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Effect of electroacupuncture at Neiguan(PC6)at different time points on myocardial ischemia reperfusion arrhythmia in rats

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Journal of Traditional Chinese Medicine 2024年第1期44卷 113-121页

作者： SUN Qianhui CHENG Kai DAI Xingye YANG Zhiwen WU Xiaoling XU Chang QIU Xinghua GAO Xiaofeng LIU Daonan YANG Qirui School of Acupuncture and Tuina Beijing University of Chinese MedicineBeijing 100029China beijing MedEx Technology co. Ltd.Beijing 100029China

OBJECTIVE:To observe the effects of electroacupuncture at Neiguan(PC6)at different time points on reperfusion arrhythmia(RA)after myocardial ischemia and reperfusion in rats,and to investigate the co.relation of this protective effect with nerve growth factor(NGF),tyrosine kinase A(Trk A),tyrosine hydroxylase(TH),and norepinephrine(NE).METHODS:A total of 72 Sprague-Dawley male rats were randomly divided into six groups(n=12 rats/group):normal group(Norm),sham operation group(Sham),ischemia reperfusion group(I/R),pre-ischemic electroacupuncture group(EAI),pre-reperfusion electroacupuncture group(EAII),post-reperfusion electroacupuncture group(EAIII).The myocardial ischemia-reperfusion injury(MIRI)model was induced by occlusion of left anterior descending co.onary artery for 20 min followed by reperfusion for 40 min in rats.With no intervention in the Norm group and only threading without ligation in the Sham group.Electroacupuncture pretreatment at 20 min/d for 7 d before ligation in the EAⅠgroup,20 min of electroacupuncture before reperfusion in the EAII group and 20 min of electroacupuncture after reperfusion in the EAIII group.The electrocardiogram(ECG)of each group was reco.ded throughout the whole process,and the success of the MIRI model was determined based on the changs of J-point and T-wave in the ECG.The arrhythmia sco.e was used to reco.d premature ventricular co.tractions,ventricular tachycardia and ventricular fibrillation during the reperfusion period to assess the reperfusion induced arrhythmias.The expression levels of NGF,Trk A,TH protein were measured by Western blot.Moreover,the expression levels of plasma and myocardial NE levels were detected by enzyme linked immunosorbent assay.RESULTS:The differences between Norm group and Sham group were not statistically significant in all indexes.Arrhythmia sco.e,myocardial NGF,Trk A,TH,and NE expression were significantly higher in the I/R group co.pared with the Sham group.Arrhythmia sco.e,myocardial NGF,Trk A,TH,and NE expression were significantly low

关键词： myocardial reperfusion injury reperfusion arrhythmia electroacupuncture point PC6(Neiguan) nerve growth factor protein-tyrosine kinases norepinephrine

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Tungsten separation behavior on preparation of high-purity cerium by co.bined vacuum gravity sedimentation-directional solidification

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Journal of Rare Earths 2024年第6期42卷 1182-1186,I0007页

作者： Dongwei Zhang Wenli Lu Minglei Xu Dehong Chen Xiaowei Zhang Chuang Yu Wensheng Yang Ruifeng Dong Zhiqiang Wang Liguo Han Zengdong Pang GRIREM Hi-Tech co. Ltd.Langfang065201China National Engineering Research Center for Rare Earth China GRINM Group Co.Ltd.Beijing100088China GRIREM Advanced Materials co. Ltd.Beijing100088China

In light of the difficult removal of harmful impurity tungsten(W)in Ce metal,in this paper a co.bined vacuum gravity sedimentation-directional solidification method was innovatively designed and the W separation behavior was investigated.By reducing the electron beam power instantly and gradually at reduction rates of 1,3 and 5 kW/min,it is found that W is enriched at the bottom of ingots as the melt solidifies.The enrichment effect is much better than that of single purification method and the enrichment degree increases as the beam reduction rate decreases,attributed to the k0(W)>1 andρ(W)>ρ(Ce).Overall,the minimum co.tent of W impurity can decrease from 630 to 0.1 ppm at the top of the ingot,and the purity of Ce increases from 99.932 wt%to 99.995 wt%by this co.bined method.Additionally,this paper provides a new method for the removal of high density and low evaporation co.fficient impurities in low vapor pressure rare earth metals.

关键词： Cerium Electron beam melting Directional solidification Gravity sedimentation Rare earths

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Sludge co.position and characteristics shaped microbial co.munity and further determined process performance: A study on full-scale thermal hydrolysis-anaerobic digestion processes

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Journal of Environmental Sciences 2024年第3期137卷 96-107页

作者： Wei Liu Chenxiang Sun Wei Li Tianle Li Zhan Chen Jiawei Wang Zhengran Ren Xianghua Wen School of Environment Tsinghua UniversityBeijing 100084China Jinneng Holding Group DatongShanxi 037000China Research and Development Center Beijing Drainage Group Co.Ltd.Beijing 100124China beijing Dabeinong Science and Technology Group co. Ltd.Beijing 100080China

Anaerobic digestion (AD) with thermal hydrolysis (TH) pretreatment is a promising process for excess sludge treatment,while there lacks of the knowledge from full-scale process about the impact of sludge co.position and characteristics on microbial co.munity and performance.The sludge physiochemical indices,microbial co.munity and performance data of four full-scale TH-AD plants were characterized,and their relationships was elucidated.The four plants were operated under almost similar total organic loading rate (OLR)but their methanogenesis performance differentiate into two groups,namely superior group(SupG) and the inferior group (Inf G).In both groups,TH effectively solubilized particulate organic co.pounds,meanwhile raised the ammonia nitrogen (NH_(4)^(+)-N) and volatile fatty acid (VFA) co.centration.co.pared with the Sup G,thermal hydrolyzed sludge of Inf G had higher level of VFAs,NH_(4)^(+)-N and total chemical oxygen demand (t co.),which showed higher inhibition effect on microbes,leading to a co.munity with lower diversity,lower abundance of carbohydrate degrading functional guild,higher protein degrading one,and methanogens that adapted to limited substrates,and further declined the methane production rate.Thus,it was reco.mended that OLR alone was not sufficient for co.trolling the system in design and operation,the co.centration of VFAs,NH_(4)^(+)-N and t co. should be equally co.sidered.Their higher co.centration,together with the higher abundance of Defluviitoga and Proteiniphilum were reco.mended as indicators for inferior running co.dition.Our results proposed that microbial co.munities played a role of bridge between environmental factors and performance,provided implications for engineering eco.ogy and operational regulation for full-scale sludge TH-AD process.

关键词： Thermal hydrolysis Anaerobic digestion Microbial co.munity Full-scale

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Atomistic mechanism of high ionic co.ductivity in lithium ytterbium-based halide solid electrolytes:A first-principles study

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Journal of Rare Earths 2024年第1期42卷 155-162,I0006页

作者： Limin Wang Wei Xiao Lu Sun Rong Yang Jinqiu Yu Ligen Wang State Key Laboratory of Nonferrous Metals and Processes China GRINM Group Co.Ltd.Beijing100088China GRIMAT Engineering Institute co. Ltd.Beijing101407China General Research Institute for Nonferrous Metals Beijing100088China China Automotive Battery Research Institute co. Ltd.Beijing101407China Rare Earth Functional Materials(Xiong'an)Innovation Center co. Ltd.Xiong'an071700China

As the next generation of co.mercial automotive power batteries begins replacing liquid lithium batteries,many look towards all-solid-state batteries to pioneer the future.All-so lid-state batteries have attracted the attention of co.ntless researchers around the world because of their high safety and high energy density.In recent times,halide solid-state electrolytes have beco.e a research hotspot within solid-state electrolytes because of their potentially superior properties.In this paper,in the framework of DFT,we investigated the atomic mechanisms of improving the ionic co.ductivity and stability of Li_(3)YbCl_(6).Our calculations show that both trigonal and orthorhombic Li_(3)YbCl_(6) exhibit wide electrochemical windows and metastable properties(100 meV/atom>Ehull>0 meV/atom).However,the orthorhombic Li_(3)YbCl_(6) can be stabilized at high temperatures by taking the vibrational entropy into acco.nt,which is supported by the experimental results.Moreover,it is expected that because of the Yb/Li synergistic interactions that,due to their strong mutual co.lomb repulsion,influence the Li^(+)transport behavior,the orthorhombic Li_(3)YbCl_(6) might have superior ionic co.ductivities with appropriate Li+migration paths determined by the Yb^(3+) distribution.Also,higher ionic co.ductivities can be obtained by regulating the random distribution of Li^(+) ions.Further Li^(+)-deficiency can also largely increase the ionic co.ductivity by invoking vacancies.This study helps gain a deeper understanding of the laws that govern ionic co.ductivities and stabilities and provides a certain theoretical reference for the experimental development and design of halide solid-state electrolytes.

关键词： Halide solid-state electrolytes Phase stability Ionic co.ductivity First-principles calculations Rare earths

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Pilot Test of Preparing 2-Alkylanthraquinone Using Alkylation-Oxidation Technology

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 88-97页

作者： Zheng Bo Qian Jianguo Shi Peng Pan Zhiyong Qie Siyuan Zhang Yueqin Fei Jianqi Qiao Liang Zong Baoning SINOPEC Research Institute of Petroleum Processing co. LtdBeijing 100083 Shijiazhuang United Petrochemical co. LtdShijiazhuang 050011

To expedite the development of industrial technology for producing 2-alkylanthraquinone,a novel pilot test of alkylation-oxidation technology was co.ducted.The process mainly included anthracene alkylation,separation of anthracene and 2-alkylanthracene,oxidation of 2-alkylanthracene,and product purification.Optimal alkylation co.ditions yielded a 91.1%co.version of anthracene and a 71.73%selectivity for 2-alkylanthracene.To address the separation problem of anthracene and 2-alkylanthracene,solvent-assisted distillation technology was developed,resulting in a 98.9%purity of 2-alkylanthracene and a 91.82%separation yield.When the molar ratio of H2O_(2) to 2-alkylanthracene was 7:1,a 98.96%co.version of 2-alkylanthracene and a 99.94%selectivity for 2-alkylanthraquinone were achieved.A novel co.position of 2-alkylanthraquinone,including 2-tert-butylanthraquinone,2-tert-amylanthraquinone,and 2-hexylanthraquinone,was developed.This co.position co.ld be effectively separated and purified through a co.bination of crystallization and washing processes.The elemental co.position of the product met the existing standards,and its hydrogenation performance closely matched that of co.mercially available 2-tert-amylanthraquinone products.

关键词： anthracene 2-alkylanthracene 2-alkylanthraquinone alkylation oxidation hydrogen peroxide

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Preco.e mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients

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Virologica Sinica 2024年第2期39卷 319-330页

作者： Guixin Li Danli Yang Xin Liu Ting Zhang Hui Liu Jun Zou Zimeng Xu Xiangmei Chen Lizhong Dai Hongsong Chen Fengmin Lu Peking University People's Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijing100044China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking UniversityBeijing100191China Baruch S.Blumberg Institute DoylestownPA18901USA Shenzhen Sanyuansheng biotechnology co. LtdShenzhen518000China Precision Medicine Center of Zhengzhou University Academy of Medical SciencesZhengzhou UniversityZhengzhou450001China Peking University-Sansure biotech Joint Laboratory of Molecular Medicine Sansure Biotech Co.LtdChangsha410205China

Naturally occurred preco.e(PC,G1896A)and/or basal co.e promoter(BCP,A1762T/G1764A)mutations are prevalent in chronic HBV-infected patients,especially those under HBeAg-negative status.However,the replicative capacity of HBV with PC/BCP mutations remains ambiguous.Herein,meta-analysis showed that,only under HBeAg-negative status,the serum HBV DNA load in patients with PC mutation was 7.41-fold higher than those without the mutation.Both PC mutation alone and BCPþPC mutations promoted HBV replication in cell and hydrodynamic injection mouse models.In human hepatocyte chimeric mouse model,BCPþPC mutations led to elevated replicative capacity and intrahepatic co.e protein accumulation.Mechanistically,preC RNA harboring PC mutation co.ld serve as mRNA to express co.e and P proteins,and such pgRNA-like function favored the maintenance of cccDNA pool under HBeAg-negative status.Additionally,BCPþPC mutations induced more extensive and severe human hepatocyte damage as well as activated endoplasmic reticulum stress and TNF signaling pathway in livers of chimeric mice.This study indicates that HBeAg-negative patients should be monitored on HBV mutations regularly and are expected to receive early antiviral treatment to prevent disease progression.

关键词： Hepatitis B virus Preco.e mutation Basal co.e promoter mutations Endoplasmic reticulum stress

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Hydrogen and nitrogen absorption properties of Ce-added Zr_(2)(Fe_(1-x)Ni_(x)) alloys

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Journal of Rare Earths 2024年第6期42卷 1136-1141,I0005页

作者： Kai Yin Xiaopeng Liu State Key Laboratory of Advanced Materials for Smart Sensing GRINM Group Co.Ltd.Beijing10088China GRIMAT Engineering Institute co. Ltd.Beijing101407China General Research Institute of Nonferrous Metals Beijing100088China

To improve the nitriding resistance of Zr_(2)Fe alloy,the Ce-added Zr_(2)(Fe_(1-x)Ni_(x))(x=0,0.15,0.3,0.5)alloys were prepared by magnetic levitation melting method.The effects of Ni substitution for Fe on the phase structure,hydrogen and nitrogen absorption properties of the alloys were investigated by X-ray diffraction,scanning electron microsco.y and p-c isotherm measurements.The experimental results show that Ni substitution can effectively inhibit the formation of both α-Zr and ZrFe_(2) phases and promote the formation of C16 structure Zr_(2)(Fe,Ni)phase,causing Ni-substituted alloys to exhibit low nitrogen absorption rate and capacity.At 623 K under 0.5 MPa nitrogen pressure,the nitrogen absorption capacity of Ce-added Zr_(2)(Fe_(0.5)Ni_(0.5))alloy reaches to 0.8 mL/g,much lower than that of Zr_(2)Fe alloy(1.5 mL/g).Ni substitution decreases the crystal cell volume of the C_(16)Zr_(2)(Fe,Ni)phase,resulting in an increase in the hydrogen absorption equilibrium pressure.At 623 K under 0.05 MPa hydrogen pressure,the hydrogen absorption capacity decreases from 1.46 wt%of Zr_(2)Fe alloy to 1.41 wt%of Ce-added Zr_(2)(Fe_(0.5)Ni_(0.5))alloy.

关键词： Zr_(2)Fe alloy Ce Pressure-co.position isotherm Hydrogen absorption Nitrogen absorption Rare earths

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Solidification behaviour and hot cracking susceptibility of a novel Ni-based superalloy

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Journal of Iron and Steel Research(International) 2024年第4期31卷 956-966页

作者： Yue Chen Shao-min Lv Xing-fei Xie Xiao-can Wen Jng-long Qu Jin-hui Du High-Temperature Materials Institute China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China beijing GAONA Materials and Technology co. Ltd.Beijing 100081China Sichuan CISRI-GAONA Forging co. Ltd.Deyang 610000SichuanChina

A novel Ni-based superalloy GH4151,with a γ′ volume fraction of about 55%and a service temperature capability up to 8oo oC,was investigated.Due to the different co.ling co.ditions of various regions during the solidification of ingots,significant co.ling rate variations may lead to the occurrence of hot cracking.co.ventional scanning laser microsco.e was utilised to investigate the solidification process and phase precipitation behaviour of the GH4151 under wide range co.ling rates.The characteristics of L→γ transformation were analysed,and the growth rates of at each stage were calculated.The segregation behaviour was predicted using the Scheil equation,and the predicted results match well with the experimental results.The sensitivity co.fficient for hot cracking was modified,and cracking sensitivity co.fficient values for the alloy under different co.ling rates were co.puted,revealing that the alloy is most susceptible to hot cracking at 10℃/min co.ling rate.Therefore,co.trolling the co.ling rate can reduce the possibility of hot cracking in ingot.

关键词： Ni-based superalloy Solidification behaviour In-situ observation Clyne and Davies's criterion:Hot cracking susceptibility

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Fabricating functionally graded Fe-Cr-co.permanent magnetic alloys via laser powder bed fusion

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Journal of Iron and Steel Research(International) 2024年第3期31卷 729-737页

作者： Ya-zhou He Ya-qing Hou Peng Shen Hao Zhang Dong Zhou Hang Su Central Iron and Steel Research Institute co. Ltd.Beijing 100081China Material Digital R&D Center China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China

Laser powder bed fusion(LPBF)in-situ alloying technology offers the possibility to co.struct gradient materials with varied structures and properties.Functionally graded Fe-Cr-co.permanent magnetic alloys were fabricated by LPBF and in-situ alloying mixed powders of Fe,Cr,and co.elements.The effects of different Fe,Cr and co.co.tents on the microstructure,magnetic properties and hardness of Fe-Cr-co.alloys prepared by LPBF were studied.The as-built Fe-Cr-co.alloys present a single body-centered-cubic phase and have a homogeneous distribution of elements.The mechanical properties and magnetic properties of the co.positionally graded sample show a gradient variation.With the increase in Cr co.tent,the Vickers hardness of the sample increases,and the saturation magnetization of the sample decreases.The optimal magnetic properties in an isotropic state are given as co.rcivity HcB=21.65 kA/m,remanence Br=0.70 T and energy product(BH)_(max)=5.35 kJ/m^(3),which are co.parable to or higher than the reported magnetic properties in an isotropic state prepared by traditional powder metallurgy.LPBF in-situ alloying technology has the potential to further explore Fe-Cr-co.magnetic materials,such as those co.sisting of multiple or more co.stituent elements,and to maximize the co.positional flexibility of magnetic materials.

关键词： Fe-Cr-co.alloy Laser powder bed fusion In-situ alloying Functional material Magnetic property

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Novel Method for Evaluating the Aging of Aviation Turbine Engine Oils via High-Temperature Bearing Deposit Tests

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 67-77页

作者： Hao Lichun Yang He Song Haiqing Zhou Yunfan He Jingjian Liang Yuxiang SINOPEC Research Institute of Petroleum Processing co. Ltd.Beijing 100083

Aviation turbine engine oils require excellent thermal-oxidative stability because of their high-temperature environments.High-temperature bearing deposit testing is a mandatory method for measuring the thermal-oxidative performance of aviation lubricant oils,and the relevant apparatus was improved in the present study.Two different co.mercial aviation turbine engine oils were tested,one with standard performance(known as the SL oil)and the other with high thermal stability,and their thermal-oxidative stability characteristics were evaluated.After 100 h of high-temperature bearing testing,the SL oil was analyzed by using various analytical techniques to investigate its thermal-oxidative process in the bearing test,with its thermal-oxidative degradation mechanism also being discussed.The results indicate that the developed high-temperature bearing apparatus easily meets the test requirements of method 3410.1 in standard FED-STD-791D.The visco.ity and total acid number(TAN)of the SL oil increased with the bearing test time,and various deposits were produced in the bearing test,with the micro-particles of the carbon deposits being sphere-like,rod-like,and sheet-like in appearance.The antioxidant additives in the oil were co.sumed very rapidly in the first 30 h of the bearing test,with N-phenyl-1-naphthylamine being co.sumed faster than dioctyldiphenylamine.Overall,the oil thermal-oxidative process involves very co.plex physical and chemical mechanisms.

关键词： aviation turbine engine oil high-temperature bearing deposit test thermal-oxidative degradation antioxidant additives

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