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Identification of overlay differentially expressed genes in both rats and goats with blast lung injury through comparative transcriptomics

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Chinese Journal of Traumatology 2024年第1期27卷 34-41页

作者： Hong Wang Jun-Hong Gao Xiao-Lin Fan Qing Lu Liang Li Ning Ma Qi Wang Yu-Hao Zhang Xi'an Key Laboratory of Toxicology and Biological Effects Research Center for Toxicological and Biological EffectsInstitute for Hygiene of Ordnance IndustryXi'an710065China

Purpose:To identify the potential target genes of blast lung injury(BLI)for the diagnosis and ***:This is an experimental *** BLI models in rats and goats were established by conducting a fuel-air explosive power test in an unobstructed environment,which was subsequently validated through hematoxylin-eosin *** sequencing was performed on lung tissues from both goats and *** expressed genes were identified using the criteria ofq≤0.05 and|log2 fold change|≥*** that,enrichment analyses were conducted for gene ontology and the Kyoto Encyclopedia of Genes and Genomes *** potential target genes were further confirmed through quantitative real-time polymerase chain reaction and enzyme linked immunosorbent ***:Observations through microscopy unveiled the presence of reddish edema fluid,erythrocytes,and instances of focal or patchy bleeding within the alveolar *** sequencing analysis identified a total of 83 differentially expressed genes in both rats and ***,49 genes exhibited a consistent expression pattern,with 38 genes displaying up-regulation and 11 genes demonstrating *** analysis highlighted the potential involvement of the interleukin-17 signaling pathway and vascular smooth muscle contraction pathway in the underlying mechanism of ***,the experimental findings in both goats and rats demonstrated a strong association between BLI and several key genes,including anterior gradient 2,ankyrin repeat domain 65,bactericidal/permeability-increasing fold containing family A member 1,bactericidal/permeability-increasing fold containing family B member 1,and keratin 4,which exhibited ***:Anterior gradient 2,ankyrin repeat domain 65,bactericidal/permeability-increasing fold containing family A member 1,bactericidal/permeability-increasing fold containing family B member 1,and keratin 4 hold potential as target genes

关键词： Blast lung injury Transcriptomic Target genes Differentially expressed genes

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Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory

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Neural Regeneration Research 2024年第5期19卷 1133-1141页

作者： baicheng Zhao Hang Zhang Ying Liu Gaoyu Zu Yuxiao Zhang Jiayi Hu Shuai Liu Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghaiChina Shanghai Key Laboratory of Brain Functional Genomics(Ministry of Education) Affiliated Mental Health Center(ECNU)School of Psychology and Cognitive ScienceEast China Normal UniversityShanghaiChina Shanghai Changning Mental Health center ShanghaiChina NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai ShanghaiChina Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai ShanghaiChina

Bromodomain and plant homeodomain(PHD)finger containing protein 1(Brpf1)is an activator and scaffold protein of a multiunit complex that includes other components involving lysine acetyltransferase(KAT)6A/6B/***1,KAT6A,and KAT6B mutations were identified as the causal genes of neurodevelopmental disorders leading to intellectual *** previous work revealed strong and specific expression of Brpf1 in both the postnatal and adult forebrain,especially the hippocampus,which has essential roles in learning and ***,we hypothesized that Brpf1 plays critical roles in the function of forebrain excitatory neurons,and that its deficiency leads to learning and memory *** test this,we knocked out Brpf1 in forebrain excitatory neurons using *** found that Brpf1 deficiency reduced the frequency of miniature excitatory postsynaptic currents and downregulated the expression of genes Pcdhgb1,Slc16a7,Robo3,and Rho,which are related to neural development,synapse function,and memory,thereby damaging spatial and fear memory in *** findings help explain the mechanisms of intellectual impairment in patients with BRPF1 mutation.

关键词： behavioral test Brpf1 CAMKIIa-Cre intellectual disability miniature excitatory postsynaptic current mRNA-Seq

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Lower limit law of welding windows for explosive welding of dissimilar metals

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Journal of Iron and Steel Research International 2017年第8期24卷 852-857页

作者： Chang-gen Shi Xuan Yang Yu-heng Ge Jun You Hong-bao Hou PI.A University of Science and Technology Nanjing 210007JiangsuChina baicheng ordnance test center Baicheng 137001JilinChina

The influence of explosive charge thickness on the quality of explosive welding of dissimilar metals was *** lower limit law should be followed in the course of explosive *** welding experiments of stainless steel（410S）and steel（Q345R）were carried out in three different kinds of explosive charge thicknesses,namely 15,25and *** of morphology and mechanical properties of three samples were observed and *** was found that micro and small wavy bonding is mainly formed for charge thickness of 15mm whose strength is the highest with minor deformation and few defects in the interface;small and middle wavy bonding are mainly formed for charge thickness of 25 mm whose strength is comparatively mediocre;big wavy bonding is mainly formed for charge thickness of 35 mm whose strength is the *** cause of high bonding strength of the micro and small wavy interface was analyzed and verified on the basis of the results of Electron Probe Micro-Analyzer（EPMA）tests of three selected samples.

关键词： Explosive welding Welding window Lower limit law Cladding plate Bonding interface

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Improving the energy release characteristics of PTFE/Al by doping magnesium hydride

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Defence Technology（防务技术） 2022年第2期18卷 219-228页

作者： Jia-xiang Wu Qiang Liu Bin Feng Qin Yin Yu-chun Li Shuang-zhang Wu Zhong-shen Yu Jun-yi Huang Xin-xin Ren College of Field Engineering Army Engineering University of PLANanjing210007China china Huayin ordnance test center Huayin714200China 31104 Troop of PLA Nanjing210001China

Magnesium hydride(MgH2)was doped into PTFE/Al to improve the energy release characteristics of the material system and strive for better application in military *** types of PTFE/Al/MgH2 reactive materials with different MgH2 content were prepared by molding sintering *** dynamic mechanical properties of the materials were studied by performing split-Hopkinson pressure bar(SHPB)tests and scanning electron microscope *** thermal behavior,reaction energy,reaction process and reaction mechanism were systematically investigated by conducting thermogravimetry-differential scanning calorimetry tests,oxygen bomb calorimeter measurements,Xray diffraction and SHPB *** results show that MgH2 particles less than 10%content contribute to heightening the dynamic mechanical properties of PTFE/Al *** product Mg generated by decomposition of MgH2 can not only react with gas phase C2F4þbut also undergo a Grignard-type reaction with condensed *** reaction energy and ignition threshold of PTFE/Al/MgH2 reactive materials enhance monotonously as MgH2 content *** the increase of MgH2 content from 0%to 20%,the reaction time is prolonged as well as the reaction intensity is enhanced dramatically arising from the massive water vapour produced by the reaction between O2 and *** gaseous products generated can form a high pressure shortly after the reaction,which helps to elevate the damage effect of the PTFE/Al system.

关键词： PTFE/Al/MgH_(2) Mechanical properties Thermal behavior Reaction energy Ignition threshold

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A method to determine the shell layout scheme for equipment battlefield damage tests under artillery fire

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Defence Technology（防务技术） 2021年第2期17卷 682-691页

作者： Cai Chen Quan Shi Zhi-feng You Hong-yu Ge Fang Zhang Equipment Command and Management Department Army Engineering UniversityShijiazhuang050003China baicheng ordnance test center of china Baicheng137001China No.32178 Troops of PLA Beijing100012China

In this paper,a new method for determining the shell layout scheme is proposed,which can make the equipment damage data by the battlefield damage test resemble as close as possible the actual combat *** method is based on the analysis of the impact point distribution and effective damage area of *** order to obtain the position of the impact points,an impact point distribution model under artillery fire was ***,in order to obtain the effective damage area of equipment,the concepts of generalized damage area and task-based equipment functional damage probability were demonstrated,and the corresponding calculation model was *** case analysis,the shell layout scheme was effectively obtained,verifying the correctness of the proposed method.

关键词： Battlefield damage test Projectile impact point Effective damage area Functional damage

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Monotonicity Evaluation Method of Monitoring Feature Series Based on Ranking Mutual Information

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Journal of Shanghai Jiaotong university(Science) 2015年第3期20卷 380-384页

作者：赵春宇刘景江马伦张伟君 baicheng ordnance test center of china Academy of Equipment Divisions 73 Unit 66362

As a prerequisite for effective prognostics, the goodness of the features affects the complexity of the prognostic methods. Comparing to features quality evaluation in diagnostics, features evaluation for prognostics is a new problem. Normally, the monotonic tendency of feature series can be used as the visual representation of equipment damage cumulation so that forecasting its future health states is easy to implement. Through introducing the concept of ranking mutual information in ordinal case, a monotonicity evaluation method of monitoring feature series is proposed. Finally, this method is verified by the simulating feature series and the results verify its effectivity. For the specific application in industry, the evaluation results can be used as the standard for selecting prognostic feature.

关键词： monotonicity evaluation monitoring feature ranking mutual information prognostics

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Single Radar Measurement Method for Antiaircraft Projectile Miss Distance

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Journal of Beijing Institute of Technology 2017年第4期26卷 542-547页

作者： Wanjun Zhang Guohui Li Xiaoying Wu Kailin Wang Xuebing Leng Department of Arms Engineering Academy of Armored Force Engineering Beijing 100072 China baicheng ordnance test center Baicheng Jilin 137001 China

To measure miss distance for antiaircraft projectile,a radial velocity identification and positioning method with a single radar is proposed. By analyzing the spatial resolution of multi-frequency ranging radar,the discrimination and testing model of this radar for multi-targets（ projectile and target） is established to analyze the systematic error of antiaircraft miss distance. Then through the aerial target flight test and contrast test with optical test equipment,the validity of the measurement method is verified. This newmethod has the potential to be used in the measurement of antiaircraft projectile miss distance.

关键词： aerial target miss distance radar test multi-target resolution

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Micro-Doppler effect testing technique for attitude of projectile in space flight

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Journal of Beijing Institute of Technology 2013年第3期22卷 350-353页

作者：张万君吴晓颖张晓炜牛敏杰冷雪冰 Department of Arms Engineering Academy of Armored Force Engineering baicheng ordnance test center

To measure projectile attitude in space flight, based on continuous wave （CW） radar, a new micro-Doppler effect testing technique is developed in this paper. It also establishes radar testing model for attitude of flying projectile and resolve micro-Doppler effect of projectile motion attitude. By distinguishing and geting attitude parameters such as micro-motion period, this technique can in- tuitively estimate the flight stability of projectile, and the validity of this technique is proved accord- ing to flight tests.

关键词： attitude of projectile micro-Doppler radar testing target micro-motion

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Research on Statistic Characteristics of the Unbiased Estimation of Hitting Probability with Rectangle Objective Domain 25th

Research on Statistic Characteristics of the Unbiased Estima...

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第25届中国控制与决策会议

作者： Wang Jun Li Yushan Guo Zhi School of Automation Nanjing University of Science and Technology china baicheng ordnance test center

ISBN: (纸本)9781467355339

With the assumption of shooting error distributed independently two-dimension normal, the traditional estimation of hitting probability with rectangle objective domain is biased. Based on an uniformly unbiased minimum variance method, in this paper the unbiased estimation of hitting probability with rectangle objective domain is compared with the traditional one, and the statistic characteristic of hitting probability is studied. Some examples are illustrated to prove that the unbiased estimation can reduce the amount of shells in test. The project of amount of shells are also provided for the test of first round hitting probability for tanks and armored vehicles.

关键词： unbiased estimation hitting probability rectangle objective domain Monte Carlo method

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Effect of rifle bullet parameters on the penetration into ballistic gelatin

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Journal of Beijing Institute of Technology 2015年第4期24卷 487-493页

作者：刘苏苏徐诚陈爱军李宏魁 School of Mechanical Engineering Nanjing University of Science and Technology School of Science Nanjing University of Science and Technology baicheng ordnance test center

To understand the effects of the rifle bullet parameters on the bullet-gelatin interaction quantitatively, a finite element model of bullet penetrating gelatin was set up and computational re- suits are compared with experimental ones. The penetration of the rifle bullet into the gelatin was simulated by the nonlinear finite element method. The quantitative analysis of the changes in the ge- latin interaction with the rifle bullet were conducted by changing the bullet parameters, such as at- tack angle on gelatin, initial velocity, warhead＇ s tip and location of mass center of bullet. Results demonstrate that with the increase of the attack angle, instable moment of the bullet moves forward, the length of narrow wound channel shortens, and when penetration is completed diameters of tem- porary cavities increase, the gelatin energy and energy transmission ratio increases; With the in- crease of the impact velocity, instable moment of the bullet moves forward, the maximum forces acting on the gelatin and the gelatin energy increase remarkably ; the length of narrow wound channel shortens, diameters of temporary cavities increase when penetration is completed, the gelatin energy and energy transmission ratio increase; The warhead＇ s tip and location of mass center have a influ- ence on the instable moment of the bullet and length of the narrow wound channel. The instable mo- ment delays and narrow wound channel increases when the warhead＇s tip flattens. The instable mo- ment moves forward a little and the narrow wound channel shortens a little when location of mass center moves back.

关键词： bullet gelatin penetration temporary cavity

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