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An Update on Abscisic Acid Signaling in Plants and More

Molecular Plant 2008年第2期1卷 198-217页

作者： Aleksandra Wasilewsk.a Florina Vlad Caroline Sirichandra Yulia Redko Fabien Jammes Christiane Valon Nicolas Frei dit Frey Jeffrey Leung Institut des Sciences du Vegetal Centre National de la Recherche Scientifique UPR 23551 Avenue de la Terrasse Bat. 23 91190 Gif-sur-Yvette France CNRS UPR9073 Institut de Biologie Physico-Chimique 13 rue Pierre et Marie Curie 75005 Paris France Laboratoire Signalisation et Regulation Coordonnee du Metabolisme Carbone et Azote Institut de Biotechnologie des Plantes (UMR8618) Universite Paris-Sud F-91405 Orsay Cedex France

The mode of abscisic acid （ABA） action, and its relations to drought adaptive responses in particular, has been a captivating area of plant hormone research for much over a decade. The hormone triggers stomatal closure to limit water loss through transpiration, as well as mobilizes a battery of genes that presumably serve to protect the cells from the ensuing oxidative damage in prolonged stress. The signaling network orchestrating these various responses is, however, highly complex. This review summarizes several significant advances made within the last few years. The biosynthetic pathway of the hormone is now almost completely elucidated, with the latest identification of the ABA4 gene encoding a neoxanthin synthase, which seems essential for de novo ABA biosynthesis during water stress. This leads to the interesting question on how ABA is then delivered to perception sites. In this respect, regulated transport has attracted renewed focus by the unexpected finding of a shoot-to-root translocation of ABA during drought response, and at the cellular level, by the identification of a B-galactosidase that releases biologically active ABA from inactive ABA-glucose ester. Surprising candidate ABA receptors were also identified in the form of the Flowering Time Control Protein A （FCA） and the Chloroplastic Magnesium Protoporphyrin-IX Chelatase H subunit （CHLH） in chloroplast-nucleus communication, both of which have been shown to bind ABA in vitro. On the other hand, the protein（s） corresponding to the physiologically detectable cell-surface ABA receptor（s） is （are） still not known with certainty. Genetic and physiological studies based on the guard cell have reinforced the central importance of reversible phosphorylation in modulating rapid ABA responses. Sucrose Non-Fermenting Related Kinases （SnRK）, Calcium-Dependent Protein Kinases （CDPK）, Protein Phosphatases （PP） of the 2C and 2A classes figure as prominent regulators in this single-cell model. Identifying their d

关键词： ABSCISIC acid PLANT hormones ADAPTATION (Biology) TRANSPIRATION of plants BIOSYNTHESIS

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Orexin receptor type 2 agonism inhibits thermogenesis in brown adipose tissue by attenuating afferent innervation

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The Journal of Biomedical research 2022年第3期36卷 195-207,I0005,I0006页

作者： Mo-qiu Jia Yong-jin Wang Kang Fu Han Jiao Jia Sun Yuanqing Gao Key laboratory of Cardiovascular and Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China

Orexin signaling has been associated with energy expenditure and brown adipose tissue(bat)***,conflicting data exist in the field about how orexin signaling regulates bat *** this study,we show that a specific orexin receptor type 2(OX2R)agonist[Ala11,D-Leu15]-OxB(OB-Ala)inhibited intrascapular brown adipose tissue(ibat)thermogenesis by reducing sympathetic output to *** effect is mediated by OX2Rs located on afferent nerve endings innervating ibat instead of brown adipocyte *** of OB-Ala into ibat inhibited ibat thermogenesis in mice upon cold exposure and neuronal activity in the paraventricular *** suggest that OB-Ala could inhibit ibat thermogenesis by attenuating sensory input thereby inhibiting the sympathetic-sensory ibat feedback *** study uncovers a novel primary action site of orexin in the regulation of energy balance.

关键词： orexin receptor type 2 brown adipose tissue thermogenesis

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Orbital X-ray modulation study of three supergiant HMXBs

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research in Astronomy and Astrophysics 2009年第12期9卷 1303-1316页

作者： Chetana Jain Biswajit Paul Anjan Dutta Department of Physics and Astrophysics University of Delhi Raman research Institute SadashivnagarC.V.Raman Avenue

We present the orbital X-ray modulation study of three high mass X-ray binary systems, IGR J18027-2016, IGR J18483-0311 and IGR J16318-4848, using data obtained with RXTE-ASM, Swift-bat and INTEGRAL-ISGRI. Using the long term light curves of the eclipsing HMXB IGR J18027-2016, obtained with Swift-bat in the energy range 15-50keV and INTEGRAL-ISGRI in the energy range 22-40 keV, we have determined three new mid eclipse times. The newly determined mid eclipse times together with the known values were used to derive an accurate value of the orbital period of 4.5693（4） d at MJD 52168 and an upper limit of 3.9（1.2）×10^-7d d-1 on the period derivative. We have also accurately determined an orbital period of 18.5482（88）d for the intermediate system IGR J 18483-0311, which displays an unusual behavior and shares many properties with the known SFXTs and persistent supergiant systems. This is a transient source and the outbursts occur intermittently at intervals of 18.55 d. Similarly, in the third supergiant system, IGR J16318-4848, we have found that the outbursts are separated by intervals of 80 d or its multiples, suggesting a possible orbital period.

关键词： X-ray: neutron stars -- X-ray binaries: individual

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Predicted secreted protein analysis reveals synaptogenic function of Clstn3 during WAT browning and bat activation in mice

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Acta Pharmacologica Sinica 2019年第8期40卷 999-1009页

作者： Shu-qin Chen Qiang Niu Li-ping Ju Miriayi Alimujiang Han Yan Ning-ning Bai Jun Xu Qi-chen Fang Jun-feng Han Ying Yang Wei-ping Jia Shanghai Key laboratory of Diabetes Shanghai Institute for DiabetesShanghai Clinical Medical Centre of DiabetesShanghai Key Clinical Centre of Metabolic DiseasesDepartment of Endocrinology and MetabolismShanghai Jiao Tong University Affiliated Sixth People’s Hospital National Engineering research Center of Die and Mold CAD Shanghai Jiao Tong University Department of Geriatrics Shanghai Jiao Tong University Affiliated Sixth People’s Hospital

Promoting white adipose tissue(WAT)browning and enhancing brown adipose tissue(bat)activity are attractive therapeutic strategies for obesity and its metabolic *** sympathetic innervation in WAT and bat represents a promising therapeutic ***,there are few reports on extracellular microenvironment remodeling,especially changes in nerve terminal *** the key molecules mediating the neuro-adipose synaptic junctions is a key *** this study,we used bioinformatics methods to identify the differentially expressed predicted secreted genes(DEPSGs)during WAT browning and bat *** DEPSGs largely reflect changes of cytokines,extracellular matrix remodeling,vascularization,and adipocyteneuronal *** then performed functional enrichment and cellular distribution specificity *** upregulated and downregulated DEPDGs during WAT browning displayed a distinctive biological pattern and cellular *** listed a cluster of adipocyte-enriched DEPSGs,which might participate in the cross-talk between mature adipocytes and other cells;then identified a synaptogenic adhesion molecule,Clstn3,as the top gene expressed enriched in both mature white and brown *** Q-PCR and immunohistochemistry,we found significantly increased Clstn3 expression level during WAT browning and bat activation in mice subjected to cold exposure(4℃).We further demonstrated that treatment with isoproterenol significantly increased Clstn3 and UCP1 expression in differentiated white and beige adipocytes in *** conclusion,our study demonstrates that the secretion pattern was somewhat different between WAT browning and bat *** reveal that Clstn3 may be a key gene mediating the neuro-adipose junction formation or remodeling in WAT browning and bat activation process.

关键词： WAT browning bat activation Calsyntenin-3 neuro-adipose synapse isoproterenol obesity

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Transmission ecology of rodent-borne diseases:New frontiers

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Integrative Zoology 2015年第5期10卷 424-435页

作者： Frédéric BORDES Kim BLASDELL Serge MORAND Centre National de la Recherche Scientifique(CNRS)-Centre de coopération Internationale en Recherche Agronomique pour le Développement(CIRAD)Animal et Gestion Intégrée des Risques Centre d’Infectiologie Christophe Mérieux du LaosVientianeLao PDR Commonwealth Scientific and Industrial research Organisation Livestock IndustriesAustralian Animal Health LaboratoryGeelongVictoriaAustralia

Rodents are recognized reservoir hosts for many human zoonotic *** current trends resulting from anthropocene defaunation suggest that in the future they,along with other small mammals,are likely to become the dominant mammals in almost all human-modified *** intricate studies on bat-borne emerging diseases have highlighted that many gaps exist in our understanding of the zoonotic transmission of rodent-borne *** has emphasized the need for scientists interested in rodent-borne diseases to integrate rodent ecology into their analysis of rodent-borne pathogen transmission in order to identify in more detail the mechanisms of spillover and chains of *** studies are required to better understand the true impact of rodent abundance and the importance of pathogen sharing and circulation in multi-host–multi-pathogen *** also need to explore in more depth the roles of generalist and abundant species as the potential links between pathogen-sharing,co-infections and disease transmission.

关键词： biodiversity dilution effect multi-infection rodent-borne diseases transmission ecology

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强连通竞赛图的圈分解(英文)

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运筹学学报 2004年第1期8卷 53-61页

作者：束金龙李皓华东师范大学数学系 L.R.I. Bat.490Universite de Paris-Sud91405Orsay CedexFrance

设T为n阶强连通竞赛图.本文通过详细刻画不能进行圈分解的强连通竞赛图的特征,证明了满足maX{δ+,δ-}>5k-5和k>2的强连通竞赛图T,能够分解为k 个圈.

关键词：强连通竞赛图圈分解传递竞赛图 hamiltonian圈

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ECO-bat: A New Routing Protocol for Energy Consumption Optimization Based on bat Algorithm in WSN

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Computers, Materials & Continua 2021年第2期66卷 1497-1510页

作者： Mohammed Kaddi Abdallah Banana Mohammed Omari LDDI laboratory Mathematics and Computer Science DepartmentUniversity of AdrarAdrar01000Algeria Mathematics and Computer Science Department University of AdrarAdrar01000Algeria

Wireless sensor network (WSN) has been widely used due to its vastrange of applications. The energy problem is one of the important problems influencingthe complete application. Sensor nodes use very small batteries as a powersource and replacing them is not an easy task. With this restriction, the sensornodes must conserve their energy and extend the network lifetime as long as ***, these limits motivate much of the research to suggest solutions in alllayers of the protocol stack to save energy. So, energy management efficiencybecomes a key requirement in WSN design. The efficiency of these networks ishighly dependent on routing protocols directly affecting the network *** is one of the most popular techniques preferred in routing *** this work we propose a novel energy-efficient protocol for WSN based on a batalgorithm called ECO-bat (Energy Consumption Optimization with bat algorithmfor WSN) to prolong the network lifetime. We use an objective function thatgenerates an optimal number of sensor clusters with cluster heads (CH) to minimizeenergy consumption. The performance of the proposed approach is comparedwith Low-Energy Adaptive Clustering Hierarchy (LEACH) and EnergyEfficient cluster formation in wireless sensor networks based on the Multi-Objective bat algorithm (EEMOB) protocols. The results obtained are interestingin terms of energy-saving and prolongation of the network lifetime.

关键词： WSNs network lifetime routing protocols ECO-bat bat algorithm CH energy consumption LEACH EEMOB

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A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

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Science Bulletin 2018年第16期63卷 1077-1086页

作者： Funian Mo Hongfei Li Zengxia Pei Guojin Liang Longtao Ma Qi Yang Donghong Wang Yan Huang Chunyi Zhi Department of Materials Science and Engineering City University of Hong Kong Hong Kong China State Key laboratory of Advanced Welding and Joining Harbin Institute of Technology Harbin 150001 China

Thermal runaway has been a long-standing safety issue impeding the development of high-energy- density batteries. Physical safety designs such as employing circuit-breakers and fuses to batteries are limited by small operating voltage windows and no resumption of original working condition when it is cooled down. Here we report a smart thermoresponsive polymer electrolyte that can be incorporated inside batteries to prevent thermal runaway via a fast and reversible sol-gel transition, and successfully combine this smart electrolyte with a rechargeable Zn/^-Mn02 battery system. At high temperature, bat- tery operation is inhibited as a result of the increased internal resistance caused by the gelation of liquid electrolyte. After cooling down, the electrolyte is spontaneously reversed to sol state and the electro- chemical performance of the battery is restored. More importantly, sol-gel transition enables the smart battery to experience different charge-discharge rates under various temperature levels, providing a smart and active strategy to achieve dynamic and reversible self-protection.

关键词： Rechargeable zinc ion battery Sol-gel electrolyte Reversible transition Gelation Thermoresponsive

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Beige adipocytes partly improved glucose intolerance of bat-denervated mice

Beige adipocytes partly improved glucose intolerance of BAT-...

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中国解剖学会2021年年会

作者： Jia Xiaowei Lu Tao Yang Chun Gao Yan Beijing Key laboratory of Cancer Invasion and Metastasis research Department of Human AnatomySchool of Basic Medical SciencesCapital Medical University

Beige adipocytes are emerging as an interesting issue in obesity and metabolism *** important question is whether beige adipocytes have same functions as brown *** we did surgical denervation (DN) of bilateral bat to examine the specific function of beige *** exposure (CE) and CL316243 (CL)treatments were used to generate beige adipocytes currently.

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Viral receptor profiles of masked palm civet revealed by single-cell transcriptomics

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Journal of Genetics and Genomics 2022年第11期49卷 1072-1075页

作者： Peiwen Ding Haoyu Wang Jiacheng Zhu Fuyu An Jinqian Xu Xiangning Ding Lihua Luo Weiying Wu Qiuyu Qin Yanan Wei Wandong Zhao Zhiyuan Lv Haimeng Li Yixin Zhu Meiling Li Wensheng Zhang Yanan Zhang Zhihua Ou Huan Liu Yan Hua College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China BGI-Shenzhen ShenzhenGuangdong 518083China Guangdong Provincial Key laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhouGuangdong 510520China Department of Neurobiology NHC and CAMS Key Laboratory of Medical NeurobiologySchool of Brain Science and Brian Medicineand the MOE Frontier Science Center for Brain Research and Brain–Machine IntegrationZhejiang University School of MedicineHangzhouZhejiang 310012China School of Basic Medicine Qingdao UniversityQingdaoShandong 266071China School of Basic Medical Sciences Binzhou Medical UniversityYantaiShandong 264003China Tsinghua-Berkeley Shenzhen Institute Tsinghua UniversityShenzhenGuangdong 518000China Shenzhen Key laboratory of Unknown Pathogen Identification BGI-ShenzhenShenzhenGuangdong 518083China

Civets are small mammals belonging to the family *** masked palm civets(Paguma larvata)served as an intermediate host in the bat-to-human transmission of severe acute respiratory syndrome coronavirus(SARS-Co V)in 2003(Guan et al.,2003).Because of their unique role in the SARS outbreak,civets were suspected as a potential intermediate host of SARS-Co V-2.

关键词： Vive mask intermediate

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