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Bloodletting at Jing-well points decreases interstitial fluid flow in the thalamus of rats

Journal of Traditional Chinese Medicine 2016年第1期36卷 107-112页

作者： FuYu LiYuliang GuoJia Liu Bin Liu Huipo Zhang Weibo Sun Wanli GaoYajuan Ren Qiushi Han Haojun Department of Neurology Peking University Third Hospital Beijing 100191 China beijing key lab of magnetic resonance imaging device and technique Beijing 100191 China Department of Biomedical Engineering College of engineering of Peking University Beijing 100191 China Department of Interventional Medicine The Second Hospital of Shandong University Jinan 250033China Institute of Applied Physics and Computational Mathematics Beijing 100094 China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences Beijing 100700China beijing key lab of magnetic resonance imaging device and technique Department of Biomedical Engineering College of engineering of Peking University Department of Radiology Peking University Third Hospital Beijing 100191 China Chang Zhi Medical College Chang Zhi 046000 China

OBJECTIVE：To investigate the changes in the neuronal microenvironment of the middle cerebral artery （MCA） territory induced by Jing-well points bloodletting acupuncture （WPBA） and to explore the neuroprotective mechanism of WPBA in stroke. METHODS： Adult male Sprague Dawley （n = 32） rats were randomly divided into four groups of eight animals each： WPBA-thalamus group （WT）, WPBA-caudate nucleus group （WC）, sham-control thalamus group （ST） and sham-control caudate nucleus group （SC）. Animals in the WT and WC groups received 2 I-μL of the extracellular tracer gadolinium-diethylene triamine pentaacetic acid （Gd-DTPA） injected into the thalamus or caudate nucleus, respectively, and 12 Jing-well points in the distal ends of the rats＇ digits were used for WPBA. Although 2 μL of Gd-DTPA was injected into the thalamus or caudate nucleus, respectively, for animals in the two sham groups （ST and SC）, no acupuncture or bloodletting was performed. Brain extracellular space and interstitial fluid flow parameters were measured using Gd-DTPA-enhanced magnetic reso- nance imaging. RESULTS： The brain interstitial fluid flow speed was decreased in the thalamus after WPBA, with a significantly lower Gd-DTPA clearance rate and longer half-life of Gd-DTPA in the thalamus of treated rats than those in sham-control rats [WPBA-treated rats＇clearance rate, （7.47 ± 3.15） x 10^-5/s （P = 0.009）; half-life, （1.52 ± 0.13） h, P = 0.000]. By contrast, no significant changes in brain extracellular space and interstitial fluid flow parameters were detected in the caudate nucleus after WPBA （P = 0.649）. In addi- tion, no differences in the morphology of the brain extracellular space or the final distribution of the traced brain interstitial fluid were demonstrated be- tween theWT and WC groups （P = 0.631, P = 0.970, respectively）. CONCLUSION： The WPBA decreased the speed of the local thalamic ISF flow in rats, which is assumed to be a beneficial protection by down-modulated the metabolic rate of the

关键词： Bloodletting Extracellular space Gado-linium ethoxybenzyl DTPA Interstitial fluid magnetic resonance imaging

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A novel neuroprotective method against ischemic stroke by accelerating the drainage of brain interstitial fluid

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Science China(Life Sciences) 2024年第10期67卷 2213-2223页

作者： Jingge Lian Liu Yang Hanbo Tan Shaoyi Su Leonor Serrano Lopes Fangxiao Cheng Junhao Yan Yu Fu Wanyi Fu Zhaoheng Xie Jianfei Sun Jicong Zhang Zhiqian Tong Yajuan Gao Hongbin Han Department of Radiology Peking University Third HospitalBeijing 100191China beijing key laboratory of magnetic resonance imaging Technology Beijing 100191China Institute of Medical Technology Peking University Health Science CenterBeijing 100191China Department of Informatics Technical University of MunichGarching 80539Germany Department of Anatomy and Histology School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Neurology Peking University Third HospitalBeijing 100191China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China State key laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China key laboratory of Alzheimer’s Disease of Zhejiang Province Institute of AgingSchool of Mental HealthWenzhou Medical UniversityWenzhou 325035China NMPA key laboratory for Evaluation of Medical imaging Equipment and technique Beijing 100191China

Ischemic stroke is a leading cause of death and disability *** response after stroke determines the outcome of ischemic injury.A recent study has reported an efficient method,epidural arterial implantation(EAI),for accelerating interstitial fluid(ISF)drainage,which provides a promising strategy to clear pro-inflammatory cytokines in the brain extracellular space(ECS).In this study,the method of EAI was modified(m-EAI)to control its function of accelerating the ISF drainage at different time points following ischemic *** neuroprotective effect of m-EAI on ischemic stroke was evaluated with the transient middle cerebral artery occlusion(tMCAO)rat *** results demonstrated the accumulation of IL-1β,IL-6,and TNF-αwas significantly decreased by activating m-EAI at 7 d before and immediately after ischemic attack in tMCAO rats,accompanied with decreased infarct volume and improved neurological *** study consolidates the hypothesis of exacerbated ischemic damage by inflammatory response and provides a new perspective to treat encephalopathy via brain *** research is essential to investigate whether m-EAI combined with neuroprotective drugs could enhance the therapeutic effect on ischemic stroke.

关键词： ischemic stroke brain extracellular space interstitial fluid modified epidural arterial implantation

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Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model

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Light(Science & Applications) 2021年第10期10卷 1863-1876页

作者： Lechan Tao Qi Liu Fuli Zhang Yuting Fu Xi Zhu Xiaofu Weng Hongbin Han Yong Huang Yuanzhen Suo Liang Chen Xiaoling Gao Xunbin Wei State key laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteMed-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Institute of Medical Technology Peking University Health Science CenterBeijing 100191China Department of Radiology Peking University Third HospitalBeijing 100191China key lab of magnetic resonance imaging device and technique Beijing 100191China Zhejiang Brainhealth Medical Technology Co. LtdHangzhou 314400China Biomedical Pioneering Innovation Center Peking UniversityBeijing 100871China School of Life Sciences Peking UniversityBeijing 100871China Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Tianqiao and Chrissy Chen Institute for Clinical Translational Research Huashan HospitalShanghai 200040China Department of Pharmacology and Chemical Biology State Key Laboratory of Oncogenes and Related GenesShanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Biomedical Engineering Department Peking UniversityBeijing 100081China key laboratory of Carcinogenesis and Translational Research(Ministry of Education/beijing) Peking University Cancer Hospital&InstituteBeijing 100142China

Photobiomodulation,by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues,has been considered as a possible therapeutic strategy for Alzheimer’s disease(AD),while its specific mechanisms have remained ***,we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebralβ-amyloid(Aβ)burden,the hallmark of *** glial cells,including microglia and astrocytes,play important roles in Aβ*** results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD *** 1070-nm lightinduced microglia responses with alteration in morphology and increased colocalization with Aβare sufficient to reduce Aβload in AD ***,1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance Aβ*** study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD.

关键词： Aβ Alzheimer cerebral

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Quantitatively relating magnetic resonance T_(1)and T_(2)to glycosaminoglycan and collagen concentrations mediated by penetrated contrast agents and biomacromolecule-bound water

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Regenerative Biomaterials 2023年第1期10卷 871-888页

作者： Jingming Gao Xian Xu Xiaoye Yu Ye Fu Hongjie Zhang Siyi Gu Dinglingge Cao Quanyi Guo Liming Xu Jiandong Ding State key laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China Department of Radiology The SecondMedical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Institute of Orthopedics The First Medical CenterChinese PLA General HospitalBeijing Key Lab of Regenerative Medicine in OrthopedicsKey Laboratory of Musculoskeletal Trauma and War Injuries of PLABeijing 100853China Institute for Medical device Control National Institutes for Food and Drug ControlBeijing 102629China

magnetic resonance imaging(MRI)is a promising non-invasive method to assess cartilage regeneration based on the quantitative relationship between MRI features and concentrations of the major components in the extracellular matrix(ECM).To this end,in vitro experiments are performed to investigate the relationship and reveal the underlying mechanism.A series of collagen(COL)and glycosaminoglycan(GAG)solutions at different concentrations are prepared,and T_(1)and T_(2)relaxation times are measured with or without a contrast agent(Gd-DTPA2−)by *** transform infrared spectrometry is also used to measure the contents of biomacromolecule-bound water and other water,allowing theoretical derivation of the relationship between biomacromolecules and the resulting T_(2)*** has been revealed that the MRI signal in the biomacromolecule aqueous systems is mainly influenced by the protons in hydrogens of biomacromolecule-bound water,which we divide into inner-bound water and outer-bound *** have also found that COL results in higher sensitivity of bound water than GAG in T_(2)*** to the charge effect,GAG regulates the penetration of the contrast agent during dialysis and has a more significant effect on T_(1)values than *** that COL and GAG are the most abundant biomacromolecules in the cartilage,this study is particularly useful for the real-time MRI-guided assessment of cartilage regeneration.A clinical case is reported as an in vivo demonstration,which is consistent with our in vitro *** established quantitative relation plays a critical academic role in establishing an international standard ISO/TS24560-1:2022‘Clinical evaluation of regenerative knee articular cartilage using delayed gadolinium-enhanced MRI of cartilage(dGEMRIC)and T_(2)mapping’drafted by us and approved by International Standard Organization.

关键词： magnetic resonance imaging collagen glycosaminoglycan bound water cartilage

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magnetic resonance imaging for non-invasive clinical evaluation of normal and regenerated cartilage

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Regenerative Biomaterials 2021年第5期8卷 50-62页

作者： Xian Xu Jingming Gao Shuyun Liu Liang Chen Min Chen Xiaoye Yu Ning Ma Jun Zhang Xiaobin Chen Lisen Zhong Lin Yu Liming Xu Quanyi Guo Jiandong Ding Department of Radiology The Second Medical Center&National Clinical Research Center of Geriatric DiseasesChinese PLA General HospitalNo.28 Fuxing RoadHaidian DistrictBeijing 100853China State key laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityNo.2005 Songhu RoadYangpu DistrictShanghai 200438China Institute of Orthopedics The First Medical CenterChinese PLA General HospitalBeijing Key Lab of Regenerative Medicine in OrthopedicsKey Laboratory of Musculoskeletal Trauma and War Injuries of PLANo.28 Fuxing RoadHaidian DistrictBeijing 100853China Institute for Medical device Control National Institutes for Food and Drug ControlNo.31 Huatuo RoadDaxing DistrictBeijing 102629China

With the development of tissue engineering and regenerative medicine,it is much desired to establish bioimaging techniques to monitor the real-time regeneration efficacy in vivo in a non-invasive ***,we tried magnetic resonance imaging(MRI)to evaluate knee cartilage regeneration after implanting a biomaterial scaffold seeded with chondrocytes,namely,matrix-induced autologous chondrocyte implantation(MACI).After summary of the T2 mapping and the T1-related delayed gadolinium-enhanced MRI imaging of cartilage(dGEMRIC)in vitro and in vivo in the literature,these two MRI techniques were tried *** this study,18 patients were followed up for 1 *** was found that there was a significant difference between the regeneration site and the neighboring normal site(control),and the difference gradually diminished with regeneration time up to 1 year according to both the quantitative T1 and T2 MRI *** further established the correlation between the quantitative evaluation of MRI and the clinical Lysholm scores for the first ***,the MRI technique was confirmed to be a feasible semiquantitative yet non-invasive way to evaluate the in vivo regeneration of knee articular cartilage.

关键词： magnetic resonance imaging cartilage regeneration T2 mapping delayed gadolinium-enhanced MRI imaging tissue engineering

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Pore scale performance evaluation and impact factors in nitrogen huff-n-puff EOR for tight oil

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Petroleum Science 2022年第6期19卷 2932-2940页

作者： Yi-Lei Song Zhao-Jie Song Yun-Fei Zhang Ze-Hui Xie Li-Chao Zhang Dai-Gang Wang Gang Hui College of Carbon Neutral Energy State Key Laboratory of Petroleum Resources and Prospecting and Unconventional Petroleum Research InstituteChina University of Petroleum-BeijingBeijing102249China

Nitrogen huff-n-puff(N_(2)HnP) appears to be an economical and high-efficiency enhanced oil recovery(EOR) technique for tight oil *** is however a lack of understanding of the pore-level EOR performance of N2HnP under tight reservoir *** this work,a non-magnetic reactor was created and combined with a nuclear magnetic resonance(NMR) device for real-time monitoring of oil distribution in the HnP experiment.N_(2)HnP experiments were then performed in a tight sandstone core sample at a temperature of 353 K and an injection pressure≥ 24 *** pore-level oil distribution under reservoir conditions was monitored and the EOR performance of N2HnP in specific pores was *** pore throat structures of the core sample and the phase behavior of the N_(2)-Oil system were analyzed to elucidate the EOR mechanism of N_(2)*** oil recovery factor of 37.52% can be achieved after four cycles,which proves the EOR potential of N_(2)HnP for tight *** highest recoveries after N_(2)HnP are obtained in the large pores,followed by the medium pores,the small pores,and finally the micro *** in soaking time and injection pressure resulted in slight and pronounced increases in oil recovery,respectively,both of which are mainly reflected in the first ***,increasing the soaking time only slightly improves the cumulative oil recovery in the small pores while increasing the injection pressure significantly improves the cumulative oil recovery in the small,medium,and large pores ***,variations in both injection pressure and soaking time have a negligible effect on the cumulative oil recovery of the micro pores.

关键词： Tight oil reservoirs N_(2)huff-n-puff Pore-level production characteristics Impact factors Nuclear magnetic resonance

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The detection of tetrahydrofuran hydrate formation and saturation using magnetic resonance imaging technique

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Journal of Natural Gas Chemistry 2010年第3期19卷 224-228页

作者： Yu Liu Yongchen Song Yongjun Chen Lei Yao Qingping Li key lab of Ocean Energy Utilization and Energy Conservation of Ministry of Education Dalian University of Technology Dalian 116024 Liaoning China Research Center of China National Offshore Oil Corporation Beijing 100027 China

Tetrahydrofuran（THF） hydrate was formed in bulk as well as in glass beads pack with a mean diameter of 3.0 mm by controlling the temperature under ambient *** of THF hydrate formation procedure were obtained using the magnetic resonance imaging（MRI） *** experiment results showed that MRI is an effective method for the detection of hydrate *** of hydrate formed both in bulk and glass beads can be confirmed by intensity integration of MRI images.

关键词： tetrahydrofuran hydrate magnetic resonance imaging glass beads saturation

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Real-time monitoring of tumor vascular disruption induced by radiofrequency assisted gadofullerene

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Science China Materials 2018年第8期61卷 1101-1111页

作者： Ruijun Deng Yuqing Wang Mingming Zhen Xue Li Toujun ZOU Jie Li Tong Yu Yue Zhou Zhigao Lu Hui Xu Chunying Shu Chunru Wang beijing National laboratory for Molecular Sciences Key Laboratory of Molecular Nanostructure and NanotechnologyCAS Research / Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049Chin CAS key lab for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China

The anti-vascular therapy has been extensively studied for high performance tumor therapy by suppressing the tumor angiogenesis or cutting off the existing tumor vasculature. We have previously reported a novel anti-tumor treatment technique using radiofrequency （RF）-assisted ga- dofullerene nanocrystals （GFNCs） to selectively disrupt the tumor vasculature. In this work, we further revealed the changes on morphology and functionality of the tumor vas-culature during the high-performance RF-assisted GFNCs treatment in vivo. Here, a dearly evident mechanism of this technique in tumor vascular disruption was elucidated. Based on the H22 tumor bearing mice with dorsal skin flap chamber （DSFC） mode] and the dynamic contrast enhanced magnetic resonance imaging （DCE-MRI） technique, it was revealed that the GFNCs would selectively inset in the gaps of tumor vas-culature due to the innately incomplete structures and unique microenvironment of tumor vasculature,＇ and they damaged the surrounding endothelia cells excited by the RF to induce a phase transition accompanying with size expansion. Soon afterwards, the blood flow of the tumor blood vessels was permanently shut off, causing the entire tumor vascular net- work to collapse within 24 h after the treatment. The RF-as- sistant GFNCs technique was proved to aim at the tumor vasculatnre precisely, and was harmless to the normal vascu- lature. The current studies provide a rational explanation on the high efficiency anticancer activity of the RF-assisted GFNCs treatment, suggesting a novel technique with potent clinical application.

关键词： gadofullerene radiofrequency dorsal skin flap chamber dynamic contrast enhanced magnetic resonance imaging tumor vasculaturegadofullerene radiofrequency dorsal skin flap chamber dynamic contrast enhanced magnetic resonance imaging tumor vasculature

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Precise Modulation Strategies for Transcranial magnetic Stimulation:Advances and Future Directions

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Neuroscience Bulletin 2021年第12期37卷 1718-1734页

作者： Gangliang Zhong Zhengyi Yang Tianzi Jiang Brainnetome Center Institute of AutomationChinese Academy of SciencesBeijing 100190China National laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Brain Science and Intelligence Technology Institute of AutomationChinese Academy of SciencesBeijing 100190China key laboratory for NeuroInformation of the Ministry of Education School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China

Transcranial magnetic stimulation(TMS)is a popular modulatory technique for the noninvasive diagnosis and therapy of neurological and psychiatric ***,current modulation strategies are only modestly *** literature provides strong evidence that the modulatory effects of TMS vary depending on device components and stimulation *** differential effects are important when designing precise modulatory strategies for clinical or research *** in TMS have been accompanied by advances in combining TMS with neuroimaging techniques,including electroencephalography,functional nearinfrared spectroscopy,functional magnetic resonance imaging,and positron emission *** studies appear particularly promising as they may not only allow us to probe affected brain areas during TMS but also seem to predict underlying research directions that may enable us to precisely target and remodel impaired cortices or ***,few precise modulation strategies are available,and the long-term safety and efficacy of these strategies need to be ***,we review the literature on possible technologies for precise modulation to highlight progress along with limitations with the goal of suggesting future directions for this field.

关键词： Transcranial magnetic stimulation Modulation strategies Precise stimulation target Coil location Individual treatment paradigm

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Porosity of gas shale:Is the NMR-based measurement reliable?

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Petroleum Science 2022年第2期19卷 509-517页

作者： Peng Zhao Bo He Bo Zhang Jun Liu key laboratory of Deep Underground Science and Engineering(Ministry of Education) College of Architecture and EnvironmentSichuan UniversityChengduSichuan 610065China Institute of New Energy and Low-Carbon Technology Sichuan UniversityChengduSichuan 610065China Institute of Science and Technology China Three Gorges CorporationBeijing100038China

Aiming at obtaining an accurate porosity of gas shale,various approaches are ***,nuclear magnetic resonance(NMR),being treated as a kind of new-developed technique,possesses the representative ***,as a booming technique,the reliability of NMR-based porosity of shale is not exactly *** on NMR device,this work measured the porosity of shale experiencing different water soaking time,accordingly,judging the reliability of NMR-based *** indicate the NMR outcomes vary with the water soaking time,making a doubt about the objectivity of NMRbased porosity in reflecting the real shale ***,some supplementary means were adopted to verify the water soaking-induced variation in the pore system of shale sample,which intensities the suspicion if the NMR-based porosity is reliable or *** sum up,this work considers that the NMR-based porosity of shale is not reliable enough when water is used as the ***,this work also offers some suggestions on how to enhance the reliability of NMR-based porosity of shale ***,this work selects a fresh perspective to analyze the NMR approach in determining shale porosity,which is hopefully helpful in promoting the development of NMR technique in the shale-related field.

关键词： Gas shale Low-field NMR Porosity measurement Low-temperature nitrogen adsorption

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