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Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang Juan Wang Zongjian Liu Xuechai Chen beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

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Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang Li beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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Potential preservative mechanisms of cardiac rehabilitation pathways on endothelial function in coronary heart disease

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Science China(Life Sciences) 2025年第1期68卷 158-175页

作者： Wen-Tao Sun Jian-Yong Du Jia Wang Yi-Long Wang Er-Dan Dong Research Center for Cardiopulmonary rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital)Schoolof Health and Life SciencesUniversityof Health and Rehabilitation SciencesQingdao 266071China Department of Cardiology and Instituteof Vascular Medicine Peking University Third HospitalTheInstituteofCardiovascular SciencesPeking UniversityState Key Laboratoryof Vascular Homeostasisand RemodelingPeking UniversityBeijing 100191China

Cardiac rehabilitation,a comprehensive exercise-based lifestyle and medical management,is effective in decreasing morbidity and improving life quality in patients with coronary heart *** function,an irreplaceable indicator in coronary heart disease progression,is measured by various methods in traditional cardiac rehabilitation pathways,including medicinal treatment,aerobic training,and smoking ***,studies on the effect of some emerging cardiac rehabilitation programs on endothelial function are *** article briefly reviewed the endothelium-beneficial effects of different cardiac rehabilitation pathways,including exercise training,lifestyle modification and psychological intervention in patients with coronary heart disease,and related experimental models,and summarized both uncovered and potential cellular and molecular mechanisms of the beneficial roles of various cardiac rehabilitation pathways on endothelial *** exercise training and some lifestyle interventions,the enhanced bioavailability of nitric oxide,increased circulating endothelial progenitor cells(EPCs),and decreased oxidative stress are major contributors to preventing endothelial dysfunction in coronary heart ***,the preservation of endothelial-dependent hyperpolarizing factors and inflammatory suppression play *** the one hand,to develop more endothelium-protective rehabilitation methods in coronary heart disease,adequately designed and sized randomized multicenter clinical trials should be advanced using standardized cardiac rehabilitation programs and existing assessment *** the other hand,additional studies using suitable experimental models are warranted to elucidate the relationship between some new interventions and endothelial protection in both macro-and microvasculature.

关键词： cardiac rehabilitation coronary heart disease endothelial function

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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway

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Neural Regeneration Research 2025年第12期20卷 3564-3573页

作者： Ya Zheng Lingyun Cao Dan Zhao Qi Yang Chunya Gu Yeran Mao Guangyue Zhu Yulian Zhu Jing Zhao Dongsheng Xu Department of rehabilitation Medicine Huashan HospitalFudan UniversityShanghaiChina School of rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of rehabilitation Medicine Ruijin HospitalShanghai Jiaotong UniversityShanghaiChina rehabilitation Medical Center Tongji Hospital Affiliated to Tongji University School of MedicineShanghaiChina Department of rehabilitation Baoshan BranchShuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina National Center for Neurological Disorders ShanghaiChina Department of Neurology Minhang Hospital Affiliated to Fudan UniversityShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent rehabilitation Ministry of EducationShanghaiChina Institute of rehabilitation Medicine Shanghai Academy of Traditional Chinese MedicineShanghaiChina

Promoting synaptic plasticity and inducing functional reorganization of residual nerve fibers hold clinical significance for restoring motor function following spinal cord *** stimulation targeting the nerve roots has been shown to improve motor function by enhancing nerve conduction in the injured spinal cord and restoring the synaptic ultrastructure of both the sensory and motor ***,our understanding of the neurophysiological mechanisms by which nerve root magnetic stimulation facilitates motor function recovery in the spinal cord is limited,and its role in neuroplasticity remains *** this study,we established a model of spinal cord injury in adult male Sprague–Dawley rats by applying moderate compression at the T10 *** then performed magnetic stimulation on the L5 nerve root for 3 weeks,beginning on day 3 *** day 22 post-injury,we observed that nerve root magnetic stimulation downregulated the level of interleukin-6 in the injured spinal cord tissue of ***,this treatment reduced neuronal damage and glial scar formation,and increased the number of neurons in the injured spinal ***,nerve root magnetic stimulation decreased the levels of acetylcholine,norepinephrine,and dopamine,and increased the expression of synaptic plasticity-related m RNA and proteins PSD95,GAP43,and Synapsin *** together,these results showed that nerve root magnetic stimulation alleviated neuronal damage in the injured spinal cord,regulated synaptic plasticity,and suppressed inflammatory *** findings provide laboratory evidence for the clinical application of nerve root magnetic stimulation in the treatment of spinal cord injury.

关键词： dendrite inflammation magnetic stimulation nerve root neurological function neuronal damage neurotransmitter spinal cord injury synaptic plasticity synaptic transmission

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu beijing Tiantan hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Assessing microcatheter-assisted 360-degree trabeculotomy combined with trabeculectomy for refractory glaucoma:1-year results

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 94-102页

作者： Jia-Yin Qin Yan Liu Tao Wang Department of Ophthalmology Peking University International HospitalBeijing 102206China beijing Key Laboratory of Ophthalmology and Visual Science Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To evaluate the efficacy and safety of microcatheterassisted 360-degree trabeculotomy combined with trabeculectomy(MATT-Trab)for treating refractory ***:Patients with refractory glaucoma who underwent MATT-Trab were retrospectively *** indicators for research statistics included the intraocular pressure(IOP)level,degree of decrease,changes in medication dosage,and success *** indicators included the best-corrected visual acuity and incidence of ***:This study comprised 31 patients,including 11 males and 20 females,with ages ranging from 8mo to 67y(mean age:29.40±22.10y).The average postoperative IOP at 1d,1wk,1mo,3mo,6mo,1y,and the last followup was significantly lower than the average preoperative IOP(31.33±9.24 mm Hg,P<0.05).The average number of postoperative medications at 1y was 0.48±1.51,which was significantly reduced compared to that used preoperatively(3.77±0.99,P=0.00).The absolute and qualified success rates were 45.16% and 83.87%,*** acuity exhibited no statistically significant difference between the postoperative and preoperative follow-up time points,except for the first day after *** most common postoperative complications were anterior chamber hemorrhage(25 cases,86.21%)and high IOP(10 cases,34.48%).CONCLUSION:Our results indicate that MATT-Trab is effective and safe for treating refractory glaucoma.

关键词： glaucoma refractor y glaucoma trabeculotomy trabeculectomy microcatheter

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Revealing and predicting the long-term biomechanical response of orthokeratology by developing a patient-specific computational model

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 152-164页

作者： Yifeng Li Zhuoran Yang Ziming Yan Huibin Shi Zhanli Liu Kaijie Wang Department of Engineering Mechanics School of Aerospace EngineeringTsinghua UniversityBeijing 100084China beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LabBeijing 100730China

Orthokeratology(OK)is widely used for effective myopia correction and ***,the incomplete understanding of its biomechanical mechanisms makes OK lens fitting rely heavily on clinician judgment,complicating accurate predictions of treatment *** this paper,we performed clinical experiments and numerical analysis to study corneal deformation modes and long-term changes in central corneal *** experiments were conducted on 194 Chinese myopic patients under OK treatment for 3 *** on the experimental data,a patient-specific computational biomechanical model for OK was established and ***,the anisotropic mechanical properties of the cornea were incorporated into the model to describe the significant difference between its shear modulus(29.5 kPa)and tensile modulus(768.4 kPa).Additionally,a viscohyperelastic material model with a prolonged corneal relaxation time of 5.6 h was developed to capture the long-term deformation *** results show that corneal thickness reduction in OK is primarily due to out-of-plane shear deformation,influenced by the cornea’s low shear *** the extended corneal relaxation time is crucial for predicting long-term biomechanical *** computational model effectively captures long-term changes in central corneal thickness,potentially improving OK lens fitting accuracy.

关键词： orthokeratology computational biomechanical model long-term viscoelasticity myopia correction

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Acupuncture Combined with Periocular Injection for Treatment of Hydroxychloroquine Retinopathy with Cystoid Macular Edema:A Case Report

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Chinese Journal of Integrative Medicine 2025年第1期31卷 68-72页

作者： LI Tian-tian WU Yan YANG Ying-xin XUE Yu-xin MA Chao-ting Department of Ophthalmology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China

Hydroxychloroquine(HCQ)is widely used in the treatment of autoimmune disorders such as systemic lupus erythematosus(SLE)and rheumatoid arthritis,and in recent years it has also been used in diseases such as cancer,neurodegenerative diseases,metabolic diseases,and microbial infections.(1)Due to the complex pharmacokinetic characteristics of HCQ,overdose or long-term use of the drug will lead to accumulation in the tissue of organism,and severe HCQ-related retinal toxicity may occur.A cohort study in America showes that after 10 and 15 years of HCQ use,the incidence of HCQ retinopathy will be 2.5%and 8.6%,respectively.(2)The clinical manifestations of HCQ retinopathy are various,mainly photoreceptor and retinal pigment epithelium(RPE)defects,some combined with cystoid macular edema(CME),and ireversible central vision loss.

关键词： Acupuncture diseases epithelium

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Human cardiac organoid model reveals antibacterial triclocarban promotes myocardial hypertrophy by interfering with endothelial cell metabolism

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Science Bulletin 2025年第3期70卷 342-346页

作者： Nana Yang Jiahong Chen Yujie Zhu Wenxin Shan Zheng Cao Yiwen Fu Huanhuan Cao Yanyan Li Yukun Xiang Shusi Ding Huiqing Wang Yaobo Zhao Liang Ji Rui Zhan Yufei Wu Zhaomeng Wang Manyuan Dong Lemin Zheng School of Bioscience and Technology Weifang Key Laboratory of Animal Model Research on Cardiovascular and Cerebrovascular DiseasesShandong Second Medical UniversityWeifang 261053China The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing Key Laboratory of Cardiovascular Receptors ResearchHealth Science CenterPeking UniversityBeijing 100191China University of Chinese Academy of Sciences Beijing 100049China beijing Tiantan hospital China National Clinical Research Center for Neurological DiseasesAdvanced Innovation Center for Human Brain ProtectionBeijing Institute of Brain DisordersThe Capital Medical UniversityBeijing 100050China Research Center for Cardiopulmonary rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital)School of Health and Life SciencesUniversity of Health and Rehabilitation SciencesQingdao 266071China

Environmental pollution is an important but often overlooked risk factor for cardiovascular diseases such as heart ***(3,4,4′-trichlorocarbanilide,TCC)is a broad-spectrum antibacterial agent commonly used in personal care products such as antibacterial soaps,detergents,toothpaste,and cosmetics[1].Unfortunately,due to its widespread use,TCC has become one of the top ten most common water pollutants globally,and it is present in the atmosphere,soil,and aquatic sediments[2].

关键词： metabolism cardiovascular diseases

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