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Cysteine peptidase and its inhibitor activity levels and vitamin E concentration in normal human serum and colorectal carcinomas

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World Journal of Gastroenterology 2005年第6期11卷 850-853页

作者： Robert Szwed Zygmunt Grzebieniak Yousif Saleh Godwin Bwire Ekonjo Maciej Siewinski Clinic of Surgery and Oncology Department of Obstetrics and Gynaecology Faculty of Public Health bartla street 5 50 -618 WroclawPoland

AIM: Cysteine peptidase (CP) and its inhibitor (CPI) are a matrix protease that may be associated with colorectal carcinoma invasion and progression, and vitamin E is also a stimulator of the immunological system. Our purpose was to determine the correlation between the expression of cysteine peptidases and their endogenous inhibitors,and the level of vitamin E in sera of patients with colorectal cancer in comparison with healthy ***: The levels of cysteine peptidases and their inhibitors were determined in the sera of patients with primary and metastatic colorectal carcinoma and healthy individuals using fluorogenic substrate, and the level of vitamin E was determined by ***: The levels of cysteine peptidases and their inhibitors were significantly higher in the metastatic colorectal cancer patients than that in the healthy controls (P＜0.05).The activity of CP increased 2.2-fold, CPI 2.8-fold and vitamin E decreased 3.4-fold in sera of patients with metastasis in comparison with controls. The level of vitamin E in healthy individuals was higher, whereas the activity of cysteine peptidases and their inhibitors associated with complexes was lower than that in patients with cancer of the digestive ***: These results suggest that the serum levels of CP and their inhibitors could be an indicator of the prognosis for patients with metastatic colorectal cancer. Vitamin E can be administered prophylactically to prevent digestive tract neoplasmas.

关键词： Cysteine peptidases Inhibitors Vitamin E Colorectal cancers

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Environmental exposure to cadmium but not lead is associated with decreased semen quality parameters:quality regionalism of sperm properties

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Asian Journal of Andrology 2022年第1期24卷 26-31页

作者： Katarzyna Olszak-Wasik Andrzej Tukiendorf Aleksandra Kasperczyk Artur Wdowiak Stanislaw Horak Department of Gynecology Obstetrics and Oncological Gynecology in BytomMedical University of SilesiaSchool of Medicine and Division of Dentistry in ZabrzeBatorego 15Bytom 41-902Poland Department of Public Health Wroclaw Medical UniversityBartla 5Wroclaw 51-618Poland Department of Biochemistry Medical University of SilesiaSchool of Medicine and Division of Dentistry in ZabrzeJordana 19Zabrze 41-808Poland Faculty of Health Sciences Diagnostic Techniques UnitMedical University of LublinStaszica 4/6Lublin 20-081Poland

Environmental factors may negatively contribute to a progressive worsening of semen quality,and differences in semen quality may result from different environmental exposures(regional differences)or lifestyle *** metals are factors with a confirmed negative influence on male *** them,lead and cadmium are commonly found in human ***,we analyzed semen parameters(according to the World Health Organization 2010 recommendations)and semen lead and cadmium concentrations in 188 men from two different regions in Poland,a typical agricultural area and an industrial area,in couples that had been diagnosed with *** assays were performed using flameless electrothermal atomic absorption *** the statistical analysis,regional comparisons and then taxonomic comparisons based on three parameters(age,semen concentration,and sperm morphology)were *** showed that more cadmium than lead accumulated in semen,a higher cadmium concentration was observed in semen obtained from men from the agricultural region,and better semen quality and lower cadmium concentrations were found in the semen of men from the industrial,more polluted *** thus showed an existing regionalism in the sperm quality ***,semen parameters such as morphology and progressive and nonprogressive motility followed the same trends,regardless of the patient’s age,region,or *** could conclude that the environment has a minor impact on sperm morphology and progressive and nonprogressive motility and that other existing factors could have an indirect influence on semen quality.

关键词： cadmium environment lead semen quality taxonomic analysis

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Cognitive function and adherence to anticoagulation treatment in patients with atrial fibrillation

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Journal of Geriatric Cardiology 2016年第7期13卷 559-565页

作者： Beata Jankowska-Polanska Lomper Katarzyna Alberska Lidia Jaroch Joanna Krzysztof Dudek Uchmanowicz Izabella Department of Clinical Nursing Wroctaw Medical University Bartla Wroclaw Poland Emergency Medicine Centre Anesthesiology Unit Marciniak Lower-Silesian Specialist Hospital Fieldorfa Wroctaw Poland Emergency Medicine Centre Cardiology Unit Marciniak Lower-Silesian Specialist Hospital Fieldorfa Wroelaw Poland Department of Logistic and Transport Systems University of Technology Wybrzeze Stanistawa Wyspianskiego Wroctaw Poland

Background Medication adherence is an integral part of the comprehensive care of patients with atrial fibrillation （AF） receiving oral anticoagulations （OACs） therapy. Many patients with AF are elderly and may suffer from some form of cognitive impairment. This study was conducted to investigate whether cognitive impairment affects the level of adherence to anticoagulation treatment in AF patients. Me- thods The study involved 111 AF patients （mean age, 73.5±8.3 years） treated with OACs. Cognitive function was assessed using the Mini Mental State Examination （MMSE）. The level of adherence was assessed by the 8-item Mot^sky Medication Adherence Scale （MMAS-8）. Scores on the MMAS-8 range from 0 to 8, with scores 〈 6 reflecting low adherence, 6 to 〈 8 medium adherence, and 8 high adherence. Re- sults 46.9% of AF patients had low adherence, 18.8% had moderate adherence, and 33.3% had high adherence to OACs. Patients with lower adherence were older than those with moderate or high adherence （76.6 ±8.7 vs. 71.3 ~ 6.4 vs. 71.1 ± 6.7 years） and obtained low MMSE scores, indicating cognitive disorders or dementia （MMSE = 22.3 ± 4.2）. Patients with moderate or high adherence obtained high MMSE test results （27.5 ±1.7 and 27,5 ± 3.6）. According to Spearman＇s rank correlation, worse adherence to treatment with OACs was determined by older age （rs = -0.372） and lower MMSE scores （rs = 0.717）. According to multivariate regression analysis, the level of cognitive function was a significant independent predictor of adherence （b = 1.139）. Conclusions Cognitive impairment is an independent determinant of compliance with pharmacological therapy in elderly patients with AF. Lower adherence, beyond the assessment of cognitive function, is related to the age of patients.

关键词： Anticoagulation treatment Atrial fibrillation Cognitive impairment Medication adherence

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