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Mechanism of action of Wuzi Yanzong pill in the treatment of oligoasthenozoospermia in rats determined via serum metabolomics

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Journal of Traditional chinese Medical Sciences 2024年第2期11卷 180-190页

作者： Zhenru Shen Zhaohua Zhang Kejin tong Chunrui Wang Shuaiqiang Wang Ping Zhao Meng Gu Jingjing Hu Yibo tang Zhenquan Liu School of chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China beijing tong ren tang co.pany Limited Beijing100062China School of Traditional chinese medicine Beijing University of Chinese MedicineBeijing102488China China beijing tong ren tang Group co. Ltd.Beijing100075China Faculty of chinese medicine Macao University of Science and TechnologyMacao999078China Department of Pathology University of California San DiegoLa JollaCA92093USA

Objective:To investigate the mechanism of action of Wuzi Yanzong pill(WYP)in rats with oligoasthenozoospermia(OAZ)via metabolomics and to provide a possible basis for improving this WYP-based ***:A rat model of OAZ was established by treating male SpragueeDawley rats with gluco.ides from Tripterygium wilfordii ***-two rats were randomly divided into six groups:co.trol,L-carnitine(positive co.trol),model,and low-,medium-,and high-dose WYP *** in the experimental groups were treated with WYP for 4 *** the end of the treatment period,sperm cell quality(density,motility,and viability)was assessed using a semen analysis system,mitochondrial membrane potential(MMP)was assessed using flow cytometry,and testicular injury was assessed using hematoxylin and eosin staining to validate the therapeutic effect of WYP in ***,serum metabolomics-based analysis was performed using high-performance liquid chromatography-mass spectrometry to identify differential metabolic pathways and possible mechanisms of action of WYP in OAZ ***:A rat model of OAZ was co.sidered successfully-established after co.paring the quality of spermatozoa in the model group to that in the co.trol ***-M and WYP-H treatments significantly improved sperm cell density,motility,and viability co.pared with those in the model group(all Pco.pared with the model group,both WYP-M and WYP-H treatments increased MMP values(P=.006 and P=.021 respectively),while there was no significant difference in the L-carnitine group.L-carnitine and WYP administration reversed damage to the testes to varying degrees co.pared with that in the model ***,44 differential metabolites and four metabolic pathways,especially autophagy pathway,related to OAZ were identified via ***:WYP improves sperm cell quality and MMP in OAZ primarily via autophagy *** findings can be employed to improve the efficacy of WYP in humans.

关键词： Wuzi Yanzong pill Oligoasthenozoospermia Sperm cell quality Metabolomics Autophagy Male infertility

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Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in co.orectal Cancer Cells

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chinese Journal of Integrative medicine 2024年第1期30卷 25-33页

作者： GAO Quan LI Lin ZHANG Qi-man SHENG Qin-song ZHANG Ji-liang JIN Li-jun SHANG Rui-yan School of Pharmacy and Department of Medical Onco.ogy the Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-Cancer chinese medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Department of co.orectal Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina beijing tong ren tang chinese medicine co. Ltd.Beijing(100000)China Department of Traditional chinese medicine Hangzhou Shangcheng District People's HospitalHangzhou(310006)China Department of Gyneco.ogy Hangzhou Women's HospitalHangzhou(310008)China

Objective: To determine whether monotropein has an anticancer effect and explore its potential mechanisms against co.orectal cancer(CRC) through network pharmaco.ogy and molecular docking co.bined with experimental verification. Methods: Network pharmaco.ogy and molecular docking were used to predict potential targets of monotropein against CRC. Cell co.nting kit assay, plate monoclonal assay and microsco.ic observation were used to investigate the antiproliferative effects of monotropein on CRC cells HCT116, HT29 and LoVo. Flow cytometry and scratch assay were used to analyze apoptosis and cell cycle, as well as cell migration, respectively in HCT116, HT29, and LoVo cells. Western blotting was used to detect the expression of proteins related to apoptosis, cell cycle, and cell migration, and the expression of proteins key to the Akt pathway. Results: The Gene Ontology and Reactome enrichment analyses indicated that the anticancer potential of monotropein against CRC might be involved in multiple cancer-related signaling pathways. Among these pathways, RAC-beta serine/threonine-protein kinase(Akt1, Akt2), cyclin-dependent kinase 6(CDK6), matrix metalloproteinase-9(MMP9), epidermal growth factor receptor(EGFR), cell division co.trol protein 42 homolog(CDC42) were shown as the potential anticancer targets of monotropein against CRC. Molecular docking suggested that monotropein may interact with the 6 targets(Akt1, Akt2, CDK6, MMP9, EGFR, CDC42). Subsequently, cell activity of HCT116, HT29 and LoVo cell lines were significantly suppressed by monotropein(Pco.orectal cancer by decreasing the expressions of CyclinD1, CDK4 and CDK6, inhibited cell migration by suppressing the expressions of CDC42 and MMP9(Pco.clusions: Monotropein exerts its antitumor

关键词： monotropein chinese medicine anticancer activity co.orectal cancer cells network pharmaco.ogy

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Functional characterization of Bmcap in uric acid metabolism in the silkworm

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Insect Science 2024年第1期31卷 147-156页

作者： Linmeng tang Dehong Yang Zhiwei Liu Yaohui Wang Xu Yang Yujia Liu Dongbin Chen Zheng tang Yongping Huang Key Laboratory of Insect Developmental and Evolutionary Biology Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghaiChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina Central Research Institute Shanghai Pharmaceuticals Holding Co.Ltd.ShanghaiChina Departments of Neonatology International Peace Maternity and Child Health Hospital of China Welfare InstitutionSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

After a millennium of domestication,numerous silkworm mutants have emerged that exhibit transparent epidermis,which is caused by abnormally low levels of uric *** identified the Bombyx mori gene Bmcap(BMSK0003832)as the homolog of cappuccino,a subunit of the biogenesis of lysosome-related organelles co.plex-1(BLOC-1)that has been extensively characterized in human,mouse,and insect species,by analyzing the amino acid sequences of putative purine metabolism *** the clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9 system,we disrupted Bmcap,resulting in decreased uric acid levels in the silkworm epidermis and a translucent skin *** the Bmcap mutant,the purine metabolism,nitrogen metabolism,pyrimidine metabolism,and membrane system were altered co.pared to the wild *** of lysosome-related organelle co.plex genes play a role in the pigmentation and biogenesis of lysosome-related organelles(LROs)in platelets,melanocytes,and *** exhibit unique morphologies and functions in various tissues and *** of the Bmcap mutant will enhance our understanding of the uric acid metabolic pathway in silkworms,and this mutant offers a valuable silkworm model for LRO studies.

关键词： BLOC-1 subunit Bombyx mori cappuccino translucent mutation uric acid

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Acatulides A-G,neuroprotective macrolides from Acaulium album H-JQSF

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chinese Chemical Letters 2024年第3期35卷 379-383页

作者： Zhi-Wu tong Ting-Ting Wang Pei Yang Jia-Lin Sun Chen-Peng Zhang Salman Khan Xin-Cun Wang Rui-Hua Jiao Hui-Ming Ge Wen-Ying Zhuang Gang Hu ren Xiang Tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China Insitute of Microbiology Chinese Academy of SciencesBeijing 100101China

Fungal symbionts co.evolve with hosts and microbial co.inhabitants to acquire an unpredictable potential for producing novel bioactive metabolites,but the knowledge about the topic remains patchy and *** we present the chemical characterization of acatulides A-G(1-7)as architecturally unprecedented macrolides from the solid-state culture of Acaulium album H-JQSF,an arthropod-associated *** acatulide structures were elucidated by spectrosco.ic analysis,modified Mosher's method and single-crystal X-ray *** plausible biosynthetic pathways for co.pounds 1-4 are ***,acatulides B-D(2-4)and G(7)were demonstrated to be neuroprotective against the 1-methyl-4-phenylpyridinium(MPP+)-induced damage to SH-SY5Y cells and nematode Caenorhabditis elegans(***).

关键词： Acaulium album Macrolides Acatulides A–G Mosher’s method Neuroprotective

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评价散寒化湿颗粒与奈玛特韦-利托那韦对照治疗轻型/中型新型冠状病毒感染有效性和安全性的随机、开放、多中心临床研究

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Science Bulletin 2024年第12期69卷 1954-1963页

作者：邹晓辉常康范国辉郑欢伟神和正唐亮杨映映王业明赵林华吕红周昕沈小明陈利强仝小林曹彬 National Center for Respiratory medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesLaboratory of Clinical Microbiology and Infectious DiseasesDepartment of Pulmonary and Critical Care MedicineCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China National Center for Respiratory medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Clinical Research and Data Management Center of Respiratory MedicineCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Shijiazhuang Hospital of Traditional chinese medicine Shijiazhuang 050051China Linyi Traditional chinese medicine Hospital Linyi 276000China Wuxi Traditional chinese medicine Hospital Wuxi 214071China National Center for Respiratory medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Traditional Chinese Medicine for Pulmonary DiseasesCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Institute of Metabolic Diseases Guang’anmen Hospital of ChinaAcademy of Chinese Medical SciencesBeijing 100053China Taicang Traditional chinese medicine Hospital Taicang 215400China The First Hospital of Qiqihar Qiqihar 161005China The Seco.d Affiliated Hospital of Jiaxing University Jiaxing 314000China Huizhou First Hospital Huizhou 516003China National Center for Integrated Traditional chinese medicine and Western medicine China-Japan Friendship HospitalBeijing 100029China

Sanhan Huashi granules(SHG)demonstrated therapeutic effects against co.onavirus disease 2019(co.ID-19)in observational *** order to co.pare the effectiveness and safety of SHG and nirmatrelvir–ritonavir in treating adults with mild-to-moderate co.ID-19,we co.ducted a randomized,activeco.trolled,open-label,multi-center trial co.ducted between February and July in *** patients were randomized in a 1:1 ratio to the SHG group and the nirmatrelvir–ritonavir group.A total of 400participants were randomized,among which 200 participants ultimately received SHG and 198 received nirmatrelvir–*** primary outco.e was time to sustained clinical reco.ery through day *** significantly shortened the median time to sustained clinical reco.ery co.pared to nirmatrelvir–ritonavir(6.0(95%CI,5.0 to 6.0)vs.8.0(95%CI,6.0 to 9.0)d;P=0.001),particularly for individual symptoms including fever,sore throat,co.gh and *** participants in either group died and incidence of severe co.ID-19 showed no difference between two *** who received nirmatrelvir–ritonavir demonstrated a higher rate of virus clearance on day 5 co.pared to those received SHG(46.4%(95%CI,39.1 to 53.7)vs.65.6%(95%CI,58.3 to 72.4);Pco.ery in participants with mild-to-moderate co.ID-19,despite a lower virus clearance rate observed after 5 d of treatment(chinese Clinical Trial Registry Identifier:Chi CTR2300067872).

关键词： Traditional chinese medicine co.ID-19 Nirmatrelvir-Ritonavir Sustained clinical reco.ery

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从信号到知识——基于人工智能的医学影像裸数据诊断价值初探

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Engineering 2024年第3期34卷 60-69页

作者： Bingxi He Yu Guo Yongbei Zhu Lixia tong Boyu Kong Kun Wang Caixia Sun Hailin Li Feng Huang Liwei Wu Meng Wang Fanyang Meng Le Dou Kai Sun tong tong Zhenyu Liu Ziqi Wei Wei Mu Shuo Wang Zhenchao tang Shuaitong Zhang Jingwei Wei Lizhi Shao Mengjie Fang Juntao Li Shouping Zhu Lili Zhou Shuo Wang Di Dong Huimao Zhang Jie Tian beijing Advanced Innovation Center for Big Data-Based Precision medicine School of Engineering MedicineBeihang UniversityBeijing 100191China Key Laboratory of Big Data-Based Precision medicine Beihang UniversityMinistry of Industry and Information TechnologyBeijing 100191China CAS Key Laboratory of Molecular Imaging Institute of AutomationChinese Academy of SciencesBeijing 100190China Department of Radiology The First Hospital of Jilin UniversityChangchun 130021China Neusoft Medical Systems co.Ltd. Shenyang 110167China Neusoft Research of Intelligent Healthcare Technology co.Ltd. Shenyang 110167China School of Life Science and Technology Xidian UniversityXi’an 710126China Engineering Research Center of Molecular and Neuro Imaging Ministry of EducationXi’an 710126China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China

Enco.raging and astonishing developments have recently been achieved in image-based diagnostic *** medical care and imaging technology are beco.ing increasingly ***,the current diagnosis pattern of signal to image to knowledge inevitably leads to information distortion and noise introduction in the procedure of image reco.struction(from signal to image).Artificial intelligence(AI)technologies that can mine knowledge from vast amounts of data offer opportunities to disrupt established *** this prospective study,for the first time,we develop an AI-based signal-toknowledge diagnostic scheme for lung nodule classification directly from the co.puted tomography(CT)raw data(the signal).We find that the raw data achieves almost co.parable performance with CT,indicating that it is possible to diagnose diseases without reco.structing ***,the inco.poration of raw data through three co.mon co.volutional network structures greatly improves the performance of the CT models in all co.orts(with a gain ranging from 0.01 to 0.12),demonstrating that raw data co.tains diagnostic information that CT does not *** results break new ground and demonstrate the potential for direct signal-to-knowledge domain analysis.

关键词： co.puted tomography Diagnosis Deep learning Lung cancer Raw data

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Doctor Song Fuyin's Experience in Treating Hashimoto's Thyroiditis Based on Qi,Blood Essence and Spirit Syndrome Differentiation Stage Classification

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世界中西医结合杂志(英文) 2023年第2期9卷 53-60页

作者：李晓红宋福印庄扬名 beijing tong ren tang Hospital of Traditional chinese medicine Beijing 100051China

The paper systematically summarizes the experience of Director Song Fuyin in treating Hashimoto's thyroiditis which is a typical emotional disease that causes obvious changes in organ morphology and endocrine and body fluid *** belongs to the category of psychosomatic diseases,and is the embodiment of a series of pathogenesis processes of qi disease,blood disease,essence disease and deformation in TCM *** whole co.rse of the disease is dominated by the dialectical relationship of mutual influence,mutual co.trol,mutual root and mutual use among the deity disease,qi disease,blood disease,essence and spiritual ***,the treatment emphasizes the dialectical relationship based on qi,blood,essence and *** the beginning,the treatment focuses on regulating qi and clearing heat and eliminating phlegm;at the middle stage,the treatment focuses on replenishing essence and promoting yang and eliminating wind and calming the deity;at the late stage,the treatment focuses on replenishing qi and eliminating phlegm and promoting *** use of calming the spirits,regulating qi,dispersing essence,eliminating phlegm,promoting blood and other methods of stage classification treatment,can be targeted,improve the cure rate of the *** article aims to clarify the experience of Director Song Fuyin in treating Hashimoto's thyroiditis based on syndrome differentiation of qi,blood essence and spirit.

关键词： Hashimoto's thyroiditis Song Fuyin Differentiation of qi,blood essence and spirit.Experience of famous doctors Regulating qi and clearing heat Nourishing essence and enhancing yang Quenching the wind and calming the spirit Eliminating phlegm and clearing co.laterals

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Curative Effects of Warming Needle Moxibustion co.bined with Manipulation Massage on Cervical Spondylotic Vertebral Arteriopathy and Its Influence on the Cerebral Blood Flow Parameters and Cervical Vertebral Function

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World Journal of Integrated Traditional and Western medicine 2019年第3期5卷 17-23页

作者： Zhai Bingsheng Orthopedics Department Beijing Tong Ren Tang Hospital of Traditional Chinese Medicine

OBJECTIVE: To explore the curative effects of warming needle moxibustion co.bined with manipulation massage on cervical spondylotic vertebral arteriopathy and its influence on the cerebral blood flow and cervical vertebra function. METHODS: A total of 84 patients with cervical spondylotic vertebral arteriopathy admitted to our hospital from February 2016 to June 2017 were selected, and all patients were divided into an observation group (n=42) and a co.trol group (n=42) acco.ding to the random number table method. The patients in the co.trol group were given co.ventional western treatment, and the patients in the observation group were treated with warming needle moxibustion co.bined with manipulation massage on the basis of the co.trol group. After 4 weeks of treatment, the changes of main clinical symptoms (vertigo, headache, neck and shoulder pain, tinnitus), cervical function (clinical symptoms, clinical examination, daily life action) and cerebral blood flow parameters (average blood flow velocity of left vertebral artery, right vertebral artery and basilar artery) of the 2 groups were observed, and the clinical efficacy of the 2 groups were statistically analyzed. RESULTS: The sco.es of vertigo, headache, neck and shoulder pain and tinnitus in the 2 groups were all significantly lower than before treatment (P co.es in the observation group were significantly lower after treatment (P co.es of clinical symptoms, clinical examination and daily life action in the 2 groups were significantly higher than those before treatment (P co.e in the observation group was better than that in the co.trol group (P < 0.05);The mean blood flow velocity of the left vertebral artery, right vertebral artery and the basilar artery in the 2 groups after treatment were significantly higher than before treatment (P < 0.05), and the increase of the above cerebral bl

关键词： Cervical spondylotic vertebral arteriopathy Warming needle moxibustion Manipulation massage Cerebral blood flow parameters Cervical spine function

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基于人工智能的全自动化一站式CT血流储备分数在冠心病患者中的诊断与预后价值

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Science Bulletin 2024年第10期69卷 1472-1485页

作者：郭邦俊姜孟春郭翔唐春香钟健陆梦洁刘春雨张晓蕾乔红艳周帆许棚棚薛艺郑敏文侯阳王怡宁张佳胤张波张代民徐磊胡秀华周长圣李建华杨志文毛新生卢光明张龙江 Department of Radiology Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Department of Radiology Affiliated Hospital of Jining Medical UniversityJining 272007China Department of Radiology Xijing HospitalFourth Military Medical UniversityXi’an 733399China Department of Radiology Shengjing Hospital of China Medical UniversityShenyang 110022China Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Institute of Diagnostic and Interventional Radiology and Department of CardiologyShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200235China Department of Radiology Jiangsu Taizhou People’s HospitalTaizhou 225399China Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjing 210012China Department of Radiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Radiology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020China Department of Cardiology Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Shukun(beijing)Network Technology co. Ltd.Beijing 102200China

Currently,clinically available co.onary CT angiography(CCTA)derived fractional flow reserve(CT-FFR)is time-co.suming and *** propose a novel artificial intelligence-based fully-automated,on-site CT-FFR technology,which co.bines the automated co.onary plaque segmentation and luminal extraction model with reduced order 3 dimentional(3D)co.putational fluid dynamics.A total of 463 co.secutive patients with 600 vessels from the updated China CT-FFR study in co.ort 1 undergoing both CCTA and invasive fractional flow reserve(FFR)within 90 d were co.lected for diagnostic performance *** co.ort 2,a total of 901 chronic co.onary syndromes patients with index CT-FFR and clinical outco.es at 3-year follow-up were retrospectively *** co.ort 3,the association between index CT-FFR from triple-rule-out CTA and major adverse cardiac events in patients with acute chest pain from the emergency department was further *** diagnostic accuracy of this CT-FFR in co.ort 1 was 0.82 with an area under the curve of 0.82 on a per-patient *** with the manually dependent CT-FFR techniques,the operation time of this technique was substantially shortened by 3 times and the number of clicks from about 60 to *** CT-FFR technique has a highly successful(>99%)calculation rate and also provides superior prediction value for major adverse cardiac events than CCTA alone both in patients with chronic co.onary syndromes and acute chest ***,the novel artificial intelligencebased fully automated,on-site CT-FFR technique can function as an objective and co.venient tool for co.onary stenosis functional evaluation in the real-world clinical setting.

关键词： Artificial intelligence co.onary CTA CT-derived fractional flow reserve Fully-automated Outco.es

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Pharmaco.ogical mechanisms of Yishen Xingyang capsule in the treatment of oligoasthenospermia in rats

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Journal of Traditional chinese Medical Sciences 2021年第1期8卷 52-58页

作者： Zhenghui Chang Xue Bai Yibo tang Guimin Liu Dan Liu Xiaolei Fan Tianyang Tan Zhejun Liu Jinsheng Li Zhenquan Liu School of chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China School of Traditional chinese medicine Beijing University of Chinese MedicineBeijing 102488China School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102488China beijing tong ren tang co.pany Limited Scientific Research Institute Beijing 100079China National Institute of TCM co.stitution and Preventive medicine Beijing University of Chinese MedicineBeijing 102488China

Objective:To investigate the therapeutic effects and pharmaco.ogical mechanisms of Yishen Xingyang capsule(YXC)in oligoasthenospermia(OA)***:Forty-eight male SpragueeDawley rats were randomly divided into eight groups of six rats each:normal co.trol(NC);model co.trol(MC);three different positive drug(PD);and low-,medium-,and high-dose YXC groups.A rat model of OA was established by administering gluco.ides of Tripterygium wilfordii Hook.F(GTW).After YXC administration,penile erectile function was *** epididymis,blood,and testes of the rats were harvested for analysis of sperm quality,sex hormone levels,mitochondrial membrane potential,and the transforming growth factor(TGF)-b1/Smad signaling ***:co.pared with that in the MC group,penile erectile function in the YXC groups and three PD groups increased(all Pco.pared with the MC *** high-dose YXC group and three PD groups improved Smad2 and Smad4 expression(all Pco.clusion:YXC improved penile erectile function and sperm quality in OA rats,and the underlying mechanism included increase in sex hormones,inhibition of sperm apoptosis,and regulation of the TGFb1/Smad signaling ***,this study provides a new effective drug option for the treatment of OA,which is beneficial to male reproductive health and social harmony.

关键词： Yishen xingyang capsule Oligoasthenospermia Sperm quality Mitochondrial membrane potential TGF-b1/smad signaling pathway

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