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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

Science China Life Sciences 2025年第1期68卷 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University beijing institute of Hepatology Beijing Youan HospitalCapital Medical University beijing engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

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The Accuracy Analysis of Zero-lag Correlation Coefficient of Dual-Polarization Radar

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Chinese Journal of Electronics 2015年第1期24卷 212-217页

作者： ZHANG Wenwen YIN Fulian JIA Yunfeng beijing Aerospace system engineering institute Information engineering School Communication University of China

Dual polarization technology is gradually promoted in our country after Doppler weather radar network. It extends the capabilities of conventional Doppler radar, and can directly detect the differential reflectivity factor and the zero-lag correlation coefficient and so on which are related with the micro-physics characteristics of precipitation. Considering that small error may lead to erroneous judgments when identify the particle phase state with the zero-lag correlation coefficient for its values is close to each other at different phase states and is between0 and 1, the error mean value and mean square root of the zero-lag correlation coefficient are deduced at alternative transmission mode, and each parameter’s effect to the precision is analyzed. It not only provides a useful polarization variable for better identifying hydrometer phase state and clutter recognition, but also provides an practical way to estimate the zero-lag correlation coefficient and relevant.

关键词： Dual polarization Doppler radar Alternative transmission Correlation coefficient Measurement accuracy.

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Multi-action-based approach for constructing knowledge map

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Journal of beijing institute of Technology 2015年第3期24卷 335-340页

作者：阎艳郝佳王国新宫林赵博 School of Mechanical engineering Beijing Institute of Technology beijing institute of Astronautic system engineering

To alleviate the information overload in the product design process,this work proposes a multiaction-based method for constructing knowledge map. Since the relationships of knowledge are implicit in the collected user activities,the method calculates the similarity according to the collected user *** concepts,including knowledge,action and user,are explained first. Based on this,the similarity calculation method is illustrated in detail. The dependencies of actions and relations of the user are considered in the calculation method. Further,the approach of applying the constructed knowledge map to alleviate information overload is proposed. At last,the proposed method is validated by a knowledge search and result comparison experiment.

关键词： design knowledge information overload user action knowledge map

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Review of Large Spacecraft Deployable Membrane Antenna Structures

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Chinese Journal of Mechanical engineering 2017年第6期30卷 1447-1459页

作者： Zhi-Quan Liu Hui Qiu Xiao Li Shu-Li Yang beijing institute of Spacecraft system engineering China Academy of Space Technology Beijing 100094 China

The demand for large antennas in future space missions has increasingly stimulated the development of deployable membrane antenna structures owing to their light weight and small stowage volume. However, there is little literature providing a comprehensive review and comparison of different membrane antenna structures. Space-borne membrane antenna structures are mainly classified as either parabolic or planar membrane antenna structures. For parabolic membrane antenna structures, there are five deploying and forming methods, including inflation, inflation-rigidization, elastic ribs driven, Shape Memory Polymer （SMP）-inflation, and electrostatic form- ing. The development and detailed comparison of these five methods are presented. Then, properties of membrane materials （including polyester film and polyimide film） for parabolic membrane antennas are compared. Additionally, for planar membrane antenna structures, frame shapes have changed from circular to rectangular, and different ten- sioning systems have emerged successively, including single Miura-Natori, double, and multi-layer tensioning systems. Recent advances in structural configurations, tensioning system design, and dynamic analysis for planar membrane antenna structures are investigated. Finally, future trends for large space membrane antenna structures are pointed out and technical problems are proposed, including design and analysis of membrane structures,materials and processes, membrane packing, surface accuracy stability, and test and verification technology. Through a review of large deployable membrane antenna structures, guidance for space membrane-antenna research and applications is provided.

关键词： Membrane antenna. Parabolic Plane.Tensioning system Dynamics

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The Effect of Send/Receive Dual Channel Parameters on Polarization Parameters Measurement

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Chinese Journal of Electronics 2017年第2期26卷 336-344页

作者： ZHANG Wenwen YIN Fulian CHAI Juanfang BAI Xuesong beijing Aerospace system engineering institute Information engineering School Communication University of China Shanghai Electromechanical engineering institute

The dual-linear polarization radar is what China will popularize gradually following the Doppler radar *** the Doppler radar technology,the dual-linear polarization radar,which has been widely applied to enhancing modem weather radar system,becomes more and more popular in *** characteristics of hydrometeors,such as differential reflectivity,specific differential phase,and zero-lag correlation coefficient,are usually provided by the *** by the angular orientation of the feed,drop canting,and backscatter depolarization,however,inevitable measurement errors exit because of the unwanted horizontal and vertical wave *** small errors in these sensitive parameters may lead to erroneous judgment,both the factors themselves and their weights of influence should be studied specifically,with the mode of simultaneous transmission and reception of horizontally and vertically polarized *** study provides theoretical basis for the design of dual polarization Doppler radar,and will be helpful in the research of cloud,precipitation physics,and weather modification.

关键词： Doppler radar Dual-polarization technology Weather modification Elliptically polarized light Send/receive

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Experimental and numerical flutter analysis of a folding fin with multiple asymmetric free-plays

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Chinese Journal of Aeronautics 2024年第5期37卷 332-348页

作者： Chenyu LIU Chao AN Changchuan XIE Xin ZHANG Lan YANG School of Aeronautic Science and engineering Beihang UniversityBeijing 100191China beijing institute of Electronic system engineering Beijing 100854China beijing institute of Astronautical systems engineering Beijing 100076China

Experimental folding fin models with an adjustable free-play are tested in a wind *** fin structure is modeled using the free-interface component mode synthesis method,and its free-play is modeled as four independent nonlinear springs with asymmetric stiffness.A nonplanar unsteady vortex-lattice method considering compressibility is employed to address nonlinear deformation and high subsonic *** spline interpolation is improved through projection and *** aeroelastic characteristics of folding fins with different free-play magnitudes,initial conditions and elastic-axis positions are analyzed using an established time-marching method because of its relatively small computation scale and high *** results show good consistency among the presented method,the wind tunnel test and the harmonic balance *** is a negative correlation between the critical speed of divergent motion and the ratio of the initial condition to the free-play *** either the free-play magnitude or the initial condition is extreme(tiny or vast),the system nonlinearity degenerates to ***,the flutter prevention design of a linear model can be applied to a nonlinear model,such as moving the elastic-axis position *** presented fin configuration exhibits an unstable limit cycle oscillation because the orders of coupled flutter modes do not change with variations in equivalent linear stiffness.

关键词： Free-play Limit cycle oscillation Flutter Component mode synthesis Vortex-lattice method

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Precipitate Characteristics and Mechanical Performance of Cast Mg–6RE–1Zn–xCa–0.3Zr(x=0 and 0.4 wt%) Alloys

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Acta Metallurgica Sinica(English Letters) 2022年第4期35卷 596-608页

作者： Zijian Yu Xi Xu Baotian Du Kang Shi Ke Liu Shubo Li Xiuzhu Han Tao Xiao Wenbo Du College of Materials Science and engineering Beijing University of TechnologyBeijing 100124China beijing institute of Spacecraft system engineering Beijing 100094China

In this study,the Mg–4Y–1Gd–1Nd–xCa–1Zn–0.3Zr(x=0 and 0.4 wt%)cast alloys with low rare earth concentration were prepared in different routes of heat treatments,and their microstructures and mechanical properties were *** Mg–4Y–1Gd–1Nd–1Zn–0.4Ca–0.3Zr cast alloy with ultimate tensile strength(UTS)of 264±7.8 MPa,tensile yield strength(TYS)of 153±1.2 MPa and elongation to failure(EL)of 17.2±1.2% was successfully developed by appropriate heat *** improved mechanical performance was attributed to the combined strengthening effects of fine grains,Mg24RE5,β′,β_(1),γ′and LPSO *** the heat treatment process,cooling method of T4 treatment affected the microstructure,which consequently determined the mechanical properties air cooling,rather than water cooling,gave rise to the formation of γ′phase in the alloy without Ca ***,Ca addition facilitated the formation of γ′phase,and the γ′phase precipitated in the alloy after T4 treatment either by water cooling or by air cooling,but the air cooling increased the number density of γ′phase in comparison to the water *** the γ′phase strengthened the studied alloys,the formation of γ′phase inhibited the precipitatition of β′and β_(1) phases in the following T6 treatment,and consequently reduced the strengthening effect ofβ′andβ_(1) *** results showed that the mechanical performance of the studied alloys was largely determined by the precipitation of γ′phase,which was regulated by the Ca addition and the cooling method of T4 treatment.

关键词： Magnesium alloy Microstructure Mechanical properties Rare earth Heat treatment

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Laser assisted phase transformation of carbon-based transition metal oxide electrode for high-performance supercapacitor application

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Science China Chemistry 2025年

作者： Mingzhen Xiu Jianghong Zhang Yu Lu Xun Cao Kang Huang Siyu Zhu Bowei Zhang Yu Liang Chunwang Zhao Junsheng Wu Yizhong Huang School of Materials Science and engineering Nanyang Technological University Energy Research institute Interdisciplinary Graduate Programme Nanyang Technological University institute of Sustainability for Chemicals Energy and Environment Agency for Science Technology and ResearchSingapore institute of Advanced Materials and Technology University of Science and Technology Beijing School of Materials Science and Technology Shenyang University of Chemical Technology School of Materials Science and Hydrogen Energy Foshan University

Transitional metal oxides have a wide range of applications due to their superior *** enhanced performance of metal oxide relies on their desirable oxidation states,which is challenging to achieve and requires complex *** study demonstrates a facile strategy enabling rapid phase transformation of transition metal *** approach involves synthesis of a tetragonal Mn3O4/carbon cloth composite using the liquid plasma discharge deposition （LPDD） technique,followed by laser irradiation with the presence of ethylene glycol under an N2gas *** resulting face-centered cubic MnO/carbon cloth electrode exhibits an excellent capacitance of 1,125 F g-1at 2 A g-1,with remarkable capacitance retention of 95%after10,000 *** approach can be extended to other transition metals including Co,Cu,Cr,Fe,Ni,and *** simulations reveal the significance of ethylene glycol and the underlying mechanism associated with the phase transformation of transition metal *** present study offers a powerful technique for the phase transformation of transition metal oxide which can guide the development of new electrode materials with enhanced electrochemical properties for high-performance energy storage applications.

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Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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Nano-Micro Letters 2025年第3期17卷 340-354页

作者： Li An Jianyi Li Yuanmiao Sun Jiamin Zhu Justin Zhu Yeow Seow Hong Zhang Nan Zhang Pinxian Xi * Zhichuan JXu Chun‑Hua Yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

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Orbit Design Elements of Chang’e 5 Mission

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Space(Science & Technology) 2021年第1期2021卷 28-49页

作者： Zhong-Sheng Wang Zhanfeng Meng Shan Gao Jing Peng beijing institute of Spacecraft system engineering Beijing 100094China

The three key orbit design technologies employed in the Chang’e 5 mission are identified and discussed in this paper:orbit design for lunar orbit rendezvous and docking,orbit design for precision lunar landing and inclination optimization,and orbit design for Moon-to-Earth ***,an overview of the Chang’e 5 mission profile is presented,which is followed by detailed discussions of the three key orbit design technologies,including an introduction of the tracking-based orbit design *** data are provided to demonstrate the correctness of the designs.

关键词： discussions orbit Earth

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