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A SPE-HPLC-MS/MS method for the simultaneous determination of pr ior itised pharmaceuticals and EDCs with high environmental risk potential in freshwater

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Journal of Environmental Sciences 2021年第2期33卷 18-27页

作者： Yuan Li MarkATaggart Craig McKenzie Zulin Zhang Yonglong Lu Sabolc Pap Stuart WGibb Environmental Research Institute North Highland CollegeUniversity of the Highlands and IslandsCastle StreetThursoCaithnessScotlandKW147JDUK Forensic Drug Research Group Centre for Anatomy and Human IdentificationSchool of Science and EngineeringUK Environm ental and biochem.ical Sciences Group Ja m es Hutton InstituteCraigiebucklerA berdeen AB158QHUK Research Centre for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Novi Sad Faculty of Technical SciencesDepartment of Environmental Engineering and Occupational Safety and H ealthUniversity of Novi Sad21000 NoviSadSerbia 不详

This work describes the development,optimisation and validation of an analytical method for the rapid determination of 17 priority pharmaceutical compounds and endocrine disrupting chemicals(EDCs).Rather than studying compounds from the same therapeutic class,the analyses aimed to determine target compounds with the highest risk potential(with particular regard to Scotland),providing a tool for further monitoring in different water *** was based on a systematic environmental risk assessment approach,using consumption data;wastewater treatment removal efficiency;environmental occurrence;toxicological effects;and pre-existing regulatory *** process highlighted 17 compounds across various therapeutic classes,which were then quantified,at environmentally relevant concentrations,by a single analytical *** determination was achieved using a single-step solid phase extraction(SPE)procedure followed by high-performance liquid chromatography with tandem mass spectrometry(HPLC-MS/MS).The fully optimised method performed well for the majority of target compounds,with recoveries>71%for 15 of 17 *** limits of quantification for most target analytes(14 of 17)ranged from 0.07 ng/L to 1.88 ng/L in river *** utility of this method was then demonstrated using real water samples associated with a rural hospital/*** compounds were targeted and detected,with the highest levels found for the analgesic,paracetamol(at up to 105,910 ng/L in the hospital discharge).This method offers a robust tool to monitor high priority pharmaceutical and EDC levels in various aqueous sample matrices.

关键词： Pharmaceuticals prioritisation Risk assessment trace level determination Water quality

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婴儿高胰岛素血症可能与SCHAD基因的一处新的剪切位点突变有关

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 59-59页

作者： Hussain K. Clayton P.T. Krywawych S. 宁亮 U. biochem. Endo crinol. and Metab. Institute of Child Health University College London 30 Guilford St London WC1N 1EH United Kingdom Dr.

Fatty acids play an important role in regulating insulin secretion, but the me chanisms are unclear. We report a case of a novel splice site mutation in the sh ort-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) gene associated with hyperi nsulinism. This mutation resulted in a nearly complete absence of immunoreactive protein and a decrease in fibroblast SCHAD activity.

关键词：剪切位点突变 SCHAD基因高胰岛素血症胰岛素分泌免疫源性成纤维细胞短链

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A sequence of 28S rRNA-derived small RNAs is enriched in mature sperm and various somatic tissues and possibly associates with inflammation

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Journal of Molecular Cell Biology 2017年第3期9卷 256-259页

作者： Chu, Chen Yu, Lu Wu, Bin Ma, Li Gou, Lan-Tao He, Miao Guo, Yunli Li, Zhi-Tong Gao, Wei Shi, Huijuan Liu, Mo-Fang Wang, Hongyan Chen, Charlie Degui Drevet, Joel R. Zhou, Yuchuan Zhang, Yonglian Univ Chinese Acad Sci Chinese Acad Sci Shanghai Inst Biochem & Cell BiolState Key Lab M CAS Ctr Excellence Mol Cell SciShanghai Key Lab Shanghai 200031 Peoples R China Fudan Univ SIPPR China Natl Populat & Family Planning Key Lab Cont Shanghai 200032 Peoples R China Univ Chinese Acad Sci Chinese Acad Sci Shanghai Inst Biochem & Cell Biol CAS Ctr Excellence Mol Cell SciState Key Lab Mol Shanghai 200031 Peoples R China Univ Calif San Diego Dept Cellular & Mol Med San Diego CA 92093 USA Chinese Acad Sci Shanghai Inst Biol Sci State Key Lab Neurosci Inst Neurosci Shanghai 200031 Peoples R China Shanghai Jiao Tong Univ Shanghai Gen Hosp Dept Geratol Shanghai 200080 Peoples R China Univ Clermont Auvergne CNRS UMR6293 INSERM U1103 Genet Reprod & Dev Lab Clermont Ferrand France

Dear Editor, The growing understanding concerning the definition, classification, and function of small non-coding RNAs （sncRNAs） has led to the discovery of new sncRNA spe- cies of various sizes. Recent studies high- lighted a group of tsRNAs derived from the 5＇ end of tRNAs （Peng et al., 2012; Zhang et al., 2014; Chen et al., 2016; Sharma et al., 2016）, which raises the question whether there are similar small RNAs derived from other housekeeping RNAs, such as rRNAs.

关键词：小RNA rRNA 28S 体细胞炎症精子成熟

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四膜虫对8-MOP处理的生长反应—真核原生生物四膜虫DNA损伤修复机理的研究(Ⅰ)

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白求恩医科大学学报 1991年第5期17卷 17-19页

作者：夏凤琴 Peter E Nielsen 白求恩医科大学许射医学研究所放射生物教研室 biochem.B.Panum Institute Copenhagen Unlv

本文研究了四膜虫在8—MOP和紫外线(波长为365nm)照射联合处理以后细胞的生长反应。我们观察到被处理的细胞或暂时性受抑(1μg 8—MOP/1ml)细胞悬液)。暂时性受抑的细胞,在经过一定的迁延期以后可恢复其生长能力,其迁延期长短与8—MOP... 详细信息

本文研究了四膜虫在8—MOP和紫外线(波长为365nm)照射联合处理以后细胞的生长反应。我们观察到被处理的细胞或暂时性受抑(1μg 8—MOP/1ml)细胞悬液)。暂时性受抑的细胞,在经过一定的迁延期以后可恢复其生长能力,其迁延期长短与8—MOP的剂量有关。

关键词：四膜虫紫外线照射细胞生长反应

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The effects of pioglitazone on constituents of myocardial cell membrane in hyperlipemia rats subjected to myocardial ischemia and reperfusion

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China Medical Abstracts (Internal Medicine) 2016年第4期 215-215页

作者：郑海亮 Dept biochem.Molecu Biol Shanxi Med Univ

Objective To observe the protective effect of pioglitazone(PIO)on myocardial cell membrane in hyperlipemia rats with myocardial ischemia/*** Hyperlipemia rat model was established and conducted intragastric administra... 详细信息

关键词： in of The effects of pioglitazone on constituents of myocardial cell membrane in hyperlipemia rats subjected to myocardial ischemia and reperfusion cell were on

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Non-starch Polysaccharide Degrading Enzymes in Corn and Wheat-Based Broiler Diets： Dual Activity for Major Substrates

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Journal of Agricultural Science and Technology(A) 2018年第2期8卷 76-88页

作者： Kirsten De Keyser Noel Dierick Leni Kuterna Olivier Maigret Sebastian Kaczmarek Andrzej Rutkowski Erik Vanderbeke AVEVE biochem.NV Eugeen Meeusstraat 6 Merksem 2170 Belgium Department of Animal Sciences and Aquatic Ecology Faculty of Bioscience Engineering Ghent University Coupure Links 653 Ghent 9000 Belgium Department of Animal Nutrition University of Life Sciences ul. Wojska Polskiego 28 Poznań60-637 Poland

This study consolidates the efficacy of a non-starch polysaccharide （NSP）ase enzyme-concept in corn and wheat-based broiler diets. The NSP building blocks of corn, wheat and soybean meal （SBM, 44% protein） were studied first. Cereal NSP primarily consists of arabinose, xylose and glucose molecules that form arabinoxylan, β-glucan and cellulose polysaccharides. In soybean meal （SBM）, glucose （cellulose） predominates, next to galactose and uronic acids that form “pectins”. Broiler performance progress using in-feed NSPase enzymes depends on the concentration, complexity and solubility of the substrate and the genetic potential of the animal, mainly. A dual NSPase enzyme-concept for cereal and SBM NSP, predominantly being arabinoxylan, β-glucan and cellulose, was developed. Methods for measuring enzyme activities （endo-1,4-β-xylanase （EC 3.***.1.8） and endo-1,3（4）-β-glucanase （EC 3.***.1.6）） were developed （AVEVE biochem.UNITS） and preparations thereof （XG） standardized to meet requirements for most challenging NSP （corn, barely soluble）. Feed intake （FI）, bodyweight gain （BWG） and feed：gain ratio （F：G） were assessed in three zootechnical studies, each using 160 Ross 308 broilers split in two feeding groups with 80 birds/group （10 replicates of eight） for 42 d （starter/grower period）. Respective corn-SBM, wheat-SBM and corn/wheat-SBM diets were used as negative control （NC） or added with the enzyme-concept （XG）. In the total period, XG ameliorated BWG and F：G compared to NC in each study, where BWG increased best in diets with corn and F：G lowered most in diets with wheat. The dual NSPase enzyme-concept offers ingredient flexibility in present setting by enhancing the nutritional content of corn, wheat and SBM, expectedly from cleaving major NSP target molecules. Thereby, broiler professionals increase feed formulation liberty and safety and production result simultaneously.

关键词： Broiler xylanase glucanase BWG F:G corn wheat SBM

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二氢吡啶类钙拮抗剂对钙调素依赖性环核苷酸磷酸二酯酶的抑制机理

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华西医科大学学报 1992年第1期23卷 17-20页

作者：吴兆锋 Rajendra K.Sharma Jerry H.Wang 华西医科大学生物化学教研室 Dept Med biochem Univ CaglaryCalgaryAlbertaCanadaT2N 4N1

用单克隆抗体纯化的60kd为亚基的牛脑钙调素依赖性环核苷酸磷酸二酯酶的动力学研究表明,二氢吡啶类钙拮抗剂Nicardipine和Felodipine是该酶的“部分”竞争性抑制剂。因为近饱和浓度的药物抑制该酶活性仅能达到某限定值,且Dixon作图法不... 详细信息

用单克隆抗体纯化的60kd为亚基的牛脑钙调素依赖性环核苷酸磷酸二酯酶的动力学研究表明,二氢吡啶类钙拮抗剂Nicardipine和Felodipine是该酶的“部分”竞争性抑制剂。因为近饱和浓度的药物抑制该酶活性仅能达到某限定值,且Dixon作图法不呈直线关系。该酶被一定浓度Felo-dipine抑制时,增加Nicardipine浓度可逆转酶的抑制而达到Nicardipine的最大抑制水平,Nicardipine不影响典型的竞争性抑制剂甲基异丁基黄嘌呤对该酶的抑制作用,说明该酶活性中心以外存在和二氢吡啶结合的部位。

关键词：二氢吡啶类钙拮抗剂钙调素依赖性环核苷酸磷酸二酯酶部分竞争性抑制

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Application value of biochem.cal and immunological indicators in Lee's classification of IgA nephropathy

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China Medical Abstracts (Internal Medicine) 2016年第4期 193-193页

作者：南京柱 Dept Clin biochem State Key Kidney Dis LabChin PLA General Hosp

Objective To analyze the differences of biochem.cal and immunological indicators in gender or Lee’s classification of Ig A nephropathy(Ig AN)and to provide laboratory evidence for clinical diagnosis and treatment of Ig *** Retrospective cohort study was *** information of biochem.cal and immunological indicators of 213 in-hospital patients admitted in Chi-

关键词： of Ig that CYS were HCY in Application value of biochem.cal and immunological indicators in Lee’s classification of IgA nephropathy

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水稻中转基因表达的“位置效应”初报

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农业生物技术学报 1999年第4期7卷 311-315页

作者：苏金吴瑞 Corned Univ!Itnaca Section of biochem.Mol.and Cell Biol. NY 14853 100081 中国农业科学院生物技术研究中心!北京 U．S．A

植物转基因表达与转基因在植物染色体上的整合位点息息相关，即转基因表达的“位置效应”。本研究利用基因枪法转化水稻，获得两个均含有三个拷贝的UidA转基因系。其中一个转基因系不仅在RNA水平高效表达，而且呈现很强的GUS活性；而另... 详细信息

植物转基因表达与转基因在植物染色体上的整合位点息息相关，即转基因表达的“位置效应”。本研究利用基因枪法转化水稻，获得两个均含有三个拷贝的UidA转基因系。其中一个转基因系不仅在RNA水平高效表达，而且呈现很强的GUS活性；而另一个转基因系的uidA在转录和翻译水平均未表达。该结果揭示了植物转基因表达的位置效应。

关键词：转基因表达位置效应水稻转化

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Editor Profiles:Guest Editors of Special Issue on Drug Metabolism and Pharmacokinetics

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Acta Pharmaceutica Sinica B 2016年第5期6卷 359-360页

作者： Xiaobo Zhong Univ Calif Davis Sch Med Dept Biochem & Mol Med Sacramento CA 95817 USA Univ Calif Davis Ctr Comprehens Canc Sacramento CA 95817 USA Univ Calif Davis Sch Med PK PD Bioanalyt Core Facil Sacramento CA 95817 USA NIH XNDA Study Sect Bldg 10 Bethesda MD 20892 USA Univ Connecticut Sch Pharm Dept Pharmaceut Sci Storrs CT USA Yale Univ Sch Med Dept Genet Human Genet & Genom New Haven CT 06520 USA Univ Kansas Med Ctr Dept Pharmacol Toxicol & Therapeut Lawrence KS 66045 USA ASPET Bethesda MD USA ISSX Bethesda MD USA

*** Yu is a tenured faculty in the Department of biochem.stry&Molecular Medicine at University of California,Davis(UC-Davis)School of Medicine in Sacramento,*** is also a member of the Comprehensive Cancer Center at *** Yu obtained a *** from the Center China Normal University in 1993 and a *** from the Nankai University in *** then received post-doctoral trainings

关键词： Profiles faculty California metabolism pharmacology distinguished devoted hepatocyte reviewer editorial

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