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Journal of Ocean Engineering and Science 2024年第1期9卷 1-8页

作者： Xiaolong Wang school of Economics and Management Binzhou UniversityBinzhou256600China

In the organizational context of marine engineering,employee individual often prefers to concentrate herself to the day-to-day routine job,but to shirk the responsibilities of the Information Security Policies(ISPs)compliance,after she has been delegated by the employer to perform the two different tasks in the same time period.This would lead to negative influences on the security of marine information systems and the employee’s routine job performance.In view of the task structures of employee’s routine job and marine ISPs compliance,the variables of emphasis on scheduling are incorporated into a multi-task principal-agent model to explore the optimal incentive scheme to motivate and control the employees to select appropriate effort levels for conducting the two highly structured tasks.The role of emphasis on scheduling on the incentive intensities for the two tasks have been clarified through modeling and simulation,and the corresponding incentive tactics are suggested.The new two-task incentive scheme is expected to provide useful insight for understanding and controlling marine engineering employee’s routine job and ISPs compliance behavior.

关键词： Marine engineering Incentive scheme Information security policy compliance Task structure Scheduling Simulation

Observer-based dynamic event-triggered control for distributed parameter systems over mobile sensor-plus-actuator networks

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Chinese Physics B 2024年第4期33卷 237-243页

作者：穆文英庄波邱芳 Shandong Engineering Research Center of Aeronautical Materials and Devices Shangdong University of AeronauticsBinzhou 256600China school of Information Engineering Shangdong University of AeronauticsBinzhou 256600China school of Science Shangdong University of AeronauticsBinzhou 256600China

We develop a policy of observer-based dynamic event-triggered state feedback control for distributed parameter systems over a mobile sensor-plus-actuator network.It is assumed that the mobile sensing devices that provide spatially averaged state measurements can be used to improve state estimation in the network.For the purpose of decreasing the update frequency of controller and unnecessary sampled data transmission, an efficient dynamic event-triggered control policy is constructed.In an event-triggered system, when an error signal exceeds a specified time-varying threshold, it indicates the occurrence of a typical event.The global asymptotic stability of the event-triggered closed-loop system and the boundedness of the minimum inter-event time can be guaranteed.Based on the linear quadratic optimal regulator, the actuator selects the optimal displacement only when an event occurs.A simulation example is finally used to verify that the effectiveness of such a control strategy can enhance the system performance.

关键词： distributed parameter systems event-triggered control mobile sensors mobile actuators

The effect of lengths of branched-chain fatty alcohols on the efficacy and safety of docetaxel-prodrug nanoassemblies

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1400-1411页

作者： Shuo Wang Tian Liu Yuetong Huang Chaoying Du Danping Wang Xiyan Wang Qingzhi Lv Zhonggui He Yinglei Zhai Bingjun Sun Jin Sun Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China school of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China school of Medical Devices Shenyang Pharmaceutical UniversityShenyang 110016China school of Pharmacy Binzhou Medical UniversityBinzhou 256600China

The self-assembly prodrugs are usually consisted of drug modules,activation modules,and assembly modules.Keeping the balance between efficacy and safety by selecting suitable modules remains a challenge for developing prodrug nanoassemblies.This study designed four docetaxel(DTX)prodrugs using disulfide bonds as activation modules and different lengths of branched-chain fatty alcohols as assembly modules(C_(16),C_(18),C_(20),and C_(24)).The lengths of the assembly modules determined the self-assembly ability of prodrugs and affected the activation modules’sensitivity.The extension of the carbon chains improved the prodrugs’self-assembly ability and pharmacokinetic behavior while reducing the cytotoxicity and increased cumulative toxicity.The use of C_(20) can balance efficacy and safety.These results provide a great reference for the rational design of prodrug nanoassemblies.

关键词： Prodrugs Nanoassemblies Self-assembly Branched-chain fatty alcohols Disulfide bond Docetaxel Efficacy Safety

LncRNAs unraveling their sponge role in glioblastoma and potential therapeutic applications

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BIOCELL 2024年第3期48卷 387-401页

作者： CAIJUAN LIU XINGHAO LI YUXUAN WU JINHUI YANG MENGHAN WANG YUNQI MA school of Pharmacy Binzhou Medical UniversityYantai264003China

Glioblastoma multiforme(GBM),the most common and aggressive primary brain tumor in adults,is the most malignant and still has no cure.However,the novel role of long non-coding RNAs(lncRNAs)in the pathogenesis of glioblastoma is attracting extensive attention.LncRNAs are transcribed RNA molecules over 200 nucleotides long that do not encode proteins.Unlike small non-coding RNAs,such as microRNAs(miRNAs),lncRNAs have more complex secondary and tertiary structures that enable them to interact with DNA,RNA,and proteins and perform multiple regulatory functions.LncRNAs act as molecular sponges,absorbing and sequestering other biomolecules,particularly miRNAs,thereby preventing these molecules from performing their normal functions.LncRNAs inﬂuence glioblastoma through gene expression regulation,molecular sponge capacity,epigenetic modulation,and signaling pathway interactions.In glioblastoma,a large number of lncRNAs have been found to be abnormally expressed,affecting tumor growth,invasion and resistance to treatment.Due to its regulatory role and disease-speciﬁc expression patterns,lncRNA has become a potential biomarker for glioblastoma and a promising new therapeutic target.This paper discusses the spongy role of lncRNAs in glioblastoma and its potential therapeutic applications,which will lay a foundation for our understanding of glioblastoma biology and the development of new diagnostic and therapeutic strategies in the future.

关键词： LncRNA miRNA Biomarker Molecular sponges Tumor microenvironment

Charge transfer complex enabled photoreduction of ether phosphonium salts for the selective oxyalkylation of enamides

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Chinese Chemical Letters 2024年第2期35卷 411-414页

作者： Sen Qiao Kunquan Chen Qiang Liu Zhixiang Wang Xiangyu Chen school of Chemical Sciences University of the Chinese Academy of SciencesBeijing 100049China binzhou Institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou 256606China

A charge transfer complex(CTC)-enabled photoreduction of ether phosphonium salts for the generation of oxyalkyl radicals was described.The photoreduction provides a convenient method to achieve selective oxyalkylation of enamides with broad substrate scope.The method features operational simplicity,mild and inherent green conditions.

关键词： Enamides Phosphonium salts Ethers Charge transfer complex Visible light

Inhibition of Defect-Induced Ice Nucleation, Propagation, and Adhesion by Bioinspired Self-Healing Anti-Icing Coatings

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Research 2024年第1期2023卷 237-246页

作者： Shu Tian Ruiqi Li Xinmeng Liu Jiancheng Wang Junyu Yu Sijia Xu Yunqing Tian Jing Yang Lei Zhang Department of Biochemical Engineering Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(MOE)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China binzhou Institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou CityShandong Province 256606China

Anti-icing coatings on outdoor infrastructures inevitably suffer from mechanical injuries in numerous icing scenarios such as hailstorms,sandstorms,impacts of foreign objects,and icing–deicing cycles.Herein,the mechanisms of surface-defect-induced icing are clarified.At the defects,water molecules exhibit stronger adsorption and the heat transfer rate increases,accelerating the condensation of water vapor as well as ice nucleation and propagation.Moreover,the ice–defect interlocking structure increases the ice adhesion strength.Thus,a self-healing(at−20℃)antifreeze-protein(AFP)-inspired anti-icing coating is developed.The coating is based on a design that mimics the ice-binding and non-ice-binding sites in AFPs.It enables the coating to markedly inhibit ice nucleation(nucleation temperature<−29.4℃),prevent ice propagation(propagation rate<0.00048 cm^(2)/s),and reduce ice adhesion on the surface(adhesion strength<38.9 kPa).More importantly,the coating can also autonomously self-heal at−20℃,as a result of multiple dynamic bonds in its structure,to inhibit defect-induced icing processes.The healed coating sustains high anti-icing and deicing performance even under various extreme conditions.This work reveals the in-depth mechanism of defect-induced ice formation as well as adhesion,and proposes a self-healing anti-icing coating for outdoor infrastructures.

关键词： coating defect clarified

Understanding the deterrence effect of punishment for marine information security policies non-compliance

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Journal of Ocean Engineering and Science 2024年第1期9卷 9-12页

作者： Xiaolong Wang Changlin Wang Tianyu Yi Wenli Li school of Economics and Management Binzhou UniversityBinzhou256600China school of Business Macao University of Science and TechnologyMacao999078China school of Economics and Management Dalian University of TechnologyDalian116024China

In the organizational setting of marine engineering,a significant number of information security incidents have been arised from the employees’failure to comply with the information security policies(ISPs).This may be treated as a principal-agent problem with moral hazard between the employer and the employee for the practical compliance effort of an employee is not observable without high cost-.On the other hand,according to the deterrence theory,the employer and the employee are inherently self-interested beings.It is worth examining to what extent the employee is self-interested in the marine ISPs compliance context.Moreover,it is important to clarify the proper degree of severity of punishment in terms of the deterrent effect.In this study,a marine ISPs compliance game model has been proposed to evaluate the deterrence effect of punishment on the non-compliance behavior of employee individuals.It is found that in a non-punishment contract,the employee will decline to comply with the marine ISPs;but in a punishment contract,appropriate punishment will lead her to select the marine ISPs compliance effort level expected by the employer,and cause no potential backfire effect.

关键词： Deterrence mechanism Marine engineering Information security policies Non-compliance behavior Principal-agent model with moral hazard Punishment

Reduction of unactivated alkyl chlorides enabled by light-induced single electron transfer

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Science China Chemistry 2024年第2期67卷 471-481页

作者： Lei Dai Zhao-Fei Zhang Xiang-Yu Chen school of Chemical Sciences University of the Chinese Academy of SciencesBeijing100049China Institute of Chemistry Chinese Academy of SciencesBeijing100190China binzhou Institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou256606China

Alkyl chlorides are abundant and easily accessible starting materials.However,due to the high reduction potentials associated with unactivated alkyl chlorides,achieving their single electron reduction remains a persistent challenge.This challenge has spurred the exploration of efficient activation methods to overcome this issue.In recent years,photocatalysis has emerged as a mild and potent tool for the single electron reduction of unactivated alkyl chlorides,opening up new possibilities in this field.Considering the rapid advancements in this area,a comprehensive review that provides a conceptual understanding of this emerging field,with a specific focus on reaction design and catalytic mechanisms,would be timely and highly valuable.Hence,we present an overview of various synthetic techniques for photoinduced single electron reduction of unactivated alkyl chlorides.Furthermore,we also discuss the limitations of the present methods and future directions that lie ahead in this field.

关键词： photocatalysis unactivated alkyl chlorides single electron transfer radical reactions

Three-Soliton Interactions and the Implementation of Their All-Optical Switching Function

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Chinese Physics Letters 2024年第4期41卷 51-58页

作者：伊厚会张鑫石领先姚延立王树斌马国利 school of Intelligent Manufacturing Weifang University of Science and TechnologyWeifang 262700China Institute of Aeronautical Engineering Shandong University of AeronauticsBinzhou 256603China Flight College Shandong University of AeronauticsBinzhou 256603China Tianjin Sino-German University of Applied Sciences Tianjin 300350China

As a key component in all-optical networks,all-optical switches play a role in constructing all-optical switching.Due to the absence of photoelectric conversion,all-optical networks can overcome the constraints of electronic bottlenecks,thereby improving communication speed and expanding their communication bandwidth.We study all-optical switches based on the interactions among three optical solitons.By analytically solving the coupled nonlinear Schr¨odinger equation,we obtain the three-soliton solution to the equation.We discuss the nonlinear dynamic characteristics of various optical solitons under different initial conditions.Meanwhile,we analyze the influence of relevant physical parameters on the realization of all-optical switching function during the process of three-soliton interactions.The relevant conclusions will be beneficial for expanding network bandwidth and reducing power consumption to meet the growing demand for bandwidth and traffic.

关键词： soliton expanding networks

Shaking table test study on performance and functionality of a typical telecommunication room after earthquakes

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 455-474页

作者： Li Bo Guo Endong Sun Guoliang Ji Shuqiang Mao Chenxi Wang Tao Han Di Li Xiaofei Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin 150080China China Academy of Information and Communications Technology Beijing 100191China school of Architecture Engineering Binzhou UniversityBinzhou 256600China

Large numbers of basic transceiver stations,where the telecommunication room is one of the main components,comprise an important part of the telecommunication system.After earthquakes,considerable economic loss from telecommunication systems is often associated with seismic damage and functional loss of the telecommunication room.However,research related to this has been limited.In this study,shaking table tests were conducted for a full-scale typical telecommunication room,including a light-steel house and the necessary communication and power supply equipment.The tests not only focused on the seismic damage to all the structures but also considered the functions of the communication and power supply of the equipment.The interactions between these facilities and their effects on communication function were also investigated.Compared with the damage to structures,the interruption of the power supply due to earthquakes is a weak link.Finally,the damage indexes,together with their threshold values of different damage states for the communication and power supply equipment,were derived from the test results.The results of this research can contribute to the literature gaps regarding seismic performance studies of telecommunication rooms,and can serve as a valuable reference for future research on its seismic fragility and economic losses evaluation.

关键词： telecommunication light-steel house communication equipment power supply equipment seismic performance functionality