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Anti-vascular endothelial growth factor drugs combined with laser photocoagulation maintain retinal ganglion cell integrity in patients with diabetic macular edema: study protocol for a prospective, non-randomized, controlled clinical trial

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Neural Regeneration Research 2024年第4期19卷 923-928页

作者： Xiangjun Li Chunyan Li Hai Huang Dan Bai Jingyi Wang Anqi Chen Yu Gong Ying Leng Department of Ophthalmology Affiliated Hospital of Beihua University Department of Endocrinology Affiliated Hospital of Beihua University

The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting *** major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser ***,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many *** might result from the incomplete recovery of retinal ganglion cell ***,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision *** this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their *** patients will be followed up for 12 *** primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after *** secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after *** measure is the incidence of adverse events at 1,3,6,9,and 12 months after *** study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up *** trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal

关键词： choroidal thickness diabetic macular edema laser photocoagulation retinal ganglion cell-inner plexiform layer thickness retinal ganglion cells retinal nerve fiber layer thickness thickness of the macular area vascular endothelial growth factor visual acuity

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Morphological changes of gonadotropin-releasing hormone neurons in the rat preoptic area across puberty

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Neural Regeneration Research 2014年第13期9卷 1303-1312页

作者： Haogang Xue Xiaodong Gai Weiqi Sun Chun Li Quan Liu Department of Orthopedic Surgery Affiliated Hospital of Beihua University Department of Pathology Beihua University College of Public Health Beihua University Department of Cardiovascular Disease the First Hospital of Jilin University

Gonadotropin-releasing hormone （GnRH） neurons in the preoptic area may undergo morphological changes during the pubertal period when their activities are upregulated. To clarify the regulatory mechanism of puberty onset, this study aimed to investigate the morphological changes of GnRH neurons in the preoptic area of GnRH-enhanced green fluorescent protein transgenic rats. Under confocal laser microscopy, pubertal GnRH neurons exhibited an inverted Y distribution pattern. Prepubertal GnRH neurons were generally unipolar and bipolar, and were distinguished as smooth type cells with few small processes or irregular type cells with many spine-like processes in the proximal dendrites. The number of GnRH neurons in the preoptic area and spine-like processes were increased during the course of reproductive maturation. There was no significant difference between male and female rats. Immunofluorescence staining revealed synaptophysin punctae close to the distal end of GnRH neurons, indicating that some presynaptic terminals may form a synaptic linkage with these neurons.

关键词： nerve regeneration preoptic area gonadotropin-releasing hormone neurons pubertalperiod luteinizing hormone transgenesis bipolar neurons neural regeneration

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Synthesis and characterization of Ce_(0.8)Sm_(0.2–x)Pr_xO_(2–δ)(x=0.02–0.08)solid electrolyte materials

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Journal of Rare Earths 2015年第4期33卷 411-416页

作者：林晓敏吕秋月朱丽丽刘晓梅 College of Physics Beihua University College of Physics Jilin University

Solid electrolytes C%sSmo.2 xPrxO2-δ （x=0.02, 0.04, 0.06, 0.08） were prepared by citric-nitrate method. The microstructure and electrical properties of such materials were examined by X-ray diffraction （XRD）, atomic force microscopy （AFM）, Raman spec- troscopy （Raman）, X-ray photoelectron spectroscopy （XPS） and impedance spectroscopy analyses, Specifically, results from XRD analysis showed that samples calcined at 800 ℃ for 4 h possessed single-phase cubic fluorite structure, and the average grain size was found to be 36--45 nm. Further Raman spectral analysis indicated that oxygen vacancies should be present in the cubic fluorite struc- ture of ***0.08Oe~, and Pr-doping seemed to increase their concentration significantly. AFM images showed that the grain size grew with the increase of Pr substitution. XPS analysis confirmed the existence of oxygen vacancies in the lattice of ***2_~ in which Pr3＋ and Pr4＋ co-existed. AC impedance spectra indicated that the conductivity of ***0.2-xPrx02＋ increased with the increase of Pr-doping but the conduction activation energy decreased. Notably, it appeared that sample ***.12Pro.o802-x （aaoooc=l.21xlO-z S/cm, Ea=0.77 eV） exhibited conductivity superior to ***.2Ol.9 （aro0.c=2.22×10-3 S/cm, Ea= 1.02 eV） because it possessed higher conductivity and lower activation energy. At 600 ℃, the conductivity of ***.12Pr0.0802m was 4.45 times higher than that of the un-doped material.

关键词： Ce0.8Smo.2-xPrx02-δ oxygen vacancy Raman spectroscopy conductivity rare earths

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Publication trends in studies examining radix notoginseng as a treatment for ischemic brain injury

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Neural Regeneration Research 2014年第17期9卷 1635-1642页

作者： Haiping Li Luo Qiang Chunyang Zhang Chaohui Wang Zhenxing Mu Ligang Jiang Department of Neurology Affiliated Hospital of Beihua University

Acute ischemic stroke has become a major disease burden with high mortality and morbidity rates. There is a lack of evidence-based medicine confirming the efficacy of common treatments. Panax notoginseng saponins, the main active ingredient of radix notoginseng, have a neuro- protective role in ischemic brain injury, and have been popularized as a maintenance treatment for acute cerebral infarction and its sequelae. We conducted literature searches on the Web of Science, ***, Cochrane Collaboration, CNKI, Wanfang and the China Scientific ＆ Technological Achievements Database and analyzed the experimental and clinical outcomes of studies investigating the use of radix notoginseng in the treatment of ischemic brain injury to improve the understanding of relevant research trends and existing problems. We found that over the past 10 years, China has maintained its interest in Panax notoginseng research, while such studies are scarce on the Web of Science. However, Chinese researchers often focus on the neuroprotective role of radix notoginseng in ischemic brain injury, but there are no large-scale clinical data to confirm its efficacy and safety. There remains a need for more rigorous large-sample randomized controlled clinical trials with long-term follow-up, to determine whether radix notoginseng lowers stroke recurrence and improves patient＇s quality of life.

关键词： nerve regeneration neuroprotection Panax notoginseng cerebral ischemia stroke Panax notoginseng saponins basic clinical neural regeneration

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Establishment of a PCR Method for the Identification of Mink-Derived Components in Common Edible Meats

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Journal of Analysis and Testing 2022年第1期6卷 51-57页

作者： Jia-Mu Niu Lin Cui Jin-Xia Ai Guang-Xin Yuan Li-Yuan Sun Li-Jun Gao Ming-Cheng Li Department of Science and Technology Beihua UniversityJilin 132013China School of Technology Medicine Beihua UniversityJilin 132013China College of Pharmacy Beihua UniversityJilin 132013China

In this study,we established a DNA extraction method of meats and a PCR method for the detection of mink-derived compo-nents in common edible *** DNA of meats was extracted by a developed mink-derived component detection method and salting-out method,the specific primers of Cyt-b were designed,and the mink-derived components in common edible meats were identified by *** results showed that the concentration and purity of mink meat DNA extracted by the two methods could meet the requirements of *** mink meat DNA extracted by the developed mink DNA detection method had a high purity and *** mink-derived DNA in common edible meats could be *** specificity of mink meat DNA primer was proved to be good by repeated *** developed mink DNA detection method has the advantages of rapid detection and simple operation,which can be used for the identification of meat products in market and provide an experimental basis for the quality control of meat products.

关键词： Mink Cyt-b Molecular biology Identification of authenticity

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Insights into stem cell therapy for diabetic retinopathy: a bibliometric and visual analysis

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Neural Regeneration Research 2021年第1期16卷 172-178页

作者： Xiang-Jun Li Chun-Yan Li Dan Bai Ying Leng Department of Ophthalmology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina Department of Endocrinology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina

Stem cells have been confirmed to be involved in the occurrence and development of diabetic retinopathy;however,the underlying mechanisms remain *** this study,we used Citespace software to visually analyze 552 articles exploring the stem cell-based treatment of diabetic retinopathy over the past 20 years,which were included in the Web of Science Core *** found the following:(1)a co-citation analysis of the references cited by all 552 articles indicated 15 *** cluster#0,representing the stem cell field,some highly cited landmark studies emerged between 2009–*** example,endothelial progenitor cells and diabetic retinopathy gradually received the full attention of scholars,in terms of their relationship and therapeutic *** researchers also verified the potential of adipose-derived stem cells to differentiate into stable retinal perivascular cells,using a variety of animal models of retinal vascular *** of these achievements provided references for the subsequent stem cell research.(2)An analysis of popular keywords among the 552 articles revealed that,during the past 20 years,a relative increase in basic research articles examining stem cells and endothelial progenitor cells for the treatment of diabetic retinopathy was *** contents of these articles primarily involved the expression of vascular endothelial growth factor,vascular regeneration,oxidative stress,and inflammatory response.(3)A burst analysis of keywords used in the 552 articles indicated that genetic and cytological research regarding the promotion of angiogenesis was an issue of concern from 2001 to 2012,including several studies addressing the expression of various growth factor genes;from 2014 to 2020,mouse models of diabetic retinopathy were recognized as mature animal models,and the most recent research has focused on macular degeneration,macular edema,neurodegeneration,and inflammatory changes in diabetic animal models.(4)Globally,the current

关键词： diabetes diabetic retinopathy epithelial cells macula progenitor cells retina stem cells visual analysis

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Elastic scattering of electrons from water molecule

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Chinese Physics B 2010年第9期19卷 354-359页

作者：刘俊伯周雅君 Institute of Atomic and Molecular Physics Jilin University College of Physics Beihua University

This paper uses the momentum-space optical potential method to calculate the e-H2O scattering elastic cross sections at the energy range from 6 eV to 50 eV, and the differential cross sections in the angle from 0 °to 180° at 40 eV and 50 eV. The polarisation is taken into account via an ab initio equivalent-local potential. The cross sections are compared with experimental measurements and other theoretical calculations.

关键词： H2o the momentum-space optical potential method elastic scattering

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Bayesian zero-failure reliability modeling and assessment method for multiple numerical control(NC) machine tools

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Journal of Central South university 2016年第11期23卷 2858-2866页

作者：阚英男杨兆军李国发何佳龙王彦鹍李洪洲 College of Mechanical Science and Engineering Jilin University College of Mechanical Engineering Beihua University

A new problem that classical statistical methods are incapable of solving is reliability modeling and assessment when multiple numerical control machine tools(NCMTs) reveal zero failures after a reliability test. Thus, the zero-failure data form and corresponding Bayesian model are developed to solve the zero-failure problem of NCMTs, for which no previous suitable statistical model has been developed. An expert-judgment process that incorporates prior information is presented to solve the difficulty in obtaining reliable prior distributions of Weibull parameters. The equations for the posterior distribution of the parameter vector and the Markov chain Monte Carlo(MCMC) algorithm are derived to solve the difficulty of calculating high-dimensional integration and to obtain parameter estimators. The proposed method is applied to a real case; a corresponding programming code and trick are developed to implement an MCMC simulation in Win BUGS, and a mean time between failures(MTBF) of 1057.9 h is obtained. Given its ability to combine expert judgment, prior information, and data, the proposed reliability modeling and assessment method under the zero failure of NCMTs is validated.

关键词： Weibull distribution reliability modeling Bayes zero failure numerical control(NC) machine tools Markov chain Monte Carlo(MCMC) algorithm

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The Strong Solution for the Viscous Polytropic Fluids with Non-Newtonian Potential

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Chinese Annals of Mathematics,Series B 2019年第2期40卷 237-250页

作者： Qiu MENG Hongjun YUAN Institute of Mathematics and Statistics Beihua University Institute of Mathematics Jilin University

The authors study an initial boundary value problem for the three-dimensional Navier-Stokes equations of viscous heat-conductive fluids with non-Newtonian potential in a bounded smooth domain. They prove the existence of unique local strong solutions for all initial data satisfying some compatibility conditions. The difficult of this type model is mainly that the equations are coupled with elliptic, parabolic and hyperbolic, and the vacuum of density causes also much trouble, that is, the initial density need not be positive and may vanish in an open set.

关键词： Compressible Navier-Stokes equations Viscous polytropic fluids Vacuum Poincare type inequality Non-Newtonian potential

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Prediction and driving factors of forest fire occurrence in Jilin Province,China

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Journal of Forestry Research 2024年第1期35卷 58-71页

作者： Bo Gao Yanlong Shan Xiangyu Liu Sainan Yin Bo Yu Chenxi Cui Lili Cao Wildland Fire Prevention and Fighting Innovation Center of beihua university Forestry College of Beihua University3999 Binjiang East RoadJilin City 132013People’s Republic of China

Forest fires are natural disasters that can occur suddenly and can be very damaging,burning thousands of square *** is better than suppression and prediction models of forest fire occurrence have developed from the logistic regression model,the geographical weighted logistic regression model,the Lasso regression model,the random forest model,and the support vector machine model based on historical forest fire data from 2000 to 2019 in Jilin *** models,along with a distribution map are presented in this paper to provide a theoretical basis for forest fire management in this *** studies show that the prediction accuracies of the two machine learning models are higher than those of the three generalized linear regression *** accuracies of the random forest model,the support vector machine model,geographical weighted logistic regression model,the Lasso regression model,and logistic model were 88.7%,87.7%,86.0%,85.0%and 84.6%,*** is the main factor affecting forest fires,while the impacts of topography factors,human and social-economic factors on fire occurrence were similar.

关键词： Forest fire Occurrence prediction Forest fire driving factors Generalized linear regression models Machine learning models

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