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Weighing the Pros and Cons: Transformation of Angle of View for Three Gorges Dam

Natural Resources 2014年第16期5卷 1048-1056页

作者： Wei Zhang Mining & Mineral Resources Division Department of Business Administration Chinalco China Copper Corporation Limited Beijing China Department of Mining and Materials Engineering McGill University Montreal Canada

Three Gorges Dam Project is the world’s largest water-control and hydraulic-electric project in the 21st century. However, it has been shrouded in controversy since long even before it began construction in 1994. On one hand, the benefits of the Three Gorges Dam are flood control, power generation, navigation, aquaculture, tourism, ecological protection, environmental purification, development-oriented resettlement, transfer of water from southern China to northern China, and water supply and irrigation. On the other hand, the drawbacks of the dam are environmental impact, effect on local culture and aesthetic values, and sedimentation. In an environmental impact point of view, the Three Gorges Dam shows evidence that it has more advantages than disadvantages. Thus, by carefully balancing the pros and cons, one can say that the Three Gorges Dam is an environmentally feasible project.

关键词： Environmental Impact Flood Control Power Generation Ecological Protection

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Fingerprinting Android malware families

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Frontiers of Computer Science 2019年第3期13卷 637-646页

作者： Nannan XIE Xing WANG Wei WANG Jiqiang LIU beijing Key Laboratory of Security and Privacy in Intelligent Transportation Beijing Jiaotong University Beijing 100044 China School of Computer Science and Technology Changchun University of Science and Technology Changchun 130022 China

The domination of the Android operating system in the market share of smart terminals has engendered increasing threats of malicious applications (apps). Research on Android malware detection has received considerable attention in academia and the industry. In particular, studies on malware families have been beneficial to malware detection and behavior analysis. However, identifying the characteristics of malware families and the features that can describe a particular family have been less frequently discussed in existing work. In this paper, we are motivated to explore the key features that can classify and describe the behaviors of Android malware families to enable fingerprinting the malware families with these features. We present a framework for signature-based key feature construction. In addition, we propose a frequency-based feature elimination algorithm to select the key features. Finally, we construct the fingerprints of ten malware families, including twenty key features in three categories. Results of extensive experiments using Support Vector Machine demonstrate that the malware family classification achieves an accuracy of 92% to 99%. The typical behaviors of malware families are analyzed based on the selected key features. The results demonstrate the feasibility and efFectiveness of the presented algorithm and fingerprinting method.

关键词： Android malware malware family feature selection behavior analysis

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Immunogenicity of DNA and Recombinant Sendai Virus Vaccines Expressing the HIV-1 gag Gene

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Virologica Sinica 2008年第4期23卷 295-304页

作者： Xia FENG Shuang-qing YU Tsugumine Shu Tetsuro Matano Mamoru Hasegawa Xiao-li WANG Hong-tao MA Hong-xia LI Yi ZENG State Key Laboratory for Infectious Disease Prevention and Control National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100052 China DNA VEC corporation Tsukuba 305-0051 Japan Department of Microbiology Graduate School of Medicine University of Tokyo Tokyo 113-0033 Japan College of Life Science and Bioengineering Beijing University of Technology Beijing 100022 China

Combinations of DNA and recombinant-viral-vector based vaccines are promising AIDS vaccine methods because of their potential for inducing cellular immune responses. It was found that Gag-specific cytotoxic lymphocyte (CTL) responses were associated with lowering viremia in an untreated HIV-1 infected cohort. The main objectives of our studies were the construction of DNA and recombinant Sendai virus vector (rSeV) vaccines containing a gag gene from the prevalent Thailand subtype B strain in China and trying to use these vaccines for therapeutic and prophylactic vaccines. The candidate plasmid DNA vaccine pcDNA3.1(+)-gag and recombinant Sendai virus vaccine (rSeV-gag) were constructed separately. It was verified by Western blotting analysis that both DNA and rSeV-gag vaccines expressed the HIV-1 Gag protein correctly and efficiently. Balb/c mice were immunized with these two vaccines in different administration schemes. HIV-1 Gag-specific CTL responses and antibody levels were detected by intracellular cytokine staining assay and enzyme-linked immunosorbant assay (ELISA) respectively. Combined vaccines in a DNA prime/rSeV-gag boost vaccination regimen induced the strongest and most long-lasting Gag-specific CTL and antibody responses. It maintained relatively high levels even 9 weeks post immunization. This data indicated that the prime-boost regimen with DNA and rSeV-gag vaccines may offer promising HIV vaccine regimens.

关键词： HIV-1 vaccines gag gene DNA vector Sendai virus

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Prediction of Scour Depth around Offshore Pipelines in the South China Sea

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Journal of Marine Science and Application 2015年第1期14卷 83-92页

作者： Yonggang Cao Yuchuan Bai Junqin Wang Shizhi Liao Dong Xu State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University Tianjin 300072 China South China Sea Marine Engineering Surveying Center State Oceanic Administration Guangzhou 510300 China China National Offshore Oil corporation General Research Institute Beijing 100027 China

Scour depth prediction of offshore pipelines is of great significance to the design and construction of the submarine pipeline projects. In this paper, based on the CFD software package FLUENT and User Defined Function （UDF）, an Eulerian two-phase model, which includes an Euler-Euler coupled model for water and sediment phases, and a turbulent model for the fluid phase, is adopted to predict the scour depth around pipelines. The model is verified by observation data obtained from laboratory experiments. On the basis of the simulations, the factors affecting the scour depth, including the effects of incipient velocity, pipe diameter and sediment particle size and so on, were investigated. Meanwhile, according to formulas of incipient velocity of various sediments, approximate calculation on theoretical scour depths is developed for pipelines of seven stations in the South China Sea, where engineering application information is available.

关键词： pipeline offshore pipelines sediment scour depth numerical simulation theoretical calculation South China Sea

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Numerical Hydrodynamics Study Around Turbine Array of Tidal Stream Farm in Zhoushan, China

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Journal of Ocean University of China 2017年第4期16卷 703-708页

作者： YU Zhiwen ZHANG Jisheng ZHAI Yanyan ZHANG Tiantian ZHENG Jinhai State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing 210098 P. R. China College of Harbor Coastal and Offshore Engineering Hohai University Nanjing 210098 P. R. China Powerchina Water Environment Governance Shenzhen 518100 P. R. China China Three Gorges corporation Beijing 100038 P. R. China

In recent decades,great efforts have been made to efficiently explore tidal stream energy due to its unique advantages of easy prediction and great *** recently launched a national tidal stream farm demonstration project in the waterway between Putuoshan and Hulu Islands in the Zhoushan *** deployment of the turbine array,it is necessary to understand the hydrodynamic changes associated with the construction of a turbine *** this study,we developed a depth-averaged hydrodynamics model that solves the shallow water governing equations to simulate the tidal hydrodynamics around the Zhoushan *** simulation results agree with field data in terms of the water elevation and stream *** considered two types of turbine arrays in this study and investigated their impacts on the local *** general,the stream velocity in the northern and southern areas is reduced due to the power take-off of the turbine array,whereas stream velocity in the western and eastern areas is slightly increased due to the blockage impact of the turbine array.

关键词： tidal stream farm turbine array tidal hydrodynamics numerical simulation demonstration project

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Preparation and Activity Identification of Recombinant Protein PACAP-PTD

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Agricultural Biotechnology 2012年第2期1卷 46-49,52页

作者： Lin HUANG Rongjie YU Juan LI Xiaofei LIU Jingjing WANG Bioengineering Institute of Jinan University Shandong New Time Pharmaceutical Co. Ltd.Lunan Pharmaceutical Group Corporation beijing Genomics Institute at Shenzhen

[Objective] This study aimed to prepare recombinant protein PACAP-PTD and measure its activity. [Method] The gene that encodes fusion protein PACAP-PTD was cloned into the expression vector pKYB to construct recombinant expression vector pKYB-PACAP-PTD, which was then transformed into E. coli ER2566. The fusion protein consisting of PACAP-PTD, intein and chitin was expressed under the induction of IPTG. Finally, the target fusion protein PACAP-PTD was purified with IMPACT system （ Intein Mediated Purification with an Affinity of chitin-binding Tag）, and its activities to cross blood-brain barrier and to promote cell proliferation were measured. [ Result~ The molecular weight of the fusion protein PACAP-PTD determined with laser time-of-flight mass spectrometry was con- sistent with the theoretical value. In addition, the protein could effectively cross the blood-brain barrier and promote cell proliferation as well. [ Conclusion] The construction and preparation of the fusion protein PACAP-PTD not only lays foundation for further study on its biological function, but also improves the route of PACAP administration, and thus expands its scope of application.

关键词： PACAP-PTD PACAP Intein FITC Blood-brain barrier Prokaryotic expression

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