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Inhibitory activity of medicinal mushroom Ganoderma lucidum on co.orectal cancer by attenuating inflammation

Precision Clinical medicine 2021年第4期4卷 231-245页

作者： Mandy M.Liu Tiantian Liu Steven Yeung Zhijun Wang Bradley Andresen Cyrus Parsa Robert Orlando Bingsen Zhou Wei Wu Xia Li Yilong Zhang Charles Wang Ying Huang Department of Pharmaceutical Sciences College of PharmacyWestern University of Health SciencesPomonaCA 91766USA Center for Genomics&Department of Basic Sciences School of MedicineLoma Linda UniversityLoma LindaCA 92350USA Department of Pharmaceutical Sciences College of PharmacyMarshall B.Ketchum UniversityFullertonCA 92831USA co.lege of Osteopathic medicine of the Pacific Western University of Health SciencesPomonaCA 91766USA Department of Pathology Beverly HospitalMontebelloCaliforniaCA 90640USA beijing tong ren tang chinese medicine co. Ltd.New TerritoriesHong Kong 999077China

The medicinal mushroom Ganoderma lucidum(GL,Reishi or Lingzhi)exhibits an inhibitory effect on ***,the underlying mechanism of the antitumor activity of GL is not fully *** this study,we characterized the gene networks regulated by a co.mercial product of GL co.taining a mixture of spores and fruiting bodies namely“GLSF”,in co.orectal *** found that in vitro co.administration of GLSF extract at non-toxic co.centrations significantly potentiated growth inhibition and apoptosis induced by paclitaxel in CT26 and HCT-15 *** inhibited NF-κB promoter activity in HEK-293 cells but did not affect the function of P-glyco.rotein in K562/DOX ***,we found that when mice were fed a modified diet co.taining GLSF for 1 month prior to the CT26 tumor cell inoculation,GLSF alone or co.bined with Nab-paclitaxel markedly suppressed tumor growth and induced ***-seq analysis of tumor tissues derived from GLSF-treated mice identified 53 differentially expressed genes co.pared to normal *** of the GLSFdown-regulated geneswere involved in NF-κB-regulated inflammation pathways,such as IL-1β,IL-11 and *** enrichment analysis suggested that several inflammatory pathways involving leukocytemigration and adhesion were most affected by the *** analysis predicted activation of multiple tumor suppressors such asα-catenin and TP53 and inhibition of critical inflammatory mediators.“Cancer”was the major significantly inhibited biological effect of GLSF *** results demonstrate that GLSF can improve the therapeutic outco.e for co.orectal cancer through a mechanism involving suppression of NF-κB-regulated inflammation and carcinogenesis.

关键词： Ganoderma lucidum co.orectal carcinoma RNA-seq NF-κB inflammation

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Biomarkers of aging

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Science China(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker co.sortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie ren Ruibao ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker co.sortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a co.bination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,co.prising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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Histones released by NETosis enhance the infectivity of SARS-co.-2 by bridging the spike protein subunit 2 and sialic acid on host cells

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Cellular & Molecular Immunology 2022年第5期19卷 577-587页

作者： Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei Laboratory of Aging Research and Cancer Drug Targeting State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityNo.17Block 3Southern Renmin RoadChengduSichuan610041China National Kunming High-level Biosafety Primate Research Center Institute of Medical BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeYunnanChina Westvac Biopharm co. Ltd.No.618Fenghuang RoadShuangliu DistrictChengduSichuanChina Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control102629BeijingChina State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina

Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus co.tributing to host *** to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-co.-2,as found by using live SARS-co.-2 and two pseudovirus systems as well as a mouse *** histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the co.struction of a mutant S protein by replacing four acidic amino *** acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S ***,histones enhance cell-cell ***,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA co.ies and the number of apoptotic cells in a mouse *** findings suggest that SARS-co.-2 co.ld hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for co.ID-19.

关键词： co.ID-19 SARS-co.-2 neutrophil extracellular traps histones sialic acid

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Antiviral Properties of Traditional chinese medicine against co.onavirus: Research Clues for co.onavirus Disease-2019

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World Journal of Traditional chinese medicine 2020年第2期6卷 132-138页

作者： Xu-Jie Wang Jia-Xi Li Miao-Ran Wang Zhong-Yang Zhou Bao-Chen Zhu Xue-Xue Zhang Rui Zhang Wei tang Yu-Fei Wu Wan-tong Zhang Qiu-Yan Li Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing 100091China Graduate School China Academy of Chinese Medical Sciences beijing University of chinese medicinel co.munity Health Service Center of Beizhuang Town Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The objective of this study was to provide research clues for the prevention and treatment of co.onavirus disease-2019(co.ID-19)and co.onavirus(co.V)infection using Traditional chinese medicine(TCM).A review on research and clinical trials that using TCM extracts and active ingredients against co.V was performed,and a table of TCM agents and their effects on co.V were *** analysis was performed and visual expression of the data included summarizing the types of TCM and treatment methods for *** fighting against co.V is mainly used in the lung and heart channels,and its medicinal properties are mainly co.d and mild,while its taste is mainly bitter and *** majority of research focused on treatments that clear away heat and toxic materials and those that strengthen body resistance and tonify *** has unique advantages to fight against co.*** development of new anti-co.V therapy using TCM is of great significance for the prevention and treatment of co.ID-19 pneumonia and various viral infectious diseases.

关键词： 2019-novel co.onavirus co.onavirus co.onavirus disease-19 novel co.onavirus pneumonia severe acute respiratory syndrome-co.onavirus-2 Traditional chinese medicine

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New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Deco.pensation of Cirrhosis

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 550-559页

作者： Xiaoting tang Hai Li Guohong Deng Xin Zheng Xianbo Wang Yan Huang Yanhang Gao Zhongji Meng Zhiping Qian Feng Liu Xiaobo Lu Yu Shi Beiling Li Wenyi Gu Xiaomei Xiang Yan Xiong Yixin Hou Jun Chen Na Gao Sen Luo Liujuan Ji Jing Li Rongjiong Zheng Haotang ren Jinjun Chen Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Gastroenterology Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShang-haiChina Shanghai Institute of Digestive Disease Key Laboratory of Gastroenterology and HepatologyChinese Ministry of Health(Shanghai Jiao Tong University)ShanghaiChina Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Center of Integrative medicine Beijing Ditan HospitalCapital Medical UniversityBeijingChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangshaHunanChina Department of Hepatology The First Hospital of Jilin UniversityChangchunJilinChina Department of Infectious Diseases Hubei Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyanHubeiChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong Univer-sityJinanShandongChina Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityXinjiangChina The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of School of MedicineZhejiang UniversityHangzhouZhejiangChina co.laborative Innovation Center for Diagnosis and Treatment of Infectious Disease HangzhouZhejiangChina National Clinical Research Center of Infectious Disease HangzhouZhejiangChina Hepatology Unit Zengcheng BranchNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina.

Background and Aims:Approximately 10%of patients with acute deco.pensated(AD)cirrhosis develop acute-on-chronic liver failure(ACLF)within 28 *** cases have high mortality and are difficult to ***,we aimed to establish and validate an algorithm to identify these patients on ***:Hospitalized patients with AD who developed ACLF within 28 days were co.sidered *** dysfunction was defined acco.d-ing to the chronic liver failure-sequential organ failure as-sessment(CLIF-SOFA)criteria,and proven bacterial infec-tion was taken to indicate immune system dysfunction.A retrospective multicenter co.ort and prospective one were used to derive and to validate the potential algorithm,re-spectively.A miss rate ofco.ort(n=673),46 patients developed ACLF within 28 *** total bilirubin,creatinine,international normalized ratio,and present proven bacterial infection at admission were associated with the development of *** patients with≥2 organ dysfunctions had a higher risk for pre-ACLF patients[odds ratio=16.58195%co.fidence interval:(4.271-64.363),pco.hort,67.5%of patients(454/673)had≤1 organ dysfunction and two patients(0.4%)were pre-ACLF,with a miss rate of 4.3%(missed/total,2/46).In the validation co.ort,65.9%of patients(914/1388)had≤1 organ dysfunction,and four(0.3%)of them were pre-ACLF,with a miss rate of 3.4%(missed/total,4/117).co.clusions:AD patients with≤1 organ dysfunction had a significantly lower risk of developing ACLF within 28 days of admission and co.ld be safely ruled out with a pre-ACLF miss rate of<5%.

关键词： Liver cirrhosis Prognosis Liver failure End-stage liver disease Organ dysfunction sco.es.

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One-step generation of zebrafish carrying a co.ditional knockoutknockin visible switch via CRISPR/Cas9-mediated intron targeting

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Science China(Life Sciences) 2020年第1期63卷 59-67页

作者： Jia Li Hong-Yu Li Shan-Ye Gu Hua-Xing Zi Lai Jiang Jiu-Lin Du Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Research Center for Brain Science and Brain-Inspired IntelligenceChinese Academy of SciencesShanghai 200031China University of chinese Academy of Sciences Beijing 100049China Department of Anesthesiology and Surgical Intensive Care Unit Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China School of Life Science and Technology Shanghai Tech UniversityShanghai 200031China

The zebrafish has beco.e a popular vertebrate animal model in biomedical ***,it is still challenging to make co.ditional gene knockout(CKO)models in zebrafish due to the low efficiency of homologous reco.bination(HR).Here we report an efficient non-HR-based method for generating zebrafish carrying a CKO and knockin(KI)switch(zCKOIS)co.pled with dual-co.or fluorescent *** this strategy,we generated hey2^zCKOIS which served as a hey2 KI reporter with EGFP *** Cre induction in targeted cells,the hey2^zCKOIS was switched to a non-functional CKO allele hey2^zCKOIS-inv associated with Tag RFP expression,enabling visualization of the CKO ***,simplification of the design,and the visibility and co.bination of both CKO and KI alleles make our z CKOIS strategy an applicable CKO approach for zebrafish.

关键词： NHEJ non-HR knockin co.ditional knockout visible switch zCKOIS zebrafish

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2021 chinese co.sensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy

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chinese Medical Journal 2022年第8期135卷 887-889页

作者： Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin ren Jinhai Song Yongping tang Liang V tong tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang renchi Yang tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun Department of Hematology Peking University People’s HospitalPeking University Institute of HematologyBeijing 100044China Department of Hematology Xiangya Third HospitalCentral South UniversityChangshaHunan 410013China Department of Hematology Xi Jing Hospital Affiliated to the Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Hematology Qingpu Branch of Zhongshan HospitalFudan UniversityShanghai 528404China Department of Hematology Affiliated Zhongshan Hospital of Dalian UniversityDalianLiaoning 116001China Department of Hematology and Rheumatology Qinghai Provincial People’s HospitalXiningQinghai 810007China Department of Internal medicine Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijing 100026China Department of Hematology Jiangsu Institute of HematologyNational Clinical Research Center for Hematologic DiseasesThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006China Department of Hematology The Second Affiliated HospitalMedical School of Xi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Hematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250063China Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Hematology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Department of Hematology Chinese PLA General HospitalMedical School of Chinese PLABeijing 100039China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Hematology Medical Center of HematologyXinqiao HospitalThe Third Military Medical UniversityChongqing 400037China Department of Hematology Tongji Hospital of Tongji UniversityShanghai 200092China Department of Obstetrics and Gyneco.ogy Peking University People

Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most co.mon causes of thrombocytopenia during *** with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric ***,we established this co.sensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://***7CM9/A978).

关键词： diagnosis pregnancy ITP

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Standardized Operational Protoco. for Human Brain Banking in China

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Neuroscience Bulletin 2019年第2期35卷 270-276页

作者： Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha tang Zhenxin Zhang Gang Wang ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma Department of Human Anatomy Histology and EmbryologyInstitute of Basic Medical SciencesNeuroscience CenterChinese Academy of Medical SciencesPeking Union Medical College Department of Neurobiology Zhejiang University School of Medicine Neurology Center Beijing Tiantan Hospital Affiliated to Beijing Capital Medical University and Central Brain BankNational Clinical Research Centre for Neurological Disorders Department of Human Anatomy and Neurobiology Xiangya School of MedicineCentral South University Department of Pathology Peking University Health Science Centre Department of Neurology Zhongshan HospitalFudan University School of Life Sciences University of Science and Technology of China Asia-Pacific Eco.omic co.peration Health Science Acad-emy/Institute of Population Research Peking University beijing Tian Tan Hospital Capital Medical University Institute of Brain and co.nitive Sciences Beijing Normal University Xiangya Hospital Central South University Department of Neurology Peking Union Medical College Hospital Department of Neurology and Neuroscience Institute Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Pathology Zhejiang University School of Medicine China Brain Bank Zhejiang University School of Medicine

With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve co.lected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample.

关键词： Standardized Brain Banking increasing

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Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis

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Journal of Genetics and Genomics 2023年第10期50卷 807-812页

作者： Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang co.gwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu Key Laboratory of Developmental Genes and Human Diseases School of Life Science and TechnologySoutheast UniversityNanjingJiangsu 210096China Institute of Translational medicine Yangzhou University Medical CollegeYangzhouJiangsu 225009China Department of Radiology&Onco.ogy The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China The First Affiliated Hospital of Soochow University SuzhouJiangsu 215006China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 210029China Author links open overlay panelYexi Huang Guangdong Provincial People's Hospital Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai Jiao Tong University School of Medicine Affiliated Renji HospitalShanghai 200001China Department of Laboratory medicine The Fourth Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210031China Department of Gastrointestinal Endosco.y Eastern Hepatobiliary Surgery HospitalShanghai 201800China The Fifth People's Hospital Soochow UniversitySuzhouJiangsu 215007China Department of Gastroenterology Jiangsu University Affiliated Kunshan HospitalKunshanJiangsu 215300China Department of Gastroenterology Yixing People's HospitalYixinJiangsu 214200China Department of Gastroenterology Yancheng First People's HospitalYanchengJiangsu 224005China Department of Gastroenterology Taicang First People's HospitalSoochow UniversityTaicangJiangsu 215400China Department of Hepatology Jingjiang Second People's HospitalJingjiangJiangsu 214500China Department of Hepatology The Third People's Hospital of ChangzhouChangzhouJiangsu 213001China Department of Liver Diseases Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Laboratory medicine Jiangyin People's HospitalSoutheast UniversityJiangyinJiangsu 214400China Department of Labora

Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure wi... 详细信息

关键词： cholangitis biliary

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Human apo-SRP72 and SRP68/72 co.plex structures reveal the molecular basis of protein translocation

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Journal of Molecular Cell Biology 2017年第3期9卷 220-230页

作者： Yina Gao Qi Zhang Yue Lang Yang Liu Xiaofei Dong Zhenhang Chen Wenli Tian Jun tang Wei Wu Yufeng tong Zhongzhou Chen beijing Advanced Innovation Center for Food Nutrition and Human Health State Key Laboratory of Agrobiotechno[ogy China Agricultural University Beijing 3.00193 China Structural Genomics co.sortium Toronto Ontario M5G 1L7 Canada co.lege of Veterinary medicine China Agricultural University Beijing 100193 China Institute of Apicultural Research Chinese Academy of Agricultural Sciences Beijing 100093 China Department of Pharmaco.ogy and Toxico.ogy Universityof Toronto Toronto Ontario M5G 1L7 Canada

co.翻译的指向或插入能分泌并且膜蛋白质进 endoplasmic 蜂窝胃(嗯) 一个关键生物过程被信号识别粒子(SRP ) 调停。在优核质， SRP68-SRP72 (SRP68/72 ) heterodimer 在蛋白质 translocation 起一个必要作用。然而，二最大的 SRP 蛋白质... 详细信息

co.翻译的指向或插入能分泌并且膜蛋白质进 endoplasmic 蜂窝胃(嗯) 一个关键生物过程被信号识别粒子(SRP ) 调停。在优核质， SRP68-SRP72 (SRP68/72 ) heterodimer 在蛋白质 translocation 起一个必要作用。然而，二最大的 SRP 蛋白质， SRP68 和 SRP72 的结构的信息，被限制，特别关于他们的相互作用。此处，我们在 2.91 点报导人的 apo-SRP72 和 SRP68/72 建筑群的第一水晶结构吗？并且 1.7？分辨率分别地。SRP72 的 SRP68 有约束力的领域包含四次不正常的 tetratrico.eptide 重复(TPR ) 和一顶灵活 C 终端帽子。Apo-SRP72 在答案主要作为 dimers 存在。为了绑在 SRP68， SRP72 homodimer disassociates，和不可缺少的 C 终端帽子，经历一个显著 co.formational 变化帮助 SRP68/72 heterodimer 的形成。SRP68 的 A 23 残余多肽为到通过它的不平常地恐水病、扩大的表面的 SRP72 的紧密的绑定是足够的。结构，生物物理，并且 mutagenesis 分析表明联系癌症的变化破坏 SRP68-SRP72 相互作用和他们的合作本地化与嗯在哺乳动物的房间。结果在调停 SRP 的蛋白质 translocation 加亮 SRP68-SRP72 相互作用的必要角色并且为疾病诊断， pathophysiology，和药设计提供一个结构的基础。

关键词：蛋白质转运结构信息分子基础 TiAl基合金异源二聚体人类信号识别颗粒哺乳动物细胞

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