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Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease:A crosssectional study

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World Journal of Gastroenterology 2025年第7期31卷 63-73页

作者： Yolanda Real Martinez Carlos Ernesto Fernandez-Garcia Esther Fuertes-Yebra Mario Calvo Soto Angela Berlana Vicente Barrios Maria Caldas Leticia Gonzalez Moreno Luisa Garcia-Buey Begoña Molina Baena Miguel Sampedro-Nuñez Maria J Beceiro C García-Monzón Águeda González-Rodríguez Servicio Aparato Digestivo Hospital Universitario La PrincesaInstituto de Investigación Sanitaria La PrincesaUniversidad Autónoma de MadridMadrid 28006Spain Unidad de Investigación Hospital Universitario Santa CristinaInstituto de Investigación Sanitaria La PrincesaMadrid 28009Spain Department of Endocrinology Department of PediatricsHospital Infantil Universitario Niño JesúsInstituto de Investigación La PrincesaMadrid 28009Spain Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición Instituto de Salud Carlos IIIMadrid 28029Spain Servicio de Endocrinología y Nutrición Hospital Universitario La PrincesaInstituto de Investigación Sanitaria La PrincesaUniversidad Autónoma de MadridMadrid 28006Spain Instituto de Investigaciones Biomédicas Sols-Morreale(IIBM) CSIC-UAMMadrid 28029Spain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas Madrid 28029Spain

BACKGROUND Skeletal muscle alterations(SMAs)are being increasingly recognized in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD)and appear to be associated with deleterious outcomes in these ***,their actual prevalence and pathophysiology remain to be *** To determine the prevalence of SMAs and to assess the significance of circulating myokines as biomarkers in patients with *** Skeletal muscle strength and muscle mass were measured in a cross-sectional study in a cohort of 62 patients fulfilling MASLD criteria,recruited from the outpatient clinics of a tertiary level *** degree of fibrosis and liver steatosis was studied using abdominal ultrasound and transitional *** and metabolic characteristics as well as serum levels of different myokines were also determined in the MASLD *** analysis was performed comparing results according to liver fibrosis and *** No significant differences were found in both skeletal muscle strength and skeletal muscle mass in patients with MASLD between different stages of liver ***,serum levels of fibroblast growth factor-21(FGF21)were significantly higher in patients with MASLD with advanced hepatic fibrosis(F3-F4)than in those with lower fibrosis stages(F0-F2)(197.49±198.27 pg/mL vs 95.62±83.67 pg/mL;P=0.049).In addition,patients with MASLD with severe hepatosteatosis(S3)exhibited significantly higher serum levels of irisin(1116.87±1161.86 pg/mL)than those with lower grades(S1-S2)(385.21±375.98 pg/mL;P=0.001).CONCLUSION SMAs were uncommon in the patients with MASLD *** serum levels of irisin and FGF21 were detected in patients with advanced liver steatosis and fibrosis,respectively,with potential implications as biomarkers.

关键词： Skeletal muscle alterations Myokines Metabolic dysfunction-associated steatotic liver disease Liver fibrosis Hepatosteatosis

How aging affects bone health via the intestinal micro-environment

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BIOCELL 2024年第3期48卷 353-362页

作者： HUAN HU YUE HUANG FANGZHOU LIU QIAN WANG YANZI YAO School of Stomatology Zunyi Medical UniversityZunyiChina Microbial Resources and Drug Development Key Laboratory of Guizhou tertiary Institution Zunyi Medical UniversityZunyiChina Department of Stomatology Luoyang Maternal and Child Health HospitalLuoyangChina

Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more *** conditions represent a common,costly and chronic burden,not only for elderly but also to society at ***,elucidating the pathophysiology and developing effective therapies for these diseases is of paramount *** advances in research have identiﬁed the gut as a novel and promising target for addressing bone disorders,giving rise to the concept of the“gut-bone axis”.An in-depth review of the latest insights into the effects of age-related physiological changes in the gastrointestinal tract on bone health is presented in this *** examines how the“gut-bone”axis interacts with bone aging across various domains,including metabolism,nutrition,intestinal permeability,immunity,and oxidative stress.

关键词： Gut barrier Skeletal system Senescent Gut-bone axis Gut microbiota

Percutaneous coronary intervention vs. medical therapy in patients on dialysis with coronary artery disease in China

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中华医学杂志(英文版) 2025年第03期

作者： Xie Enmin Wu Yaxin Ye Zixiang He Yong Zeng Hesong Luo Jianfang Chen Mulei Pang Wenyue Xu Yanmin Gao Chuanyu Guo Xiaogang Cai Lin Ji Qingwei Yang Yining Wu Di Yuan Yiqiang Wan Jing Ma Yuliang Zhang Jun Du Zhimin Yang Qing Cheng Jinsong Ding Chunhua Ma Xiang Yin Chunlin Fan Zeyuan Tang Qiang Li Yue Sun Lihua Lu Chengzhi Chi Jufang Yao Zhuhua Gao Yanxiang Yu Changan Ren Jingyi Zheng Jingang Department of Cardiology China-Japan Friendship Hospital Beijing China Department of Cardiology China-Japan Friendship Hospital (Institute of Clinical Medical Sciences) Chinese Academy of Medical Sciences Peking Union Medical College Beijing China Department of Cardiology Fuwai Central China Cardiovascular Hospital Zhengzhou Henan China Department of Cardiology Peking University China-Japan Friendship School of Clinical Medicine Beijing China Department of Cardiology West China Hospital Chengdu Sichuan China Department of Cardiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Cardiology Guangdong Provincial People’s Hospital Guangzhou Guangdong China Department of Cardiology Beijing Chaoyang Hospital Beijing China Department of Cardiology Shengjing Hospital of China Medical University Shenyang Liaoning China Department of Cardiology Second Hospital of Tianjin Medical University Tianjin China Department of Cardiology The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China Department of Cardiology The Third People’s Hospital of Chengdu Chengdu Sichuan China Department of Cardiology The People’s Hospital of Guangxi Zhuang Autonomous Region Nanning Guangxi China Department of Cardiology People’s Hospital of Xinjiang Uygur Autonomous Region Xinjiang China Department of Cardiology Emergency General Hospital Beijing China Department of Cardiology Henan Provincial Chest Hospital Zhengzhou Henan China Department of Cardiology Zhongnan Hospital of Wuhan University Wuhan Hubei China Department of Cardiology Peking University People’s Hospital Beijing China Department of Cardiology Cangzhou Central Hospital of Tianjin Medical University Cangzhou Hebei China Department of Cardiology Dongguan Tungwah Hospital Dongguan Guangdong China Department of Cardiology Tianjin Medical University General Hospital Tianjin China Department of Cardiology

Background: The available evidence regarding the benefits of percutaneous coronary intervention (PCI) on patients receiving dialysis with coronary artery disease (CAD) is limited and inconsistent. This study aimed to evaluate the association between PCI and clinical outcomes as compared with medical therapy alone in patients undergoing dialysis with CAD in ***: This multicenter, retrospective study was conducted in 30 tertiary medical centers across 12 provinces in China from January 2015 to June 2021 to include patients on dialysis with CAD. The primary outcome was major adverse cardiovascular events (MACE), defined as a composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. Secondary outcomes included all-cause death, the individual components of MACE, and Bleeding Academic Research Consortium criteria types 2, 3, or 5 bleeding. Multivariable Cox proportional hazard models were used to assess the association between PCI and outcomes. Inverse probability of treatment weighting (IPTW) and propensity score matching (PSM) were performed to account for potential between-group ***: Of the 1146 patients on dialysis with significant CAD, 821 (71.6%) underwent PCI. After a median follow-up of 23.0 months, PCI was associated with a 43.0% significantly lower risk for MACE (33.9% [n = 278]vs. 43.7% [n = 142]; adjusted hazards ratio 0.57, 95% confidence interval 0.45-0.71), along with a slightly increased risk for bleeding outcomes that did not reach statistical significance (11.1%vs. 8.3%; adjusted hazards ratio 1.31, 95% confidence interval, 0.82-2.11). Furthermore, PCI was associated with a significant reduction in all-cause and cardiovascular mortalities. Subgroup analysis did not modify the association of PCI with patient outcomes. These primary findings were consistent across IPTW, PSM, and competing risk ***: This study indicated that PCI in patients on dialysis with CAD was significantly assoc

关键词： Coronary artery disease Dialysis End-stage renal disease Percutaneous coronary intervention Prognosis

Evaluation of a Possible Effect of In-House Cryoprecipitate Transfusion on Outcome of Severe Upper Gastrointestinal Bleeding: A Retrospective Cohort Study

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Open Journal of Blood Diseases 2019年第1期9卷 20-29页

作者： Hiroshi Fujita Shigeko Nishimura Kazuhiro Sugiyama Department of Transfusion Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan tertiary Emergency Medical Center Tokyo Metropolitan Bokutoh Hospital Tokyo Japan

Purposes: Hypofibrinogenemia is usually complicated with severe and massive upper gastrointestinal (GI) bleeding, especially in liver cirrhosis. In Japan, neither fibrinogen concentrate nor cryoprecipitate (CRYO) is available for cases of acquired hypofibrinogenemia to recover the hemostatic level of fibrinogen rapidly. We prepared and produced in-house CRYO from fresh frozen plasma, and compared mortality between pre-implementation and post-implementation of CRYO. Methods: We performed a retrospective cohort study of patients admitted to our single tertiary medical center with upper GI bleeding from January 2011 to December 2016. The observational control period was from January 2011 to February 2013. From March 2013 to December 2016, we implemented the transfusion of CRYO, which was prepared and produced in our hospital. Clinical outcomes were compared between the patients in the two periods. Patients: Eleven patients in the control period and 10 in the intervention period were eligible for analysis. Results: In-hospital mortality (55% vs. 20%, P = 0.238) and mortality within 24 hour after admission (27% vs. 0%, P = 0.246) tended to be lower in the intervention period than in the control period, although the patients had more severe coagulation on admission than those in the control period. The plasma fibrinogen level before the treatment of hemostasis in the intervention period was higher than that in the control period (80 ± 9 mg/dL vs. 127 ± 15 mg/dL, P Conclusion: Implementation of in-house CRYO transfusion may reduce the rate of mortality due to severe upper GI bleeding.

关键词： Esophageal Varix Resuscitation Mortality Hypofibrinogenemia

Intravesical Migration of Intrauterine Device and Calculi Formation 12 Years Post Missing: A Case Report

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Case Reports in Clinical Medicine 2017年第1期6卷 24-30页

作者： Ahmad Rezaee Azandaryani Pezhman Ghaderzadeh Leili Ebrahimi Farsangi Radiology Department Hamadan University of Medical Sciences Besat Hospital Hamadan Iran Cardiology Department Alborz University of Medical Sciences Karaj Iran

Intraunterine device (IUD) is a safe, effective and feasible method used for reversible contraception worldwide. Transvesical migration of an Intrauterine device (IUD) is a rare complication. We describe a case in whom initially a plain abdominopelvic radiography demonstrated calcified string of an IUD in a 42-year-old woman with recurrent lower urinary symptoms (LUTS) and urinary tract infection since 2 years earlier. The IUD had been inserted 12 years earlier and 3 years after placement of the IUD, the patient experienced an uneventful pregnancy and a successful delivery. Sonographic images and later on the cystoscopic procedure confirmed the diagnosis of transvesical migration of the IUD. The IUD was removed using cystoscopic procedure, leaving no complication.

关键词： Bladder Stone Intrauterine Contraceptive Device Intravesical Migration

Identification of subgroups of self-reported outcomes among breast cancer patients undergoing surgery and chemotherapy:A crosssectional study

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International Journal of Nursing Sciences 2025年第1期12卷 51-58,I0003页

作者： Feixia Ni Tingting Cai Tingting Zhou Changrong Yuan Department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina School of Nursing Fudan UniversityShanghaiChina

Objectives:To identify the subgroups of self-reported outcomes and associated factors among breast cancer patients undergoing surgery and ***:A cross-sectional study was conducted between January and November *** recruited patients from two tertiary hospitals in Shanghai,China,using convenience sampling during their *** were assessed using a questionnaire that included sociodemographic and clinical characteristics,the Patient Reported Outcomes Measurement Information System profile-29(PROMIS-29),and the PROMIS-cognitive function short form *** class analysis was performed to examine possible classes regarding self-reported *** logistic regression analysis was used to determine the associated *** of variance(ANOVA)was conducted for symptoms across the different ***:A total of 640 patients participated in this *** findings revealed three subgroups in terms of self-reported outcomes among breast cancer patients undergoing surgery and chemotherapy:low physical-social-cognitive function,high physical-low cognitive function,and high physical-socialcognitive *** logistic regression analysis showed that age(≥60 years old),menopause,the third chemotherapy cycle,undergoing simple mastectomy and breast reconstruction,duration of disease 3-12 months,stageⅢ/Ⅳcancer,and severe pain were associated factors of the functional decline ***,significant differences in depression and sleep disorders were observed among the three ***:Breast cancer patients receiving surgery and chemotherapy can be divided into three ***,menopause,chemotherapy cycle,surgery type,duration and stage of disease,and severe pain affected the functional decline ***,healthcare professionals should make tailored interventions to address the specific functional rehabilitation and symptom relief needs.

关键词： Breast neoplasms Latent class analysis Function Surgery Chemotherapy

Glomerular filtration rate and comorbidity factors in elderly hospitalizations

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World Journal of Nephrology 2025年第1期14卷 93-98页

作者： Hatice Hamarat Department of Internal Medicine Eskişehir City HospitalEskişehir 26080Türkiye

BACKGROUND With an increase in the elderly population,the frequency of hospitalizations in recent years has also risen at a rapid ***,in turn,has resulted in poor outcomes and costly *** rates increase in elderly patients due to a decline in glomerular filtration rate(GFR).AIM To investigate the connection between GFR and comorbidity and reasons for hospitalization in elderly *** We analyzed patients aged 75 years and over who were admitted to the internal medicine clinic of a tertiary hospital in *** admission,we calculated GFR values using the Modification of Diet in Renal Disease study formula and classified them into six categories:G1,G2,G3a,G3b,G4,and *** analyzed associations with hospitalization diagnoses and comorbidity *** The average age of the patients was 80.8 years(±4.5 years).GFR was 57.287±29.5 mL/kg/1.73 m2 in women and 61.3±31.5 mL/kg/1.73 m2 in men(P=0.106).Most patients were admitted to the hospital at G2 stage(32.8%).The main reasons for hospitalization were anemia(34.4%and 28.6%)and malnutrition(20.9%and 20.8%)in women and men,respectively(P=0.078).The most frequent comor-bidity leading to hospitalization was arterial hypertension(n=168,28%),fo-llowed by diabetes(n=166,27.7%)(P=0.001).CONCLUSION When evaluating geriatric patients,low GFR alone does not provide sufficient ***’comorbid factors should also be taken into *** is no association between low GFR during hospitalization and hospitalization-Hamarat *** and GFR related *** the GFR value before hospitalization will be more informative in such studies.

关键词： Aging Glomerular filtration rate hospitalization Comorbidity Elderly hospitalizations

9-Year Clinical Audit on Complications of Cleft Lip and Palate Charity Surgeries in China Shenzhen Area

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International Journal of Otolaryngology and Head & Neck Surgery 2025年第1期14卷 19-28页

作者： Yangliu Liao Takkun Chow Sikkuen Chow Wenbo Huang Deheng Chen Huizhi Zeng Division of Plastic and Reconstructive Surgery Department of Surgery The University of Hong Kong-Shenzhen Hospital Shenzhen China Department of Surgery The University of Hong Kong Hong Kong China

Background: In developing countries, charity cleft surgical mission is always operated by sporadic surgical teams without systematic follow up and quality assurance. In the past few decades, many mission projects have been held regularly in China. The purpose of this audit was a retrospective analysis of a 9-year cleft lip and palate charity project operated in a tertiary hospital in China Shenzhen Area to evaluate perioperative and postoperative complications. Nevertheless, understanding the risk profile is essential for establishing a sustainable in-house cleft service in Shenzhen. Methods: A detailed analysis of hospital centralized record in the The University of Hong Kong-Shenzhen hospital (HKUSZH) was reviewed since the first charity project held in 2015. The parameters of this audit were focused on perioperative complications including anesthesia related problems, early postoperative complications in patients who underwent primary or secondary cleft surgeries. A total of 430 consecutive admitted cases of 311 non-syndromic cleft lip & palate patients were enrolled into the charity project from June 2015 to July 2024. The main anesthesia related complications that occurred during general anesthesia were respiratory tract problems, while intraoperative complication was excessive bleeding, so as wound local infection and reaction were the main early postoperative complications. Results: In our 9-year clinical audit of 430 cleft lip and palate charity surgeries in Shenzhen, we observed no mortalities and a anesthesia-related complication rate of 1.16%. Specific intraoperative complications included excessive bleeding, while early postoperative issues were dominated by wound infections. The fistula rate of 18.7% post palate repair and the average hospital stay of 3.71 days complete the profile of our surgical outcomes. These data underscore the project’s efficacy and offer a reference for international cleft missions aiming for safe and efficient surgical care. Con

关键词： Cleft Lip Cleft Palate Charity Surgery Complication

Transanal eco-Doppler evaluation after hemorrhoidal artery embolization

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World Journal of Gastroenterology 2024年第17期30卷 2332-2342页

作者： Roberta Tutino Tommaso Stecca Fabrizio Farneti Marco Massani Giulio Aniello Santoro Dipartimento Chirurgia Generale e Specialistica AOU Cittàdella Salute e della Scienza di TorinoTorino 10126Italy Division of General Surgery 1 Treviso Regional HospitalAULSS 2 Marca TrevigianaTreviso 31100Italy Division of Radiology Treviso Regional HospitalAULSS 2 Marca TrevigianaTreviso 31100Italy tertiary Referral Pelvic Floor Center Division of General Surgery 2AULSS 2 Marca TrevigianaTreviso 31100Italy

BACKGROUND Hemorrhoidal artery embolization(Emborrhoid)is a novel method for the treatment of severe hemorrhoidal *** having a technical success rate of 93%-100%,the clinical success ranges between 63%and 94%,with a rebleeding rate of 13.6%.AIM To evaluate the effectiveness of this procedure in reducing hemorrhoidal flow and hemorrhoidal *** This prospective observational pilot study was conducted at Division of General Surgery 1 and tertiary Referral Pelvic Floor Center,Treviso Regional hospital,*** a 2 months period(February-March 2022),consecutive patients with hemorrhoidal bleeding scores(HBSs)≥4,Goligher scores of II or III,failure of non-operative management,and a candidate for Emborrhoid were *** ultrasound with eco-Doppler was performed preoperatively and 1 month after the *** primary endpoint was to quantify the changes in arterial hemorrhoidal flow after *** secondary endpoint was to evaluate the correlation between the flow changes and the *** Eleven patients underwent *** overall pretreatment mean systolic peak(MSP)was 14.66 cm/*** highest MSP values were found in the anterior left lateral(17.82 cm/s at 1 o’clock and 15.88 cm/s at 3 o’clock)and in the posterior right lateral(14.62 cm/s at 7 o’clock and 16.71 cm/s at 9 o’clock)quadrants of the anal *** treatment,the overall MSP values were significantly reduced(P=0.008)although the correlation between MSP and HBS changes was weak(P=0.570).A statistical difference was found between distal embolization compared with proximal embolization(P=0.047).However,the coil landing zone was not related to symptoms improvement(P=1.000).A significant difference in MSP changes was also reported between patients with type 1 and type 2 superior rectal artery(SRA)anatomy(P=0.040).No relationship between hemorrhoidal grades(P=1.000),SRA anatomy(P=1.000)and treatment outcomes was *** The preliminary findings of this pilo

关键词： Hemorrhoidal artery embolization Hemorrhoidal embolization Hemorrhoidal vascularization Transanal eco-Doppler Transanal ultrasound