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Towards an actionable One Health approach

贫困所致传染病(英文) 2024年第2期13卷 77-82页

作者： Zhang Xiao-Xi Lederman Zohar Han Le-Fei Schurer Janna M. Xiao Li-Hua Zhang Zhi-Bing Chen Qiu-Lan Pfeiffer Dirk Ward Michael P. Sripa Banchob Gabri?l Sarah Dhama Kuldeep Acharya Krishna Prasad Robertson Lucy J. Deem Sharon L. Aenishaenslin Cécile Dantas-Torres Filipe Otranto Domenico Grace Delia Wang Yang Li Peng Fu Chao Poeta Patrícia Rahman Md. Tanvir Kassegne Kokouvi Zhu Yong-Zhang Yin Kun Liu Jiming Wang Zhao-Jun Guo Xiao-Kui Gong Wen-Feng Schwartl?nder bernhard Ren Ming-Hui Zhou Xiao-Nong Sydney School of Veterinary Science The University of Sydney Camden Australia tropical Disease Research Center Department of Tropical Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand Laboratory of foodborne parasitic zoonoses Department of translational physiology infectiology and public health Chair Faculty Committee on Internationalisation Faculty of Veterinary Medicine Ghent University Merelbeke Belgium Division of Pathology ICAR-Indian Veterinary Research Institute (IVRI) Bareilly Uttar Pradesh India Department of Livestock Services Animal Quarantine Office-Kathmandu Budhanilkantha Kathmandu Nepal Parasitology Department of Paraclinical Sciences Faculty of Veterinary Medicine Norwegian University of Life Sciences ?s Norway One Government Drive Saint Louis Zoo Institute for Conservation Medicine St. Louis USA Groupe de Recherche en épidémiologie des Zoonoses et Santé Publique (GREZOSP) Faculté de médecine vétérinaire Université de Montréal Saint-Hyacinthe Québec Canada Centre de recherche en santé publique de l Université de Montréal et du CIUSSS du Centre-Sud-de-l’?le-de-Montréal Montréal Québec Canada Department of Immunology Aggeu Magalh?es Institute Oswaldo Cruz Foundation (Fiocruz) Recife Brazil School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Department of Veterinary medicine University of Bari Valenzano Italy Department of Pathobiology Faculty of Veterinary Science Bu-Ali Sina University Hamedan Iran Natural Resources institute University of Greenwich Chatham Maritime UK International Livestock Research institute Nairobi Kenya Director of Key Laboratory of Animal Antimicrobial Resistance Surveillance Ministry of Agriculture and Rural Affairs Beijing People’s Republic of China institute of Animal Science Chinese Academy of Agricultural Sciences Beijing People’s Republic of China Key Laboratory of Ecosystem Network O

Background Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest *** text This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health *** By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.

关键词： One Health Global Health One Health Action Commission Research agenda

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Screening agars for MRSA:evaluation of a stepwise diagnostic approach with two different selective agars for the screening for methicillin-resistant Staphylococcus aureus(MRSA)

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Military Medical Research 2015年第4期3卷 213-219页

作者： Volker Micheel Benedikt Hogan Thomas Koller Philipp Warnke Sabine Crusius Rebecca Hinz Ralf Matthias Hagen Norbert Georg Schwarz Hagen Frickmann Department of tropical medicine at the bernhard nocht institute German Armed Forces Hospital of Hamburg Department of Infectious Disease Epidemiology Bernhard Nocht Institute for Tropical Medicine Hamburg institute for Microbiology Virology and Hygiene University Medicine Rostock

Background: Colonization with methicillin-resistant Staphylococcus aureus(MRSA) poses a hygiene risk that does not spare field hospitals or military medical field camps during military deployments. Diagnostic options for unambiguously identifying MRSA isolates are usually scarce in military environments. In this study, we assessed the stepwise application of two different selective agars for the specific identification of MRSA in screening ***: Nasal swabs from 1,541 volunteers were subjected to thioglycollate broth enrichment and subsequently screened on CHROMagar MRSA selective agar for the identification of MRSA. The MRSA identity of suspiciouslooking colonies was confirmed afterwards or excluded by another selective agar, chrom ID MRSA. All isolates from the selective agars with MRSA-specific colony morphology were identified by biochemical methods and mass ***: The initial CHROMagar MRSA screening identified suspicious colonies in 36 out of 1541 samples. A total of 25 of these 36 isolates showed MRSA-like growth on chrom ID agar. Out of these 25 isolates, 24 were confirmed as MRSA, while one isolate was identified as Staphylococcus kloosii. From the 11 strains that did not show suspicious growth on chrom ID agar, 3 were methicillin-sensitive Staphylococcus aureus(MSSA, with one instance of cocolonization with Corynebacterium spp.), 2 were confirmed as MRSA(with 1 instance of co-colonization with MSSA), 2 were lost during passaging and could not be re-cultured, one could not be identified by the applied approaches, and the remaining 3 strains were identified as Staphylococcus saprophyticus, Staphylococcus hominis(co-colonized with Macrococcus caseolyticus) and Staphylococcus cohnii, ***: The application of the selective agar CHROMagar MRSA alone proved to be too non-specific to allow for a reliable diagnosis of the presence of MRSA. The combined use of two selective agars in a stepwise approach reduced this non-s

关键词： Methicillin-resistant Staphylococcus aureus Selective agar Chromogenic agar Screening Hygiene Stepwise diagnostics CHROMagar Chrom ID agar

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What are the pathways between poverty and malaria in sub-Saharan Africa?A systematic review of mediation studies

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Infectious Diseases of Poverty 2023年第3期12卷 13-30页

作者： Solomon T.Wafula Theresa Habermann Mara Anna Franke Jürgen May Dewi Ismajani Puradiredja Eva Lorenz Johanna Brinkel Department of Infectious Disease Epidemiology Bernhard Nocht Institute for Tropical MedicineHamburgGermany Department of Disease Control and Environmental Health School of Public HealthMakerere UniversityKampalaUganda Charité Global Health Charité Universitätsmedizin BerlinBerlinGermany German Center for Infection Research(DZIF) Partner Site Hamburg-Borstel-Lubeck-RiemsHamburgGermany Department of tropical medicine University Medical Center Hamburg-Eppendorf(UKE)HamburgGermany institute of Medical Biostatistics Epidemiology and InformaticsUniversity Centre of the Johannes Gutenberg UniversityMainzGermany

Background Malaria remains a major burden in sub-Saharan Africa(SSA).While an association between poverty and malaria has been demonstrated,a clearer understanding of explicit mechanisms through which socioeconomic position(SEP)influences malaria risk is needed to guide the design of more comprehensive interventions for malaria risk *** systematic review provides an overview of the current evidence on the mediators of socioeconomic disparities in malaria in *** We searched PubMed and Web of Science for randomised controlled trials,cohort,case-control and cross-sectional studies published in English between January 1,2000 to May 31,*** studies were identified following reviews of reference lists of the studies *** included studies that either(1)conducted a formal mediation analysis of risk factors on the causal pathway between SEP and malaria infections or(2)adjusted for these potential mediators as confounders on the association between SEP and malaria using standard regression *** least two independent reviewers appraised the studies,conducted data extraction,and assessed risk of bias.A systematic overview is presented for the included *** We identified 41 articles from 20 countries in SSA for inclusion in the final *** these,30 studies used cross-sectional design,and 26 found socioeconomic inequalities in malaria *** formal mediation analyses showed limited evidence of mediation of food security,housing quality,and previous antimalarial ***,education,insecticide-treated nets,and nutrition were highlighted in the remaining studies as being protective against malaria independent of SEP,suggesting potential for ***,methodological limitations included the use of cross-sectional data,insufficient confounder adjustment,heterogeneity in measuring both SEP and malaria,and generally low or moderate-quality *** studies considered exposure mediator interactions or considered iden

关键词： Malaria Mediation Socioeconomic disparity Sub-Saharan Africa

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Introduction of invasive mosquito species into Europe and prospects for arbovirus transmission and vector control in an era of globalization

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Infectious Diseases of Poverty 2023年第6期12卷 109-109页

作者： Renke Lühken Norbert Brattig Norbert Becker bernhard nocht institute for tropical medicine Hamburg Germany institute for Dipterology Speyer Germany institute for Organismal Studies (COS) University of Heidelberg Heidelberg Germany

Background Mosquito research in Europe has a long history,primarily focused on malaria *** recent years,invasive mosquito species like the Asian tiger mosquito(Aedes albopictus)and the spread of arboviruses like dengue virus,chikungunya virus or bluetongue virus have led to an intensifcation of research and monitoring in *** risk of further dissemination of exotic species and mosquito-borne pathogens is expected to increase with ongoing globalization,human mobility,transport geography,and climate *** have conducted various studies to understand the ecology,biology,and efective control strategies of mosquitoes and associated *** body Three invasive mosquito species are established in Europe:Asian tiger mosquito(Aedes albopictus),Japanese bush mosquito(***),and Korean bush mosquito(Aedes koreicus).*** is the most invasive species and has been established in Europe since *** the past two decades,there has been an increasing number of outbreaks of infections by mosquito-borne viruses in particular chikungunya virus,dengue virus or Zika virus in Europe primary driven by *** the same time,climate change with rising temperatures results in increasing threat of invasive mosquito-borne viruses,in particular Usutu virus and West Nile virus transmitted by native Culex mosquito *** mosquito control programs require a high level of community participation,going along with comprehensive information campaigns,to ensure source reduction and successful *** strategies for container breeding mosquitoes like *** or Culex species involve community participation,door-to-door control activities in private *** measures can involve integration of sterile insect techniques,applying indigenous copepods,Wolbachia ***,or genetically modifed mosquitoes,which is very unlike to be practiced as standard method in the near *** Climate change and globaliza

关键词： Invasive mosquito Spread Outbreak Mosquito-borne virus Asian tiger mosquito Arbovirus Control strategy Globalization Europe

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An unfolding monkeypox outbreak in Europe and beyond

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Military Medical Research 2023年第2期10卷 277-278页

作者： Gabriel Luz Wallau Rafael Maciel-de-Freitas Jonas Schmidt-Chanasit Departamento de Entomologia and Nucleo de Bioinformatica Instituto Aggeu Magalhaes(IAM)Fundacao Oswaldo Cruz(Fiocruz)Avenida Fernando Simoes Barbosas/nCidade UniversitariaRecifeBrazil Department of Arbovirology Bernhard Nocht Institute for Tropical MedicineWHO Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and ResearchNational Reference Center for Tropical Infectious DiseasesBernhard-Nocht-StraBe 7420359 HamburgGermany Laboratorio de Mosquitos Transmissores de Hematozoarios Instituto Oswaldo CruzFundacao Oswaldo Cruz(Fiocruz)Avenida Brasil4365ManguinhosRio de JaneiroBrazil Faculty of Mathematics Informatics and Natural SciencesUniversity of HamburgOhnhorststrasse 1822609 HamburgGermany

Dear Editor,Monkeypox is a zoonotic disease caused by the monkeypox virus(MPXV),a double-stranded DNA virus in the genus Orthopoxvirus,family *** is known to be transmitted between animals such as rats and squirrels,but animal-to-human and human-to-human transmission has been known in Africa since *** is linked to direct contact with body fluids,skin lesions,and patient items as well as respiratory droplets in case of prolonged face-to-face contact[1].Until recently,only a few cases were associated with travel to endemic countries or contact with infected animals imported from endemic countries.

关键词： Monkeypox virus Poxvirus Zoonotic virus Human transmission

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Epidemiology of co-infections in pregnant women living with human immunodeficiency virus 1 in rural Gabon:a cross-sectional study

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Infectious Diseases of Poverty 2023年第4期12卷 83-92页

作者： Saskia Dede Davi Dearie Glory Okwu Marc Luetgehetmann Frederique Mbang Abba Martin Aepfelbacher Lillian Rene Endamne Ayodele Alabi Rella Zoleko-Manego Ghyslain Mombo-Ngoma Saidou Mahmoudou Marylyn Martina Addo Michael Ramharter Johannes Mischlinger Centre of tropical medicine Bernhard-Nocht Institute for Tropical Medicine and I.Department of MedicineUniversity Medical Center Hamburg-EppendorfHamburgGermany German Centre for Infection Research Partner Site Hamburg-Lübeck-Borstel-RiemsHamburg-Lübeck-Borstel-RiemsHamburgGermany Centre de Recherches Médicales de Lambaréné LambarénéGabon Saskia Dede DaviDearie Glory OkwuFrederique Mbang AbbaAyodele Center for Diagnostics Institute of Medical MicrobiologyVirology and HygieneUniversity Medical Center Hamburg-Eppendorf(UKE)HamburgGermany Albert-Schweitzer Hospital LambarénéGabon Department of Parasitology Leiden University Medical CenterAlbinusdreefThe Netherlands Department for Clinical Immunology of Infectious Diseases and I.Department of medicine University Medical Center Hamburg-EppendorfHamburgGermany

Background There is no recent epidemiological data on HIV infection in Gabon,particularly in pregnant *** close this gap,an HIV-prevalence survey was conducted among Gabonese pregnant women,followed by a cross-sectional case-control study in which the prevalence of various co-infections was compared between HIV-positive and HIV-negative pregnant *** Between 2018 and 2019,data for the HIV-prevalence survey were collected retrospectively in 21 Gabonese antenatal care centres(ANCs).Subsequently,for the prospective co-infection study,all HIV-positive pregnant women were recruited who frequented the ANC in Lambarénéand a comparator sub-sample of HIV-negative pregnant women was recruited;these activities were performed from February 2019 to February *** mean number of coinfections was ascertained and compared between HIV-positive and HIV-negative ***,the odds for being co-infected with at least one co-infection was evaluated and compared between HIV-positive and HIV-negative *** HIV-positivity was 3.9%(646/16,417)among pregnant women.183 pregnant women were recruited in the co-infection study.63%of HIV-positive and 75%of HIV-negative pregnant women had at least one *** was a trend indicating that HIV-negative women were more often co-infected with sexually transmitted infections(STIs)than HIV-positive women[mean(standard deviation,SD):2.59(1.04)vs 2.16(1.35),respectively;P=0.056];this was not the case for vector-borne infections[mean(SD):0.47(0.72)vs 0.43(0.63),respectively;P=0.59].Conclusions Counterintuitively,the crude odds for concomitant STIs was lower in HIV-positive than in HIV-negative *** change of magnitude from the crude to adjustedOR is indicative for a differential sexual risk factor profile among HIV-positive and HIV-negative women in this *** might potentially be explained by the availability of sexual health care counselling for HIV-positive women within the framework of the nati

关键词： HIV Cross-sectional study Pregnancy Sexually transmitted infections Gabon

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Ultrasonography-triggered diagnosis of putrid,ulcero-phlegmonous,hemorrhagic appendicitis and periappendicitis with an atypical symptom pattern:a case report

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Journal of Medical Colleges of PLA(China) 2016年第3期31卷 168-172页

作者： Hagen Frickmann Sven A.Jungblut Department of tropical medicine at the bernhard nocht institute German Armed Forces Hospital of Hamburg institute for Microbiology Virology and HygieneUniversity Medicine Rostock Practice Dr. Jungblut Frankfurt/Main

Background:Asymptomatic and oligosymptomatic appendicitis are rare and challenging diagnoses that should not be *** presentation:A young female patient presented with mild to moderate pain in the middle and lower abdomen,and the results of physical examination,including digital rectal examination,were otherwise *** demonstrated a marked increase of the outer appendiceal diameter up to 12.0mm and a trace of free liquid around the terminal *** surgical exploration and histological examination allowed for a final diagnosis of putrid,ulcero-phlegmonous,hemorrhagic appendicitis and ***:Ultrasonography is increasingly used for the diagnosis of appendiceal inflammation,particularly in military medical *** in the outer appendiceal diameter up to>6.0mm under compression have recently been demonstrated to be indicative of acute *** a minimum,in cases with doubtful physical examination results,ultrasonography should be considered as an element in the diagnosis of acute appendicitis.

关键词： Acute appendicitis Ultrasound Oligosymptomatic Surgery

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Syncope as a health risk for soldiers: Influence of medical history and clinical findings on the sensitivity of head-up tilt table testing

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Journal of Medical Colleges of PLA(China) 2015年第2期30卷 82-90页

作者： Hans-Joachim Gilfrich Lena Marie Heidelmann Franziska Grube Hagen Frickmann Sven Andreas Jungblut The Practice of Dr.Jungblut Frankfurt/Main The Flight medicine Clinic at Fassberg German Armed Forces The Department of tropical medicine at the bernhard nocht institute German Armed Forces Hospital of Hamburg The Department of Microbiology Virology and HygieneUniversity Medicine Rostock

Background: Syncope is a relevant health problem in military environments. Reliable diagnosis is challenging. Tilt table testing is an important tool for syncope diagnosis. The aim of this study was to determine whether signs such as prodromal symptoms, co-morbidity, frequency of syncopal events, body length, body mass index, and electrocardiography(ECG) abnormalities can be used to predict the success of tilt table testing at diagnosing ***: Data from 100 patients with histories of syncope or pre-syncope, who were diagnosed using head-up tilt table testing, were retrospectively analyzed in a cross-sectional analysis. The diagnostic procedure was based upon a modified version of the Westminster protocol without any pharmacological provocation. Results: Patients showing pathological reaction patterns during tilt table testing suffered from prodromal symptoms, such as dizziness and sweating, significantly more often. The patients reported more injuries resulting from syncopal events and more previous syncopal events, and the prevalence of co-morbidity was greater among patients presenting negative findings during tilt testing. An asthenic-leptosomal physique was not confirmed as a risk factor for syncopal events as is the case for idiopathic arterial hypotension. However, patients with pathological reaction patterns during tilt table testing were significantly taller. This finding was detected for both females and males. No significant predictors were found in the ECG patterns of patients showing syncope during tilt table ***: Frequency of prior syncope and prodromal symptoms, and increased body length with an otherwise good state of health influence the predictive value of tilt table testing for syncope diagnosis. In particular, if these factors are present, tilt table testing should be considered part of the diagnostic algorithm for soldiers with recurrent syncope.

关键词： Syncope Head-up tilt testing Predictor Soldiers Assessment Hypotension

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Surveillance of arthropod-borne viruses in Benin,West Africa 2020–2021:detection of dengue virus 3 in Aedes aegypti(Diptera:Culicidae)

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Military Medical Research 2023年第5期10卷 730-732页

作者： Carine Tchibozo Gildas Hounkanrin Anges Yadouleton Alexandra Bialonski Eric Agboli Renke Luhken Jonas Schmidt‑Chanasit Hanna Jost Laboratory of Viral Haemorrhagic Fevers and Arboviruses of Benin 01BP 918CotonouBenin Centre de Recherche Entomologique de Cotonou 01BP 918CotonouBenin Ecole Normale Supérieure de Natitingou National Universityof ScienceTechnologyEngineering and MathematicsAbomeyBenin bernhard nocht institute for tropical medicine WHO Collaborating Centrefor Arbovirus and Haemorrhagic Fever Reference and Research20359 Ham‑burgGermany University of Health and Allied Sciences PMB 31HoGhana Faculty of Mathematics Informatics and Natural SciencesUniversitat Hamburg22609 HamburgGermany

Dear Editor,Dengue virus(DENV,family Flaviviridae,genus Flavivirus)serotypes 1 to 4(DENV-1,-2,-3,and-4)are responsible for more than 100 million infections per year *** of DENV infection can be diverse,reaching from a... 详细信息

关键词： Dengue virus Arbovirus Mosquitoes Aedes aegypti Benin

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Microbiological screenings for infection control in unaccompanied minor refugees： the German Armed Forces Medical Service＇s experience

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Military Medical Research 2018年第1期5卷 33-40页

作者： Winfried Maaβen Dorothea Wiemer Claudia Frey Christina Kreuzberg Egbert Tannich Rebecca Hinz Andreas Wille Andreas Fritsch Ralf Matthias Hagen Hagen Frickmann Department of tropical medicine at the bernhard nocht institute German Armed Forces Hospital of Hamburg Bernhard Nocht Street 74 D-20359 Hamburg Germany German Society for International Cooperation (GIZ) Bonn Germany Department of Molecular Parasitology Bernhard Nocht Institute for Tropical Medicine Hamburg Hamburg Germany institute of Medical Microbiology Virology and Hygiene University Medical Center Hamburg-Eppendorf Hamburg Germany institute for Hygiene and Environment Hamburg Germany Department of Laboratory medicine German Armed Forces Hospital of Hamburg Hamburg Germany NATO Center of Excellence for Military medicine (MilMedCOE) Deployment Health Surveillance Capability (DHSC) Munich Germany institute for Microbiology Virology and Hygiene University Medicine Rostock Rostock Germany

Background:The German Military Medical Service contributed to the medical screening of unaccompanied minor refugees(UMRs)coming to Germany in 2014 and *** this study,a broad range of diagnostic procedures was applied to identify microorganisms with clinical or public health ***,those tests had only been used to screen soldiers returning from tropical *** instance is the first time the approach has been studied in a humanitarian ***:The offered screenings included blood cell counts,hepatitis B serology and microscopy of the stool to look for protozoa and worm eggs as well as PCR from stool samples targeting pathogenic bacteria,protozoa and *** individuals refused certain assessments,their decision to do so was accepted.A total of 219 apparently healthy male UMRs coming from Afghanistan,Egypt,Somalia,Eritrea,Syria,Ghana,Guinea,Iran,Algeria,Iraq,Benin,Gambia,Libya,Morocco,Pakistan,and Palestine were *** UMRs who were examined at the study department were included in the ***:We detected decreasing frequencies of pathogens that included diarrhoea-associated bacteria[Campylobacter(C.)jejuni,enteropathogenic Escherichia(E.)coli(EPEC),enterotoxic ***(ETEC),enteroaggregative ***(EAEC),enteroinvasive ***(EIEC)/Shigella spp.),Giardia(G.)duodenalis,helminths(comprising Schistosoma spp.,Hymenolepis(H.)nana,Strongyloides(S.)stercoralis]as well as hepatitis B *** microorganisms dominated the samples by *** *** was detected in 11.4%of the assessed UMRs,the incidence of newly identified cases in the German population was 4.5 cases per 100,000 ***:We conclude that the applied in-house PCR screening systems,which have proven to be useful for screening military returnees from tropical deployments,can also be used for health assessment of immigrants from the respective *** healthy UMRs may be enterically colonized with a broad variety of

关键词： Refugee Migration Asylum seeker Infection control Screening Gastrointestinal pathogens

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