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A pilot study for distinguishing basal cell carcinoma from normal human skin tissues using visible resonance Raman spectroscopy

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Journal of Cancer Metastasis and Treatment 2019年第1期4卷 41-54页

作者： Cheng-hui Liu Binlin Wu Laura ASordillo Susie Boydston-White Vidyasagar Sriramoju ChunyuanZhang Hugh beckman Lin Zhang Zhe Pei Lingyan Shi Robert RAlfano Institute for Ultrafast Spectroscopy and Lasers The City College of the City University of New YorkNew YorkNY 10031USA Physics Department and CSCU center for Nanotechnology Southern Connecticut State UniversityNew HavenCT 06515USA Department of Electrical Engineering The Grove School of EngineeringThe City College of the City University of New YorkNew YorkNY 10031USA Science Department City University of New YorkBorough of Manhattan Community CollegeNew YorkNY 10007-1097USA Bermuda Village Dr. Boca RatonFlorida 33487-1041USA517150 Department of Chemistry Columbia UniversityNew YorkNY 10027USA

Aim: The aim of the study is to test visible resonance Raman (VRR) spectroscopy for rapid skin cancer diagnosis,and evaluate its effectiveness as a new optical biopsy method to distinguish basal cell carcinoma (BCC) from normal skin ***: The VRR spectroscopic technique was undertaken using 532 nm excitation. Normal and BCC human skin tissue samples were measured in seconds. The molecular fingerprints of various native biomolecules as biomarkers were analyzed. A principal component analysis - support vector machine (PCA-SVM) statistical analysis method based on the molecular fingerprints was developed for differentiating BCC from normal skin ***: VRR provides a rapid method and enhanced Raman signals from biomolecules with resonant and nearresonant absorption bands as compared with using a near-infrared excitation light source. The VRR technique revealed chemical composition changes of native biomarkers such as tryptophan, carotenoids, lipids and *** VRR spectra from BCC samples showed a strong enhancement in proteins including collagen type I combined with amide I and amino acids, and a decrease in carotenoids and lipids. The PCA-SVM statistical analysis based on the molecular fingerprints of the biomarkers yielded a 93.0% diagnostic sensitivity, 100% specificity, and 94.5%accuracy compared with histopathology ***: VRR can enhance molecular vibrational modes of various native biomarkers to allow for very fast display of Raman modes in seconds. It may be used as a label-free molecular pathology method for diagnosis of skin cancer and other diseases and be used for combined treatment with Mohs surgery for BCC.

关键词： visible resonance Raman spectroscopy human skin basal cell carcinoma principal componentanalysis supports vector machine molecular fingerprints tryptophan carotenoids

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Program for Solar Water Heating Systems Based on the F-Chart Method

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Journal of Mechanics Engineering and Automation 2014年第9期4卷 752-762页

作者： Felix do Rego Barros Adriano Gatto Lemos Sildenir Alves Ribeiro Manoel Antonio da Fonseca Costa Filho Coordination of Industrial Automation CEFET (Federal Center of Technological Education) Rio de Janeiro 20785-902 Brazil Coordination of Automotive Maintenance CEFET (Federal Center of Technological Education) Rio de Janeiro 20785-902 Brazil Department of Mechanical Engineering UERJ (State University of Rio de Janeiro) Rio de Janeiro 20940-200 Brazil

This paper aims at presenting an application developed in Java for optimizing the design of centralized solar water heating systems with forced circulation, based on the f-chart method. The program uses data from the Brazilian Solar Atlas, performance data of flat plate collectors and thermal reservoirs from the standardized tests run within the Brazilian Labeling Program, and values of water consumption of appliances defined by the ABNT. The program finds the inclination of the collector that maximizes the annual solar fraction, or for the winter, and enables the use of arrays in series and parallel collectors. From the investment costs and O & M (operations and maintenance) of solar heating systems, the program carries out economical analysis using classical parameters as net present value, discounted payback and internal rate of return. The program was validated through examples from the book of Duffie & beckman and also by comparison with the results from a project developed at UFRGS, having obtained good agreement.

关键词：太阳能热水系统图法基础 Java应用程序平板集热器标准化考试强制循环数据显示

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Human IgG1 antibodies suppress angiogenesis in a target-independent manner

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Signal Transduction and Targeted Therapy 2016年第1期1卷 158-171页

作者： Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoyaJapan Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.a.r.l.NaplesItaly Istituto di Biostrutture e Bioimmagini CNRNaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands School of Pathology and Laboratory Medicine University of Western AustraliaCrawleyWAAustralia Division of Immunology Department of PathologyUniversity of CambridgeCambridgeUK Department of Immunology Unit of Antibodies in Therapy and PathologyInstitut PasteurParisFrance Institut National de la Santéet de la Recherche Médicale(INSERM)U1222 ParisFrance Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly Department of Physiology University of KentuckyLexingtonKYUSA.

Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s *** most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human *** bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in *** we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage *** approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized *** anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated ***,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA ***,mice deficient in FcγRI exhibited increased developmental and pathological *** findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies.

关键词： CD64 angiogenesis antibodies

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Uniaxially crumpled graphene as a platform for guided myotube formation

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Microsystems & Nanoengineering 2019年第1期5卷 144-153页

作者： Junghoon Kim Juyoung Leem Hong Nam Kim Pilgyu Kang Jonghyun Choi Md Farhadul Haque Daeshik Kang SungWoo Nam Department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA center for BioMicrosystems Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea Department of Mechanical Engineering George Mason UniversityFairfaxVA 22030USA Department of Mechanical Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Materials Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Graphene,owing to its inherent chemical inertness,biocompatibility,and mechanical flexibility,has great potential in guiding cell behaviors such as adhesion and ***,due to the two-dimensional(2D)nature of graphene,the microfabrication of graphene into micro/nanoscale patterns has been widely adopted for guiding cellular *** this study,we report crumpled graphene,i.e.,monolithically defined graphene with a nanoscale wavy surface texture,as a tissue engineering platform that can efficiently promote aligned C2C12 mouse myoblast cell *** imparted out-of-plane,nanoscale crumpled morphologies to flat graphene via compressive straininduced *** C2C12 mouse myoblast cells were seeded on the uniaxially crumpled graphene,not only were the alignment and elongation promoted at a single-cell level but also the differentiation and maturation of myotubes were enhanced compared to that on flat *** results demonstrate the utility of the crumpled graphene platform for tissue engineering and regenerative medicine for skeletal muscle tissues.

关键词： Uniaxial graphene alignment

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平衡冷冻过程中细胞体积的确定

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科学通报 2003年第10期48卷 1019-1022页

作者：赵刚何立群王沛涛丁卫平解晓健刘忠张海峰舒志全罗大为高大勇中国科技大学热科学和能源工程系低温生物医学工程研究所中国科技大学热科学和能源工程系低温生物医学工程研究所中国科技大学生命科学学院中国科技大学热科学和能源工程系低温生物医学工程研究所中国科技大学热科学和能源工程系低温生物医学工程研究所合肥红十字会输血中心中国科技大学热科学和能源工程系低温生物医学工程研究所中国科技大学热科学和能源工程系低温生物医学工程研究所中国科技大学热科学和能源工程系低温生物医学工程研究所中国科技大学热科学和能源工程系低温生物医学工程研究所合肥 230027 合肥 230027 合肥 230027 合肥 230027 合肥 230027 合肥 230022 合肥 230027 合肥 230027 合肥 230027 Department of Mechanical Engineering and center for Biomedical Engineering University of Kentucky Lexington KY40506 USA. 合肥 230027

使用新型的电子粒子计数仪(EPC)(Electronic Particle Counter, MultisizerTM 3, beckman Coulter Inc., USA)测定了人RBC(红细胞)在不同渗透压的NaCl溶液中的体积, 并使用冷冻过程细胞模型预测了RBC在生理盐水(0.9% NaCl溶液)中平衡冷... 详细信息

使用新型的电子粒子计数仪(EPC)(Electronic Particle Counter, MultisizerTM 3, beckman Coulter Inc., USA)测定了人RBC(红细胞)在不同渗透压的NaCl溶液中的体积, 并使用冷冻过程细胞模型预测了RBC在生理盐水(0.9% NaCl溶液)中平衡冷冻的体积变化. 假定温度对RBC的体积的影响相对渗透压而言可以忽略, 则通过NaCl-H2O二元溶液的相图可获得不同温度下NaCl溶液的渗透压值(通过质量百分比浓度换算得到), 从而将计算的体积值与以上测量值相互验证.

关键词： EPC 渗透压 RBC Van’t Hoff 细胞体积

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