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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

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Is it possible to foot reflexology for infants with sensorineural hearing loss?

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World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： Min Ai Hang-Hang Zhang Jun-Bang Feng Chuan-Ming Li Wen-Jing Wang Meng-Die Hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss Future perspectives Limitations Neural conduction

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Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong Fei Luan Juanjuan Yang Feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong Wei Jin Liu Tao Zhu Cheng Zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

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Combination of acoustic radiation force impulse imaging, serological indexes and contrast-enhanced ultrasound for diagnosis of liver lesions

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World Journal of Gastroenterology 2017年第30期23卷 5602-5609页

作者： Xiao-Lan Sun Hui Yao Qiong Men Ke-Zhu Hou Zhen Chen Chang-Qing Xu Li-Wei Liang Department of Ultrasound Shanghai Yangpu District East Hospital Department of Radiotherapy Shanghai Yangpu District East Hospital Department of Oncology Shanghai Yangpu District East Hospital Department of Surgery Shanghai Yangpu District East Hospital Department of Pathology Shanghai Yangpu District East Hospital Department of Radiography Shanghai Yangpu District East Hospital Department of Gastroenterology Shanghai Yangpu District East Hospital

AIM To assess the value of combined acoustic radiation force impulse(ARFI) imaging, serological indexes and contrast-enhanced ultrasound(CEUS) in distinguishing between benign and malignant liver lesions. METHODS Patients with liver lesions treated at our hospital were included in this study. The lesions were divided into either a malignant tumor group or a benign tumor group according to pathological or radiological findings. ARFI quantitative detection, serological testing and CEUS quantitative detection were performed and compared. A comparative analysis of the measured indexes was performed between these groups. Receiver operating characteristic(ROC) curves were constructed to compare the diagnostic accuracy of ARFI imaging, serological indexes and CEUS, alone or in different combinations, in identifying benign and malignant liver lesions. RESULTS A total of 112 liver lesions in 43 patients were included, of which 78 were malignant and 34 were benign. Shear wave velocity(SWV) value, serum alpha-fetoprotein(AFP) content and enhancement rate were significantly higher in the malignant tumor group than in the benign tumor group(2.39 ± 1.20 m/s vs 1.50 ± 0.49 m/s, 18.02 ± 5.01 ng/m L vs 15.96 ± 4.33 ng/m L, 2.14 ± 0.21 d B/s vs 2.01 ± 0.31 d B/s; P < 0.05). The ROC curve analysis revealed that the areas under the curves(AUCs) of SWV value alone, AFP content alone, enhancement rate alone, SWV value + AFP content, SWV value + enhancement rate, AFP content + enhancement rate and SWV value + AFP content + enhancement rate were 85.1%, 72.1%, 74.5%, 88.3%, 90.4%, 82.0% and 92.3%, respectively. The AUC of SWV value + AFP content + enhancement rate was higher than those of SWV value + AFP content and SWV value + enhancement rate, and significantly higher than those of any single parameter or the combination of any two of *** The combination of SWV, AFP and enhancement rate had better diagnostic performance in distinguishing between benign and malignant live

关键词： Combined diagnosis Liver lesions Benign Malignant Differentiation

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Effect of anesthesia on cognitive status and MMP-2 expression in rats

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Asian Pacific Journal of Tropical Medicine 2014年第4期7卷 333-336页

作者： Hong-Tu Li Quan-Jun Cao Xiang-Jie Qi Wei-Ling Lu Department of Anesthesiology People's Hospital of Linzi District Department of Urology People's Hospital of Linzi District Operating Room People's Hospital of Linzi District

Objective:To investigate the effect of anesthesia on the cognitive status damage and MMP-2expression in ***:A total of 120 healthy rats were selected and randomly divided into the control group,CF3-CH(OCH2F)-CF3(Sevoflurane)group and CF3-CH2-O-CHF-CF3group(Sevoflurane)(n=40).After training for 3 d by the Morris water maze,the control group were injected with fentanyl for analgesia,the CF3-CH(OCH2F)-CF3 group and the CF3-CH2-O-CHFCF3 group were anesthesia with CF3-CH(OCH2F)-CF3 and CF3-CH2-O-CHF-CF3 on the basis of fentanyl,then rats in three groups underwent open surgery and suture conventional *** water maze was used to measure the rats cognitive ability in three groups on the 1st d,3rd d,5th d and 7th d,and the brain tissue MMP-2 expression was ***:After1 d/7 d of the surgery,Morris water maze performance and MMP-2 expression were not significantly different among three groups(P>0.05);After 3 d/5 d of the surgery,compared with the control group,the Morris water maze test result was significantly worsened,MMP-2expression levels were significantly increased(P<0.05);After 3 d/5 d of the surgery,compared with the CF3-CH2-O-CHF-CF3 group,Morris water maze test result of CF3-CH(OCH2F)-CF3group was significantly worsened,MMP-2 expression levels were significantly increased(P<0.05).Conclusions:Anesthesia can cause some injury on cognitive status,different anesthetic drugs may cause different injury,and the cognitive status injury is related to the MMP-2 expression.

关键词： Anesthesia Cognition Matrix metalloproteinase-2 Influence study

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Investigation of photodynamic therapy on streptococcus mutans of oral biofilm

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Chinese Optics Letters 2008年第12期6卷 947-949页

作者：邹朝晖高平阴慧娟李迎新 Heping district of Tianjin Laser Medicine Laboratory Biomedical Engineering Department of Tianjin Medical University Heping district of Tianjin Dental Hospital of Tianjin Medical University Heping district of Tianjin Dental hospital of Tianjin Medical University

We investigated the effect of photodynamic therapy （PDT） with hematoporphyrin monomethyl ether （HMME） on the viability of Streptococcus mutans （S. mutans） cells on biofilms in vitro. Streptococcus mutans is the primary etiological agent of human dental caries. Since dental caries are localized infections, such plaque-related diseases would be well suited to PDT. The diode laser used in this study had the wavelength of 635 nm, whose output power was 10 mW and the energy density was 12.74 J/cm^2. HMME was used as photosensitizer. Samples were prepared and divided into five groups：（1） HMME; （2） Laser; （3） HMME＋Laser; （4） Control group （＋） with chlorhexidine; and （5） Control group （-） with sterile physiological saline. Inoculum of S. mutans incubated with HMME also examined with fluorescence microscopy. PDT exhibited a significantly （P 〈 0.05） increased antimicrobial potential compared with 20 μm/mL HMME only, laser only, 0.05% chlorhexidine, and 0.9% sterile physiological saline, which reduced the S. mutans of the biofilm most effectively. Laser and 0.05% chlorhexidine were caused reduction in the viable counts of S. mutans significantly different （P 〈 0.05） also, but these two test treatments did not statistically differ from each other. HMME group did not statistically differ with negative control group. Fluorescence microscopy indicated that HMME localized primarily in the S. mutans of the biofilm. It was demonstrated that HMME-mediated PDT was efficient at killing S. mutans of biofilms and a useful approach in the treatment of dental plaque-related diseases.

关键词： Biofilms Biofilters Ethers Fluorescence Fluorescence microscopy Lasers Optical materials Photosensitizers Plasmons Porphyrins

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Therapeutic efficacy and safety of various botulinum toxin A doses and concentrations in spastic foot after stroke: a randomized controlled trial

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Neural Regeneration Research 2017年第9期12卷 1451-1457页

作者： Jiang Li Ru Zhang Bo-li Cui Yong-xiang Zhang Guang-tao Bai Si-shan Gao Wen-jian Li Affiliated hospital of Qingdao University Department of Neurology Traditional Medicine Hospital of Huangdao District

No recommended guidelines currently exist for the therapeutic concentration or dose of botulinum toxin type A （BTXA） injected into the muscle to treat limb spasticity. Therefore, in this randomized controlled trial, we explored the safety and efficacy of two concentrations and two doses of BTXA in the treatment of spastic toot after stroke to optimize this treatment in these patients. Eligible patients （n = 104） were randomized into four groups. The triceps surae and tibialis posterior on the affected side were injected with BTXA at one of two doses （200 U or 400 U） and two concentrations （50 U/mL or 100 U/mL）. 2he following assessments were conducted before as well as 4 days and 1, 2, 4, and 12 weeks after treatment： spasticity, assessed using the modified Ashworth scale; basic functional mobility, assessed using a timed up and go test; pace, assessed using a 10-meter timed walking test; and the ability to walk, assessed using Holden＇s graded scale and a visual analog scale. The reported results are based on the 89 patients that completed the study. We found significant differences for the two doses and concentrations of BTXA to improve the ability of patients to walk independently, with the high-dose/low-concentration combination providing the best effect. Onset and duration of the ameliorating effects of BTXA were 4-7 days and 12 weeks, respectively. Thus, BTXA effectively treated foot spasms after stroke at an optimal dose of 400 U and concentration of 50 U/mL.

关键词： nerve regeneration stroke Jbot spasms botulinum toxin type A foot varus foot drop walking function neural regeneration

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Efficacy of topical vs intravenous tranexamic acid in reducing blood loss and promoting wound healing in bone surgery:A systematic review and meta-analysis

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World Journal of Clinical Cases 2021年第17期9卷 4210-4220页

作者： Jian-Wen Xu Hong Qiang Ting-Li Li Yi Wang Xiao-Xiao Wei Fei Li Nursing Department Yangpu District Shidong HospitalShanghai 200438China Emergency Services Department Yangpu District Shidong HospitalShanghai 200438China The Second Neurological Department Yangpu District Shidong HospitalShanghai 200438China

BACKGROUND Tranexamic acid(TXA)has been used as an anti-fibrinolytic drug for over half a century and has received much attention in recent *** To evaluate the efficacy of topical vs intravenous TXA in reducing blood loss and promoting wound healing in bone *** From the electronic resources,PubMed,Cochrane Library,Embase,ISI,and Scopus were used to perform a literature search over the last 10 years between 2010 and ***™X8 was used for managing the electronic *** were performed with mesh *** data were retracted blindly by two independent *** effects were used to deal with potential heterogeneity and I2 showed ***-square(I2)tests were used to quantify the extent of heterogeneity(P<0.01 was considered statistically significant).The efficacy of topical TXA in reducing blood loss and promoting wound healing in bone surgery was compared with intravenous TXA and *** According to the research design,1360 potentially important research abstracts and titles were discovered in our electronic searches,and 18 papers remained in agreement with our inclusion *** was found that TXA reduced 277.51 mL of blood loss compared to placebo,and there was no significant difference between topical TXA and IV TXA in reducing blood loss in bone *** analyses also showed that TXA significantly reduced blood transfusion compared to placebo and there was no significant difference between topical TXA and IV *** The use of both topical and intravenous TXA are equally effective in reducing blood loss in bone surgery,which might be beneficial for wound healing after surgery.

关键词： Tranexamic acid Blood loss Wound healing Bone surgery Meta-analysis

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Combined treatment with dihydrotestosterone and lipopolysaccharide modulates prostate homeostasis by upregulating TNF-α from M1 macrophages and promotes proliferation of prostate stromal cells

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Asian Journal of Andrology 2022年第5期24卷 513-520页

作者： Yu Tong Yi-Jun Guo Qin Zhang Hai-Xia Bi Kai Kai Ren-Yuan Zhou Department of Urology Jing’an District Central HospitalFudan UniversityShanghai 200040China Department of Pathology Jing’an District Central HospitalFudan UniversityShanghai 200040China

Androgens and chronic inflammation,which play essential roles in the development of benign prostatic hyperplasia(BPH),are considered to be important factors in disorders of prostate *** two factors may lead to pathological hyperplasia in the prostate transition zone of patients with ***,few studies have examined the mechanism of how dihydrotestosterone(DHT)affects chronic inflammation in prostate tissue during the progression of *** study examined the performance of DHT in lipopolysaccharide-treated M1 macrophages and the subsequent effects on the proliferation of prostate stromal and epithelial *** found that DHT increased secretion of the pro-inflammatory factor tumor necrosis factor(TNF)-αfrom M1 macrophages differentiated from THP-1 *** supernatant of M1 macrophages promoted the proliferation of WPMY-1 prostate stromal cells by upregulating B-cell lymphoma-extra large(Bcl-xL)and cellular Myc(c-Myc)levels by activating TNF-α-mediated nuclear factor-kappa B(NF-κB)and mitogen-activated protein kinase(MAPK)***,this supernatant increased the expression of androgen receptor in WPMY-1 cells,which was TNF-α-***,TNF-αprotein expression was significantly higher in patients with BPH and a large prostate volume than that in those with a small prostate *** analysis showed that higher serum testosterone combined with prostate-specific androgen concentrations was related to TNF-α*** study suggests that DHT modulates the inflammatory environment of BPH by increasing TNF-αexpression from lipopolysaccharide-treated M1 macrophages and promotes the proliferation of prostate stromal *** TNF-α,but not DHT,may be a promising strategy for patients with BPH.

关键词： benign prostatic hyperplasia dihydrotestosterone inflammation macrophage tumor necrosis factor-alpha

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