检索结果-南通市图书馆

Promising applications of D-amino acids in periprosthetic joint infection

Bone Research 2023年第2期11卷 248-272页

作者： Matthew Caldwell Megan Hughes Fei Wei Christopher Ngo Raven Pascua Abinaya Sindu Pugazhendhi Melanie J.Coathup biionix cluster&college of medicine University of Central FloridaBlvdOrlandoFL32827USA School of Biosciences Cardiff UniversityCF103AT WalesUK Burnett School of Biomedical Sciences College of MedicineUniversity of Central Florida6900 Lake NonaBlvdOrlandoFL32827USA

Due to the rise in our aging population,a disproportionate demand for total joint arthroplasty(TJA)in the elderly is *** joint infection(PJI)represents one of the most challenging complications that can occur following TJA,and as the number of primary and revision TJAs continues to rise,an increasing PJI burden is *** advances in operating room sterility,antiseptic protocols,and surgical techniques,approaches to prevent and treat PJI remain difficult,primarily due to the formation of microbial *** difficulty motivates researchers to continue searching for an effective antimicrobial *** dextrorotatory-isoforms of amino acids(D-AAs)are essential components of peptidoglycan within the bacterial cell wall,providing strength and structural integrity in a diverse range of *** many tasks,D-AAs regulate cell morphology,spore germination,and bacterial survival,evasion,subversion,and adhesion in the host immune *** administered exogenously,accumulating data have demonstrated that D-AAs play a pivotal role against bacterial adhesion to abiotic surfaces and subsequent biofilm formation;furthermore,D-AAs have substantial efficacy in promoting biofilm *** presents D-AAs as promising and novel targets for future therapeutic *** their emerging antibacterial efficacy,their role in disrupting PJI biofilm formation,the disassembly of established TJA biofilm,and the host bone tissue response remains largely *** review aims to examine the role of D-AAs in the context of *** to date suggest that D-AA bioengineering may serve as a promising future strategy in the prevention and treatment of PJI.

关键词： prevention spite furthermore

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Changes in interstitial fluid flow,mass transport and the bone cell response in microgravity and normogravity

引用

Bone Research 2022年第4期10卷 696-714页

作者： Fei Wei Kendal Flowerdew Michael Kinzel Luigi EPerotti Jackson Asiatico Mahmoud Omer Candice Hovell Veerle Reumers Melanie J.Coathup biionix cluster Department of Internal MedicineCollege of MedicineUniversity of Central FloridaOrlandoFLUSA Marian University college of Osteopathic medicine IndianapolisINUSA Department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFLUSA Imec USA 194 NeoCity WyOrlandoFLUSA

In recent years,our scientific interest in spaceflight has grown exponentially and resulted in a thriving area of research,with hundreds of astronauts spending months of their time in space.A recent shift toward pursuing territories farther afield,aiming at near-Earth asteroids,the Moon,and Mars combined with the anticipated availability of commercial flights to space in the near future,warrants continued understanding of the human physiological processes and response mechanisms when in this extreme *** skeletal loss,more severe than any bone loss seen on Earth,has significant implications for deep space exploration,and it remains elusive as to why there is such a magnitude of difference between bone loss on Earth and loss in *** removal of gravity eliminates a critical primary mechano-stimulus,and when combined with exposure to both galactic and solar cosmic radiation,healthy human tissue function can be negatively *** additional effect found in microgravity,and one with limited insight,involves changes in dynamic fluid *** provide the most fundamental way to transport chemical and biochemical elements within our bodies and apply an essential mechano-stimulus to ***,the cell cytoplasm is not a simple liquid,and fluid transport phenomena together with viscoelastic deformation of the cytoskeleton play key roles in cell *** microgravity,flow behavior changes drastically,and the impact on cells within the porous system of bone and the influence of an expanding level of adiposity are not well *** review explores the role of interstitial fluid motion and solute transport in porous bone under two different conditions:normogravity and microgravity.

关键词： flow flow apply

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss

引用

骨研究:英文版 2023年第3期11卷 512-531页

作者： Fei Wei Zewen Kelvin Tuong Mahmoud Omer Christopher Ngo Jackson Asiatico Michael Kinzel Abinaya Sindu Pugazhendhi Annette R.Khaled Ranajay Ghosh Melanie Coathup biionix cluster and Department of Internal MedicineCollege of MedicineUniversity of Central FloridaOrlandoFLUSA Molecular Immunity Unit Department of MedicineUniversity of CambridgeCambridgeUK Cellular Genetics Wellcome Sanger InstituteHinxtonUK Department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFLUSA Burnett School of Biomedical Sciences College of MedicineUniversity of Central FloridaOrlandoFLUSA

Radiotherapy is a critical component of cancer care but can cause osteoporosis and pathological insufficiency fractures in surrounding and otherwise healthy ***,no effective countermeasure exists,and ionizing radiation-induced bone damage continues to be a substantial source of pain and *** purpose of this study was to investigate a small molecule aminopropyl carbazole named P7C3 as a novel radioprotective *** studies revealed that P7C3 repressed ionizing radiation(IR)-induced osteoclastic activity,inhibited adipogenesis,and promoted osteoblastogenesis and mineral deposition in *** also demonstrated that rodents exposed to clinically equivalent hypofractionated levels of IR in vivo develop weakened,osteoporotic ***,the administration of P7C3 significantly inhibited osteoclastic activity,lipid formation and bone marrow adiposity and mitigated tissue loss such that bone maintained its area,architecture,and mechanical *** findings revealed significant enhancement of cellular macromolecule metabolic processes,myeloid cell differentiation,and the proteins LRP-4,TAGLN,ILK,and Tollip,with downregulation of GDF-3,SH2B1,and *** proteins are key in favoring osteoblast over adipogenic progenitor differentiation,cell matrix interactions,and shape and motility,facilitating inflammatory resolution,and suppressing osteoclastogenesis,potentially via Wnt/β-catenin signaling.A concern was whether P7C3 afforded similar protection to cancer ***,and remarkably,at the same protective P7C3 dose,a significant reduction in triple-negative breast cancer and osteosarcoma cell metabolic activity was found in ***,these results indicate that P7C3 is a previously undiscovered key regulator of adipo-osteogenic progenitor lineage commitment and may serve as a novel multifunctional therapeutic strategy,leaving IR an effective clinical tool while diminishing the risk of adverse post-IR *** data uncov

关键词： protective inhibited prevention

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme

引用

Bioactive Materials 2023年第3期21卷 547-565页

作者： Fei Wei Craig J.Neal Tamil Selvan Sakthivel Yifei Fu Mahmoud Omer Amitava Adhikary Samuel Ward Khoa Minh Ta Samuel Moxon Marco Molinari Jackson Asiatico Michael Kinzel Sergey N.Yarmolenko Vee San Cheong Nina Orlovskaya Ranajay Ghosh Sudipta Seal Melanie Coathup biionix cluster Department of Internal MedicineCollege of MedicineUniversity of Central FloridaOrlandoFLUSA Advanced Materials Processing and Analysis Centre Nanoscience Technology Center(NSTC)Materials Science and EngineeringCollege of MedicineUniversity of Central FloridaOrlandoFLUSA CMC Materials 870 North CommonsDrAuroraILUSA Department of Chemistry Oakland UniversityRochesterMIMIUSA School of Applied Sciences Department of Chemical SciencesUniversity of HuddersfieldUK Department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFLUSA Engineering Research Center for Revolutionizing Biomaterials North Carolina A&T UniversityGreensboroNCUSA Department of Automatic Control and Systems Engineering Insigneo Institute for In Silico MedicineUniversity of SheffieldSheffieldS13JDUK

The disability,mortality and costs due to ionizing radiation(IR)-induced osteoporotic bone fractures are sub-stantial and no effective therapy *** radiation increases cellular oxidative damage,causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing *** demonstrate that rats exposed to sublethal levels of IR develop fragile,osteoporotic *** reactive surface sites,cerium ions have the ability to easily undergo redox cycling:drastically adjusting their electronic con-figurations and versatile catalytic *** properties make cerium oxide nanomaterials *** show that an engineered artificial nanozyme composed of cerium oxide,and designed to possess a higher fraction of trivalent(Ce^(3+))surface sites,mitigates the IR-induced loss in bone area,bone architecture,and *** investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species,protecting the rats against IR-induced DNA damage,cellular senescence,and elevated osteoclastic activity in vitro and in ***,we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells,favoring new bone formation despite its exposure to harmful levels of IR in *** findings open a new approach for the specific prevention of IR-induced bone loss using synthesis-mediated designer multifunctional nanomaterials.

关键词： Ionizing radiation Osteoporosis Nanozyme Cerium oxide Bone strength Bone resorption

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：