport mechanism is dominated by hopping processes, which is the context in which we frame the discussion in this Review. Factors such as disorder, mobility anisotropy, traps, grain boundaries or film morphology all impact charge transport. To take these features fully into account in an OFET device model requires considering a nano-scale, molecular-level resolution. Here, we discuss the recent development of such molecular-resolution OFET models based on a kinetic Monte Carlo approach relevant to the hopping regime. We also briefly describe the applicability of these models to high-mobility OFETs,where we underline the need to extend them to incorporate aspects related to charge delocalization.

关键词： organic semiconductors charge transport kinetic Monte Carlo simulations mobility measurements gradual channel approximation

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苏氨酸在昆虫抗冻蛋白抗冻活性中的作用

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高等学校化学学报 2007年第3期28卷 526-529页

作者：周艳霞张勇谭宏伟贾宗超陈光巨北京师范大学化学学院北京100875 department of biochemistry Queen's University

设计系列昆虫抗冻蛋白CfAFP突变体,通过分子动力学模拟确定各突变体与冰晶的最佳作用模式,并用半经验分子轨道方法AM1和PM3研究了其与冰晶的相互作用.结果表明,TXT面上的苏氨酸在蛋白与冰晶相互识别和结合过程中十分关键,对CfAFP与冰晶... 详细信息

设计系列昆虫抗冻蛋白CfAFP突变体,通过分子动力学模拟确定各突变体与冰晶的最佳作用模式,并用半经验分子轨道方法AM1和PM3研究了其与冰晶的相互作用.结果表明,TXT面上的苏氨酸在蛋白与冰晶相互识别和结合过程中十分关键,对CfAFP与冰晶间相互作用的贡献大,用其它疏水或亲水氨基酸残基替换都将削弱抗冻蛋白与冰晶的相互作用强度,从而降低蛋白的抗冻活性.但是,在维系蛋白和冰晶结构匹配的基础上,疏水基团的增加加强了抗冻蛋白与冰晶的结合,从而增加蛋白的抗冻活性.

关键词：昆虫抗冻蛋白基因突变亲水作用疏水作用分子动力学模拟

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