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Analysis of factors impacting postoperative pain and quality of life in patients with mixed hemorrhoids:A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 731-739页

作者： Xiao-Wen Sun Jing-Yi Xu chang-Zhen Zhu Si-Jia Li Lu-Jia Jin Zhi-Dong Zhu Department of Gastrointestinal Surgery Tsinghua University Affiliated Beijing Tsinghua Changgeng HospitalBeijing 102218China Surgical Department Tsinghua University Affiliated Beijing Tsinghua Changgeng HospitalBeijing 102218China

BACKGROUND Hemorrhoids are among the most common and frequently encountered chronic anorectal diseases in anorectal *** are venous clusters formed by con-gestion,expansion,and flexion of the venous plexus in the lower part of the *** hemorrhoids bleed easily and recurrently,and this can result in severe ***,they may have a negative effect on the health of the patient and surgical treatment is ***-Morgan hemorrhoidectomy has been widely used since 1937 for the treatment of grade III and IV ***-ever,most patients experience different degrees of postoperative pain that may cause *** mixed hemorrhoids *** The clinical data of patients with mixed hemorrhoids who underwent Milligan-Morgan hemorrhoidectomy were collected *** basic character-istics of the enrolled patients with mixed hemorrhoids were recorded,and based on the Goligher clinical grading system,the hemorrhoids were classified as grades III or *** endpoint of this study was the disappearance of pain in all *** data were presented as mean±SD,such as age,pain score,and QoL ***’s t-test was used to compare the *** A total of 164 patients were *** distribution of the visual analog scale pain scores of all patients at 3,7,14 and 28 d after surgery showed that post-surgery pain was significantly reduced with the passage of *** days after the operation,the pain had completely disappeared in some ***-eight days after the surgery,none of the patients experienced any *** the World Health Or-ganization Quality of Life-BREF self-reporting questionnaire scores of patients between 14 and 28 d after surgery,we observed that the quality-of-life scores of the patients post-surgery had significantly *** were six items that were compared at 14-and 28-d *** mean QoL score 28 d after surgery(4.79±0.46)was higher than that at 14 d p

关键词： Hemorrhoids Mixed hemorrhoids Milligan organ hemorrhoidectomy Postoperative pain Quality of life Anesthesia mode

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Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning Dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai Jessica D.Eisner Li Xie Minhu Chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China Department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda Development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CI<0%)was also *** 12 weeks,endoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

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RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 307-318页

作者： Lu Xu Zhi-Hao Xie Jun Li Shi Tao Fang-Li Ren Yin-Yin Wang Zhi-Jie chang Xin-Bao Hao Department of Hematology The First Affiliated Hospital of Hainan Medical UniversityHaikou570102China State Key Laboratory of Membrane Biology School of MedicineTsinghua UniversityBeijing 100084China Heya beijing Med-Biotech Inc. Beijing 100084China Department of Hematology Roswell Park Comprehensive Cancer CenterNY 14263USA

Objective:To investigate the role of RPRD1B in the progression of diffuse large B-cell lymphoma(DLBCL)and its potential as a therapeutic ***:This study analyzed RPRD1B expression in DLBCL and normal tissues using public databases and assessed its prognostic impact through survival *** vitro and in vivo experiments were conducted to explore the mechanisms by which RPRD1B influences tumor growth and ***:RPRD1B expression was significantly elevated in DLBCL compared to normal tissues and was associated with poor *** vitro and in vivo experiments demonstrated that RPRD1B promoted lymphoma cell proliferation and inhibited apoptosis through the NF-κB signaling ***:RPRD1B plays a critical role in the progression of DLBCL by modulating apoptosis and cellular *** RPRD1B may offer a novel therapeutic strategy for DLBCL,suggesting its potential as a prognostic marker and therapeutic target in hematological malignancies.

关键词： RPRD1B RNAPⅡ Diffuse large B-cell lymphoma NF-κB Apoptosis

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Pathological diagnosis and immunohistochemical analysis of giant retrosternal goiter in the elderly: A case report

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World Journal of Clinical Cases 2024年第3期12卷 643-649页

作者： Yong-chang Meng Liu-Sheng Wu Ning Li Hong-Wei Li Jing Zhao Jun Yan Xiao-Qiang Li Peng Li Jiang-Qi Wei Department of Cardiothoracic Surgery Xinxiang First People's HospitalXinxiang 453000Henan ProvinceChina School of Clinical Medicine Tsinghua UniversityBeijing 100084China Graduate School Qinghai UniversityXining 810016Qinghai ProvinceChina Department of Pathology Xinxiang First People's HospitalXinxiang 453000Henan ProvinceChina Department of Thoracic Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina

BACKGROUND Elderly giant retrosternal thyroid goiter is a rare yet significant medical condition,often presenting clinical symptoms that can be confused with other diseases,posing diagnostic and therapeutic *** study aims to delve into the characteristics and potential mechanisms of this ailment through pathological diagnosis and immunohistochemical analysis,providing clinicians with more precise diagnostic and treatment strategies.A 77-year-old male,was admitted to hospital with the chief complaint of finding a goiter in the semilunar month during physical examination,accompanied by *** protruding into the superior mediastinum,the adjacent structure was compressed,the trachea was compressed to the right,and the local lumen was slightly *** patient was diagnosed with giant retrosternal *** dyspnea caused by trachea compression,our department planned to perform giant retrosternal *** results:Tg(+),TTF-1(+),Calcitonin(CT)(I),Ki-67(+,about 20%),CD34(-).Retrosternal goiter means that more than 50%of the volume of the thyroid gland is below the upper margin of the *** retrosternal goiter disease is a relatively rare disease,once the disease is diagnosed,it should be timely surgical treatment,and the treatment is more difficult,the need for professional medical team for comprehensive *** The imaging manifestations of giant retrosternal goiter are atypical,histomorphology and immunohistochemistry can assist in its *** article reviews the relevant literature of giant retrosternal goiter immunohisto-chemistry and shows that giant retrosternal goiter is positive for Tg,TTF-1,and Ki-67.

关键词： Giant retrosternal goiter Pathology Immunohistochemistry Case report

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Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma

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Oncology Research 2024年第4期32卷 679-690页

作者： XINFENG ZHANG SHUANG LI MEIRU SONG YUE CHEN LIANGZHENG chang ZHERUI LIU HONGYUAN DAI YUTAO WANG GANGQI YANG YUN JIANG YINYING LU The PLA 307 Clinical College of Anhui Medical University The Fifth Clinical Medical College of Anhui Medical UniversityHefei230032China Liver Tumor Diagnosis and Research Center 5th Medical Center of the PLA General HospitalBeijing100039China Department of Infection Diseases Guizhou Medical UniversityGuiyang550025China 4302 Clinical Medical School Peking UniversityBeijingChina Cell and Gene Therapy Innovation Center Beijing Lotuslake BiomedicalScience and Technology ParkBeijing102206China State Key Laboratory of Chemical Oncogenomics and the Institute of Biopharmaceutical and Health Engineering(iBHE) Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China

Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality *** and recurrence primarily contribute to the high mortality rate of liver *** carcinoma(HCC)has low expression of focal adhesion kinase(FAK),which increases the risk of metastasis and ***,the efficacy of FAK phosphorylation inhibitors is currently ***,investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC *** study examined the correlation between FAK expression and the prognosis of ***,we explored the impact of FAK degradation on HCC metastasis through wound healing experiments,transwell invasion experiments,and a xenograft tumor *** expression of proteins related to epithelial-mesenchymal transition(EMT)was measured to elucidate the underlying *** results showed that FAK PROTAC can degrade FAK,inhibit the migration and invasion of HCC cells in vitro,and notably decrease the lung metastasis of HCC in *** expression of E-cadherin and decreased expression of vimentin indicated that EMT was ***,degradation of FAK through FAK PROTAC effectively suppressed liver cancer metastasis,holding significant clinical implications for treating liver cancer and developing innovative anti-neoplastic drugs.

关键词： Hepatocellular carcinoma(HCC) Focal adhesion kinase(FAK) Proteolytic targeting chimera technology(PROTAC) Epithelial-mesenchymal transformation(EMT) Metastasis

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Non-coding RNAs expression in SARS-CoV-2 infection:pathogenesis,clinical significance,and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第1期9卷 55-78页

作者： Xiaoxing Liu Wandi Xiong Maosen Ye Tangsheng Lu Kai Yuan Suhua chang Ying Han Yongxiang Wang Lin Lu Yanping Bao Peking University Sixth hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)100191 BeijingChina Peking-tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research Peking University100871 BeijingChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan University570228 HaikouChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of Sciences650204 KunmingYunnanChina National Institute on Drug Dependence and beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Institute of Brain Science and Brain-inspired Research Shandong First Medical University&Shandong Academy of Medical Sciences250117 JinanShandongChina Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina School of Public Health Peking University100191 BeijingChina

The coronavirus disease 2019(COVID-19)pandemic has been looming globally for three years,yet the diagnostic and treatment methods for COVID-19 are still undergoing extensive exploration,which holds paramount importance in mitigating future *** non-coding RNAs(ncRNAs)display aberrations in the context of ***,microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs)exhibit a close association with viral infection and disease *** this comprehensive review,an overview was presented of the expression profiles of host ncRNAs following SARS-CoV-2 invasion and of the potential functions in COVID-19 development,encompassing viral invasion,replication,immune response,and multiorgan deficits which include respiratory system,cardiac system,central nervous system,peripheral nervous system as well as long ***,we provide an overview of several promising host ncRNA biomarkers for diverse clinical scenarios related to COVID-19,such as stratification biomarkers,prognostic biomarkers,and predictive biomarkers for treatment *** addition,we also discuss the therapeutic potential of ncRNAs for COVID-19,presenting ncRNA-based strategies to facilitate the development of novel *** an in-depth analysis of the interplay between ncRNA and COVID-19 combined with our bioinformatic analysis,we hope to offer valuable insights into the stratification,prognosis,and treatment of COVID-19.

关键词： invasion therapeutic infection

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Single-cell immune landscape of measurable residual disease in acute myeloid leukemia

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Science China Life Sciences 2024年

作者： Xiaodong Mo Weilong Zhang Guomei Fu Yingjun chang Xiaohui Zhang Lanping Xu Yu Wang Chenhua Yan Mengzhu Shen Qiuxia Wei changjian Yan Xiaojun Huang Peking University People's hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Department of Hematology Lymphoma Research Center Peking University Third Hospital Peking-tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical Sciences

Measurable residual disease(MRD) is a powerful prognostic factor of relapse in acute myeloid leukemia(AML). We applied the single-cell RNA sequencing to bone marrow(BM) samples from patients with(n=20) and without(n=12) MRD after allogeneic hematopoietic stem cell transplantation. A comprehensive immune landscape with 184,231 cells was created. Compared with CD8+T cells enriched in the MRDnegative group(MRD-＿CD8), those enriched in the MRD-positive group(MRD+＿CD8) showed lower expression levels of cytotoxicity-related genes. Three monocyte clusters(i.e., MRD+＿M) and three B-cell clusters(i.e., MRD+＿B) were enriched in the MRD-positive group. Conversion from an MRD-positive state to an MRD-negative state was accompanied by an increase in MRD-＿CD8 clusters and vice versa. MRDenriched cell clusters employed the macrophage migration inhibitory factor pathway to regulate MRD-＿CD8 clusters. These findings revealed the characteristics of the immune cell landscape in MRD positivity, which will allow for a better understanding of the immune mechanisms for MRD conversion.

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Role of Liquid-based Cytology and Cell Block in the Diagnosis of Endometrial Lesions

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Chinese Medical Journal 2016年第12期129卷 1459-1463页

作者： Hui Zhang Jia Wen Pi-Li Xu Rui Chen Xi Yang Lian-Er Zhou Ping Jiang An-Xia Wan Qin-Ping Liao Department of Obstetrics and Gynecology Xuanwu Hospital Capital Medical University Beijing 100053 China Department of Obstetrics and Gynecology Tsinghua Chang Gung Hospital Beijing 102218 China

Background： Liquid-based cytology （LBC） offers an alternative method to biopsy in screening endometrial cancer. Cell block （CB）, prepared by collecting residual cytological specimen, represents a novel method to supplement the diagnosis of endometrial cytology. This study aimed to compare the specimen adequacy and diagnostic accuracy of LBC and CB in the diagnosis of endometrial lesions. Methods： A total of 198 women with high risks of endometrial carcinoma （EC） from May 2014 to April 2015 were enrolled in this study. The cytological specimens were collected by the endometrial sampler （SAP-1 ） followed by histopathologic evaluation of dilatation and curettage or biopsy guided by hysteroscopy. The residual cytological specimens were processed into paraffin-embedded CB after LBC preparation. Diagnostic accuracies of LBC and CB for detecting endometrial lesions were correlated with histological diagnoses. Chi-square test was used to compare the specimen adequacies of LBC and CB. Results： The specimen inadequate rate of CB was significantly higher than that of LBC （22.2% versus 7.1%, P 〈 0.01）. There were 144 cases with adequate specimens for LBC and CB preparation. Among them, 29 cases were atypical endometrial hyperplasia （ 11 cases） or carcinoma （18 cases） confirmed by histology evaluation. Taking atypical hyperplasia and carcinoma as positive, the diagnostic accuracy of CB was 95.1% while it was 93.8% in LBC. When combined LBC with CB, the diagnostic accuracy was improved to 95.8%, with a sensitivity of 89.7% and specificity of 97.4%. Conclusions： CB is a feasible and reproducible adjuvant method for screening endometrial lesions. A combination of CB and LBC can improve the diagnostic accuracy of endometrial lesions.

关键词： Atypical Endometrial Hyperplasia Cytological Technique Endometrial Carcinoma Paraffin Embedding Sensitivity Specificity

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Synergy stent for treating unprotected left main stenosis with the large reference vessel diameter

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Journal of Geriatric Cardiology 2020年第6期17卷 365-372页

作者： Wen-Long XING Hong-Xu LIU Ai-Yong LI Qi ZHOU Da-Wei ZHANG Chiung-Jen WU Wei TIAN Teng-Fei LI Zi-Hao LIU Department of Cardiology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijingChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaiwanChina

For many years,unprotected left main stenosis(ULMS)has been remained as the forbidden fruit of interventional ***,with the remarkable improvement in medical device technology,procedural techniques and antithrombotic agents during the last decades,percutaneous coronary intervention(PCI)with stenting for ULMS has become technically feasible and has exhibited favorable clinical outcomes.

关键词： stenosis stent protected

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Factors relating to bone mineral density in young and middle-aged patients with ankylosing spondylitis

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Chinese Medical Journal 2021年第21期134卷 2556-2563页

作者： Xin Wu Jia-Yun Zhong Geng Wang Hu-ji Xu department of Rheumatology and Immunology Changzheng HospitalSecond Military Medical UniversityShanghai 200003China Graduate School Second Military Medical UniversityShanghai 200433China University of Queensland Diamantina Institute University of QueenslandBrisbaneAustralia Peking-tsinghua Center for Life Sciences Tsinghua UniversityBeijing 100083China beijing tsinghua chang gung hospital School of Clinical MedicineTsinghua UniversityBeijing 102218China

Background:Ankylosing spondylitis(AS)is a common chronic progressive rheumatic *** aim of this study was to explore factors influencing abnormal bone mineral density(BMD)in young and middle-aged patients with ***:From July 2014 to August 2018,hospitalized patients with AS and health examinees in the health examination center of our clinics,ranging in age from 20 to 50 years,were *** BMD of the lumbar spine and femoral neck of AS patients and those of a healthy control group were measured using dual-energy X-ray *** BMDs of AS patients were compared with respect to age,course of disease,iritis,smoking habits,sex,height,weight,body mass index(BMI),medication use,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),platelet volume,platelet count,uric acid(UA),alkaline phosphatase(AKP),and calcium ion ***-nucleotide polymorphisms(SNPs)related to BMD were screened using genome-wide association ***:There was no statistical difference in the proportion of abnormal bone masses between the different body *** BMD of all bones in AS patients was lower than that in healthy controls(P<0.05).Additionally,BMD was correlated with serum calcium and CRP in AS patients(P<0.05),but not with age,platelet volume,platelet count,ESR,UA,AKP,height,weight,and *** incidence of abnormal bone mass in AS patients was correlated with sex(P<0.05),but not with medication use,iritis,or *** of the lumbar spine in AS patients did not correlate linearly with the course of the disease,but BMD of the femoral neck correlated linearly with the course of the disease(P<0.05).BMD was correlated with multiple SNPs in patients with *** BMD was correlated with rs7025373 and *** head BMD was correlated with 3:102157365,3:102157417,rs1252202,rs1681355,rs3891857,rs7842614,and rs9870734,suggesting that genetic factors play a role in BMD in patients with ***:The proportion of abnormal bone mass in AS pat

关键词： Ankylosing spondylitis Bone mineral density Genome-wide association analysis

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