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Association between smoking and the risk of acute mountain sickness： a meta-analysis of observational studies

Military Medical Research 2017年第1期4卷 14-19页

作者： Chen Xu Hong-Xiang Lu Yu-Xiao Wang Yu Chen Sheng-hong Yang Yong-Jun Luo Department of Military Medical Geography Third Military Medical University Chongqing 400038 China battalion 5 of cadet brigade Third Military Medical University Chongqing 400038 China Key Laboratory of High Altitude Environmental Medicine (Ministry of Education) Third Military Medical University Chongqing 400038 China Mountain Sickness Research Institute 18th Hospital of PLA Yecheng Xinjiang 844900 China

Background: People rapidly ascending to high altitudes(>2500m) may suffer from acute mountain sickness(AMS). The association between smoking and AMS risk remains unclear. Therefore, we performed a meta-analysis to evaluate the association between smoking and AMS ***: The association between smoking and AMS risk was determined according to predefined criteria established by our team. Meta-analysis was conducted according to the PRISMA guidelines. We included all relevant studies listed in the Pub Med and Embase databases as of September 2015 in this meta-analysis and performed systemic searches using the terms "smoking", "acute mountain sickness" and "risk factor". The included studies were required to provide clear explanations regarding their definitions of smoking, the final altitudes reached by their participants and the diagnostic criteria used to diagnose AMS. Odds ratios(ORs) were used to evaluate the association between smoking and AMS risk across the studies, and the Q statistic was used to test OR heterogeneity, which was considered significant when P5. We also computed 95% confidence intervals(CIs). Data extracted from the articles were analyzed with Review Manager 5.3(Cochrane Collaboration, Oxford, UK).Results: We used seven case-control studies including 694 smoking patients and 1986 non-smoking controls to analyze the association between smoking and AMS risk. We observed a significant association between AMS and smoking(OR=0.71, 95% CI 0.52–0.96, P=0.03).Conclusion: We determined that smoking may protect against AMS development. However, we do not advise smoking to prevent AMS. More studies are necessary to confirm the role of smoking in AMS risk.

关键词： Smoking Acute mountain sickness Association High altitude Meta-analysis Risk factor

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Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori eradication: A prospective single-center study from China

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World Journal of Gastroenterology 2015年第39期21卷 11179-11184页

作者： Chun-Hua Wang Sheng-Tao Liao Jun Yang Chun-Xia Li Ying-Ying Yang Ran Han Dong-Feng Chen Chun-Hui Lan Department of Gastroenterology Daping Hospital the Third Military Medical University cadet brigade the Third Military Medical University Department of Gastroenterology Guizhou Aerospace Hospital

AIM: To investigate the effects of daily telephonebased re-education(TRE) before taking medicine for the eradication of Helicobacter pylori(H. pylori) on the compliance and the eradication rate in a Chinese patient *** : Aprospective, physician-blind e d, randomized, controlled clinical study was conducted. The patients were randomly assigned to receive TRE every day before taking medicine(TRE group) or no TRE(control group). The patients in the TRE group received regular instructions before taking medicine for the eradication of H. pylori during the entire courseof treatment through telephone calls. The patients in the control group received detailed instructions at the time of seeing a doctor for the guidance. The primary outcome was the H. pylori eradication rate after treatment. The secondary outcomes included the clinical remissions after treatment, adverse events, compliance, and patients' ***: A total of 140 patients were randomized, 70 to the TRE group and 70 to the control group. As the primary outcome, the H. pylori eradication rates in the TRE and control groups were 62.7% and 71.2% in per protocol analysis(P = 0.230), and 52.9% and 52.9% in intention-to-treat analysis(P = 0.567), respectively. As the secondary outcomes, there were no significant differences in the patients' satisfaction between the two groups(good, 79.7% vs 76.9%; fair, 13.6% vs 19.2%; poor, 6.7% vs 3.9%, for the TRE group and control group, respectively; P > 0.05 for all); the rates of adverse effects were 15.2% and 63.5% in the TRE and control groups, respectively(P 5.7% and 74.3%, respectively(P = 0.069).CONCLUSION: Daily TRE before taking medicine had no significant impact on the patients' compliance, satisfaction, or H. pylori eradication, but reduced the rate of adverse events.

关键词： Helicobacter pylori Eradication Telephone re-educa

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Epidemiology of esophageal squamous cell carcinoma

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转化医学电子杂志 2017年第5期4卷 25-28页

作者：刘媛王安辉 WANG Bo ZHU Qing-Hao SHANG Qing-Chao LI Bo HU Zhi-Hao ZHANG Guan-Wen Clinic of Xi'an Communication College Xi'an 710106 China Department of Epidemiology School of Public Health cadet brigade Fourth Military Medical University Xi'an 710032 China

Esophageal cancer( EC) caused about more than390 000 deaths in 2010. EC is the fourth leading cause of cancer death in China. Esophageal squamous cell carcinoma( ESCC) is the predominant histologic type in China. This study briefly reviews the epidemiology of ESCC,especially focus on the environmental and genetic risk factors of ESCC.

关键词： esophageal carcinoma squamous cell epidemiology

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Sequencing and analysis of the complete mitochondrial genome in Anopheles sinensis(Diptera:Culicidae)

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Infectious Diseases of Poverty 2017年第1期6卷 1324-1329页

作者： Kai Chen Yan Wang Xiang-Yu Li Heng Peng Ya-Jun Ma Department of Tropical Infectious Diseases Second Military Medical UniversityShanghai 200433China Department of Medical Microbiology and Parasitology Second Military Medical UniversityShanghai 200433China Team ten cadet brigade Second Military Medical UniversityShanghai 200433China

Background:Anopheles sinensis(Diptera:Culicidae)is a primary vector of Plasmodium vivax and Brugia malayi in most regions of *** addition,its phylogenetic relationship with the cryptic species of the Hyrcanus Group is complex and remains *** genome sequences are widely used as molecular markers for phylogenetic studies of mosquito species complexes,of which mitochondrial genome data of *** is not ***:*** samples was collected from Shandong,China,and identified by molecular *** DNA was extracted,followed by the Illumina *** complete mitochondrial genomes were assembled and annotated using the mitochondrial genome of *** as *** mitochondrial genomes sequences of the 28 known Anopheles species were aligned and reconstructed phylogenetic tree by Maximum Likelihood(ML)***:The length of complete mitochondrial genomes of *** was 15,076 bp and 15,138 bp,consisting of 13 protein-coding genes,22 transfer RNA(tRNA)genes,2 ribosomal RNA(rRNA)genes,and an AT-rich control *** in other insects,most mitochondrial genes are encoded on the J strand,except for ND5,ND4,ND4L,ND1,two rRNA and eight tRNA genes,which are encoded on the N *** bootstrap value was set as 1000 in ML *** topologies restored phylogenetic affinity within subfamily *** ML tree showed four major clades,corresponding to the subgenera Cellia,Anopheles,Nyssorhynchus and Kerteszia of the genus ***:The complete mitochondrial genomes of *** were *** number,order and transcription direction of *** mitochondrial genes were the same as in other species of family Culicidae.

关键词： Anopheles sinensis Mitochondrial genome Phylogenetic relationship

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Chinese Journal of Traumatology 2021年第4期24卷 221-230页

作者： Lu-Na Sun Jing-Wen Gu Li-Jun Huang Zhi-Lei Shang Yao-Guang Zhou Li-Li Wu Yan-Pu Jia Nian-Qi Liu Wei-Zhi Liu Lab for Post-traumatic Stress Disorder Faculty of Psychology and Mental HealthNaval Medical UniversityShanghai200433China The Emotion&Cognition Lab Faculty of Psychology and Mental HealthNaval Medical UniversityShanghai200433China The battalion 3 of cadet brigade School of Basic MedicineNaval Medical UniversityShanghai200433China Department of Radiology Changshu Hospital Affiliated to Suzhou UniversityChangshu215500Jiangsu ProvinceChina

Purpose:Posttraumatic stress disorder(PTSD)is a significant global mental health concern,especially in the *** study aims to estimate the efficacy of mindfulness meditation in the treatment of military-related PTSD,by synthesizing evidences from randomized controlled ***:Five electronic databases(Pubmed,EBSCO Medline,Embase,PsychINFO and Cochrane Library)were searched for randomized controlled trials focusing on the treatment effect of mindfulness meditation on military-related *** selection of eligible studies was based on identical inclusion and exclusion *** about study characteristics,participant characteristics,intervention details,PTSD outcomes,as well as potential adverse effects was extracted from the included *** of bias of all the included studies was critically assessed using the Cochrane Collaboration's tool.R Statistical software was performed for data ***:A total of 1902 records were initially identified and *** duplicates removal and title&abstract review,finally,19 articles in English language with 1326 participants were included through strict inclusion and exclusion *** results revealed that mindfulness meditation had a significantly larger effect on alleviating military-related PTSD symptoms compared with control conditions,such as treatment as usual,present-centered group therapy and PTSD health education(standardized mean difference(SMD)=-0.33;95%CI[-0.45,-0.21];p5%CI[-0.46,-0.19];SMD=-0.49,95%CI[-0.88,-0.10],respectively),formats of delivery(group-based or individual-based,SMD=-0.30,95%CI[-0.42,-0.17],SMD=-0.49,95%CI[-0.90,-0.08],respectively)and intervention durations(short-term or standard duration,SMD=-0.27,95%CI[-0.46,-0.08],SMD=-0.40,95%CI[-0.58,-0.21],respectively)were equally effective in improving military-related PTSD ***:Finding

关键词： Posttraumatic stress disorder Military personnel Mindfulness meditation Meta-analysis

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Histones of Neutrophil Extracellular Traps Induce CD11b Expression in Brain Pericytes Via Dectin-1 after Traumatic Brain Injury

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Neuroscience Bulletin 2022年第10期38卷 1199-1214页

作者： Yang-Wuyue Liu Jingyu Zhang Wanda Bi Mi Zhou Jiabo Li Tiantian Xiong Nan Yang Li Zhao Xing Chen Yuanguo Zhou Wenhui He Teng Yang Hao Wang Lunshan Xu Shuang-Shuang Dai Department of Biochemistry and Molecular Biology School of Basic MedicineArmy Medical UniversityChongqing400038China Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqing400042China Molecular Biology Center State Key Laboratory of TraumaBurnand Combined InjuryDaping HospitalArmy Medical UniversityChongqing400042China Department of Pathophysiology College of High Altitude MedicineArmy Medical UniversityChongqing400038China brigade 1 of Medical Undergraduates School of Basic MedicineArmy Medical UniversityBattalion 1Chongqing400038China

The brain pericyte is a unique and indispensable part of the blood-brain barrier(BBB),and contributes to several pathological processes in traumatic brain injury(TBI).However,the cellular and molecular mechanisms by which pericytes are regulated in the damaged brain are largely ***,we show that the formation of neutrophil extracellular traps(NETs)induces the appearance of CD11b^(+)pericytes after *** CD11b^(+)pericyte subsets are characterized by increased permeability and pro-inflammatory profiles compared to ***,histones from NETs by Dectin-1 facilitate CD11b induction in brain pericytes in PKC-c-Jun dependent manner,resulting in neuroinflammation and BBB dysfunction after *** data indicate that neutrophil-NET-pericyte and histone-Dectin-1-CD11b are possible mechanisms for the activation and dysfunction of *** NETs formation and Dectin-1 are promising means of treating TBI.

关键词： Pericyte Neutrophil TBI NET Dectin-1

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Experiences and challenges in the health protection of medical teams in the Chinese Ebola treatment center,Liberia:a qualitative study

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Infectious Diseases of Poverty 2018年第1期7卷 951-962页

作者： Ying Li Huan Wang Xu-Rui Jin Xiang Li Michelle Pender Cai-Ping Song Sheng-Lan Tang Jia Cao Hao Wu Yun-Gui Wang Department of Social Medicine and Health Service Management Army Medical University(Third Military Medical University)ChongqingChina Bureau of Medical Affairs Administration First affiliated HospitalArmy Medical University(Third Military Medical University)ChongqingChina The cadet brigade of Clinic Medicine Army Medical University(Third Military Medical University)Chongqing 400038China Duke Global Health Institute Duke UniversityDurhamNCUSA Bureau of nurse Administration Second affiliated hospitalArmy Medical University(Third Military Medical University)ChongqingChina Department of Hygienic Toxicology Army Medical University(Third Military Medical University)ChongqingChina Army Medical University(Third Military Medical University) No.30 Gaotanyan RoadShapingba districtChongqing 400038China

Background:Health care workers are at the frontline in the fight against infectious disease,and as a result are at a high risk of *** the 2014-2015 Ebola outbreak in West Africa,many health care workers contracted Ebola,some ***,no members of the Chinese Anti-Ebola medical team,deployed to provide vital medical care in Liberia were *** study aims to understand how this zero infection rate was ***:Data was collected through 15 in-depth interviews with participants from the People’s Liberation Army of China medical team which operated the Chinese Ebola Treatment Center from October 2014 to January 2015 in *** were analysed using systematic framework ***:This study found numerous bio-psycho-socio-behavioural risk factors that directly or indirectly threatened the health of the medical team working in the Chinese Ebola Treatment *** factors included social and emotional stress caused by:(1)the disruption of family and social networks;(2)adapting to a different culture;(3)and anxiety over social and political unrest in *** to Ebola from patients and local co-workers,and the incorrect use of personal protective equipment due to fatigue was another major risk *** risk factors identified were:(1)shortage of supplies;(2)lack of trained health personnel;(3)exposure to contaminated food and water;(4)and long working *** efforts were taken throughout the mission to mitigate these *** measure was taken to prevent the medical team’s exposure to the Ebola virus,and to provide the medical team with safe,comfortable working and living *** were many challenges in maintaining the health safety of the team,such as the limited capability of the emergency command system(the standardized approach to the command,control,and coordination of an emergency response),and the lack of comprehensive international protocols for dealing with emerging infectiou

关键词： Infectious diseases Ebola China Ebola treatment center Medical team Liberia

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全科医生参与社会控烟的伦理责任

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中国全科医学 2018年第28期21卷 3411-3416页

作者：姚弥徐志杰李海昕 Joan Mitchell RN(EC) 张晨北京市西城区新街口社区卫生服务中心北京市100034 第二军医大学学员旅上海市200433 第二军医大学药学院上海市200433 Byron Family Medical Centre LondonCanada N5L 1H1 第二军医大学人文社会科学部上海市200433

2016年,世界卫生组织(WHO)在其发布的关于世界烟草使用情况的报告中指出,每年大约有600万人死于吸烟诱发的疾病,危害居民身心健康的同时,也给社会造成了严重的经济负担。作为社区居民健康的"守门人",全科医生在推动社会控烟事业进步的... 详细信息

2016年,世界卫生组织(WHO)在其发布的关于世界烟草使用情况的报告中指出,每年大约有600万人死于吸烟诱发的疾病,危害居民身心健康的同时,也给社会造成了严重的经济负担。作为社区居民健康的"守门人",全科医生在推动社会控烟事业进步的过程中应扮演重要的角色。本文基于全科医生职业使命的伦理考量,提出全科医生在社会控烟事业中应承担的伦理责任:第一,全科医生应该在行为上树立榜样,自身坚决杜绝烟草;第二,全科医生应尽力规劝其患者戒烟,同时在社区中倡导建立无烟环境;第三,全科医生应在整个医疗体系内积极宣传无烟化的理念,将戒烟辅助纳入常规诊疗服务流程。此外,全科医生还应该致力于促进政府对烟草控制框架公约的履行,推动全社会控烟事业的进步。

关键词：烟草控制戒烟伦理学,医学社会责任全科医生无烟医院

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