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Numerical Simulation on Radon Retardation Behavior of Covering Floats in Radon-Containing Water

Biomedical and Environmental Sciences 2024年第4期37卷 406-417页

作者： LIU Shu Yuan ZHANG Li YE Yong Jun DING Ku Ke National Institute for Radiological Protection Chinese Center for Disease Control and PreventionBeijing 100088China Office for Public Health Management Chinese Center for Disease Control and PreventionBeijing 102206China Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy University of South ChinaHengyang 421001HunanChina

Objective This study aimed to efficiently reduce the release of radon from water bodies to protect the *** Based on the sizes of the experimental setup and modular float,computational fluid dynamics(CFD)was used to assess the impact of the area coverage rate,immersion depth,diffusion coefficient,and radon transfer velocity at the gas–liquid interface on radon migration and exhalation of radon-containing *** on the numerical simulation results,an estimation model for the radon retardation rate was *** effectiveness of the CFD simulation was evaluated by comparing the experimental and simulated variation values of the radon retardation rate with the coverage area *** The effect of radon transfer velocity on radon retardation in water bodies was minor and insignificant according to the appropriate value;therefore,an estimation model of the radon retardation rate of the coverage of a radon-containing water body was constructed using the synergistic impacts of three factors:area coverage rate,immersion depth,and diffusion *** deviation between the experimental and simulated results was<4.3%.Conclusion Based on the numerical simulation conditions,an estimation model of the radon retardation rate of covering floats in water bodies under the synergistic effect of multiple factors was obtained,which provides a reference for designing covering floats for radon retardation in radoncontaining water.

关键词： Radon-containing water Radon retardation rate CFD Coverage experiment Optimized design

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Analysis of Epidemiological and Issues Encountered in Case Reports on Echinococcosis—China,2022

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China CDC weekly 2024年第6期6卷 100-104页

作者： Yan Kui Shuai Han Xiaojuan Zhang Guangzhong Shi Yale Yu Ruirui Li Peizheng Zhan Hongju Duan Wenbo Luo Benfu Li Shaoqi Ning Yalan Zhang Aiya Zhu Jingbo Xue National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)National Health Commission Key Laboratory of Parasite and Vector BiologyWorld Health Organization Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Gansu Provincial center for disease control and prevention Lanzhou CityGansu ProvinceChina The center for disease control and prevention of Xinjiang Uygur Autonomous Region Urumuqi CityXinjiang Uygur Autonomous RegionChina Xinjiang Production and Construction Corps center for disease control and prevention Urumuqi CityXinjiang Uygur Autonomous RegionChina Sichuan Provincial center for disease control and prevention Chengdu CitySichuan ProvinceChina Qinhai Institute for Endemic disease control and prevention Xining CityQinghai ProvinceChina Ningxia center for disease control and prevention Yinchuan CityNingxia Hui Autonomous RegionChina Inner Mongolia Autonomous Region center for Comprehensive disease control and prevention Hohhot CityInner Mongolia AutonomousChina Yunnan Institute of Parasitic diseases Puer CityYunnan ProvinceChina Shaanxi Provincial center for disease control and prevention Xi'an CityShaanxi ProvinceChina Henan Provincial center for disease control and prevention Zhengzhou CityHenan ProvinceChina Guizhou Provincial center for disease control and prevention Guiyang CityGuizhou ProvinceChina

Summary What is already known about this topic?Echinococcosis is classified as a Class C infectious disease in *** is endemic in 370 counties located in the agricultural and pastoral regions of western *** is added by this report?This report provides a comprehensive overview of the cases of echinococcosis reported in China in *** a thorough evaluation conducted by provincial CDCs.

关键词： China Ech counties

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Iodine Nutrition, Thyroid-stimulating Hormone, and Related Factors of Postpartum Women from three Different Areas in China: A Cross-sectional Survey

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Biomedical and Environmental Sciences 2024年第3期37卷 254-265页

作者： SHAN Xiao Yun ZOU Yan HUANG Li Chun JIANG Shan ZHOU Wei Wen QIN Qiu Lan LIU Chang Qing LUO Xiao Yan LU Jia Xi MAO De Qian LI Min YANG Zhen Yu YANG Li Chen Key Laboratory of Trace Element Nutrition of National Health Committee National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 241001HunanChina Zhejiang Provincial center for disease prevention and control Hangzhou 310051ZhejiangChina Guangxi Zhuang Autonomous Region center for disease control and prevention Nanning 530028GuangxiChina Hebei Provincial center for disease control and prevention Shijiazhuang 050021HebeiChina

Objective Studies on the relationship between iodine,vitamin A(VA),and vitamin D(VD)and thyroid function are *** study aimed to analyze iodine and thyroid-stimulating hormone(TSH)status and their possible relationships with VA,VD,and other factors in postpartum *** A total of 1,311 mothers(896 lactating and 415 non-lactating)from Hebei,Zhejiang,and Guangxi provinces were included in this *** urinary iodine concentration(UIC),TSH,VA,and VD were *** The median UIC of total and lactating participants were 142.00µg/L and 139.95µg/L,*** median TSH,VA,and VD levels in all the participants were 1.89 mIU/L,0.44μg/mL,and 24.04 ng/mL,*** differences in the UIC were found between lactating and non-lactating *** and TSH levels were significantly different among the three *** rural UIC was higher than the urban *** mothers had a higher UIC and a higher prevalence of excessive *** UICs and TSHs levels were observed in both the VD deficiency and insufficiency groups than in the VD-sufficient *** adjustment,no linear correlation was observed between UIC and VA/*** interaction was found between vitamins A/D and UIC on TSH *** The mothers in the present study had no iodine ***,area type,BMI,and VD may be related to the iodine status or TSH levels.

关键词： Median urinary iodine concentration Thyroid-stimulating hormone Vitamin A Vitamin D Postpartum women

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Toward tuberculosis elimination by understanding epidemiologic characteristics and risk factors in Hainan Province, China

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Infectious diseases of Poverty 2024年第1期13卷 107-108页

作者： Changqiang Zhou Tao Li Jian Du Dapeng Yin Xiujun Li Shixue Li Department of Biostatistics School of Public Health Cheeloo College of Medicine Shandong University Jinan People’s Republic of China National center for Tuberculosis control and prevention Chinese Center for Disease Control and Prevention Beijing People’s Republic of China Clinical center On TB control Beijing Chest Hospital Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing People’s Republic of China Hainan center for disease control and prevention Haikou People’s Republic of China Research center for Tuberculosis control Shandong University Jinan People’s Republic of China

Background The disease burden of tuberculosis(TB)was heavy in Hainan Province,China,and the information on transmission patterns was limited with few *** atudy aims to further explore the epidemiological charac-teristics and influencing factors of TB in Hainan Province,and thereby contribute valuable scientific evidences for TB elimination in Hainan *** The TB notification data in Hainan Province from 2013 to 2022 were collected from the Chinese National disease control Information System Tuberculosis Surveillance System,along with socio-economic *** spatial-temporal and population distributions were analyzed,and spatial autocorrelation analysis was conducted to explore TB notification rate *** addition,the epidemiological characteristics of the cases among in-country migrants were described,and the delay pattern in seeking medical care was ***,a geographically and tem-porally weighted regression(GTWR)model was adopted to analyze the relationship between TB notification rate and socio-economic *** tailored control suggestions in different regions for TB elimination was provided by understanding epidemiological characteristics and risk factors obtained by *** From 2013 to 2022,64,042 cases of TB were notified in Hainan *** estimated annual percent-age change of TB notification rate in Hainan Province from 2013 to 2020 was-6.88%[95%confidence interval(CI):-5.30%,-3.69%],with higher rates in central and southern *** majority of patients were males(76.33%)and farmers(67.80%).Cases among in-country migrants primarily originated from Sichuan(369 cases),Heilongjiang(267 cases),Hunan(236 cases),Guangdong(174 cases),and Guangxi(139 cases),accounting for 53%.The majority(98.83%)of TB cases were notified through passive case finding approaches,with delay in seeking *** GTWR analysis showed that gross domestic product per capita,the number of medical institutions and health personnel

关键词： Tuberculosis Elimination Hainan Province China Epidemiological characteristics Geographically Temporally weighted regression

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Using Healthcare Big Data Analytics to Improve Women’s Health:Benefits,Challenges,and Perspectives

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China CDC weekly 2024年第10期6卷 173-174页

作者： Heling Bao Hui Liu Linhong Wang Institute of Medical Information Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina National center for Chronic and Non-communicable disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina Women’s Health Care Branch Chinese Preventive Medicine AssociationBeijingCh

Women’s health is of paramount importance for the attainment of the Sustainable Development Goals(SDGs)and Healthy China 2030,encompassing reproductive health and physical and mental *** multifaceted concept of healt... 详细信息

关键词： Sustainable maternal Analytics

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Seizing Opportunities for Further Advancements——Address at the 35th Anniversary Symposium of BES

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Biomedical and Environmental Sciences 2024年第1期37卷 1-2页

作者： SHEN Hong Bing Chinese Academy of Engineering Director General Chinese Center for Disease Control and Prevention

The year 2023 marks the 35^(th) anniversary of the establishment of Biomedical and Environmental Sciences(BES) by the Chinese center for disease control and prevention (China CDC).This milestone provides an opportunity to review past achievements and envisage future ***-Five-Year Progress and Achievements In 1988,Professor Chunming Chen,the founding Director General of the Chinese Academy of Preventive Medicine (CAPM,renamed the China CDC in 2002),established the international journal BES to publish research results from Chinese scientists in ***,Professor Chen,along with the renowned toxicologist Professor Frederick Coulston of Albany Medical College in the United States,jointly served as the editors-in-chief,propelling the growth and development of this pioneering journal,while the editorial team is composed exclusively of professionals from the China CDC,and the editorial office was located at the China CDC.

关键词： journal founding jointly

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Food-Borne Poisoning Accident from Amanitin Toxin in Wild Mushrooms—Xingtai City,Hebei Province,China,2023

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China CDC weekly 2024年第3期6卷 56-59页

作者： Baopu Lv Liang Liu Hao Xiao Qingbing Meng Rui Zhang Yaqing An Yingli Jin Yu Ma Hengbo Gao Yongkai Li Qian He Yutao Zhang Changqing Liu Xiaoyan Luo Xiaomin Xu Fenshuang Zheng Yingping Tian Hongshun Zhang Dongqi Yao Emergency Department The Second Hospital of Hebei Medical UniversityShijiazhuang CityHebei ProvinceChina National Institute of Occupational Health and Poison control Chinese Centre for Disease Control and PreventionBeijingChina Hebei Provincial center for disease control and prevention Shijiazhuang CityHebei ProvinceChina Zhejiang Provincial center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Emergency Department The Affiliated Hospital of Yunnan UniversityKunming CityYunnan ProvinceChina

What is already known about this topic?Fatal poisonings caused by wild mushrooms containing amanita toxins pose a significant threat in the southern regions of *** toxins primarily induce gastrointestinal symptoms initially,which are then followed by potentially life-threatening acute liver *** is added by this report?This report contributes to the existing knowledge on these cases of poisoning by documenting the second occurrences in Hebei Province and the first occurrences in Xingtai *** individuals reported consuming wild mushrooms from the same origin,and laboratory tests confirmed the presence ofα-amanitin in their blood *** are the implications for public health practice?This underscores the risk associated with the collection and consumption of amanita toxin-containing mushrooms in *** is important to note that the identification of toxic and non-toxic mushrooms should not solely rely on personal experience or appearance.

关键词： Hebei consuming initially

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Superior effectiveness and acceptability of saliva samples for the detection of SARS-CoV-2 in China

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Biosafety and Health 2024年第2期6卷 88-91页

作者： Hui Yao Ying Shen Zhichao Liang Xiaoyu Xue Chenxi Zhao Xiang Xu Yuxin Cai Yonghong Liu Wei Zhang Yang Pan Xiaoli Wang beijing Office of Global Health Beijing Center for Disease Prevention and ControlBeijing 100013China Institute for Infectious disease and Endemic disease control Beijing Center for Disease Prevention and ControlBeijing 100013China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China center for Drug Evaluation National Medical Products AdministrationBeijing 100176China School of Public Health Capital Medical UniversityBeijing 100069China

In response to problems of poor sampling quality,low sensitivity,and high demand for medical personnel regarding the current severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)oropharyngeal(OP)swab sampling used in China,we aimed to evaluate the diagnostic performance and acceptability of saliva-based nucleic acid amplification tests(NAATs)in *** results showed that,using nasopharyngeal(NP)swab results as the gold standard,the overall sensitivities for saliva specimens and OP swabs were 93.3%and 85.0%,the specificities were 92.6%and 93.8%,*** results of an acceptability survey showed that the scores for saliva,OP,and NP samples were 9.46±1.69,8.11±2.42,and 4.58±3.82 out of 10,respectively,with significant differences among the three groups(P<0.05).With higher sensitivity,comparable specificity,and strong public preference,saliva-based NAATs represent a convenient and effective method for detecting SARS-CoV-2 in future epidemics.

关键词： SARS-CoV-2 Saliva sample Sensitivity Acceptability

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Establishment of a Multiplex Detection Method for Common Bacteria in Blood Based on Human Mannan-Binding Lectin Protein-Conjugated Magnetic Bead Enrichment Combined with Recombinase-Aided PCR Technology

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Biomedical and Environmental Sciences 2024年第4期37卷 387-398页

作者： ZHAO Zi Jin CHEN Xiao Ping HUA Shao Wei LI Feng Yu ZHAO Meng XING Chen Hao WANG Jie TIAN Feng Yu ZHANG Rui Qing LYU Xiao Na HAN Zhi Qiang WANG Yu Xin LI Hong Yi SHEN Xin Xin MA Xue Jun TIE Yan Qing Graduate School Hebei North UniversityZhangjiakou 075000HebeiChina Department of Clinical Laboratory Hebei General HospitalShijiazhuang 050051HebeiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases NHC Key Laboratory of Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China National Institute for Communicable disease control and prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Clinical Laboratory Pathology Diagnostic center Shiyan General HospitalShiyan 442000HubeiChina Graduate School Hebei Medical University Shijiazhuang 050031HebeiChina

Objective Recombinase-aided polymerase chain reaction(RAP)is a sensitive,single-tube,two-stage nucleic acid amplification *** study aimed to develop an assay that can be used for the early diagnosis of three types of bacteremia caused by Staphylococcus aureus(SA),Pseudomonas aeruginosa(PA),and Acinetobacter baumannii(AB)in the bloodstream based on recombinant human mannanbinding lectin protein(M1 protein)-conjugated magnetic bead(M1 bead)enrichment of pathogens combined with *** Recombinant plasmids were used to evaluate the assay *** blood influenza bacteria were used for the specific *** and clinical plasma samples were enriched with M1 beads and then subjected to multiple recombinase-aided PCR(M-RAP)and quantitative PCR(qPCR)*** analysis was used to evaluate the consistency between the two *** The M-RAP method had sensitivity rates of 1,10,and 1 copies/μL for the detection of SA,PA,and AB plasmids,respectively,without cross-reaction to other bacterial *** M-RAP assay obtained results for<10 CFU/mL pathogens in the blood within 4 h,with higher sensitivity than qPCR.M-RAP and qPCR for SA,PA,and AB yielded Kappa values of 0.839,0.815,and 0.856,respectively(P<0.05).Conclusion An M-RAP assay for SA,PA,and AB in blood samples utilizing M1 bead enrichment has been developed and can be potentially used for the early detection of bacteremia.

关键词： Staphylococcus aureus Pseudomonas aeruginosa Acinetobacter baumannii Human Mannan-binding lectin protein Bloodstream infection Recombinase-aided PCR assay Multiple detection

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Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation

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Biomedical and Environmental Sciences 2024年第4期37卷 354-366页

作者： MEI Peng DING En Min YIN Hao Yang DING Xue Xue WANG Huan WANG Jian Feng HAN Lei ZHANG Heng Dong ZHU Bao Li School of Public Health Nanjing Medical UniversityNanjing 210000JiangsuChina Institute of Occupational disease prevention Jiangsu Province Center for Disease Prevention and ControlNanjing 21000JiangsuChina Suzhou center for disease prevention and control Suzhou 215004JiangsuChina center for Global Health School of Public HealthNanjing Medical UniversityNanjing 210000JiangsuChina

Objective This study investigated the impact of occupational mercury(Hg) exposure on human gene transcription and expression, and its potential biological *** Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTEN lowexpression models were established in vitro using 293T cells. PTEN gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTEN, AKT, and PI3K protein levels. IL-6 expression was determined by *** Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTEN gene in the high-concentration Hg exposure group. In the Hg-exposed cell model(25 and 10 μmol/L), a significant decrease in PTEN expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 ***, a low-expression cell model demonstrated that PTEN gene knockdown led to a significant decrease in PTEN protein expression and a substantial increase in PI3K, AKT, and IL-6 *** This is the first study to report that Hg exposure downregulates the PTEN gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.

关键词： PTEN Occupational mercury exposure Occupational health PI3K/AKT pathway 293T cell IL-6

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