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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

Neural Regeneration research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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Trends in the Incidence of High-Risk Newborns Based on a New Conceptual Framework-beijing municipality,China,2013-2022

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China CDC weekly 2024年第31期6卷 767-771页

作者： Yongxian Zhao Zhaoxia Jia Lei Wang Qingqing Wu Moning Guo Dong Han Lili Huang Junhua Wang Di Zhang Zhao Wang Minghui Wu beijing Obstetrics and Gynecology Hospital Capital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijingChina beijing municipal health big data and policy research center BeijingChina

Summary What is already known on this topic?A new conceptual term,small and vulnerable newborns(SVN),bringing preterm birth,small for gestational age(SGA),or low birth weight(LBW)together is being advocated for assessing whether a child is at high *** is added by this report?According to the new conceptual term,the increasing incidence of high-risk newborns(from 9.82%to 10.96%)has been observed among 2,005,408 newborns over the period from 2013 to 2022,which is higher than using any of the three definitions of *** age≥35,primiparity,and multiple births are high risks for *** are the implications for public health practice?The new conceptual framework should be used to better assess the number of high-risk *** should be paid to multiple births to prevent preterm-related *** reduce term newborns who are SGA,we need to be concerned not only with multiple pregnancies but also with first-time mothers.

关键词： beijing bringing mother

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Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang Li beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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Reproductive Characteristics and Trends of Major Pregnancy Outcomes of Women at Different Parities-beijing municipality,China,2013-2022

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China CDC weekly 2024年第31期6卷 786-792页

作者： Zhaoxia Jia Yongxian Zhao Lei Wang Qingqing Wu Moning Guo Jianpeng Zheng Lili Huang Junhua Wang Zhao Wang Di Zhang Minghui Wu Department of information and statistics Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijingChina Department of data resources and statistics Beijing Municipal Health Big Data and Policy Research CenterBeijingChina

Summary What is already known about this topic?With socioeconomic development,the increase of older pregnancies and multiparas has brought risks to mothers and *** is added by this report?As parities increased,the proportion of women of advanced maternal age(AMA)and non-local domicile increased,while the proportion of women with higher education levels *** with≥3 parities are more likely to have preterm birth(PTB)and *** are the implications for public health practice?A comprehensive analysis of pregnancy traits among women at different parities offers a robust foundation for tailored strategies against adverse pregnancy outcomes.

关键词： mother pregnancy likely

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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An Autoregressive Integrated Moving Average Model for Predicting Varicella Outbreaks — China, 2019

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China CDC weekly 2023年第31期5卷 698-702,I0002,I0003页

作者： Miaomiao Wang Zhuojun Jiang Meiying You Tianqi Wang Li Ma Xudong Li Yuehua Hu Dapeng Yin Office of Epidemiology Chinese Center for Disease Control and PreventionBeijingChina Training and Outreach Division National Center for Mental HealthBeijingChina data Resources and Statistics Department Beijing Municipal Health Big Data and Policy Research CenterBeijingChina Hefei center for Disease Control and Prevention Hefei CityAnhui ProvinceChina Technical Guidance Office for Patriotic health Work Chinese Center for Disease Control and PreventionBeijingChina Hainan center for Disease Control and Prevention Haikou CityHainan ProvinceChina.

Introduction:Varicella,a prevalent respiratory infection among children,has become an escalating public health issue in *** potential to considerably mitigate and control these outbreaks lies in surveillance-based early warning *** research employed an autoregressive integrated moving average(ARIMA)model with the objective of predicting future varicella outbreaks in the ***:An ARIMA model was developed and fine-tuned using historical data on the monthly instances of varicella outbreaks reported in China from 2005 to *** determine statistically significant models,parameter and Ljung-Box tests were *** coefficients of determination(R2)and the normalized Bayesian Information Criterion(BIC)were compared to selecting an optimal *** chosen model was subsequently utilized to forecast varicella outbreak cases for the year ***:Four models passed parameter(all P0.05).ARIMA(1,1,1)×(0,1,1)12 was determined to be the optimal model based on its coefficient of determination R2(0.271)and standardized BIC(14.970).Fitted values made by the ARIMA(1,1,1)×(0,1,1)12 model closely followed the values observed in 2019,the average relative error between the actual value and the predicted value is 15.2%.Conclusion:The ARIMA model can be employed to predict impending trends in varicella *** serves to offer a scientific benchmark for strategies concerning varicella prevention and control.

关键词： ARIMA prevention utilized

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Identifying the Optimal Age for Herpes Zoster Vaccination—Yichang City,Hubei Province,China,2017–2019

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China CDC weekly 2022年第29期4卷 631-634页

作者： Meiying You Tianqi Wang Miaomiao Wang Wei Jiang Jing Jiang Xudong Li Yuehua Hu Dapeng Yin Office of Epidemiology Chinese Center for Disease Control and PreventionBeijingChina data resources and Statistics Department Beijing Municipal Health Big Data and Policy Research CenterBeijingChina Yichang center for Disease Control and Prevention Yichang CityHubei ProvinceChina Hainan center for Disease Control and Prevention Haikou CityHainan ProvinceChina.

Summary What is already known about this topic?Herpes zoster(shingles)is a common skin condition in older adults,which usually presents as a painful rash with *** is the most effective method to prevent ***,there is not sufficient population-based epidemiological data in China to optimize the timing of zoster *** is added by this report?Clustering analyses of population-wide epidemiological data from the healthcare big data Platform in Yichang,China showed that the average annual zoster incidence is the highest among people 55 years or older,at 10 cases per thousand persons per year,making this age group the optimal target population for *** was lower but increased with age among younger adults,28–54 years *** are the implications for public health practice?With limited vaccination resources,zoster vaccinations should be targeted at adults 55 years or older who are at the greatest risk for *** should be conducted to understand the risk of shingles among young and middle-aged adults and identify triggers of shingles:potentially leading to preventive measures.

关键词： younger zoster vaccination

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Revealing and predicting the long-term biomechanical response of orthokeratology by developing a patient-specific computational model

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 156-168页

作者： Yifeng Li Zhuoran Yang Ziming Yan Huibin Shi Zhanli Liu Kaijie Wang Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University beijing Tongren Eye center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Lab

Orthokeratology(OK) is widely used for effective myopia correction and control. However, the incomplete understanding of its biomechanical mechanisms makes OK lens fitting rely heavily on clinician judgment, complicating accurate predictions of treatment outcomes. In this paper, we performed clinical experiments and numerical analysis to study corneal deformation modes and long-term changes in central corneal thickness. Clinical experiments were conducted on 194 Chinese myopic patients under OK treatment for 3 months. Based on the experimental data, a patient-specific computational biomechanical model for OK was established and validated. Specifically, the anisotropic mechanical properties of the cornea were incorporated into the model to describe the significant difference between its shear modulus(29.5 kPa) and tensile modulus(768.4 kPa). Additionally, a viscohyperelastic material model with a prolonged corneal relaxation time of 5.6 h was developed to capture the long-term deformation response. The results show that corneal thickness reduction in OK is primarily due to out-of-plane shear deformation,influenced by the cornea's low shear resistance. Modeling the extended corneal relaxation time is crucial for predicting long-term biomechanical responses. The computational model effectively captures long-term changes in central corneal thickness, potentially improving OK lens fitting accuracy.

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Service Customized Space-Air-Ground Integrated Network for Immersive Media: Architecture, Key Technologies, and Prospects

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China Communications 2022年第1期19卷 1-13页

作者： LinhuiWei Jiacheng Shuai Yu Liu YumeiWang Lin Zhang School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China research center of Networks and Communications Peng Cheng LaboratoryShenzhen 518000China beijing big data center Beijing Municipal Bureau of Economy and Information TechnologyBeijing 100101China

The space-air-ground integrated network(SAGIN) is regarded as the key approach to realize global coverage in future network and it reaches broad access for various services. Being the new paradigm of service, immersive media(IM) has attracted users’ attention for its virtualization, but it poses challenges to network performance, e.g. bandwidth, rate, latency. However, the SAGIN has limitations in supporting IM services, such as 4 K/8 K video, virtual reality, and interactive games. In this paper, a novel service customized SAGIN architecture for IM applications(SAG-IM) is proposed, which achieves content interactive and real-time communication among terminal users. State-of-the-art research is investigated in detail to facilitate the combination of SAGIN and service customized technology, which provides endto-end differentiated services for users. Besides, the functional components of SAG-IM contain the infrastructure layer, perception layer, intelligence layer, and application layer, reaching the capabilities of intelligent management of the network. Moreover, to provide IM content with ultra-high-definition and high frame rate for the optimal user experience, the promising key technologies on intelligent routing and delivery are discussed. The performance evaluation shows the superiority of SAG-IM in supporting IM ***, the prospects in practical application are high-lighted.

关键词： space-air-ground integrated network architecture immersive media service customized network intelligent

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Increases in Height among Chinese Children and Adolescents by Gender: An Age-Period-Cohort Analysis

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Biomedical and Environmental Sciences 2021年第5期34卷 348-355页

作者： HU Yue Hua WANG Xin Yu YAO Hong Yan ZHANG Jian YIN Da Peng FENG Guo Shuang Epidemiology Office Chinese Center for Disease Control and PreventionBeijing 102206China beijing Advanced Innovation center for big data-Based Precision Medicine Beihang University&Capital Medical UniversityBeijing 100045China big data and Engineering research center Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China National Institute Nutrition and health Chinese center for Disease Control and Prevention Beijing 100050China

Objective To examine increases in average height among Chinese children and *** The data were obtained from the China health and Nutrition Survey conducted during the period 1989–2015. A stratified multistage cluster sampling method was utilized to select participants aged 2–22 years in each province. Linear regression was used to examine the effects of age, birth cohort, and survey period on *** A total of 15,227 males and 13,737 females were included in the final analysis. Age(A) showed a continuous effect on height. The average heights of the investigated groups increased continuously during the investigation period. By 2015, the average height of the overall group increased by 7.87 cm compared to the average height during the 1989 survey. Moreover, birth year(cohort, C) also had a stable effect on height. Using the height of individuals born in or before 1975 as a reference, the average height of each birth cohort increased in comparison to the previous birth *** The height of Chinese children and adolescents was affected by age, period, and cohort effects, and this effect is governed by certain rules. The age-period-cohort model can be used to analyze the trends of children’s and adolescent’s heights. The findings provide a scientific basis for the formulation of children’s and adolescents’ growth and development policies in China.

关键词： Age-period-cohort analysis Children and adolescents Height

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