检索结果-南通市图书馆

New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1085-1086页

作者： Charis Ma Krystyna Rytel Yu Chen Ellen Sidransky Medical Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medical research,there are times when the introduction of a new tool can launch scientific discovery in new *** antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic *** recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).

关键词： antibodies cerebro

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Diabetes mellitus and glymphatic dysfunction:Roles for oxidative stress,mitochondria,circadian rhythm,artificial intelligence,and imaging

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2025年第1期16卷 39-48页

作者： Kenneth Maiese National Heart Lungand Blood InstituteNational Institutes of HealthBethesdaMD 20810United States

Diabetes mellitus(DM)is a debilitating disorder that impacts all systems of the body and has been increasing in prevalence throughout the *** represents a significant clinical challenge to care for individuals and prevent the onset of chronic disability and ultimately *** cellular mechanisms for the onset and development of DM are multi-factorial in origin and involve pathways associated with the production of reactive oxygen species and the generation of oxidative stress as well as the dysfunction of mitochondrial cellular organelles,programmed cell death,and circadian rhythm *** pathways can ultimately involve failure in the glymphatic pathway of the brain that is linked to circadian rhythms disorders during the loss of metabolic *** studies incorporate a number of promising techniques to examine patients with metabolic disorders that can include machine learning and artificial intelligence pathways to potentially predict the onset of metabolic dysfunction.

关键词： Artificial intelligence Circadian rhythm Clock genes Diabetes mellitus magnetic resonance imaging Glymphatic pathway Mitochondria Oxidative stress Programmed cell death Sleep fragmentation

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

RECENT PROGRESS IN INCOMPRESSIBLE REYNOLDSAVERAGED NAVIER-STOKES SOLVERS

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 1996年第1期8卷 13-30页

作者： C. H. Sung T. T. Huang(David Taylor Model Basin,CD/NSWC bethesda, MD 20084- 5000,USA) David Taylor Model Basin Bethesda United States

A new numerical approach based on a multiblock, multigrid, local refinement method has been developed. The multiblock structure makes grid generation for complex geometries easier,multigrid techniques significantly accelerate the rate of convergence and the local refinement method provides high spatial resolution of boundary lay6r and separated vortical flows with much reduced computer memory and CPU time. Sample three-dimensional flow computations for complex geometries are presented to illustrate the advantages in term of memory savings and reductions of CPU time in obtaining high spatial resolution solutions. High spatial resolution in the inner viscous layer is achieved by using the values of y+ for the first grid centers rom the wall in the order of 1 to 7. The required solution resolution in the dominantly viscous flow region (boundary layer, vortex core, or three-dimensional separated zone) dictates the acceptable spacing of grid cells in that region. It is very desirable to be able to reduce grid spacing locally in the critical region without changing the overall grid. The local refinement technique doubles grid numbers in all three directions for every level of refinement. Multiple levels of local grid refinement with moderate grid stretching can be used to provide fine grid spacing in rapidly changing flow regions such as near the wall, vortex core and separated shear layer. Thus, the method provides the required fine spatial resolution in the dominantly viscous region which is relatively small compared to the entire computational domain. This also avoids the used of excessively large aspect ratios of the grid cells near the rapidly changing now regions thus reduces truncation error and improves robustness. Furthermore, the results of numerical experimentation indicate that the present multigrid local refinement technique provides very effective numerical communications across the fine and coarse grid interfaces because the finer mesh is embedde

关键词： ultiblock multigrid local refinement

Breast Cancer Immunotherapy

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2004年第4期1卷 247-255页

作者： JuhuaZhou YinZhong NationalCancerInstitute NationalInstitutesofHealthBethesdaMD20892USA.

Breast cancer is a leading cause of cancer-related deaths in women *** tumorectomy, radiotherapy,chemotherapy and hormone replacement therapy have been used for the treatment of breast cancer,there is no effective therapy for patients with invasive and metastatic breast *** may be proved effective in treating patients with advanced breast *** cancer immunotherapy includes antibody based immunotherapy,cancer vaccine immunotherapy,adoptive T cell transfer immunotherapy and T cell receptor gene transfer *** based immunotherapy such as the monoclonal antibody against HER-2/neu (trastuzumab) is successfully used in the treatment of breast cancer patients with over-expressed HER-2/neu,however,HER-2/neu is over-expressed only in 25-30% of breast cancer *** vaccine immunotherapy is a promising method to treat cancer *** vaccines can be used to induce specific anti-tumor immunity in breast cancer patients,but cannot induce objective tumor *** T cell transfer immunotherapy is an effective method in the treatment of melanoma *** advances in anti-tumor T cell generation ex vivo and limited clinical trial data have made the feasibility of adoptive T cell transfer immunotherapy in the treatment of breast cancer patients.T cell receptor gene transfer can redirect the specificity of T *** receptor,scFv(anti-HER-2/neu)/zeta receptor,was successfully used to redirect cytotoxic T lymphocyte hybridoma cells to obtain anti-HER-2/neu positive tumor cells,suggesting the feasibility of treatment of breast cancer patients with T cell receptor gene transfer *** trials will approve that immunotherapy is an effective method to cure breast cancer disease in the near *** & Molecular Immunology.2004;1(4):247-255.

关键词： breast cancer antibody based immunotherapy cancer vaccine adoptive T cell transfer T cell receptor gene transfer immunotherapy

Cytokines,STATs and Liver Disease

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2005年第2期2卷 92-100页

作者： BinGao SectiononLiverBiology LaboratoryofPhysiologicStudiesNationalInstituteonAlcoholAbuseandAlcoholismNationalInstitutesofHealthBethesdaMD20892USA

The Janus kinase-signal transducers and activators of transcription(JAK-STAT)signaling pathway,activated by more than 50 cytokines or growth factors,plays critical roles in a wide variety of cellular functions in the hematopoietic,immune,neuronal and hepatic *** the liver,this signaling pathway,activated by more than 20 cytokines,growth factors,hormones,and hepatitis viral proteins,plays critical roles in antiviral defense,acute phase response,hepatic injury,repair,inflammation,transformation,and *** article reviews the biological significance of STAT1,2,3,4,5,6 in hepatic functions and *** & Molecular Immunology. 2005;2(2):92-100.

关键词： cytokine STAT liver

Ketamine,a trauma analgesic with sex-specific immunomodulatory function

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第6期18卷 1263-1264页

作者： Haley F.Spencer Rina Y.Berman Martin Boese Kwang H.Choi Program in Neuroscience Uniformed Services UniversityBethesdaMDUSA Center for the Study of Traumatic Stress Uniformed Services UniversityBethesdaMDUSA Daniel K.Inouye Graduate School of Nursing Uniformed Services UniversityBethesdaMDUSA Department of Psychiatry F.E.Hébert School of MedicineUniformed Services UniversityBethesdaMDUSA

Ketamine,a multimodal dissociative anesthetic,produces powerful analgesia at subanesthetic doses in traumatically injured *** ketamine does not induce respiratory depression or hemodynamic instability,the Committee on Tactical Combat Casualty Care for the US military recommends the use of subanesthetic doses of ketamine for acute pain management(Butler et al.,2014).Additionally,ketamine may have immunomodulatory effects after injury at subanesthetic doses,mediating the balance of pro-and anti-inflammatory processes(Loix et al.,2011;De Kock et al.,2013).

关键词： doses acute

Hydrodynamic Gene Delivery of Interleukin-22 Protects the Mouse Liver from Concanavalin A-, Carbon Tetrachloride-,and Fas Ligand-Induced Injury via Activation of STAT3

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2004年第1期1卷 43-49页

作者： HongnaPan FengHong SvetlanaRadaeva BinGao SectiononLiverBiology LaboratoryofPhysiologicStudiesNationalInstituteonAlcoholAbuseandAlcoholismNationalInstitutesofHealthBethesdaMD20892.USA Chief.SectiononLiverBiology NIAAA／NIH.ParkBldgRm12012420ParklawnDrive.MSC8115.Bethesda.MD20892USA

Interleukin-22 (IL-22) is a recently identified T cell-derived cytokine whose biological significance remains ***,we have shown that IL-22 plays a protective role in T cell-mediated hepatitis induced by Concanavalin A (Con A),acting as a survival factor for *** the present paper,we demonstrate that hydrodynamic gene delivery of IL-22 cDNA driven either by a liver-specific albumin promoter or a human cytomegalovirus (CMV) promoter results in IL-22 protein expression,STAT3 activation,and expression of several anti-apoptotic proteins,including Bcl-xL,Bcl-2,and Mcl-1 in the *** analysis reveals that IL-22 protein expression is mainly detected in the cytoplasm of *** of IL-22 by hydrodynamic gene delivery significantly protects against liver injury,necrosis,and apoptosis induced by administration of Con A,carbon tetrachloride (CCl_4),or the Fas agonist Jo-2 *** blot analyses show that overexpression of IL-22 significantly enhances activation of STAT3 and expression of Bcl-xL,Bcl-2, and Mcl-1 proteins in liver injury induced by Con *** conclusion,hydrodynamic gene delivery of IL-22 protects against liver injury induced by a variety of toxins,suggesting the therapeutic potential of IL-22 in treating human liver *** & Molecular Immunology.2004;1(1):43-49.

关键词： IL-22 STAT3 hydrodynamic gene therapy liver injury