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Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state

Neural Regeneration research 2024年第10期19卷 2229-2239页

作者： Yubo Wang Ling Zhang Tianjie Lyu Lu Cui Shunying Zhao Xuechun Wang Meng Wang Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical research center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain research BeijingChina research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina beijing Engineering research center of Digital Healthcare for Neurological Diseases BeijingChina

Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effect of DNA methylation on stroke at high levels of inflammation is unclear. In this study, we constructed a hyperinflammatory cerebral ischemia mouse model and investigated the effect of hypomethylation and hypermethylation on the functional outcome. We constructed a mouse model of transient middle cerebral artery occlusion and treated the mice with lipopolysaccharide to induce a hyperinflammatory state. To investigate the effect of DNA methylation on stroke, we used small molecule inhibitors to restrain the function of key DNA methylation and demethylation enzymes. 2,3,5-Triphenyltetrazolium chloride staining, neurological function scores, neurobehavioral tests, enzyme-linked immunosorbent assay, quantitative reverse transcription PCR and western blot assay were used to evaluate the effects after stroke in mice. We assessed changes in the global methylation status by measuring DNA 5-mc and DNA 5-hmc levels in peripheral blood after the use of the inhibitor. In the group treated with the DNA methylation inhibitor, brain tissue 2,3,5-triphenyltetrazolium chloride staining showed an increase in infarct volume, which was accompanied by a decrease in neurological scores and worsening of neurobehavioral performance. The levels of inflammatory factors interleukin 6 and interleukin-1 beta in ischemic brain tissue and plasma were elevated, indicating increased inflammation. Related inflammatory pathway exploration showed significant overactivation of nuclear factor kappa B. These results suggested that inhibiting DNA methylation led to poor functional outcome in mice with high inflammation following stroke. Further, the effects were reversed by inhibition of DNA demethylation. Our findings suggest that DNA methylation regulates the inflammatory response in stroke

关键词： DNA demethylation DNA methylation DNMT3A functional outcome hyperinflammatory state interleukin neuroinflammation stroke TET2

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Diagnosing Thermalization Dynamics of Non-Hermitian Quantum Systems via GKSL Master Equations

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Chinese Physics Letters 2024年第7期41卷 1-11页

作者：毛奕廷钟佩耕林海青王孝群胡时杰 beijing Computational Science research center Beijing 100084China School of Physics Zhejiang UniversityHangzhou 310058China Department of Physics Beijing Normal UniversityBeijing 100875China

The application of the eigenstate thermalization hypothesis to non-Hermitian quantum systems has become one of the most important topics in dissipative quantum chaos, recently giving rise to intense debates. The process of thermalization is intricate, involving many time-evolution trajectories in the reduced Hilbert space of the system. By considering two different expansion forms of the density matrices adopted in the biorthogonal and right-state time evolutions, we derive two versions of the Gorini–Kossakowski–Sudarshan–Lindblad(GKSL)master equations describing the non-Hermitian systems coupled to a bosonic heat bath in thermal equilibrium. By solving the equations, we identify a sufficient condition for thermalization under both time evolutions, resulting in Boltzmann biorthogonal and right-eigenstate statistics, respectively. This finding implies that the recently proposed biorthogonal random matrix theory needs an appropriate revision. Moreover, we exemplify the precise dynamics of thermalization and thermodynamic properties with test models.

关键词： quantum implies precise

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Control of electromechanical performance in 3D printing latticestructured BaTiO_(3) piezoelectric ceramics

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Journal of Advanced Ceramics 2024年第7期13卷 987-1001页

作者： Zhujun Jiang Yinghong Sun Jimin Chen Yong Zeng Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China beijing Engineering research center of 3D Printing for Digital Medical Health Beijing University of TechnologyBeijing 100124China

Barium titanate(BaTiO_(3))piezoelectric ceramics with triply periodic minimal surface(TPMS)structures have been frequently used in filters,engines,artificial bones,and other fields due to their high specific surface area,high thermal stability,and good heat ***,only a limited number of studies have analyzed the effect of various parameters,such as different wall thicknesses and porosities of TPMS structures,on ceramic electromechanical *** this study,we first employed vat photopolymerization(VPP)three-dimensional(3D)printing technology to fabricate high-performance BaTiO_(3) *** investigated the slurry composition design and forming process and designed a stepwise sintering postprocessing technique to achieve a density of 96.3%and a compressive strength of 250±25 MPa,with the piezoelectric coefficient(d_(33))reaching 263 pC/***,we explored the influence of three TPMS structures,namely,diamond,gyroid,and Schwarz P,on the piezoelectric and mechanical properties of BaTiO_(3) ceramics,with the gyroid structure identified as exhibiting optimal ***,we examined the piezoelectric and mechanical properties of BaTiO_(3) ceramics with the gyroid structure of varying wall thicknesses and porosities,thus enabling the modulation of ceramic electromechanical performance.

关键词： three-dimensional(3D)printing piezoelectric ceramics porous structure mechanical properties electrical properties

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The Burden of Hypertension-Related Chronic Kidney Disease—China,2010–2019

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China CDC weekly 2024年第14期6卷 282-288页

作者： Youyuan Bu Yueru Liu Maigeng Zhou Peng Yin Kejun Liu Yamin Bai Xuancheng Lu Chinese center for Disease Control and Prevention BeijingChina National center for Chronic and Non-Communicable Disease Control and Prevention Chinese Center For Disease Control and PreventionBeijingChina China National Health Development research center BeijingChina

What is already known about this topic?The global burden of chronic kidney disease(CKD)is on the *** is added by this report?In 2019,5.58 million individuals in China were affected by CKD related to hypertension,leading to 70,260 fatalities and 1.69 million disability-adjusted life years(DALYs).The most affected groups were men,older individuals,and residents of western *** the period from 2010–2019,the age-standardized prevalence rate(ASPR)remained constant,and the agestandardized mortality rate(ASMR)and agestandardized DALY rate(ASDR)showed a decreasing ***,there was an increase in the number of cases,deaths,and DALYs associated with this *** are the implications for public health practice?Hypertension significantly contributes to the burden of CKD;therefore,raising awareness and implementing early screening measures are essential.

关键词： Kidney mortality burden

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TIMP-1 Promotes Expression of MCP-1 and Macrophage Migration by Inducing Fli-1 in Experimental Liver Fibrosis

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 634-645页

作者： Xiaoli Huang Xiaofan Wang Yanhong Wang Shuangjun Shen Wei Chen Tianhui Liu Ping Wang Xu Fan Lin Liu Jidong Jia Min Cong Liver research center Beijing Friendship HospitalCapital Medical UniversityBeijingChina beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical research center of Digestive Disease BeijingChina Dongying People’s Hospital DongyingShandongChina Experimental and Translational research center Beijing Friendship HospitalCapital Medical UniversityBeijingChina

Background and Aims:Tissue inhibitor of metalloproteinase-1(TIMP-1)plays a role in the excessive generation of extracellular matrix in liver *** study aimed to explore the pathways through which TIMP-1 controls monocyte chemoattractant protein-1(MCP-1)expression and promotes hepatic macrophage ***:Liver fibrosis was triggered through carbon tetrachloride,and an adenoassociated virus containing small interfering RNA targeting TIMP-1(siRNA-TIMP-1)was administered to both rats and *** assessed the extent of fibrosis and macrophage *** molecular mechanisms regulating macrophage recruitment by TIMP-1 were investigated through transwell migration assays,luciferase reporter assays,the use of pharmacological modulators,and an analysis of extracellular vesicles(EVs).Results:siRNA-TIMP-1 alleviated carbon tetrachloride-induced liver fibrosis,reducing macrophage migration and MCP-1 ***-culturing macrophages with hepatic stellate cells(HSCs)post-TIMP-1 downregulation inhibited macrophage *** siRNATIMP-1-treated HSCs,microRNA-145(miRNA-145)expression increased,while the expression of Friend leukemia virus integration-1(Fli-1)and MCP-1 was *** of Fli-1 led to decreased MCP-1 expression,whereas Fli-1 overexpression increased MCP-1 expression within *** with miRNA-145 mimics reduced the expression of both Fli-1 and MCP-1,while miRNA-145 inhibitors elevated the expression of both Fli-1 and MCP-1 in ***-145 bound directly to the 3'-UTR of Fli-1,and mi RNA-145-EN-riched EVs secreted by HSCs after TIMP-1 downregulation influenced macrophage ***:TIMP-1 induces Fli-1 expression through miRNA-145,subsequently increasing MCP-1 expression and macrophage ***-145-enriched EVs from HSCs can transmit biological information and magnify the function of TIMP-1.

关键词： TIMP-1 Fli-1 MCP-1 miRNA-145 Liver fibrosis Extracellular vesicles

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A Composite Ansatz for Calculation of Dynamical Structure Factor

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Chinese Physics Letters 2024年第1期41卷 92-103页

作者：张玉佩莫崇杰张平康炜 HEDPS Center for Applied Physics and Technologyand School of PhysicsPeking UniversityBeijing 100871China beijing Computational Science research center Beijing 100193China Institute of Applied Physics and Computational Mathematics Beijing 100088China HEDPS Center for Applied Physics and Technologyand College of EngineeringPeking UniversityBeijing 100871China

We propose an ansatz without adjustable parameters for the calculation of a dynamical structure *** ansatz combines the quasi-particle Green’s function,especially the contribution from the renormalization factor,and the exchange-correlation kernel from time-dependent density functional theory together,verified for typical metals and semiconductors from a plasmon excitation regime to the Compton scattering *** has the capability to reconcile both small-angle and large-angle inelastic x-ray scattering(IXS)signals with muchimproved accuracy,which can be used as the theoretical base model,in inversely inferring electronic structures of condensed matter from IXS experimental signals *** may also be used to diagnose thermal parameters,such as temperature and density,of dense plasmas in x-ray Thomson scattering experiments.

关键词： excitation inverse verified

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Simulations of superconducting quantum gates by digital flux tuner for qubits

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Chinese Physics B 2024年第7期33卷 210-222页

作者：耿霄何楷泳刘建设陈炜 Laboratory of Superconducting Quantum Information Processing School of Integrated CircuitsTsinghua UniversityBeijing 100084China beijing Innovation center for Future Chips Tsinghua UniversityBeijing 100084China beijing National research center for Information Science and Technology Beijing 100084China26

The interconnection bottleneck caused by limitations of cable number, inner space and cooling power of dilution refrigerators has been an outstanding challenge for building scalable superconducting quantum computers with the increasing number of qubits in quantum processors. To surmount such an obstacle, it is desirable to integrate qubits with quantum–classical interface(QCI) circuits based on rapid single flux quantum(RSFQ) circuits. In this work, a digital flux tuner for qubits(DFTQ) is proposed for manipulating flux of qubits as a crucial part of the interface circuit. A schematic diagram of the DFTQ is presented, consisting of a coarse tuning unit and a fine-tuning unit for providing magnetic flux with different precision to qubits. The method of using DFTQ to provide flux for gate operations is discussed from the optimization of circuit design and input signal. To verify the effectiveness of the method, simulations of a single DFTQ and quantum gates including a Z gate and an iSWAP gate with DFTQs are performed for flux-tunable transmons. The quantum process tomography corresponding to the two gates is also carried out to analyze the sources of gate error. The results of tomography show that the gate fidelities independent of the initial states of the Z gate and the iSWAP gate are 99.935% and 99.676%,respectively. With DFTQs inside, the QCI would be a powerful tool for building large-scale quantum computers.

关键词： quantum computation superconducting electronics quantum control

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Microstructure evolution and strengthening mechanism of high -performance powder metallurgy TA15 titanium alloy by hot rolling

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1426-1436页

作者： Ying Gao Ce Zhang Jiazhen Zhang Xin Lu beijing Advanced Innovation center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsInstitute for Advanced Ma-terials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China National Engineering research center for Advanced Rolling Technology National Engineering Research Center for Flat Rolling EquipmentInstitute of Engin-eering TechnologyUniversity of Science and Technology BeijingBeijing 100083China

Hot deformation of sintered billets by powder metallurgy(PM)is an effective preparation technique for titanium alloys,which is more significant for high-alloying *** this study,Ti–6.5Al–2Zr–Mo–V(TA15)titanium alloy plates were prepared by cold press-ing sintering combined with high-temperature hot *** microstructure and mechanical properties under different process paramet-ers were *** microscope,electron backscatter diffraction,and others were applied to characterize the microstructure evolution and mechanical properties strengthening *** results showed that the chemical compositions were uniformly dif-fused without segregation during sintering,and the closing of the matrix craters was accelerated by increasing the sintering *** block was hot rolled at 1200℃ with an 80%reduction under only two passes without *** strength and elongation of the plate at 20–25℃ after solution and aging were 1247 MPa and 14.0%,respectively,which were increased by 24.5%and 40.0%,respect-ively,compared with the as-sintered alloy at 1300℃.The microstructure was significantly refined by continuous dynamic recrystalliza-tion,which was completed by the rotation and dislocation absorption of the substructure surrounded by low-angle grain *** hot rolling combined with heat treatment,the strength and plasticity of PM-TA15 were significantly improved,which resulted from the dense,uniform,and fine recrystallization structure and the synergistic effect of multiple slip systems.

关键词： elemental powder powder metallurgy titanium alloy hot rolling strength and plasticity

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Trace inequalities, isocapacitary inequalities, and regularity of the complex Hessian equations

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Science China Mathematics 2024年第3期67卷 557-576页

作者： Jiaxiang Wang Bin Zhou beijing International center for Mathematical research Peking UniversityBeijing 100871China School of Mathematical Sciences Peking UniversityBeijing 100871China

In this paper, we study the relations between trace inequalities(Sobolev and Moser-Trudinger types), isocapacitary inequalities, and the regularity of the complex Hessian and Monge-Amp`ere equations with respect to a general nonnegative Borel measure. We obtain a quantitative characterization for these relations through the properties of the capacity-minimizing functions.

关键词： complex Monge-Ampère equations plurisubharmonic functions Sobolev inequality Moser-Trudinger inequality

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Strengthening Organizational Support Is Essential for the High-Quality Development of Disease Prevention and Control Initiatives

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China CDC weekly 2024年第38期6卷 982-985页

作者： Ying Cui Qingfeng Chen Hao Chen Kaixuan Liu Yuan Wang Chengyu Lai Zhi Zeng Jun Yan Office of Policy and Planning research Chinese Center for Disease Control and PreventionBeijingChina Chinese center for Disease Control and Prevention BeijingChina

Organizational security in public health encompasses structural and supportive measures designed to ensure public health security and effectively prevent and control disease *** measures include organizational leadership,investment mechanisms,information technology support,scientific research,and international exchange and *** prevention and control is often described as an“invisible war”,emphasizing the need for preparedness and proactive measures(1).As the adage states,“Before soldiers and horses move,food and grass go first,”highlighting the critical role of a robust organizational security foundation for successful disease prevention and control *** foundation is essential for promoting high-quality development within the *** its 14th Five-Year Plan period,the Chinese government has implemented policies to bolster organizational *** this commitment,on December 25,2023,the State Council issued the“Guiding Opinions on Promoting the High-Quality Development of Disease Prevention and Control.”

关键词： prevention measures foundation

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