检索结果-南通市图书馆

STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats

World Journal of Gastroenterology 2019年第39期25卷 5926-5935页

作者： Mohamed T Khayyal Walaa Wadie Enas A Abd El-Haleim Kawkab A Ahmed Olaf Kelber Ramy M Ammar Heba Abdel-Aziz Department of Pharmacology Faculty of PharmacyCairo UniversityCairo 11562Egypt Department of Pathology Faculty of Veterinary MedicineCairo UniversityCairo 12211Egypt Steigerwald Arzneimittelwerk GmbH Bayer Consumer HealthDarmstadt 64295Germany Department of Pharmacology Faculty of PharmacyKafrelsheikh UniversityKafrelsheikh 33511Egypt

BACKGROUND Proton pump inhibitors are often used to prevent gastro-intestinal lesions induced by nonsteroidal anti-inflammatory ***,they are not always effective against both gastric and duodenal lesions and their use is not devoid of side *** To explore the mechanisms mediating the clinical efficacy of STW 5 in gastroduodenal lesions induced by nonsteroidal anti-inflammatory drugs(NSAIDs),exemplified here by diclofenac,in a comparison to *** Gastro-duodenal lesions were induced in rats by oral administration of diclofenac(5 mg/kg)for 6 successive *** group was given concurrently STW 5(5 mL/kg)while another was given omeprazole(20 mg/kg).A day later,animals were sacrificed,stomach and duodenum excised and divided into 2 segments:One for histological examination and one for measuring inflammatory mediators(tumor necrosis factorα,interleukins-1βand 10),oxidative stress enzyme(heme oxygenase-1)and apoptosis regulator(B-cell lymphoma 2).RESULTS Diclofenac caused overt histological damage in both tissues,associated with parallel changes in all parameters *** 5 and omeprazole effectively prevented these changes,but STW 5 superseded omeprazole in protecting against histological damage,particularly in the *** The findings support the therapeutic usefulness of STW 5 and its superiority over omeprazole as adjuvant therapy to NSAIDs to protect against their possible gastro-duodenal side effects.

关键词： Diclofenac STW 5 Omeprazole Gastro-intestinal lesions Inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新的合成拟除虫菊酯Baythroid

引用

农药译丛 1982年第1期 61-62页

作者：程志明西德bayer公司

西德bayer公司的新产品Baythroid是具有广谱杀虫活性的合成拟除虫菊酯.1.有效成份的化学和物理性质化学名称:3-(2,2-二氯乙烯)-2,2-二甲基-环丙烷羧酸(4-氟-3-苯氧基苯基)氰基甲基酯.通用名称:Cyfloxylate(建议)结构式:

关键词：大白鼠 Baythroid 家鼠属拟除虫菊酯除虫菊素类小白鼠环丙烷环烷烃除虫菊宿根花卉西德德国 LD 耐药性抗药性剂量用药量

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Tumor Markers;Long March:From Prototype to Clinical Use

Tumor Markers;Long March:From Prototype to Clinical Use

引用

2000全国肿瘤学术大会

作者： Anna Meng-ai Zhou M.D. Ph.D.bayer Corporation TarrytownNYUSA

＜正＞Tumor markers,long journey from prototype to clinical use includes testingfeasibility of the prototype and optimizing industrial process *** validation and clinical evaluation of threemanufacturing lots with pre- marketing approval granted by FDA,tumor markersare available for clinical *** focus of this presentation is

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The spatial dynamics of Ukraine air quality impacted by the war and pandemic

引用

International Journal of Digital Earth 2023年第1期16卷 3680-3705页

作者： vizhi Qian Liu Theodore S.Trefonidesc Sina Hasheminassab Jennifer Smith Thomas Huang Kevin M.Marlis Joe T.Roberts Zifu Wang Dexuan Sha Ana Beatriz Moura Pereira Heramb Podar Jacob Cain Chaowei Yang Department of Geography and GeoInformation Science George Mason UniversityFairfaxVAUSA Jet Propulsion Laboratory California Institute of TechnologyPasaden1CAUSA Dartmouth College HanoverNHUSA bayer WashingtonDCUSA Northern Virginia Community College AnnandaleVAUSA Indian Institute of Technology RoorkeeIndia

In recent years,our world has experienced significant disruptions due to the COviD-19 pandemic,and Russia's 2022 invasion of Ukraine,impacting human activities and the global *** paper explored air quality changes in Ukraine due to COVID-19,and Russia's invasion of Ukraine using on-demand with a what-you-see-is-what-you-get *** the cOVID-19 pandemic,strict quarantine policies in Ukraine led to a 2%reduction in tropospheric NO_(2) concentration before the lockdown and 4%during the lockdown *** like Kyiv,Donetsk,and Dnipro exhibited reductions of 5%,11%,and 16%,*** SO_(2) column concentration decreased by 6%before the lockdown and 2.5%during the lockdown period,except in high population density *** showed the highest reduction of 17%in SO_(2) concentration,while Donetsk and Dnipro exhibited an 11%***,during the Russian invasion,there was a significant increase in tropospheric NO_(2) concentration in heavily destroyed Kharkiv while most eastern regions experienced a *** total SO_(2) column was 48%higher before the war but reduced throughout the country after the war,except for in Kyiv and a few central *** findings can contribute to analyzing air pollution and building digital twin simulations for future reconstruction scenarios.

关键词： ukraine war air pollution pandemic climate change environment spatiotemporal computing digital twins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical synthesis and racemic crystallization of rat C5a-desArg

引用

Chinese Chemical Letters 2020年第3期31卷 693-696页

作者： Chao Zuo Baochang Zhang Meng Wu Donald Bierer Jing Shi Ge-Min Fang School of Life Science Institutes of Physical Science and InformationTechnologyAnhui UniversityHefei 230601China Department of Chemistry Tsinghua UniversityBeijing 100084China Department of Chemistry University of Science and Technology of ChinaHefei 230601China bayer AG Department of Medicinal ChemistryAprather Weg 18A42096WuppertalGermany

The deletion of the C-terminal arginine of the anaphylatoxin protein C5a reduces it receptor binding *** how C-terminal arginine affects the structure and bioactivity of C5a is important for the development of C5a C-terminal mimics as drug ***,we report the total chemical synthesis of rat C5a and its D-enantiomer with its C-terminal arginine deleted,namely L-rC5a-desArg and *** structure of rC5a-desArg was then determined by racemic crystallography for the first *** C-terminal residues of rC5a-Arg were found to expand from the fourth helix in a continuous helical confo *** C-terminal conformation is significantly different from that of the previously reported full-length of C5a,indicating that the deletion of C-terminal arginine residue could result in the destruction of a positively charged surface formed by two adjacent Arg residues in C5a.

关键词： Anaphylatoxin C5a Racemic crystallization Solid phase peptide synthesis Chemical protein synthesis Hydrazide-based native chemical ligation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Field resistance to spinosad in western flower thrips Frankliniella occidentalis(Thysanoptera:Thripidae)

引用

Journal of Integrative Agriculture 2016年第12期15卷 2803-2808页

作者： LI Dong-gang SHANG Xiao-yong Stuart Reitz Ralf Nauen LEI Zhong-ren Si Hyeock Lee GAO Yu-lin State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural Sciences Institute of Plant Protection Dezhou Academy of Agricultural Sciences Malheur County Extension Oregon State University bayer Crop Science RD-SMRPest Control Biology Department of Agricultural Biotechnology Seoul National University

The western flower thrips, Frankliniella occidentalis, is one of the most destructive sucking pests of vegetables, fruits and ornamental crops in China. Spinosad is one of the most commonly used insecticides to manage thrips. To assess the incidence of spinosad resistance in F. occidentalis field populations in eastern China, survival rates for 24 different populations were compared with those of a susceptible laboratory strain. All populations showed significantly higher resistance to spinosad compared with the control as determined by comparing median lethal concentrations. Two populations from Shouguang and Liaocheng in Shandong Province were classified as having moderate and high levels of resistance to spinosad with a mean resistance ratio of 17.0 and 89.2, respectively. Our research indicates a widespread reduction in spinosad efficacy for controlling F. occidentalis field populations, and that resistance management strategies should be implemented as soon as practicable, to reduce the potential of progressive resistance development and loss of efficacy.

关键词： insecticide resistance spinosad bioassay Frankliniella occidentalis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mating behavior of Psammotettix alienus （Hemiptera： Cicadellidae）

引用

Insect Science 2018年第1期25卷 148-160页

作者： Maja Derlink Isabelle Abt Romain Mabon Charlotte Julian Meta Virant-DoberletI Emmanuel Jacquot Department of Organisms and Ecosystems Research National Institute of Biology Vecna pot 111 1000 Ljubljana Slovenia INRA- Cirad-Montpellier SupAgro UMR 385 BGPI Cirad TA A-54K 34398 Montpellier France bayer CropScience 16 rue Jean Marie Leclair - CS 90106 69266 Lyon Cedex 09 France

The Wheat dwarf virus, the causal agent of the wheat dwarf disease, is trans- mitted by leafhoppers from the genus Psammotettix and currently the main protection strategy is based on the use of insecticide treatments. Sustainable management strategies for insect vectors should include methods that are targeted to disrupt reproductive behavior and here we investigated the mating behavior of Psammotettix alineus （Dahlbom 1850） in order to determine the role of vibrational signals in intra-specific communication and pair formation. Both genders spontaneously emit species- and sex-specific calling songs that consisted of regularly repeated pulse trains and differ primarily in pulse train duration and pulse repetition time. Females preferred the conspecific male calling song. After a coordinated exchange of pulse trains, the male approached the stationary female. During the close range courtship and also immediately prior to copulatory attempts distinct male vibrational signals associated with wing flapping and wing vibrations were recorded from the substrate. In the presence of a receptive female, competing males emitted vibrational signals most likely aimed to interfere with male-female interaction. Mated females re- gained sexual receptivity after they laid eggs. Although results suggest that the viruliferous status of insects may have an effect on vibrational songs, our current results did not reveal a significant effect of virus on leafhopper performance in mating behavior. However, this study also suggests, that detailed understanding ofplant-vecto^virus interactions relevant for vector mating behavior is essential for trying new approaches in developing future control practices against plant viruses transmitted by insect vectors.

关键词： mating behavior Psammotettix alienus vibrational communication wheat dwarf virus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Deleted Deletion Site in a New Vector Strain and Exceptional Genomic Stability of Plaque-Purified Modified Vaccinia Ankara(MVA)

引用

Virologica Sinica 2020年第2期35卷 212-226页

作者： Ingo Jordan Deborah Horn Kristin Thiele Lars Haag Katharina Fiddeke Volker Sandig ProBioGen AG.Herbert-bayer-StraBe 8 13086 BerlinGermany Sartorius Stedim Cellca GmbH.Erwin-Rentschler-Str 21 88471 LaupheimGermany Vironova AB Giivlegatan 2211330 StockholmSweden Department of Laboratory Medicine Karolinska Universitetsjukhuset i Huddinge14152 HuddingeSweden

Vectored vaccines based on highly attenuated modified vaccinia Ankara(MVA) are reported to be immunogenic, tolerant to pre-existing immunity, and able to accommodate and stably maintain very large transgenes. MVA is usually produced on primary chicken embryo fibroblasts, but production processes based on continuous cell lines emerge as increasingly robust and cost-effective alternatives. An isolate of a hitherto undescribed genotype was recovered by passage of a nonplaque-purified preparation of MVA in a continuous anatine suspension cell line(***) in chemically defined *** novel isolate(MVA-CR19) replicated to higher infectious titers in the extracellular volume of suspension cultures and induced fewer syncytia in adherent cultures. We now extend previous studies with the investigation of the point mutations in structural genes of MVA-CR19 and describe an additional point mutation in a regulatory gene. We furthermore map and discuss an extensive rearrangement of the left telomer of MVA-CR19 that appears to have occurred by duplication of the right telomer. This event caused deletions and duplications of genes that may modulate immunologic properties of MVACR19 as a vaccine vector. Our characterizations also highlight the exceptional genetic stability of plaque-purified MVA:although the phenotype of MVA-CR19 appears to be advantageous for replication, we found that all genetic markers that differentiate wildtype and MVA-CR19 are stably maintained in passages of recombinant viruses based on either wildtype or MVA-CR.

关键词： Modified vaccinia Ankara(MVA) MVA-CR19 CR.pIX Suspension cell line Vaccine production Genome stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

弹力纺织品整理的实践

引用

国际纺织导报 1998年第3期26卷 72-75,65页

作者： H.Hueber 罗艳 bayer纤维公司

本文从实践的立场出发,阐述了对弹力纺织品的染色和整理。首先涉及织物的收缩倾向,继而对每种整理工艺进行了讨论。其中纺织织物的整理样品通过列表的形式给出。然后对弹性纤维的混纺变体织物也进行了全面的描述。

关键词：纺织品整理热定形羊毛织物弹力纱弹力织物染色载体弹性纤维扁平长丝纱色牢度织物结构

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evidence of active oviposition avoidance to systemically applied imidacloprid in the Colorado potato beetle

引用

Insect Science 2024年第5期31卷 1543-1554页

作者： Alitha Edison Anja Michelbach Dominique Sowade Hanna Kertzel Luise Schmidt Martin Schafer Maximilian Hackhausen Raif Nauen Pablo Duchen Shuqing Xu Institute for Evolution and Biodiversity University of MunsterHufferstraBe 1Munster48149Germany Institute of Organismic and Molecular Evolution(iomE) University of MainzHanns-Dieter-Husch-Weg 15Mainz55128Germany Current address:Department of Cell and Tissue Dynamics MunsterGermany Crop Science Division Research and Development DepartmentBayer AGMonheimGermany

Agricultural pests can develop behavioral resistance to insecticides by choosing to feed or oviposit on insecticide-free *** young larvae have relatively low mobility,oviposition preferences from female adults may play a critical role in shaping the evolu-tionary trajectory of pest *** oviposition avoidance of insecticide-treated hosts was found in different agriculture pests,it remains unclear whether female adults actively choose to occupy insecticide-free *** address this question,we investigated feeding and oviposition preferences between imidacloprid-treated and imidacloprid-free plants in the Colorado potato beetle,Leptinotarsa decemlineata Say,a major potato *** performed behavioral choice assays on two strains that differed in both fecundity and insecticide *** found that one strain preferred to feed on the insecticide-free plants and that this preference is not ***,the other strain chose plants for feeding and oviposition *** analyses of the moving patterns of the beetles suggested that the oviposition preference in the first strain is likely due to active learning.

关键词： Colorado potato beetle host preferences imidacloprid insecticide resis-tance oviposition pesticide avoidance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：