检索结果-南通市图书馆

i2dash:Creation of Flexible,Interactive,and Web-based Dashboards for Visualization of Omics Data

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2022年第3期20卷 568-577页

作者： Arsenij Ustjanzew Jens Preussner Mette Bentsen Carsten Kuenne Mario Looso Max Planck Institute for Heart and Lung Research Bioinformatics UnitD-61231 Bad NauheimGermany

Data visualization and interactive data exploration are important aspects of illustrating complex concepts and results from analyses of omics data.A suitable visualization has to be intuitive and ***-based dashboards have become popular tools for the arrangement,consolidation,and display of such ***,the combination of automated data processing pipelines handling omics data and dynamically generated,interactive dashboards is poorly ***,we present i2dash,an R package intended to encapsulate functionality for the programmatic creation of customized *** supports interactive and responsive(linked)visualizations across a set of predefined graphical layouts.i2dash addresses the needs of data analysts/software developers for a tool that is compatible and attachable to any R-based analysis pipeline,thereby fostering the separation of data visualization on one hand and data analysis tasks on the other *** addition,the generic design of i2dash enables the development of modular extensions for specific *** a proof of principle,we provide an extension of i2dash optimized for single-cell RNA sequencing analysis,supporting the creation of dashboards for the visualization needs of such *** with these features,i2dash is suitable for extensive use in large-scale sequencing/bioinformatics *** this line,we provide i2dash as a containerized solution,enabling a straightforward large-scale deployment and sharing of dashboards using cloud services.i2dash is freely available via the R package archive CRAN(https://***/package=i2dash).

关键词： Data visualization Dashboard Cloud Data analysis Automation

Traumatic aortic rupture mimicking intramural hematoma of the entire thoracic aorta

在线全文

学校读者我要写书评

暂无评论

中华胸心血管外科杂志 2003年第4期 68-69页

作者： Paul R. Vogt , Joerg Babin-Ebell , Erwin P. Bauer Department for Cardiovascular Surgery University Hospital Giessen and the Kerckhoff Clinic Foundation bad nauheim Germany Department for Cardiovascular Surgery University Hospital Giessen and the Kerckhoff Clinic Foundation bad nauheim Germany Department for Cardiovascular Surgery University Hospital Giessen and the Kerckhoff Clinic Foundation bad nauheim Germany

抢救 1例因摩托车事故急诊入院男病人。X线胸片发现病人右气管旁外侧纹理和左纵隔影异常增宽 ,并扩展至主动脉弓水平。经食管心脏超声检查发现围绕主动脉根部和升主动脉的壁间水肿 ,延伸至主动脉弓和左横膈下水平的全程降主动脉 ;左锁... 详细信息

抢救 1例因摩托车事故急诊入院男病人。X线胸片发现病人右气管旁外侧纹理和左纵隔影异常增宽 ,并扩展至主动脉弓水平。经食管心脏超声检查发现围绕主动脉根部和升主动脉的壁间水肿 ,延伸至主动脉弓和左横膈下水平的全程降主动脉 ;左锁骨下动脉起始点远端降主动脉上端全层断裂。急诊手术行降主动脉上端端端吻合 ,终因心跳骤停未及手术死亡。尸检证实全程胸主动脉自破裂处向前和逆向延伸 ,引起双向主动脉夹层。

关键词：降主动脉主动脉降部主动脉弓主动脉结 Traumatic aortic rupture mimicking intramural hematoma of the entire thoracic aorta

Calorie restriction or dietary restriction: how far they can protect the brain against neurodegenerative diseases?

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第8期17卷 1640-1644页

作者： Tayana Silva de Carvalho Herz-und Diabeteszentrum NRW(HDZ NRW) Bad OeynhausenGermany

Finding the correct nutritional intervention is one of the biggest challenges in treating patients with neurodegenerative *** general,these patients develop strong metabolic alterations,resulting in lower treatment efficacy and higher mortality ***,there are still many open questions regarding the effectiveness of dietary interventions in *** studies have shown that a reduction in calorie intake activates key pathways that might be important for preventing or slowing down the progression of such ***,it is still unclear whether these neuroprotective effects are associated with an overall reduction in calories(hypocaloric diet)or a specific nutrient restriction(diet restriction).Therefore,here we discuss how commonly or differently hypocaloric and restricted diets modulate signaling pathways and how these changes can protect the brain against neurodegenerative diseases.

关键词： Alzheimer’s disease diet therapy dietary intervention epilepsy fasting glucose restriction hypocaloric diet multiple sclerosis Parkinson’s disease stroke

Long-term assist device patients admitted to ICU: Tips and pitfalls

在线全文

学校读者我要写书评

暂无评论

Journal of Intensive Medicine 2023年第2期3卷 81-88页

作者： Michiel Morshuis Hendrik Fox Volker Lauenroth Rene Schramm Heart and Diabetes Center North Rhine-Westphalia Bad Oeynhausen 32545Germany

Left ventricular assist device(LVAD)therapy is well-established in the treatment of end-stage cardiac *** are bridge to transplant(BTT),bridge to candidacy(BTC),bridge to recovery(BTR),and destination therapy(DT).The durability and adverse event(AE)rate of LVADs have improved over the ***,due to donor shortage,the duration of support in the BTT population has increased tremendously;similarly,DT patients are on the device for a long ***,the number of readmissions of long-term LVAD patients has *** cases of severe AEs,intensive care unit(ICU)treatment can be *** complications are the most common ***,embolic or hemorrhagic strokes can occur due to foreign surfaces,acquired von Willebrand syndrome,and anticoagulation *** consequence of the coagulative status,in combination with the continuous flow,are gastrointestinal bleeding ***,in most patients,an isolated LVAD is implanted,and this involves the risk of late right heart *** of pump speed and optimization of the volume status can help solve this *** arrhythmias,pre-existing or de novo after LVAD implantation,can be a life-threatening *** medical therapy or ablation are potential treatment *** for specific LVADs,the Medtronic HeartWare TM ventricular assist device(HVAD)is not manufactured and distributed currently;however,4000 patients are still on the *** thrombosis can occur,wherein thrombolytic therapy is the first-line treatment ***,the HVAD can fail to restart after controller exchange due to technical issues,and precautions must be *** Momentum 3 trial showed superior survival without pump exchange or disabling stroke in patients treated with the HeartMate 3■(HM3;Abbott,Abbott Park,IL,USA)device in comparison to the HeartMate II(HMII).However,in a few cases,a twisted graft or bio debris formation between the outflow graft and bend reli

关键词： Heart failure Left ventricular assist device(LVAD)therapy Adverse events

Patients ≥ 75 years with acute coronary syndrome but without critical epicardial coronary disease： prevalence, characteristics, and outcome

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2015年第1期12卷 11-16页

作者： Vincent Wong Ahmed Farah Hubertus von Korn Nedim Memisevic Stefan Richter KetevanTukhiashvili Bernward Lauer Marc-Alexander Ohlow Cardiology Clinic Zentralklinik Bad Berka Robert-Koch-Allee 9 99437 Bad Berka Germany

重要 epicardial 的 ObjectiveAbsence 在有胸疼痛和心肌的坏死标记的举起的尖锐发作的病人的冠的动脉疾病(CAD ) 偶尔被观察。学习是回顾地与先进 *** 分析如此的病人的临床的特征和结果的这的目的加坏死标记举起与胸疼痛的尖锐发作分... 详细信息

重要 epicardial 的 ObjectiveAbsence 在有胸疼痛和心肌的坏死标记的举起的尖锐发作的病人的冠的动脉疾病(CAD ) 偶尔被观察。学习是回顾地与先进 *** 分析如此的病人的临床的特征和结果的这的目的加坏死标记举起与胸疼痛的尖锐发作分析了 4,311 个病人。没有 angiogram (6.3%) 上的 CAD 的二百和 72 个病人被识别。从他们， 50 (1.2%) 病人 ≥；75 年(组我) 与相比(1 ) 没有 angiogram < 上的 CAD 的 222 个急性冠的症候群(交流) 病人；75 年(组 II ) ，并且(2 ) 610 连续病人 ≥；有经历经皮的冠的干预(组 III ) 的 Non-ST-elevation 心肌的梗塞(NSTEMI ) 的 75 年 .ResultsGroup 我与组 III 病人相比补救了更多的女性(64.0% 对 49.2% ；P <；0.0001 ) ，并且在表示上有更严重的心绞痛的症状[加拿大的心血管的社会(CCS ) 班 I/II， 26.0% 对 49.8% ；P = 0.02 ] 。组我也有的病人降低 troponin 层次(0.62 ±；0.8 ng/mL 对 27 ±；74 ng/mL；P <；0.02 ) ，更低的白血球计数(9.4 ±；3.13 ×；10 9 对 12 ±；5.1 ×；10 9 ；P = 0.001 ) 并且更好保存的左室的功能(56.7%±；14.3% 对 45%±；11% ；P <；0.0001 ) 。没有事件的幸存(心脏的死亡，心肌的梗塞，周期性的咽峡炎，和 re-hospitalisation ) 在组是更经常的我和与组 III 病人相比的 II 病人(64.9% ， 66.7% ，和 41.6% 分别地；P <；0.0001 ) 在病人 ≥ 的 .ConclusionsACS；没有 CAD 的 75 年是很很少发生的，与联系了一(1 ) 与交流病人 < 相比的类似的结果；没有 CAD 的 75 年，并且(2 ) 与 NSTEMI 病人 ≥ 相比的重要更好的结果；75 年。

关键词：急性冠脉综合征冠状动脉疾病患者外膜患病率特征和心肌梗死血管造影

Influence of Ca addition on the dynamic and static recrystallization behavior of direct extruded flat profiles of Mg-Y-Zn alloy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2023年第10期11卷 3736-3748页

作者： Maria Nienaber Jan Bohlen Sangbong Yi Gerrit Kurz Karl Ulrich Kainer Dietmar Letzig Institute of Material and Process Design Helmholtz-Zentrum Hereon GmbHMax-Planck-Str.1Geesthacht 21502Germany Agnes-Miegel Str.11Bad Essen 49152Germany

This paper investigates the influence of addition of Ca in a Y-Zn-containing magnesium alloy on the dynamic and static recrystallization behaviors and reveals the formation mechanism of the quadrupole texture during thermomechanical processing. Direct extrusion of flat bands has been conducted at various process conditions to study the difference between the two alloys WZ10 and WZX100 in terms of microstructure and texture development. It can be shown that, Ca addition promotes the DRX of WZ10 alloy. During additional heat treatment,the absence of Y segregation at the grain boundaries and the associated lack of solute drag to the boundary mobility leads to a pronounced grain growth during SRX in WZX100 alloy. Furthermore, it is shown that the addition of Ca to Y-Zn is not beneficial in terms of *** is demonstrated that alloying elements can have different effects depending on the recrystallization mechanisms. Partially recrystallized microstructure is a prerequisite at the as-extruded status to form the quadrupole texture and during subsequent annealing, which stands for high formability.

关键词： Extrusion Recrystallization Magnesium alloy Mg-Y-Zn-Ca alloy Formability quadrupole texture

Clinical profile of patients with advanced age and inflammatoric dilated cardiomyopathy on endomyocardial biopsy

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2015年第6期12卷 605-612页

作者： Marc-Alexander Ohlow Ting-Hui Chen Andreas Schmidt Joerg Saenger Bemward Lauer Department of Cardiology Zentralklinik Bad Berka Germany Institute of Pathology Zentralklinik Bad Berka Germany

当有 inflammatoric 心肌症(DCMi ) 的病人被评估时， BackgroundEndomyocardial 活体检视(EMB ) 是一个重要工具。我们试图在经历 EMB 的 DCMi 的临床的怀疑地从 2007 年 1 月就医到 2011 年 12 月的所有连续病人的 *** 学习上与 DCMi... 详细信息

当有 inflammatoric 心肌症(DCMi ) 的病人被评估时， BackgroundEndomyocardial 活体检视(EMB ) 是一个重要工具。我们试图在经历 EMB 的 DCMi 的临床的怀疑地从 2007 年 1 月就医到 2011 年 12 月的所有连续病人的 *** 学习上与 DCMi 估计老病人的临床的侧面。有 EMB 上的 DCMi 的证据的病人(组 1 ≥；70 年， n = 85；组织 3 <；70 年；n = 418 ) 没有 DCMi 的证据，与一样的年龄组的病人相比(组 2 ≥；70 年， n = 45；组织 4 <；70 年；n = 147 ) 24,275 个病人在学习时期期间在我们的机构对待的 .ResultsAmong， 695 有 DCMi 的临床的怀疑并且经历了 EMB；503 (2.1%) 病人们在 EMB 上有 DCMi。在组 1 有更多的男病人，吝啬的年龄是 74 ±；2.8 年，吝啬的喷射部分是 38%±；14% 。在表示上，血液动力学的妥协(NYHA 功能的班 III/IV，低心脏的产量 / 索引，和低心脏的力量索引) 的符号在组 1 是更经常的。EMB 在 78% 病人，揭示了病毒的染色体 parvovirus B19 (PVB ) 经常在两个年龄组被遇到(组 1：69.4% 对组 2：59.6%) ；超过一个病毒的染色体的察觉在组 1 是更经常的(21.2% 对 11.2% ；P = 0.02 ) 而有免疫力的反应的程度在有先进 *** 病人 ≥ 的个人是显著地更低的；有血液动力学的妥协的 EMB 符号上的 DCMi 的 70 年，和有免疫力的反应的全面更低的程度的多重病毒的染色体的察觉更经常被观察。

关键词：临床资料心肌病心内膜患者活检病毒基因组血流动力学平均年龄

Coarctation of aorta with complete aortic occlusion

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2013年第4期10卷 383-385页

作者： Marc-Alexander Ohlow Bernward Lauer Department of Cardiology Zentralklinik Bad Berka Robert-Koch-Allee 999437 Bad Berka Germany

Survival to advanced age is exceptional in patients with unrepaired aortic *** report the case of an 81-year-old man with aortic coarctation and total occlusion who was othersise *** was suspected when a femoral-radial pulse delay was noted during his routine physical examination.A 70-mmHg systolic blood pressure gradient between the upper and lower extremities was detected.

关键词： Aortic occlusion Coarctation of the aorta Congenital heart disease

Predictors of long-term outcome in patients with biopsy proven inflammatory cardiomyopathy

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2018年第5期15卷 363-371页

作者： Ohlow Marc-Alexander Michel Christoph Ting-Hui Chen Schmidt Andreas Saenger Joerg Lauer Bernward Brunelli Michele Department of Cardiology Zentralklinik Bad Berka Germany Institute of Pathology Zentralklinik Bad Berka Germany Department of Cardiology Staedtisehes Klinikum Magdeburg Germany

这研究客观的 BackgroundThe 是在 endomyocardial 上与煽动性的心肌症(iCM ) 在病人识别预示的指示物活体检视(EMB ).Methods 和 resultsBetween 2007 和 2011 个所有连续病人与在 EMB 与 iCM 诊断了回顾地被分析。联合主要端点(EP )(1... 详细信息

这研究客观的 BackgroundThe 是在 endomyocardial 上与煽动性的心肌症(iCM ) 在病人识别预示的指示物活体检视(EMB ).Methods 和 resultsBetween 2007 和 2011 个所有连续病人与在 EMB 与 iCM 诊断了回顾地被分析。联合主要端点(EP )(1 ????? 呓？？

关键词：预言检视活体心肌证明免疫组织化学持续时间风险因素