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Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

Military Medical Research 2024年第1期11卷 115-147页

作者： Yuan-Peng Zhang Xin-Yun Zhang Yu-Ting Cheng Bing Li Xin-Zhi Teng Jiang Zhang Saikit Lam Ta Zhou Zong-Rui Ma Jia-Bao Sheng Victor CWTam Shara WYLee Hong Ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

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An Image Fingerprint and Attention Mechanism Based Load Estimation Algorithm for Electric Power System

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computer Modeling in Engineering & Sciences 2024年第7期140卷 577-591页

作者： Qing Zhu Linlin Gu Huijie Lin Electricity Technology Branch Nari Technology Co.Ltd.Nanjing211106China NARI-TECH Nanjing control Systems co. Ltd.Nanjing211106China

With the rapid development of electric power systems,load estimation plays an important role in system operation and ***,load estimation techniques contain traditional,time series,regression analysis-based,and machine learning-based *** the machine learning-based method can lead to better performance,in this paper,a deep learning-based load estimation algorithm using image fingerprint and attention mechanism is ***,an image fingerprint construction is proposed for training *** the data preprocessing,the training data matrix is constructed by the cyclic shift and cubic spline ***,the linear mapping and the gray-color transformation method are proposed to form the color image ***,a convolutional neural network(CNN)combined with an attentionmechanism is proposed for training performance *** last,an experiment is carried out to evaluate the estimation *** with the support vector machine method,CNN method and long short-term memory method,the proposed algorithm has the best load estimation performance.

关键词： Load estimation deep learning attention mechanism image fingerprint construction

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A Blockchain-Based Proxy Re-Encryption Scheme with conditional Privacy Protection and Auditability

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China communications 2024年第7期21卷 267-277页

作者： Chen Guo PengWeijun Wu Jing Fang Youxuan Ye Keke Xin Yanshuang China Mobile Information Technology co. LtdBeijing 100037China China Mobile Information Technology co. LtdShenzhen 518048China

With the development of Internet of Things technology,intelligent door lock devices are widely used in the field of house *** the traditional housing leasing scenario,problems of door lock information disclosure,tenant privacy disclosure and rental contract disputes frequently occur,and the security,fairness and auditability of the housing leasing transaction cannot be *** solve the above problems,a blockchain-based proxy re-encryption scheme with conditional privacy protection and auditability is *** scheme implements fine-grained access control of door lock data based on attribute encryption technology with policy hiding,and uses proxy re-encryption technology to achieve auditable supervision of door lock information *** encryption technology and zero-knowledge proof technology are introduced to ensure the confidentiality of housing rent information and the fairness of rent *** construct a decentralized housing lease transaction architecture,the scheme realizes the efficient collaboration between the door lock data ciphertext stored under the chain and the key information ciphertext on the chain based on the blockchain and InterPlanetary File ***,the security proof and computing performance analysis of the proposed scheme are carried *** results show that the scheme can resist the chosen plaintext attack and has low computational cost.

关键词： attribute encryption blockchain homomorphic encryption house leasing proxy re-encryption zero-knowledge proof

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Solidification behaviour and hot cracking susceptibility of a novel Ni-based superalloy

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Journal of Iron and Steel Research International 2024年第4期31卷 956-966页

作者： Yue Chen Shao-min Lv Xing-fei Xie Xiao-can Wen Jng-long Qu Jin-hui Du High-Temperature Materials Institute China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China Beijing GAONA Materials and Technology co. Ltd.Beijing 100081China Sichuan CISRI-GAONA Forging co. Ltd.Deyang 610000SichuanChina

A novel Ni-based superalloy GH4151,with a γ′ volume fraction of about 55%and a service temperature capability up to 8oo oC,was *** to the different cooling conditions of various regions during the solidification of ingots,significant cooling rate variations may lead to the occurrence of hot *** scanning laser microscope was utilised to investigate the solidification process and phase precipitation behaviour of the GH4151 under wide range cooling *** characteristics of L→γ transformation were analysed,and the growth rates of at each stage were *** segregation behaviour was predicted using the Scheil equation,and the predicted results match well with the experimental *** sensitivity coefficient for hot cracking was modified,and cracking sensitivity coefficient values for the alloy under different cooling rates were computed,revealing that the alloy is most susceptible to hot cracking at 10℃/min cooling ***,controlling the cooling rate can reduce the possibility of hot cracking in ingot.

关键词： Ni-based superalloy Solidification behaviour In-situ observation Clyne and Davies's criterion:Hot cracking susceptibility

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A Gel-Based Solidification Technology for Large Fracture Plugging

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Fluid Dynamics & Materials Processing 2024年第3期20卷 563-578页

作者： Kunjian Wang Ruibin He Qianhua Liao Kun Xu Wen Wang Kan Chen Tianjin Branch of CNOOC(China)co. Ltd.Tianjin300450China Jingzhou Jiahua Technology co. Ltd.Jingzhou434001China

Fault fractures usually have large openings and considerable extension. Accordingly, cross-linked gel materials aregenerally considered more suitable plugging agents than water-based gels because the latter often undergo contaminationvia formation water, which prevents them from being effective over long times. Hence, in this study, aset of oil-based composite gels based on waste grease and epoxy resin has been developed. These materials havebeen observed to possess high compressive strength and resistance to the aforementioned contamination, therebyleading to notable increase in plugging success rate. The compressive strength, thickening time, and resistance toformation water pollution of these gels have been evaluated indoors. The results show that the compressivestrength of the gel can reach 11 MPa;additionally, the related gelation time can be controlled to be more than3 h, thereby providing a safe construction time;Invasion of formation water has a small effect on the gel strengthand does not shorten the thickening time. All considered performance indicators of the oil-based gel confirm itssuitability as a plugging agent for fault fractures.

关键词： Drilling loss fault fracture oil-based gel compressive strength gel plugging

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Modeling Method of Multi-Energy Systems Based on LSTM Algorithm

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1701-1709页

作者： Di Qiu Fei Chen Dong Liu Min Cao Siyang Liu Shanghai Jiao Tong University Shanghai 200240China Yunnan Power Grid co. Ltd

The development of the Energy Internet has improved the efficiency of energy utilization and promoted sustainable development of power and energy *** multi-energy system modeling considering the dynamic process of transmission line is one of the key research points of Energy Internet operation *** the energy circuit theory,the lumped parameter model of natural gas pipelines is built and the dynamic characteristic parameters under the control instruction are *** with dynamic characteristic parameters,the long short-term memory(LSTM)neural network is designed to fit the natural gas pipeline dynamic process into discrete linear time-varying(LTV)*** with the equations,an energy hub method is used to build a control model of industrial parks with multi-energy distribution *** the rolling optimal control strategy given in this paper,the model is solved by the Matlab-Yalmip solver and rolling control instructions of each energy conversion unit are ***,the case study demonstrates that the LSTM neural network-based modeling method presented in this paper can accurately fit the dynamic process of a natural gas pipeline *** rolling control model of the multi-energy system can improve the efficiency of energy utilization,exhibit the transmission line status constraints during the optimization control process and improve reliability of the multi-energy system operation.

关键词： Energy hub LSTM multi-energy supply system pipeline system modeling

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Development and Catalytic Cracking Performance of Ultrastable Y Zeolite Rich in Secondary Pores

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China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 13-21页

作者： Li Jiaxing Wang Shengji Sha Hao Wang Juan Zhou Lingping Wang Lixia SINOPEC Research Institute of Petroleum Processing co. LtdBeijing 100083China Catalyst co. Ltd.Qilu BranchSINOPECZibo 255336China

A novel ultra-stable zeolite, NSZ, rich in secondary pores was developed through the combination of gas-phase andmild hydrothermal methods. This zeolite was successfully tested in an industrial setting for the first time in the world. The porestructure characteristics of the NSZ zeolite prepared for industrial use were analyzed and characterized using BET. The resultsindicate a significant increase in the secondary pore volume of NSZ zeolite compared to the existing ultra-stable zeolite HSZ-5, which is produced through a conventional gas-phase method. The average secondary pore volume to total pore volume ratioin NSZ zeolite was found to be 58.96% higher. The catalytic cracking performance of NSZ zeolite was evaluated. The resultsshowed that the NSC-LTA catalyst, with NSZ as the active component, outperformed the HSC-LTA catalyst with HSZ-5 zeolitein terms of obtaining more high-value products (gasoline and liquefied petroleum gas) during the hydrogenated light cycle oilprocessing. Additionally, the NSC-LTA catalyst showed a significant improvement in coke selectivity.

关键词： gas-phase ultra-stable zeolite catalyst catalytic cracking

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Fabricating functionally graded Fe-Cr-co permanent magnetic alloys via laser powder bed fusion

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Journal of Iron and Steel Research International 2024年第3期31卷 729-737页

作者： Ya-zhou He Ya-qing Hou Peng Shen Hao Zhang Dong Zhou Hang Su Central Iron and Steel Research Institute co. Ltd.Beijing 100081China Material Digital R&D Center China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China

Laser powder bed fusion(LPBF)in-situ alloying technology offers the possibility to construct gradient materials with varied structures and *** graded Fe-Cr-co permanent magnetic alloys were fabricated by LPBF and in-situ alloying mixed powders of Fe,Cr,and co *** effects of different Fe,Cr and co contents on the microstructure,magnetic properties and hardness of Fe-Cr-co alloys prepared by LPBF were *** as-built Fe-Cr-co alloys present a single body-centered-cubic phase and have a homogeneous distribution of *** mechanical properties and magnetic properties of the compositionally graded sample show a gradient *** the increase in Cr content,the Vickers hardness of the sample increases,and the saturation magnetization of the sample *** optimal magnetic properties in an isotropic state are given as coercivity HcB=21.65 kA/m,remanence Br=0.70 T and energy product(BH)_(max)=5.35 kJ/m^(3),which are comparable to or higher than the reported magnetic properties in an isotropic state prepared by traditional powder *** in-situ alloying technology has the potential to further explore Fe-Cr-co magnetic materials,such as those consisting of multiple or more constituent elements,and to maximize the compositional flexibility of magnetic materials.

关键词： Fe-Cr-co alloy Laser powder bed fusion In-situ alloying Functional material Magnetic property

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Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons

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Neural Regeneration Research 2024年第4期19卷 908-914页

作者： Yalan Chen Junxin Kuang Yimei Niu Hongyao Zhu Xiaoxia Chen Kwok-Fai So Anding Xu Lingling Shi Guangdong-Hong Kong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan University Department of Neurology and Stroke Center The First Affiliated HospitalJinan University Department of Psychiatry The First Affiliated HospitalJinan University co-innovation Center of Neuroregeneration Nantong University

Midbrain dopaminergic neurons play an important role in the etiology of neurodevelopmental and neurodegenerative *** also represent a potential source of transplanted cells for therapeutic *** vitro differentiation of functional midbrain dopaminergic neurons provides an accessible platform to study midbrain neuronal dysfunction and can be used to examine obstacles to dopaminergic neuronal *** evidence and impressive advances in human induced pluripotent stem cells,with tuned neural induction and differentiation protocols,makes the production of induced pluripotent stem cell-derived dopaminergic neurons *** SB431542 and dorsomorphin dual inhibitor in an induced pluripotent stem cell-derived neural induction protocol,we obtained multiple subtypes of neurons,including 20%tyrosine hydroxylase-positive dopaminergic *** obtain more dopaminergic neurons,we next added sonic hedgehog(SHH)and fibroblast growth factor 8(FGF8)on day 8 of *** increased the proportion of dopaminergic neurons,up to 75%tyrosine hydroxylase-positive neurons,with 15%tyrosine hydroxylase and forkhead box protein A2(FOXA2)co-expressing *** further optimized the induction protocol by applying the small molecule inhibitor,CHIR99021(CHIR).This helped facilitate the generation of midbrain dopaminergic neurons,and we obtained 31-74%midbrain dopaminergic neurons based on tyrosine hydroxylase and FOXA2 ***,we have established three induction protocols for dopaminergic *** on tyrosine hydroxylase and FOXA2 immunostaining analysis,the CHIR,SHH,and FGF8 combined protocol produces a much higher proportion of midbrain dopaminergic neurons,which could be an ideal resource for tackling midbrain-related diseases.

关键词： dopaminergic neurons FGF signal induced pluripotent stem cells midbrain neural differentiation SHH signal SMAD signal WNT signal

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Engagement of N^(6)-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1644-1660页

作者： Ying Bai Di Chang Hui Ren Minzi Ju Yu Wang Biling Chen Han Li Xue Liu Daxing Li Xinchen Huo Xiaofei Guo Mengze Tong Ying Tan Honghong Yao Bing Han Department of Pharmacology Jiangsu Provincial Key Laboratory of Critical Care MedicineSchool of MedicineSoutheast UniversityNanjing 210009China Department of Radiology Zhongda HospitalJiangsu Key Laboratory of Molecular and Functional ImagingMedical School of Southeast UniversityNanjing 210009China co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute of Life Sciences Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166China

The N^(6)-methyladenosine(m^(6)A)modification is the most prevalent modification of eukaryotic mRNAs and plays a crucial role in various physiological processes by regulating the stability or function of target *** evidence has suggested that m6A methylation may be involved in the pathological process of major depressive disorder(MDD),a common neuropsychiatric disorder with an unclear ***,we found that the levels of the circular RNA HECW2(circHECW2)were significantly increased in the plasma of both MDD patients and the chronic unpredictable stress(CUS)mouse ***,the downregulation of circHECW2 attenuated astrocyte dysfunction and depression-like behaviors induced by ***,we demonstrated that the downregulation of circHECW2 increased the expression of the methylase WTAP,leading to an increase in Gng4 expression via m^(6)A *** findings provide functional insight into the correlation between circHECW2 and m^(6)A methylation,suggesting that circHECW2 may represent a potential target for MDD treatment.

关键词： N^(6)-Methyladenosine Depression circHECW2 Astrocyte WTAP Ubiquitination GNG4 Dysfunction

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