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Association between acute mountain sickness(AMS) and age: a meta-analysis

Military Medical Research 2019年第1期6卷 31-38页

作者： Yu Wu Chi Zhang Yu Chen Yong-Jun Luo Department of Military Medical Geography Army Medical Service Training Base Army Medical University battalion 5 of cadet brigade Army Medical University Key Laboratory of High Altitude Environmental Medicine of PLA Army Medical University

Background: Acute mountain sickness(AMS) is a potentially lethal condition caused by acute hypoxia after ascending to altitudes higher than 2500 m in a short time. The main symptom of AMS is headache. Numerous risk factors of AMS have been examined, including gender, obesity, ascent rate, age and individual susceptibility. In previous studies, age was considered a predisposing factor for AMS. However, different opinions have been raised in recent years. To clarify the association between AMS and age, we conducted this ***: We obtained observational studies that explored risk factors for AMS by searching PubMed, Embase, China National Knowledge Internet(CNKI), the Wanfang database and CQVIP for articles published before March *** studies included were required to provide the mean age and its standard deviation for subjects with and without AMS, the maximum altitude attained and the mode of ascent. The Lake Louse Score(LLS) or the Chinese AMS score(CAS) was used to judge the severity of AMS symptoms and incidence. Studies were pooled for the analysis by using a random effects model in RevMan 5.0. Meta-regression and subgroup analyses were conducted to identify sources of heterogeneity using Stata 14.2 and RevMan ***: In total, 17 studies were included, and the overall number of subjects with and without AMS was 1810 and3014, respectively. The age ranged from 10 to 76 years. Analysis of the 17 included studies showed that age was not associated with AMS(mean difference(MD)=0.10; 95%CI: —0.38-0.58; P=0.69).Conclusions: This meta-analysis suggests that there is no association between age and the risk of AMS. Race, age,and ascent mode are common sources of heterogeneity, which may provide an analytical orientation for future heterogeneity analyses.

关键词： Meta-analysis Age Acute mountain sickness Individual susceptibility

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Association of iodized salt with goiter prevalence in Chinese populations: a continuity analysis over time

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Military Medical Research 2017年第3期4卷 149-156页

作者： Zhen Liang Chen Xu Yong-Jun Luo Department of Military Medical Geography College of High Altitude Military Medicine Third Military Medical University battalion 5 of cadet brigade Third Military Medical University Key Laboratory of High Altitude Medicine of PLA Third Military Medical University

Background: Iodine deficiency disorders(IDD) refer to diseases that are caused by insufficient iodine intake, and the best strategy to prevent IDD is the addition of iodine to dietary salt. Because iodine deficiency is a common cause of goiter, the prevalence as effectively controlled after the implementation of universal salt iodization(USI) in China. However, there is substantial controversy as to whether the incidence of thyroid disorders is related to iodized salt intake. Therefore, we aimed to clarify whether the risk of goiter can be promoted by ***: A longitudinal continuous study based on the national monitoring results of IDD in China was performed for 3 consecutive years. We recorded the following indicators of IDD from 31 provinces: goiter number, two degrees of goiter(the degree of goiter severity) and cretinism(three endemic diseases), iodized salt intake, median urinary iodine concentration(UIC), soil iodine content and coverage rates of iodized salt. One-way Analysis of Variance(ANOVA) and linear regression analyses examined the differences between the three groups and correlations, respectively. Data were collected from the Chinese national IDD surveillance data in 2011-2013, and the background values of Chinese soil elements were published in ***: A reference male's daily intake of maximum iodine was 378.9μg, 379.2μg and 366.9μg in 2011, 2012, and 2013, respectively. No statistical association between daily iodized salt intake and the three endemic diseases was observed in 2011-2013(P >0.05). No association was observed between daily iodized salt intake and the UIC of children in 2011(P>0.05). Linear regression revealed no significant correlation between the soil iodine content and three endemic diseases. The present study indicated no difference in the daily iodized salt intake in each province during three years(F=0.886, P=0.647). The coverage rate of iodized salt remained above 98.7%, and goiter rates were stable in ***

关键词： Iodine deficiency disorders(IDD) Iodized salt China

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The update of prostatic ductal adenocarcinoma

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Chinese Journal of Cancer Research 2016年第1期28卷 50-57页

作者： Tantan Liu Yingmei Wang Ru Zhou Haiyang Li Hong Cheng Jing Zhang State Key Laboratory of Tumor Biology Department of Pathology Xijing Hospital cadet brigade The Fourth Military Medical University

Since initially described in 1967, prostatic ductal adenocarcinoma （PDA） has engendered a series of controversies on its origin, histological features, and biological behavior. Owing to the improvement of molecular biological technique, there are some updated findings on the characteristics of PDA. In the current review, we will mainly analyze its origin, clinical manifestations, morphological features, differential diagnosis, immunophenotype and molecular genetics, with the purpose of enhancing recognition of this tumor and making a correct diagnosis and treatment choice.

关键词： Prostatic cancer ductal adenocarcinoma elinieopathology differential diagnosis

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PCA3 and TMPRSS2-ERG gene fusions as diagnostic biomarkers for prostate cancer

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Chinese Journal of Cancer Research 2016年第1期28卷 65-71页

作者： Zheng Yang Lu Yu Zhe Wang State Key Laboratory of Cancer Biology Department of Pathology Xi Jing Hospital The First cadet brigade Fourth Military Medical University

The incidence of prostate cancer （PCa） is rising steadily among males in many countries. Serum prostate-specific antigen （PSA） is widely applied to clinical diagnosis and screening of PCa. However, the so-called grey area of PSA levels 4.0-10.0 ng/mL has a low specificity of 25-40% resulting in a high rate of negative biopsy and overtreatment. So in order to treat PCa patients in early stage, there is an urgent need for new biomarkers in PCa diagnosis. The PCA3 gene, a non-coding RNA （ncRNA） that is highly expressed in prostate cancer （PCa） cells, has been identified as a molecular biomarkers to detect PCa, of which PCA3 has already under clinical application. PCA3 is strongly overexpressed in malignant prostate tissue compared to benign or normal adjacent one. Newly, PCA3 is considered to be a promising biomarker in clinical diagnosis and targeted therapy. The diagnostic significance of PCA3, however, is awaiting further researches. Moreover, it has been demonstrated recently that TMPRSS2-ERG gene fusion is identified as the predominant genetic change in patients diagnosed with PCa. Recent study revealed that combination of the PC43 and TMPRSS2-ERG gene fusion test optimizes PCa detection compared with that of single biomarker, which would lead to a considerable reduction of the number of prostate biopsies. In this review, we focused on the potential use of PCA3 and TMPRSS2-ERG gene fusion detection in the diagnosis of PCa.

关键词： Prostate prostate cancer antigen 3 (PCA3) TMPRSS2-ERG gene fusion prostate cancer (PCa) biomarker

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The benign mimickers of prostatic acinar adenocarcinoma

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Chinese Journal of Cancer Research 2016年第1期28卷 72-79页

作者： Yuqiao Xu Yingmei Wang Ru Zhou Haiyang Li Hong Cheng Zhe Wang Jing Zhang Department of Pathology State Key Laboratory of Tumor Biology Xijing Hospital The Fourth Military Medical University cadet brigade The Fourth Military Medical University

As the most frequent malignant histological subtype in prostatic cancer, prostatic acinar adenocarcinoma （PAA） has a series of benign mimickers including prostatic or non-prostatic lesions and normal structures, which may lead to an erroneous diagnosis and inappropriate treatment. It is very important to be aware of the existence of these mimickers and to recognize their histological features. The differential diagnosis should be based on a comprehensive evaluation of clinical history, histological structure, cytological morphology and the results of immunohistochemistry （IHC） straining, rather than on single criteria （e.g., the presence of prominent nueleoli or basal cell layer）.

关键词： Prostatic acinar adenocarcinoma (PAA) differential diagnosis immunohistochemistry

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Association between endothelial nitric oxide synthase(ENOS) G894T polymorphism and high altitude(HA) adaptation： a meta-analysis

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中国应用生理学杂志 2015年第6期31卷 517-523页

作者： Hong-xiang LU Yu-xiao WANG Yu CHEN Yong-jun LUO Department of Military Medical Geography College of High Altitude Military Medicine the Third Military Medical University Chongqing 400038 China battalion 5 of cadet brigade the Third Military Medical University Chongqing 400038 China Key Laboratory of High Altitude Medicine (Ministry of Education) the Third Military Medical University Chongqing 400038 China

Objective: Highland natives adapt well to the hypoxic environment at high altitude(HA). Several genes have been reported to be linked to HA adaptation. Previous studies showed that the endothelial nitric oxide synthase(ENOS) G894 T polymorphism contributed to the physiology and pathophysiology of humans at HA by regulating the production of NO. In this meta-analysis, we evaluate the association between the ENOS G894 T polymorphism and HA adaptation through analyzing the published data. Methods: We searched all relevant literature about the ENOS G894 T polymorphism and HA adaptation in Pub Med, Medline, and Embase before Step 2015. A random-effects model was applied(Revman 5.0), and study quality was assessed in duplicate. Six studies with 634 HA native cases and 621 low-altitude controls were included in this meta-analysis. Results: From the results, we observed that the wild-type allele G was significantly overrepresented in the HA groups(OR=1.85; 95% CI, 1.47–2.33; P5% CI, 1.54–2.57; P<0.0001). Conclusion: Our results showed that in 894 G allele carriers, the GG genotype might be a beneficial factor for HA adaptation through enhancing the level of NO. However, more studies were needed to confirm our findings due to the limited sample size.

关键词：内皮型一氧化氮合酶 eNOS 多态性 HA 高海拔高原低氧环境 MEDLINE 病理生理学

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Role of medical resource level in iodine deficiency disorder

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Military Medical Research 2018年第1期5卷 53-61页

作者： Chen Xu Zhen Liang Yong-Jun Luo Department of Military Medical Geography College of High Altitude Military MedicineThird Military Medical University battalion 5 of cadet brigade Third Military Medical University Key Laboratory of High Altitude Medicine (PLA) Third Military Medical University

Background:Iodine deficiency disorders(IDDs)refer to a series of diseases caused by the human body's insufficient iodine *** salt became iodized in China in 1996,which yielded remarkable *** have known that IDDs is associated with iodine in the human body,but it is not clear whether IDDs is related to medical resource ***:We collected the number of IDDs cases and an index for the level of medical resource from 31 provinces,autonomous regions and municipalities directly under the central government in *** data came from the China Statistical Yearbook of Health and Family Planning issued in 2013 by the Peking Union Medical College Publishing *** standardization and linear regression analysis were ***:The results showed that IDDs correlated with the number of beds in medical and health institutions,number of medical health personnel,number of medical and health institutions,total health expenditure,average health expenditure per capita,medical insurance for urban resident and new rural cooperative medical rural residents(P<0.01).In a multiple linear regression,IDDs was most significantly associated with the number of beds in hospitals,the number of rural health personnel,the number of basic medical and health institutions and government health expenditure for these institutions. Conclusion:Based on the experimental data,we concluded that IDDs had a positive connection with the medical resource level,and basic and rural areas had a more significant association with *** analysis provides new and explicit ideas for iodine prevention and control work in China.

关键词： Iodine deficiency disorders(IDDs) Health level Medical security China

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Medical humanity： how do we learn it？

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Chinese Medical Journal 2014年第24期127卷 4292-4294页

作者： Chang Yifan Zhou Xiaoyi Zhang Yan Department of Urology Changhai Hospital Shanghai 200433 China cadet brigade Department of Foreign Languages the Second Military Medical University Shanghai 200433 China

Medical humanity, as ambiguous and inclusive as the concept seems at first glance, is broadly defined as an interdisciplinary field in humanities, social science and the arts, involving such extensive fields as ethics, history, religion, cultural studies, sociology, psychology, literature, etc., and their application to medical education and practice.1 In the United States, Europe and Canada, many medical universities have integrated the learning of medical humanities in their curricula, which many scholars claim may help medical students to build up a humane and holistic orientation in the future.2

关键词： humanities medical education medical students

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DNA vaccine encoding Hantavirus Gn, targeted to MIIC by trafficking molecule LAMP, significantly enhances specific immune responses

DNA vaccine encoding Hantavirus Gn, targeted to MIIC by traf...

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第十届全国免疫学学术大会

作者： Jinpeng Zhang Shaobo Xiao Peihan He Yunwei Wang Dongbo Jiang Kun Yang Department of Immunology the Fourth Military Medical University brigade of cadet the Fourth Military Medical University

Lysosome-associated membrane protein(LAMP)can target and bind to endosome/lysosome,one of the most important components of the MHC class II-processing compartment(MIIC)in the exogenous antigen-processing *** trafficking greatly enhance the immune response because endogenous antigen can take advantage of LAMP being directly carried into MIIC,activating CD4+helper T cells for effective immue response and long-term immune *** glycoprotein N-terminal,named Gn,could induce neutralizing antibody production with a low serum titer as natural *** analyze the influence of LAMP on Hantaan virus(HTNV)Gn vaccine potency and develop a novel effective vaccine against HTNV,we constructed three eukaryotic vectors as naked DNA vaccine named p VAX-Gn,p VAX-LAMP and p VAX-LAMP/Gn,***/c mice were immunized with those plasmids,the specific humoral and cellular responses elicited against HTNV Gn were measured by ELISA,cytotoxicity assays and ELISPOT assay(IFN-γ).To measure the protective efficacy,virus challenging in vivo and neutralizing antibody valence were conducted by viral load detection(q RT-PCR and sandwich ELISA)and the cell microculture neutralization *** found that HTNV Gn showed a strong immunogenicity to elicit both humoral and cellular responses with LAMP as a *** with the current prophylactic inactive vaccine,p VAX-LAMP/Gn showed a stronger cellular *** worth raising,a significant long term memory reponse was observed only from the group of p VAXLAMP/*** analysis by HE staining demonstrated that p VAX-LAMP/Gn was not *** of protection assay in vivo indicated that the immune response established was HTNV specific and *** findings not only demonstrated that the LAMP as a trafficking molecule can introduce Gn to MHCII presenting pathway and significantly enhanced HTNV specific immune response,but also suggested that the p VAX-LAMP/Gn as a DNA vaccine had potentia

关键词： DNA vaccine Hantavirus LAMP targeting Immune responses

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Changes in oxygen saturation can not help diagnose acute mountain sickness(AMS)： ascending to Lhasa on the Qinghai-Tibet train

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中国应用生理学杂志 2016年第6期32卷 519-524页

作者： Jun-bo AN Hao-ran GU Yu WU Yong-jun LUO Department of Military Medical Geography College of High Altitude Military Medicine Third Military Medical University Chongqing 400038 China battalion 5 of cadet brigade Third Military Medical University Chongqing 400038 China Key Laboratory of High Altitude Medicine (Ministry of Education) Third Military Medical University Chongqing 400038 China The 12th hospital of PLA Kashi 844200 China

Objective: Acute mountain sickness(AMS) is a common condition in individuals who ascend to altitudes over 2 500 m. There is no measurements that can reliably predict or diagnose this condition. We therefore determined whether pulse oximetry data are associated with the development of AMS and can help diagnose AMS. Methods: We studied 58 young male undergraduates who traveled from Chongqing(300 m) to Lhasa(3 658 m) by train. We collected data on the ascent profiles and AMS symptoms based on the Lake Louise Score(LLS). The resting arterial oxygen saturation(R-Sp O2) and pulse rate were then measured using finger pulse oximetry. Results: In Golmud(2 800 m) and Tanggula(5 200 m), R-SpO_2 was significantly lower in the AMS group than in the group without AMS(P5). However, upon arrival in Lhasa(3 658 m), the R-SpO_2 was higher in the AMS group than in the non-AMS group(P5). In Tanggula, the change in the SpO_2(CR-SpO_2) in the AMS group was higher than that in the non-AMS group(P5). But in Lhasa, the CR-SpO_2 in the AMS group was lower than that in the non-AMS group(P5). We also monitored heart rate(HR) throughout the study. In Xining(2 200 m) and Golmud, the HRs in the AMS group were higher than those in the non-AMS group. However, the HRs in the AMS group were lower than those in the non-AMS group in Tanggula and Lhasa. Conclusion: Based on the results of this study, the R-SpO_2 graph was not consistent. We can thus conclude that the utility of SpO_2 remains limited in the diagnosis of AMS. The results suggest that using pulse oximetry to diagnose AMS is not valuable in people ascending to Lhasa on the Qinghai-Tibet train.

关键词：脉搏血氧饱和度诊断系统 AMS 高原病拉萨火车西藏青海

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