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水稻中转基因表达的“位置效应”初报

农业生物技术学报 1999年第4期7卷 311-315页

作者：苏金吴瑞 Corned Univ!Itnaca Section of biochem.Mol.and Cell Biol. NY 14853 100081 中国农业科学院生物技术研究中心!北京 U．S．A

植物转基因表达与转基因在植物染色体上的整合位点息息相关，即转基因表达的“位置效应”。本研究利用基因枪法转化水稻，获得两个均含有三个拷贝的UidA转基因系。其中一个转基因系不仅在RNA水平高效表达，而且呈现很强的GUS活性；而另... 详细信息

植物转基因表达与转基因在植物染色体上的整合位点息息相关，即转基因表达的“位置效应”。本研究利用基因枪法转化水稻，获得两个均含有三个拷贝的UidA转基因系。其中一个转基因系不仅在RNA水平高效表达，而且呈现很强的GUS活性；而另一个转基因系的uidA在转录和翻译水平均未表达。该结果揭示了植物转基因表达的位置效应。

关键词：转基因表达位置效应水稻转化

Editor Profiles:Guest Editors of Special Issue on Drug Metabolism and Pharmacokinetics

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Acta Pharmaceutica Sinica B 2016年第5期6卷 359-360页

作者： Xiaobo Zhong Univ Calif Davis Sch Med Dept Biochem & Mol Med Sacramento CA 95817 USA Univ Calif Davis Ctr Comprehens Canc Sacramento CA 95817 USA Univ Calif Davis Sch Med PK PD Bioanalyt Core Facil Sacramento CA 95817 USA NIH XNDA Study Sect Bldg 10 Bethesda MD 20892 USA Univ Connecticut Sch Pharm Dept Pharmaceut Sci Storrs CT USA Yale Univ Sch Med Dept Genet Human Genet & Genom New Haven CT 06520 USA Univ Kansas Med Ctr Dept Pharmacol Toxicol & Therapeut Lawrence KS 66045 USA ASPET Bethesda MD USA ISSX Bethesda MD USA

*** Yu is a tenured faculty in the Department of biochem.stry&Molecular Medicine at University of California,Davis(UC-Davis)School of Medicine in Sacramento,*** is also a member of the Comprehensive Cancer Center at *** Yu obtained a *** from the Center China Normal University in 1993 and a *** from the Nankai University in *** then received post-doctoral trainings

关键词： Profiles faculty California metabolism pharmacology distinguished devoted hepatocyte reviewer editorial

Guest Editors of Special Column on Drug Targets and Drug Development for Alzheimer’s Disease

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1685-1685页

作者： Ding, Wen-Xing Swerdlow, Russell Univ Kansas Dept Pharmacol Toxicol & Therapeut Med Ctr Kansas City KS 66042 USA Univ Kansas Dept Neurol Sch Med Kansas City KS USA Univ Kansas Dept Mol & Integrat Physiol Sch Med Kansas City KS USA Univ Kansas Dept Biochem & Mol Biol Sch Med Kansas City KS USA

***-Xing Ding is the William Warner Abercrombie Professor at Department of Pharmacology,Toxicology and Therapeutics,University of Kansas Medical Center,Kansas City,KS,*** graduated from Shanghai Medical University(now Fudan University)in China in 1992 and later obtained his PhD in Molecular Toxicology in 2002 from National University of *** then did his Postdoc training at University of Pittsburgh and became an assistant professor in 2009 at The University of Kansas Medical Center.

关键词： Kansas Singapore Pittsburgh

Resistance of Nanoclay Reinforced Epoxy Composites to Hyperthermal Atomic Oxygen Attack

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Chinese Journal of Chemical Physics 2019年第5期32卷 543-552页

作者： Hei-long Wang Vanessa J. Murray Min Qian Donna J. Minton Ai-yi Dong Kin-tak Lau Bo-han Wu Li Che Timothy K. Minton College of Science Dalian Maritime University Dalian 116026 China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Department of Chemistry and biochem.stry Montana State University 103 Chemistry and Biochem- istry Bldg. Bozeman Montana 59717 United States of America Department of Physics School of Science East China University of Science and Technology Shanghai 200237 China Faculty of Science Engineering and Technology Swinburne University of Technology Hawthorn VIC 3122 Australia Beijing Institute of Spacecraft Environment Engineering Beijing 100094 China

Due to outstanding mechanical properties, heat resistance, and relatively facile production,nanoclay reinforced epoxy composites(NCRE composites) have been suggested as candidate materials for use on external surfaces of spacecraft residing in the low Earth orbit(LEO) environment. The resistance of the NCRE composites to bombardment by atomic oxygen(AO), a dominant component of the LEO environment, has been investigated. Four types of samples were used in this study. They were pure epoxy(0 wt% nanoclay content), and NCRE composites with different loadings of nanoclay—1 wt%, 2 wt%, and 4 wt%. Etch depths decreased with increasing nanoclay content, and for the 4 wt% samples it ranged from 28% to 37% compared to that of pure epoxy. X-ray photoelectron spectroscopy(XPS) indicates that after AO bombardment, relative area of C-C/C-H peak decreased,while the area of the C-O, ketones peaks increased, and the oxidation degree of surfaces increased. New carbon-related component carbonates were detected on nanoclay containing composite surfaces. Scanning electron microscopy indicates that aggregates formed on nanoclay-containing surfaces after AO bombardment. The sizes and densities of aggregates increased with nanoclay content. The combined erosion depths, XPS and SEM results indicate that although all the studied surfaces got eroded and oxidized after AO bombardment,the nanoclay containing composites showed better AO resistance compared to pure epoxy,because the produced aggregates on surface potentially act as a physical "shield", effectively retarding parts of the surface from further AO etching.

关键词： Atomic oxygen Epoxy Nanoclay Low Earth orbit

人Aγ珠蛋白基因增强子功能在转基因鼠系统的验证

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人Aγ珠蛋白基因增强子功能在转基因鼠系统的验证

Newly elected Chinese Academy of Sciences academicians in chemistry division in 2021

“科技增强国力，青年开创未来——携手走向辉煌的新世纪”中国科协第三届青年学术年会

作者：刘庆辉 Jrg Bungert James Dovglas Engel 中国医学科学院基础医学研究所生化重点室 Dept.biochem.Mol.Biol.& cell Biol.Northwestern University USA

人β-珠蛋白基因簇位于第11号染色体上,含有5个编码基因和多个调控序列。A-珠蛋白基因3’增强子为-750bp片段;在转染细胞中,该片段可提高报告基因的表达水平;在转基因动物实验中,该增强子的存在可避免内括基因受到外界"位置效应"的影响... 详细信息

人β-珠蛋白基因簇位于第11号染色体上,含有5个编码基因和多个调控序列。A-珠蛋白基因3’增强子为-750bp片段;在转染细胞中,该片段可提高报告基因的表达水平;在转基因动物实验中,该增强子的存在可避免内括基因受到外界"位置效应"的影响。但另有报导显示该片段为一抑制性序列或中性序列。上述不同实验系统所产生的差异显现出利用短小基因片段的局限性。本文以150kb整个β-珠蛋白基因簇为实验体系,用同源重组方法去除上述750bp片段,发现整个基因簇中各基因的表达与正常无显著区别,提示该增强子功能可能被其他结构补偿;或者该片段为一中性序列。提醒人们对小片段基因体外功能实验结果需谨慎诠释。

关键词：珠蛋白基因 YAC 增强子

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Aggregate 2021年第6期2卷 4-7页

作者： Chi, Lifeng Xian-He Bu Fang, Yu Liu, Maili Ma, Yu Guang Ma, Guanghi Mei-Xiang Wang Yu, Biao Su-Yuan Xie Yuan, Yingjin Zhou, Xiang Soochow Univ Suzhou Peoples R China Nankai Univ Sch Mat Sci & Engn Tianjin Peoples R China Shaanxi Normal Univ Xian Peoples R China Chinese Acad Sci Innovat Acad Precis Measurement Sci & Technol Wuhan Peoples R China South China Univ Technol Guangzhou Peoples R China Chinese Acad Sci State Key Lab Biochem Engn Inst Proc Engn Beijing Peoples R China Tsinghua Univ Dept Chem Beijing Peoples R China Chinese Acad Sci Shanghai Inst Organ Chem Shanghai Peoples R China Xiamen Univ Xiamen Peoples R China Tianjin Univ Sch Chem Engn & Technol Tianjin Peoples R China Wuhan Univ Wuhan Peoples R China

On November 18,2021,the Chinese Academy of Sciences(CAS)announced the names of newly elected *** to all the elected academicians!In this Profile column,we introduce 11 scientists in the Chemistry Division of the *** expertise covers organic chemistry,inorganic chemistry,physical chemistry,analytical chemistry,polymer chemistry and physics,biochem.cal engineering,and chemical biology.

关键词： chemistry inorganic academic

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断奶背膘与饲喂模式对母猪繁殖性能的影响

猪业科学 2023年第9期40卷 98-100页

作者：赵勤辉殷颖珊许婷婷德国百欧康biochem.Zusatzstoffe Handels-u.Produktionsges.mbH Küstermeyerstr.16.49393 Lohne.Germany 广东省中山市农业科技推广中心广东中山528400

1引言影响母猪繁殖的因素有许多,包括遗传、营养、疾病、饲养管理和环境。母猪背膘厚度和体况已被确定为优化高产母猪活产仔数量和随后繁殖成功的关键因素(Maes et al,2004)。背膘厚度包括断奶背膘、妊娠背膘和临产背膘等,对于相同条件... 详细信息

1引言影响母猪繁殖的因素有许多,包括遗传、营养、疾病、饲养管理和环境。母猪背膘厚度和体况已被确定为优化高产母猪活产仔数量和随后繁殖成功的关键因素(Maes et al,2004)。背膘厚度包括断奶背膘、妊娠背膘和临产背膘等,对于相同条件下的母猪来说,背膘与体重呈正相关关系。Douglas等人(2014)对23项研究和5个生产数据集进行了meta分析,量化了多个因素及其相互作用对妊娠母猪生产性能的影响,产活仔数与母猪妊娠初期与末期的活重相关,妊娠末期母猪活重与产活仔猪呈线性正相关关系。

关键词：背膘厚度母猪妊娠产活仔数母猪繁殖性能活重母猪生产性能 meta分析妊娠末期

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大型污水处理厂工艺优化及改造案例分析

中国给水排水 2007年第14期23卷 29-32页

作者：朱石清 George Lee 尚爱安张欣麦穗海杨彩凤徐鸿德张善发上海市水务局上海200003 biochem.Technology Inc 美国生化科技公司上海代表处上海200336 上海市政工程设计研究院上海200092 上海市南运营公司白龙港水质净化厂上海201203 上海市城市建设设计研究院上海200120

对上海某大型污水处理厂(原设计处理量为120×104m3/d,采用高效沉淀池处理工艺)进行了工艺优化及模拟改造,介绍了优化模拟改造系统的分析步骤,建立了污水厂达标改造和扩建工艺模型。污水厂达标改造工艺模型模拟结果表明,高效沉淀池的处... 详细信息

对上海某大型污水处理厂(原设计处理量为120×104m3/d,采用高效沉淀池处理工艺)进行了工艺优化及模拟改造,介绍了优化模拟改造系统的分析步骤,建立了污水厂达标改造和扩建工艺模型。污水厂达标改造工艺模型模拟结果表明,高效沉淀池的处理出水应根据具体情况,部分进入二级生物处理,以达到排放标准;扩建工艺模拟结果表明,应根据实际进水量和水温情况合理控制DO,出水水质才能达到排放标准。

关键词：污水处理厂高效沉淀池达标改造工艺优化

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对营养代谢组学—技术思考

对营养代谢组学—技术思考