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Mapping tree species distribution in support of China's integrated tree-livestock-crop system

Circular Agricultural Systems 2021年第1期1卷 9-19页

作者： Sailesh Ranjitkar Dengpan Bu Nani Maiya Sujakhu Marius Gilbert Timothy PRobinson Roeland Kindt Jianchu Xu Honghe Center for Mountain Futures Kunming Institute of BotanyHonghe County 654400YunnanChina N.gene Solution of Natural Innovation Pvt.Ltd. Kathmandu 44614Nepal Mid-Western University Faculty of Humanities and Social ScienceNaya BatoLalitpur 44600Nepal State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China Hunan co.Innovation Center of Animal Production Safety ChangshaHunanChina National Centre for Borderland Ethnic Studies in Southwest China Yunnan UniversityKunming 650091China UniversitéLibre de Bruxelles(ULB) Brussels 1050Belgium Animal Production and Health Division(AGA) Food and Agriculture Organization of the United NationsRome 00153Italy World Agroforestry(ICRAF) United Nations AvenueGigiriNairobi 00100Kenya Key Laboratory of Eco.omic Plants and Biotechnology Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China East and Central Asia Regional World Agroforestry Centre(ICRAF)Kunming 650201China

The primary challenge of the co.temporary world is to meet accelerating requirements for *** land,co.petition between crop and livestock farming and climate change are major *** offer a form of sustainable agriculture through the direct provision of food by raising farmers’inco.es and through various eco.ystem *** first essential step in adopting agroforestry is the selection of appropriate tree species that fit local *** this paper,we mapped 20 fodder trees and important crops in China using the multi-model ensemble and Eco.rop modelling *** on the intersectional co.cept of set theory,the fuzzy logic technique was applied to identify regions where candidate trees co.ld be grown with appropriate crops and *** resulting models provide important insights into the climatic suitability of trees and crops and offer knowledge critical to the proper integration of trees with crops and livestock at specific *** results offer support for developing appropriate strategies regarding potential land-use within agroforestry systems in order to maximize eco.ystem services and the benefits of sustainable *** outputs co.ld easily co.vert into co.ventional maps with clearly defined boundaries for site-specific planning for tree-crop-livestock *** next step for actualizing an integrated system is to investigate specifically what these different species may co.tribute to the existing farming systems,quantify the benefits and estimate any possible tradeoffs.

关键词： system intersection crops

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DNA crosslinking and reco.bination-activating genes 1/2(RAG1/2)are required for onco.enic splicing in acute lymphoblastic leukemia

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Cancer co.munications 2021年第11期41卷 1116-1136页

作者： Hao Zhang Nuo Cheng Zhihui Li Ling Bai Chengli Fang Yuwen Li Weina Zhang Xue Dong Minghao Jiang Yang Liang Sujiang Zhang Jianqing Mi Jiang Zhu Yu Zhang Sai-Juan Chen Yajie Zhao Xiang-Qin Weng Weiguo Hu Zhu Chen Jinyan Huang Guoyu Meng Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational MedicineRui-Jin HospitalSchool of Medicine and School of Life Sciences and BiotechnologyShanghai JiaoTong UniversityShanghai 200025P.R.China Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Department of Hematologic Onco.ogy State key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Geriatrics Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025P.R.China Medical Center on Aging of Ruijin Hospital Shanghai Jiao Tong University School of MedicineShanghai 200025P.R.China Department of Laboratory Medicine West China HospitalSichuan UniversityChengduSichuan 610044P.R.China Biomedical Big Data Center the First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310000P.R.China Cancer Center Zhejiang UniversityHangzhouZhejiang 310000P.R.China

Background:Abnormal alternative splicing is frequently associated with *** B-cell acute lymphoblastic leukemia(B-ALL),double homeobox 4 fused with immunoglobulin heavy chain(DUX4/IGH)can lead to the aberrant production of E-26 transformation-specific family related gene abnormal transcript(ERGalt)and other splicing ***,the molecular mechanism underpinning this process remains ***,we aimed to know how DUX4/IGH triggers abnormal splicing in ***:The differential intron retention analysis was co.ducted to identify novel DUX4/IGH-driven splicing in B-ALL patients.X-ray crystallography,small angle X-ray scattering(SAXS),and analytical ultracentrifugation were used to investigate how DUX4/IGH reco.nize double DUX4 responsive element(DRE)-DRE *** ERGalt biogenesis and B-cell differentiation assays were performed to characterize the DUX4/IGH crosslinking *** check whether reco.bination-activating gene 1/2(RAG1/2)was required for DUX4/IGH-driven splicing,the proximity ligation assay,co.immunoprecipitation,mammalian two hybrid characterizations,in vitro RAG1/2 cleavage,and shRNA knock-down assays were ***:We reported previously unreco.nized intron retention events in Ctype lectin domain family 12,member A abnormal transcript(CLEC12Aalt)and chromosome 6 open reading frame 89 abnormal transcript(C6orf89alt),where also harbored repetitive DRE-DRE ***,X-ray crystallography and SAXS characterization revealed that DUX4 homeobox domain(HD)1-HD2 might dimerize into a dumbbell-shape trans co.figuration to crosslink two adjacent DRE *** DUX4/IGH-mediated crosslinking abolishes ERGalt,CLEC12Aalt,and C6orf89alt biogenesis,resulting in marked alleviation of its inhibitory effect on B-cell ***,we also observed a rare RAG1/2-mediated reco.bination signal sequence-like DNA edition in DUX4/IGH target ***,shRNA knock-down of RAG1/2 in leukemic Reh cells c

关键词： Acute lymphoblastic leukemia alternative splicing DUX4/IGH ERG_(alt) RAG1/2

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